Avances investigativos en nefritis lúpica

El lupus eritematoso sistémico (LES) es una enfermedad autoinmune recurrente-remitente caracterizada por la pérdida de tolerancia a los ácidos nucleicos y manifestaciones clínicas muy diversas. la heterogeneidad clínica, junto con la posible gravedad de estas manifestaciones, hacen que el tratamient...

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Autores:: Aroca Martínez, Gustavo
Vélez-Verbel, María D.
González-Torres, Henry J.
De La Cruz, Fernando
Navarro Quiroz, Roberto
Navarro Quiroz, Elkin
Pacheco Lugo, Lisandro
Arrieta Bravo, Valentina
Díaz Olmos, Yirys
Gómez Escorcia, Lorena
Acosta-Hoyos, Antonio J.

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad Simón Bolívar

Repositorio:: Repositorio Digital USB

Idioma:: spa

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dc.title.spa.fl_str_mv	Avances investigativos en nefritis lúpica
title	Avances investigativos en nefritis lúpica
spellingShingle	Avances investigativos en nefritis lúpica Nefrología Riñones Lupus Eritematoso Insuficiencia renal crónica
title_short	Avances investigativos en nefritis lúpica
title_full	Avances investigativos en nefritis lúpica
title_fullStr	Avances investigativos en nefritis lúpica
title_full_unstemmed	Avances investigativos en nefritis lúpica
title_sort	Avances investigativos en nefritis lúpica
dc.creator.fl_str_mv	Aroca Martínez, Gustavo Vélez-Verbel, María D. González-Torres, Henry J. De La Cruz, Fernando Navarro Quiroz, Roberto Navarro Quiroz, Elkin Pacheco Lugo, Lisandro Arrieta Bravo, Valentina Díaz Olmos, Yirys Gómez Escorcia, Lorena Acosta-Hoyos, Antonio J.
dc.contributor.author.none.fl_str_mv	Aroca Martínez, Gustavo Vélez-Verbel, María D. González-Torres, Henry J. De La Cruz, Fernando Navarro Quiroz, Roberto Navarro Quiroz, Elkin Pacheco Lugo, Lisandro Arrieta Bravo, Valentina Díaz Olmos, Yirys Gómez Escorcia, Lorena Acosta-Hoyos, Antonio J.
dc.subject.spa.fl_str_mv	Nefrología Riñones Lupus Eritematoso Insuficiencia renal crónica
topic	Nefrología Riñones Lupus Eritematoso Insuficiencia renal crónica
description	El lupus eritematoso sistémico (LES) es una enfermedad autoinmune recurrente-remitente caracterizada por la pérdida de tolerancia a los ácidos nucleicos y manifestaciones clínicas muy diversas. la heterogeneidad clínica, junto con la posible gravedad de estas manifestaciones, hacen que el tratamiento del LES sea un desafío distinto. A pesar de los avances recientes en los protocolos de tratamiento, varios estudios han señalado que los pacientes con LES todavía tienen un riesgo general de muertes de 2 a 3 veces mayor. Adicionalmente, existe grandes desafíos a nivel diagnóstico y la búsqueda de biomarcadores que permitan una rápida detención de afecciones como la real. El libro Avances Investigativos en Nefritis Lúpica compila conocimientos recientes sobre la base genética, molecular de la nefritis lúpica, nuevos biomarcadores diagnóstico, su potencial uso y el rol de las infecciones en esta enfermedad.
publishDate	2020
dc.date.issued.none.fl_str_mv	2020
dc.date.accessioned.none.fl_str_mv	2022-04-29T19:58:34Z
dc.date.available.none.fl_str_mv	2022-04-29T19:58:34Z
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dc.identifier.citation.spa.fl_str_mv	Aroca Martínez, G. y Navarro Quiroz, E. (Edit.) (2020). Avance investigativos en nefritis lúpica. Barranquilla: Ediciones Universidad Simón Bolívar.
