Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications
Electroconvulsive therapy (ECT) is based on conducting an electrical current through the brain to stimulate it and trigger generalized convulsion activity with therapeutic ends. Due to the efficient use of ECT during the last years, interest in the molecular bases involved in its mechanism of action...
- Autores:
-
Rojas, Milagros
Ariza, Daniela
Ortega, Ángel
Riaño-Garzón, Manuel E.
Chávez-Castillo, Mervin
Pérez, José Luis
Cudris-Torres, Lorena
Bautista, María Judith
Medina-Ortiz, Oscar
Rojas-Quintero, Joselyn
Bermúdez, Valmore
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/11317
- Palabra clave:
- electroconvulsive therapy
mood disorders
neuroinflammatory diseases
neurogenesis
neurotransmitter agents
hippocampus
refractory depression
schizophrenia
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| title |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| spellingShingle |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications electroconvulsive therapy mood disorders neuroinflammatory diseases neurogenesis neurotransmitter agents hippocampus refractory depression schizophrenia |
| title_short |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| title_full |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| title_fullStr |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| title_full_unstemmed |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| title_sort |
Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications |
| dc.creator.fl_str_mv |
Rojas, Milagros Ariza, Daniela Ortega, Ángel Riaño-Garzón, Manuel E. Chávez-Castillo, Mervin Pérez, José Luis Cudris-Torres, Lorena Bautista, María Judith Medina-Ortiz, Oscar Rojas-Quintero, Joselyn Bermúdez, Valmore |
| dc.contributor.author.none.fl_str_mv |
Rojas, Milagros Ariza, Daniela Ortega, Ángel Riaño-Garzón, Manuel E. Chávez-Castillo, Mervin Pérez, José Luis Cudris-Torres, Lorena Bautista, María Judith Medina-Ortiz, Oscar Rojas-Quintero, Joselyn Bermúdez, Valmore |
| dc.subject.eng.fl_str_mv |
electroconvulsive therapy mood disorders neuroinflammatory diseases neurogenesis neurotransmitter agents hippocampus refractory depression schizophrenia |
| topic |
electroconvulsive therapy mood disorders neuroinflammatory diseases neurogenesis neurotransmitter agents hippocampus refractory depression schizophrenia |
| description |
Electroconvulsive therapy (ECT) is based on conducting an electrical current through the brain to stimulate it and trigger generalized convulsion activity with therapeutic ends. Due to the efficient use of ECT during the last years, interest in the molecular bases involved in its mechanism of action has increased. Therefore, different hypotheses have emerged. In this context, the goal of this review is to describe the neurobiological, endocrine, and immune mechanisms involved in ECT and to detail its clinical efficacy in different psychiatric pathologies. This is a narrative review in which an extensive literature search was performed on the Scopus, Embase, PubMed, ISI Web of Science, and Google Scholar databases from inception to February 2022. The terms “electroconvulsive therapy”, “neurobiological effects of electroconvulsive therapy”, “molecular mechanisms in electroconvulsive therapy”, and “psychiatric disorders” were among the keywords used in the search. The mechanisms of action of ECT include neurobiological function modifications and endocrine and immune changes that take place after ECT. Among these, the decrease in neural network hyperconnectivity, neuroinflammation reduction, neurogenesis promotion, modulation of different monoaminergic systems, and hypothalamus–hypophysis–adrenal and hypothalamus–hypophysis–thyroid axes normalization have been described. The majority of these elements are physiopathological components and therapeutic targets in different mental illnesses. Likewise, the use of ECT has recently expanded, with evidence of its use for other pathologies, such as Parkinson’s disease psychosis, malignant neuroleptic syndrome, post-traumatic stress disorder, and obsessive–compulsive disorder. In conclusion, there is sufficient evidence to support the efficacy of ECT in the treatment of different psychiatric disorders, potentially through immune, endocrine, and neurobiological systems. |
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2022 |
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2022-11-16T13:40:41Z |
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2022-11-16T13:40:41Z |
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2022 |
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Artículo científico |
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Rojas, M., Ariza, D., Ortega, Á., Riaño-Garzón, M. E., Chávez-Castillo, M., Pérez, J. L., Cudris-Torres, L., Bautista, M. J., Medina-Ortiz, O., Rojas-Quintero, J., & Bermúdez, V. (2022). Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications. International Journal of Molecular Sciences, 23(13), 6918. https://doi.org/10.3390/ijms23136918 |
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14220067 |
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https://hdl.handle.net/20.500.12442/11317 |
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https://doi.org/10.3390/ijms23136918 |
