Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela
Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR...
- Autores:
-
Bermúdez, Valmore
Salazar, Juan
Fuenmayor, Jorge
Nava, Manuel
Ortega, Ángel
Duran, Pablo
Rojas, Milagros
Añez, Roberto
Rivas-Montenegro, Alejandra
Angarita, Lissé
Chacín, Maricarmen
Cano, Clímaco
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/8389
- Palabra clave:
- Insulin resistance
Hyperinsulinemia
Metabolic syndrome
Homeostatic model assessment
Diabetes
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| spellingShingle |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela Insulin resistance Hyperinsulinemia Metabolic syndrome Homeostatic model assessment Diabetes |
| title_short |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_full |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_fullStr |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_full_unstemmed |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| title_sort |
Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela |
| dc.creator.fl_str_mv |
Bermúdez, Valmore Salazar, Juan Fuenmayor, Jorge Nava, Manuel Ortega, Ángel Duran, Pablo Rojas, Milagros Añez, Roberto Rivas-Montenegro, Alejandra Angarita, Lissé Chacín, Maricarmen Cano, Clímaco |
| dc.contributor.author.none.fl_str_mv |
Bermúdez, Valmore Salazar, Juan Fuenmayor, Jorge Nava, Manuel Ortega, Ángel Duran, Pablo Rojas, Milagros Añez, Roberto Rivas-Montenegro, Alejandra Angarita, Lissé Chacín, Maricarmen Cano, Clímaco |
| dc.subject.eng.fl_str_mv |
Insulin resistance Hyperinsulinemia Metabolic syndrome Homeostatic model assessment Diabetes |
| topic |
Insulin resistance Hyperinsulinemia Metabolic syndrome Homeostatic model assessment Diabetes |
| description |
Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables. Results. 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665–0.714) and 0.645 (0.619–0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37–2.65; ) and 3rd (OR: 5.40; 95% CI: 3.48–8.39; ) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR). Conclusion. Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR. |
| publishDate |
2021 |
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2021-09-15T14:59:29Z |
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2021-09-15T14:59:29Z |
| dc.date.issued.none.fl_str_mv |
2021 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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Artículo científico |
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20900716 |
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https://hdl.handle.net/20.500.12442/8389 |
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https://doi.org/10.1155/2021/5514901 |
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20900716 |
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https://hdl.handle.net/20.500.12442/8389 https://doi.org/10.1155/2021/5514901 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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pdf |
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Hindawi |
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Journal of Obesity |
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Vol. 2021 |
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Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663aSalazar, Juanfbd053e7-5aea-424c-812f-92153ecb9181Fuenmayor, Jorgebfa974a2-892d-464b-9536-e528f4b04931Nava, Manuelf9865b69-841a-4eea-b7da-6a174b033d10Ortega, Ángelb6a809bb-4d26-4e53-9419-e4eb9fb40a9bDuran, Pablo09ab4429-4e0a-42c4-a4e2-27b3560375bcRojas, Milagrosd07a9d4d-cce2-438c-b4a0-fc5ed4af1a67Añez, Roberto0a8ecfdc-a89a-4435-9859-b66bba8947faRivas-Montenegro, Alejandra4646037f-f634-44bd-9688-a2c0dadc854bAngarita, Lissécd37d36e-0d41-457f-9dc8-1ed5b9201b16Chacín, Maricarmen5c3b3d7c-4444-47e2-b2be-11f08df10409Cano, Clímacob7d55d6b-f1bf-4136-9b90-54a80ab90ab22021-09-15T14:59:29Z2021-09-15T14:59:29Z202120900716https://hdl.handle.net/20.500.12442/8389https://doi.org/10.1155/2021/5514901Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables. Results. 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665–0.714) and 0.645 (0.619–0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37–2.65; ) and 3rd (OR: 5.40; 95% CI: 3.48–8.39; ) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR). Conclusion. Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR.pdfengHindawiAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Journal of ObesityVol. 2021Insulin resistanceHyperinsulinemiaMetabolic syndromeHomeostatic model assessmentDiabetesLipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuelainfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1J. Rojas, V. Berm´udez, E. Leal et al., “Insulinorresistencia e hiperinsulinemia como factores de riesgo para enfermedad cardiovascular,” International Journal of Diabetes in Developing Countries, vol. 2, no. 3, pp. 53–64, 2012R. Liu, K. K. 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