dc.identifier.isbn.none.fl_str_mv	9789585318410
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12442/9611
identifier_str_mv	Aroca Martínez, G. y Navarro Quiroz, E. (Edit.) (2020). Avance investigativos en nefritis lúpica. Barranquilla: Ediciones Universidad Simón Bolívar. 9789585318410
url	https://hdl.handle.net/20.500.12442/9611
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dc.publisher.spa.fl_str_mv	Ediciones Universidad Simón Bolívar
institution	Universidad Simón Bolívar
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spelling	Aroca Martínez, Gustavod6bf7d66-bf9b-492a-be14-677f6ecdad05Vélez-Verbel, María D.e76666c2-0cb9-46f3-a966-798a72430c82González-Torres, Henry J.b2b56f8b-392d-4598-87b4-b87427fdebe8De La Cruz, Fernando56218414-b601-456a-846d-a38633cba18dNavarro Quiroz, Roberto1246844f-5707-438a-808b-1f8c2761977eNavarro Quiroz, Elkind586f4e1-e86b-4364-8aa2-1b1dc7c1bb5ePacheco Lugo, Lisandro51b70dab-9baa-4f8f-afc1-f2b44b87c346Arrieta Bravo, Valentinac77f6fb8-d969-46a9-a6d5-a26a7f050fbeDíaz Olmos, Yirys2aa28cc2-129e-4b9a-aa82-5898abcd4966Gómez Escorcia, Lorena0f8da4a7-1326-4e31-9e08-4432548de4e7Acosta-Hoyos, Antonio J.6b712d95-7eef-4f3a-ba0b-6647f66d07492022-04-29T19:58:34Z2022-04-29T19:58:34Z2020Aroca Martínez, G. y Navarro Quiroz, E. (Edit.) (2020). Avance investigativos en nefritis lúpica. Barranquilla: Ediciones Universidad Simón Bolívar.9789585318410https://hdl.handle.net/20.500.12442/9611El lupus eritematoso sistémico (LES) es una enfermedad autoinmune recurrente-remitente caracterizada por la pérdida de tolerancia a los ácidos nucleicos y manifestaciones clínicas muy diversas. la heterogeneidad clínica, junto con la posible gravedad de estas manifestaciones, hacen que el tratamiento del LES sea un desafío distinto. A pesar de los avances recientes en los protocolos de tratamiento, varios estudios han señalado que los pacientes con LES todavía tienen un riesgo general de muertes de 2 a 3 veces mayor. Adicionalmente, existe grandes desafíos a nivel diagnóstico y la búsqueda de biomarcadores que permitan una rápida detención de afecciones como la real. El libro Avances Investigativos en Nefritis Lúpica compila conocimientos recientes sobre la base genética, molecular de la nefritis lúpica, nuevos biomarcadores diagnóstico, su potencial uso y el rol de las infecciones en esta enfermedad.pdfspaEdiciones Universidad Simón BolívarAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2NefrologíaRiñonesLupus EritematosoInsuficiencia renal crónicaAvances investigativos en nefritis lúpicainfo:eu-repo/semantics/bookLibrohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2f33Silvariño DR, Ottati G, Noboa Ó. Nefropatía lúpica. Rev medica del Uruguay. 2015;31(1):64-78.Pinto P L, Velásquez F C, Márquez H J. Subgrupos de Lupus Eritematoso Sistémico: influencia de la edad de inicio, la raza, el sexo y el perfil de anticuerpos en las manifestaciones clínicas de la enfermedad. Rev Colomb Reumatol. 2008;15(4):291–8.Aroca-Martínez G. Propuesta de un modelo de gestion de salud de la nefritis lupica. Universida. 2017. 43 p.Arroyo A, García R, Aroca G, Cadena A, Acosta J. Correlación clínica e inmunohistopatológica de la nefropatía lúpica en un centro de referencia del Caribe colombiano durante los años 2012 a 2013. Rev Colomb Nefrol. 