Car T Cells in Solid Tumors: Overcoming Obstacles
Chimeric antigen receptor T cell (CAR T cell) therapy has emerged as a prominent adoptive cell therapy and a therapeutic approach of great interest in the fight against cancer. This approach has shown notorious efficacy in refractory hematological neoplasm, which has bolstered its exploration in the...
- Autores:
-
Rojas-Quintero, Joselyn Joanna
Diaz, Maria del Pilar
Palmar, Jim
Galan, Nataly
Morillo, Valery
Escalona, Daniel
González-Torres, Henry Joseth
Torres, Wheeler
Navarro Quiroz, Elkin
Rivera-Porras, Diego
Bermudez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/16206
- Palabra clave:
- Cancer
Immunotherapy
Solid tumors
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivs 3.0 United States
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Car T Cells in Solid Tumors: Overcoming Obstacles |
| title |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| spellingShingle |
Car T Cells in Solid Tumors: Overcoming Obstacles Cancer Immunotherapy Solid tumors |
| title_short |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| title_full |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| title_fullStr |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| title_full_unstemmed |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| title_sort |
Car T Cells in Solid Tumors: Overcoming Obstacles |
| dc.creator.fl_str_mv |
Rojas-Quintero, Joselyn Joanna Diaz, Maria del Pilar Palmar, Jim Galan, Nataly Morillo, Valery Escalona, Daniel González-Torres, Henry Joseth Torres, Wheeler Navarro Quiroz, Elkin Rivera-Porras, Diego Bermudez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Rojas-Quintero, Joselyn Joanna Diaz, Maria del Pilar Palmar, Jim Galan, Nataly Morillo, Valery Escalona, Daniel González-Torres, Henry Joseth Torres, Wheeler Navarro Quiroz, Elkin Rivera-Porras, Diego Bermudez, Valmore |
| dc.subject.keywords.eng.fl_str_mv |
Cancer Immunotherapy Solid tumors |
| topic |
Cancer Immunotherapy Solid tumors |
| description |
Chimeric antigen receptor T cell (CAR T cell) therapy has emerged as a prominent adoptive cell therapy and a therapeutic approach of great interest in the fight against cancer. This approach has shown notorious efficacy in refractory hematological neoplasm, which has bolstered its exploration in the field of solid cancers. However, successfully managing solid tumors presents considerable intrinsic challenges, which include the necessity of guiding the modified cells toward the tumoral region, assuring their penetration and survival in adverse microenvironments, and addressing the complexity of identifying the specific antigens for each type of cancer. This review focuses on outlining the challenges faced by CAR T cell therapy when used in the treatment of solid tumors, as well as presenting optimizations and emergent approaches directed at improving its efficacy in this particular context. From precise localization to the modulation of the tumoral microenvironment and the adaptation of antigen recognition strategies, diverse pathways will be examined to overcome the current limitations and buttress the therapeutic potential of CAR T cells in the fight against solid tumors. |
| publishDate |
2024 |
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2024 |
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2025-02-04T15:43:13Z |
| dc.date.available.none.fl_str_mv |
2025-02-04T15:43:13Z |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
Rojas-Quintero, J.; Díaz, M.P.; Palmar, J.; Galan-Freyle, N.J.; Morillo, V.; Escalona, D.; González-Torres, H.J.; Torres, W.; Navarro-Quiroz, E.; Rivera-Porras, D.; et al. Car T Cells in Solid Tumors: Overcoming Obstacles. Int. J. Mol. Sci. 2024, 25, 4170. https://doi.org/ 10.3390/ijms25084170 |
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14220067 |
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https://hdl.handle.net/20.500.12442/16206 |