| identifier_str_mv |
Rojas, M., Ariza, D., Ortega, Á., Riaño-Garzón, M. E., Chávez-Castillo, M., Pérez, J. L., Cudris-Torres, L., Bautista, M. J., Medina-Ortiz, O., Rojas-Quintero, J., & Bermúdez, V. (2022). Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications. International Journal of Molecular Sciences, 23(13), 6918. https://doi.org/10.3390/ijms23136918 14220067 |
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https://hdl.handle.net/20.500.12442/11317 https://doi.org/10.3390/ijms23136918 |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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pdf |
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International Journal of Molecular Sciences Vol. 23, Issue 13 (2022) |
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Rojas, Milagros3283fd88-1355-4c19-9a5a-47a9e268ad27Ariza, Danielad25a8393-79fc-472e-8dd8-79dbbf383c79Ortega, Ángel8d5202ae-209e-4b41-bcb4-75e934b9d415Riaño-Garzón, Manuel E.1112ed6b-3d02-4b55-9f7a-fd51a24d05bfChávez-Castillo, Mervin912e1d3d-18fb-43af-8edb-826137f74a5aPérez, José Luisb5af26c7-c81e-4332-8e91-8bb1074b94d0Cudris-Torres, Lorenaf795de95-c059-4cdf-9b5e-0f60feec0752Bautista, María Judith9fb93110-ebfa-4e21-bccc-0507ccf7a089Medina-Ortiz, Oscar7c447a42-58e2-4ad4-be32-82d6e7b6a6c5Rojas-Quintero, Joselyn92c4552a-ab55-45b7-90e1-f2c46ff07916Bermúdez, Valmore29f9aa18-16a4-4fd3-8ce5-ed94a0b8663a2022-11-16T13:40:41Z2022-11-16T13:40:41Z2022Rojas, M., Ariza, D., Ortega, Á., Riaño-Garzón, M. E., Chávez-Castillo, M., Pérez, J. L., Cudris-Torres, L., Bautista, M. J., Medina-Ortiz, O., Rojas-Quintero, J., & Bermúdez, V. (2022). Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implications. International Journal of Molecular Sciences, 23(13), 6918. https://doi.org/10.3390/ijms2313691814220067https://hdl.handle.net/20.500.12442/11317https://doi.org/10.3390/ijms23136918Electroconvulsive therapy (ECT) is based on conducting an electrical current through the brain to stimulate it and trigger generalized convulsion activity with therapeutic ends. Due to the efficient use of ECT during the last years, interest in the molecular bases involved in its mechanism of action has increased. Therefore, different hypotheses have emerged. In this context, the goal of this review is to describe the neurobiological, endocrine, and immune mechanisms involved in ECT and to detail its clinical efficacy in different psychiatric pathologies. This is a narrative review in which an extensive literature search was performed on the Scopus, Embase, PubMed, ISI Web of Science, and Google Scholar databases from inception to February 2022. The terms “electroconvulsive therapy”, “neurobiological effects of electroconvulsive therapy”, “molecular mechanisms in electroconvulsive therapy”, and “psychiatric disorders” were among the keywords used in the search. The mechanisms of action of ECT include neurobiological function modifications and endocrine and immune changes that take place after ECT. Among these, the decrease in neural network hyperconnectivity, neuroinflammation reduction, neurogenesis promotion, modulation of different monoaminergic systems, and hypothalamus–hypophysis–adrenal and hypothalamus–hypophysis–thyroid axes normalization have been described. The majority of these elements are physiopathological components and therapeutic targets in different mental illnesses. Likewise, the use of ECT has recently expanded, with evidence of its use for other pathologies, such as Parkinson’s disease psychosis, malignant neuroleptic syndrome, post-traumatic stress disorder, and obsessive–compulsive disorder. In conclusion, there is sufficient evidence to support the efficacy of ECT in the treatment of different psychiatric disorders, potentially through immune, endocrine, and neurobiological systems.pdfengMDPIAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2International Journal of Molecular SciencesVol. 23, Issue 13 (2022)electroconvulsive therapymood disordersneuroinflammatory diseasesneurogenesisneurotransmitter agentshippocampusrefractory depressionschizophreniaElectroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine–Immune Therapeutic Mechanisms and Clinical Implicationsinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Fink, M. Meduna and the Origins of Convulsive Therapy. Am. J. Psychiatry 1984, 141, 1034–1041.Gazdag, G.; Ungvari, G.S.; Czech, H. Mass Killing under the Guise of ECT: The Darkest Chapter in the History of Biological Psychiatry. Hist. Psychiatry 2017, 28, 482–488.Duxbury, A.; Smith, I.; Mair-Edwards, B.; Bennison, G.; Irving, K.; Hodge, S.; Anderson, I.; Weatherhead, S. What Is the Process by Which a Decision to Administer Electroconvulsive Therapy (ECT) or Not Is Made? A Grounded Theory Informed Study of the Multi-Disciplinary Professionals Involved. Soc. Psychiatry Psychiatr. Epidemiol. 2018, 53, 785–793.Chávez, M.E. Propuesta de protocolización para la práctica de la Terapia Electroconvulsiva en el Hospital de Clínicas de la Universidad Nacional de Asunción, Paraguay: Protocol’s proposal for the practice of Electroconvulsive Therapy at Hospital De Clínicas of the National University of Asunción, Paraguay. Med. Clín. Y Soc. 2017, 1, 126–142.Cortez-Vergara, C.; Cruzado, L.; Rojas-Rojas, I.G.; Sánchez-Fernández, M.; Ladd-Huarachi, G. 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