2014;Naranjo LAG, Duque GMV, Uribe OU, Gómez LAR. Nefropatía lúpica. Presentación clínica, clasificación y tratamiento. Rev Colomb Reumatol. 2006;13(4):307–33.Alba P. Factores pronósticos en nefritis lúpica. Rev Arg Reum. 2014;25(3):6–7.Roverano S, Schmid M, Paira S. Recaída en nefritis lúpica: factores de riesgo e impacto en el pronóstico en una población de Santa Fe - Argentina. Rev Argent Reumatol. 2014;25(2):30–4.Rivera F. Micofenolato en nefritis lupica. NefroPlus. 2009;2(3):1–60.Baltar JM, Marín R, Ortega F. Ciclofosfamida en glomerulonefritis primarias y secundarias. NefroPlus [Internet]. 2010;3:9–15. Available from: http://www.elsevier.es/es-revista- nefroplus-48 5-pdf-X1888970010000603-S300Restrepo Valencia CA, Vélez Álvarez C. Experiencia en la utilización de inhibidores de calcineurin a bajas dosis en el tratamiento de nefritis lúpica refractaria. Rev Colomb Nefrol. 2014;1(2):80–91.Garavito de Egea, G., Egea Bermejo, E. A., Malagón, C., Fang Mercado, L., Olmos, C., González, L., … Iglesias, A. (2016). Estudio de Variantes Moleculares de los Genes PTPN22, TNF Y VDR en Madres de Niños con Nefritis Lúpica y su Asociación como Factores de Riesgo. Revista Medicina, 38(1), 113.Martha Ramírez de Olano, Gerardo Quintana, A. I. G. (2012). Asociación entre manifestaciones clínicas de enfermedades autoinmunes con los polimorfismos de PTPN22, STAT4, CTLA-4 en población colombiana. Iatreia Revista Médica Universidad de Antioquia, Vol. 23(Núm. 4-S).Anaya JM, Uribe M, Pinto LF, Matute G, Molina JF, Calle I. Nefritis Lúpica. Definición clínica, patológica y terapéutica. Rev Colomb Reumatol 2001; 8: 61-74Rivas-Larrauri F, Yamazaki-Nakashimada MA. Lupus eritematoso sistémico: ¿es una sola enfermedad? Reumatol Clin. 2016;12(5):274–81.Pons-Estel GJ, Ugarte-Gil MF, Alarcon GS. Epidemiology of systemic lupus erythematosus. Expert Rev Clin Immunol. 2017 Aug;13(8):799–814.Gaviria-garcia G, Zarza M De, Aroca-martinez G. Artículo Original / Original Article Características sociodemográficas y clínicas de pacientes Sociodemographic and clinical characteristics of patients with lupus nephritis . Barranquilla , Colombia. 2018;16(2):32–7.Koutsokeras T, Healy T. Systemic lupus erythematosus and lupus nephritis. Natures Rev Drug Discov. 2014;13(3):173-4.Gurevitz SL, Snyder JA, Wessel EK, Frey J, Williamson BA. Systemic lupus erythematosus: A review of the disease and treatment options. Consult Pharm. 2013;28(2):110-21.Zubair A, Frieri M. Lupus nephritis: Review of the LITERATURE. Curr Allergy Asthma Rep. 2013;13(6):580-6.Yap DYH, Yung S, Chan TAKMAO. Lupus nephritis: An update on treatments and pathogenesis. Nephrology. 2018;23:80-3.Yu F, Haas M, Glassock R, Zhao MH. Redefining lupus nephritis: Clinical implications of pathophysiologic subtypes. Nat Rev Nephrol. 2017;13(8):483–95.Mohan C, Putterman C. Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol [Internet]. 2015;11(6):329–41. Available from: http://dx.doi. org/10.1038/nrneph.2015.33Rees F, Doherty M, Grainge M, Davenport G, Lanyon P, Zhang W. The incidence and prevalence of systemic lupus erythematosus in the UK, 1999-2012. Ann Rheum Dis. 2016;75(1):136– 41.Pons-Estel GJ, Ugarte-Gil MF, Alarcón GS. Epidemiology of systemic lupus erythematosus. Expert Rev Clin Immunol. 2017 Aug;13(8):799–814.Hahn BH, McMahon MA, Wilkinson A, Wallace WD, Daikh DI, Fitzgerald JD, et al. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res. 2012;64(6):797–808.HM B, JM R, Jr MG, GS A, AW F, BJ F, et al. Systemic lupus erythematosus in three ethnic groups. XII. Risk factors for lupus nephritis after diagnosis. Lupus. 2002;11(3):152–60.Anaya JM, Cañas C, Mantilla RD, Pineda-Tamayo R, Tobón GJ, Herrera-Diaz C, et al. Lupus nephritis in colombians: Contrasts and comparisons with other populations. Clin Rev Allergy Immunol. 2011;40(3):199–207.Cervera R, Khamashta M a, Font J, Sebastiani GD, Gil A, Lavilla P, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003;82(5):299–308.Davidson A. What is damaging the kidney in lupus nephritis? Nat Rev Rheumatol. 2016;12(3):143–53.Lech M, Anders H-J. The Pathogenesis of Lupus Nephritis. J Am Soc Nephrol [Internet]. 2013;24(9):1357–66. Available from: http://www.jasn.org/lookup/doi/10.1681/ ASN.2013010026Petri M, Orbai A-M, Alarcón GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012 Aug;64(8):2677–86.Peñaranda LFP. Nefropatía lúpica. Rev Colomb Nefrol. 2014;2(1):104–17.Ruiz-Irastorza G, Espinosa G, Frutos MA, Jiménez-Alonso J, Praga M, Pallarés L, et al. Diagnosis and treatment of Lupus nephritis: Consensus document from the systemic auto-immune disease group (GEAS) of the Spanish society of internal medicine (SEMI) and the Spanish society of nephrology (S.E.N.). Nefrologia. 2012;32(SUPPL. 1):1–45.Seshan S V., Jennette JC. Renal disease in systemic lupus erythematosus with emphasis on classification of lupus glomerulonephritis advances and implications. Arch Pathol Lab Med. 2009;133(2):233–48.Mittal B, Rennke H, Singh AK. The role of kidney biopsy in the management of lupus nephritis. Curr Opin Nephrol Hypertens. 2005;14(1):1–8.Greloni G, Scolnik M, Marin J, Lancioni E, Quiroz C, Zacariaz J, et al. Value of repeat biopsy in lupus nephritis flares. Lupus Sci Med. 2014;1(1):1–6.Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, et al. Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices. Kidney Int. 2018;93(4):789–96.Wakasugi D, Gono T, Kawaguchi Y, Hara M, Koseki Y, Katsumata Y, et al. Frequency of class III and IV nephritis in systemic lupus erythematosus without clinical renal involvement: An analysis of predictive measures. J Rheumatol. 2012;39(1):79–85.Appel GB, Mahmood N, Mahmood F, Shumi SI, Siddiqui MMR. Mycophenolate Mofetil versus Cyclophosphamide for Induction Treatment of Lupus Nephritis. Anwer Khan Mod Med Coll J. 2018 Mar 1;9(1):63–7.Liang MH, Schur PH, Fortin P, St.Clair EW, Balow JE, Costenbader K, et al. The American College of Rheumatology response criteria for proliferative and membranous renal disease in systemic lupus erythematosus clinical trials. Arthritis Rheum. 2006;54(2):421–32.Gonzalez LA, Molina JF, Vasquez GM. Actualidad en el tratamiento de la nefritis lúpica proliferativa Update on the treatment of proliferative lupus nephritis. RevColombReumatol. 2009;16(1):76–96.Beier UH, Green C, Meyers KE. Caring for adolescent renal patients. Kidney Int [Internet]. 2010;77(4):285–91. Available from: http://dx.doi.org/10.1038/ki.2009.462Rivera F, Romera A, Anaya S, Lm G, Vozmediano C. Nefropatía Lúpica. Nefrol al día [Internet]. 2018; Available from: http:// www.revistanefrologia.com/es-monografias-nefrologia-dia-articulo- nefropatia-lupica-164Mok CC, Cheung TT, Lo WH. Minimal mesangial lupus nephritis: A systematic review. Scand J Rheumatol. 