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https://doi.org/10.3390/ijms25084170 |
| identifier_str_mv |
Rojas-Quintero, J.; Díaz, M.P.; Palmar, J.; Galan-Freyle, N.J.; Morillo, V.; Escalona, D.; González-Torres, H.J.; Torres, W.; Navarro-Quiroz, E.; Rivera-Porras, D.; et al. Car T Cells in Solid Tumors: Overcoming Obstacles. Int. J. Mol. Sci. 2024, 25, 4170. https://doi.org/ 10.3390/ijms25084170 14220067 |
| url |
https://hdl.handle.net/20.500.12442/16206 https://doi.org/10.3390/ijms25084170 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivs 3.0 United States |
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Attribution-NonCommercial-NoDerivs 3.0 United States http://creativecommons.org/licenses/by-nc-nd/3.0/us/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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MDPI |
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International Journal of Molecular Sciences |
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Vol. 25, Issue 8 (2024) |
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Universidad Simón Bolívar |
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Rojas-Quintero, Joselyn Joannad2320328-d7ac-4289-aa3a-5598c747b3fc600Diaz, Maria del Pilar70dc2c48-1446-47bc-8d12-9bc7e1ffb8b6600Palmar, Jim 29f758ae-176d-4a3c-858e-3479c54f770b600Galan, Nataly8649b6ec-1f17-4821-900a-0209149e74b1600Morillo, Valeryecf6eba9-3780-4d53-b4c4-69646fafd1ba600Escalona, Daniel55f2efef-1016-4092-9149-764d5e80704f600González-Torres, Henry Josetha06ebdd2-9fe7-4e06-b73d-bf1779e34c24600Torres, Wheeler0fef2900-592c-46c6-97c8-bee750bf3ddf600Navarro Quiroz, Elkin07248f7d-1833-4915-a1d0-d57ca6fb587f600Rivera-Porras, Diego1a1d9bdd-12a0-4df5-875b-cd0c71ccd676600Bermudez, Valmore461a7322-8e98-4067-a797-5ede7544d2d36002025-02-04T15:43:13Z2025-02-04T15:43:13Z2024Rojas-Quintero, J.; Díaz, M.P.; Palmar, J.; Galan-Freyle, N.J.; Morillo, V.; Escalona, D.; González-Torres, H.J.; Torres, W.; Navarro-Quiroz, E.; Rivera-Porras, D.; et al. Car T Cells in Solid Tumors: Overcoming Obstacles. Int. J. Mol. Sci. 2024, 25, 4170. https://doi.org/ 10.3390/ijms2508417014220067https://hdl.handle.net/20.500.12442/16206https://doi.org/10.3390/ijms25084170Chimeric antigen receptor T cell (CAR T cell) therapy has emerged as a prominent adoptive cell therapy and a therapeutic approach of great interest in the fight against cancer. This approach has shown notorious efficacy in refractory hematological neoplasm, which has bolstered its exploration in the field of solid cancers. However, successfully managing solid tumors presents considerable intrinsic challenges, which include the necessity of guiding the modified cells toward the tumoral region, assuring their penetration and survival in adverse microenvironments, and addressing the complexity of identifying the specific antigens for each type of cancer. This review focuses on outlining the challenges faced by CAR T cell therapy when used in the treatment of solid tumors, as well as presenting optimizations and emergent approaches directed at improving its efficacy in this particular context. From precise localization to the modulation of the tumoral microenvironment and the adaptation of antigen recognition strategies, diverse pathways will be examined to overcome the current limitations and buttress the therapeutic potential of CAR T cells in the fight against solid tumors.pdfengMDPIAttribution-NonCommercial-NoDerivs 3.0 United Stateshttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 25, Issue 8 (2024)Car T Cells in Solid Tumors: Overcoming Obstaclesinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1CancerImmunotherapySolid tumorsAlmåsbak, H.; Aarvak, T.; Vemuri, M.C. CAR T Cell Therapy: A Game Changer in Cancer Treatment. J. Immunol. Res. 2016, 2016, 5474602.Palucka, A.K.; Coussens, L.M. The Basis of Oncoimmunology. 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