2010;39(3):181–9.Houssiau FA, Vasconcelos C, D’Cruz D, Sebastiani GD, De Ramon Garrido E, Danieli MG, et al. Immunosuppressive therapy in lupus nephritis: The Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum. 2002;46(8):2121–31.Mak A, Cheak AAC, Tan JYS, Su HC, Ho RCM, Lau CS. Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: A meta-analysis and meta-regression. Rheumatology. 2009;48(8):944–52.Austin HA, Illei GG, Braun MJ, Balow JE. Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. J Am Soc Nephrol. 2009;20(4):901–11.Lee SJ, Silverman E, Bargman JM. The role of antimalarial agents in the treatment of SLE and lupus nephritis. Nat Rev Nephrol [Internet]. 2011;7(12):718–29. Available from: http:// dx.doi.org/10.1038/nrneph.2011.150Ruiz-Irastorza G, Ramos-Casals M, Brito-Zeron P, Khamashta MA. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: A systematic review. Ann Rheum Dis. 2010;69(1):20–8.Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, et al. Blood pressure-lowering treatment based on cardiovascular risk: A meta-analysis of individual patient data. Lancet [Internet]. 2014;384(9943):591–8. Available from: http://dx.doi.org/10.1016/S0140-6736(14)61212-5Masood S, Jayne D, Karim Y. Beyond immunosuppression - challenges in the clinical management of lupus nephritis. Lupus. 2009;18(2):106–15.Catapano F, Chiodini P, De Nicola L, Minutolo R, Zamboli P, Gallo C, et al. Antiproteinuric Response to Dual Blockade of the Renin-Angiotensin System in Primary Glomerulonephritis: Meta-analysis and Metaregression. Am J Kidney Dis. 2008;52(3):475–85.Tse KC, Li FK, Tang S, Tang CSO, Lai KN, Chan TM. Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria. Lupus. 2005;14(12):947–52.Gomez Mendez LM, Cascino MD, Katsumoto TR, Brakeman P, Brunetta P, Jayne D, et al. Outcome of participants with nephrotic syndrome in combined clinical trials of lupus nephritis. Lupus Sci Med. 2019;6(1):1–9.Haarhaus ML, Svenungsson E, Gunnarsson I. Ofatumumab treatment in lupus nephritis patients. Clin Kidney J. 2016;9(4):552–5.Narain S, Furie R. Update on clinical trials in systemic lupus erythematosus. Curr Opin Rheumatol. 2016;28(5):477–87.Murphy G, Isenberg DA. New therapies for systemic lupus erythematosus — past imperfect, future tense. Nat Rev Rheumatol [Internet]. 2019;15(7):403–12. Available from: http://dx.doi.org/10.1038/s41584-019-0235-5Furie R, Aroca G, Alvarez A, Fragoso-Loyo H, Santillán EZ, Rovin B, et al. A Phase II Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Obinutuzumab or Placebo in Combination with Mycophenolate Mofetil in Patients with Active Class III or IV Lupus Nephritis. Arthritis Rheumatol. 2018;71(10):i636–7.Furie R, Nicholls K, Cheng TT, Houssiau F, Burgos-Vargas R, Chen S Le, et al. Efficacy and safety of abatacept in lupus nephritis: A twelve-month, randomized, double-blind study. Arthritis Rheumatol. 2014;66(2):379–89.Navarra S V., Guzmán RM, Gallacher AE, Hall S, Levy RA, Jimenez RE, et al. Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: A randomised, placebo-controlled, phase 3 trial. Lancet [Internet]. 2011;377(9767):721–31. Available from: http://dx.doi. org/10.1016/S0140-6736(10)61354-2Furie R, Petri M, Zamani O, Cervera R, Wallace DJ, Tegzová D, et al. 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Universidad Simón 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