ADHD Endophenotypes in Caribbean Families

Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The geneti...

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Autores:
Cervantes-Henríquez, M. L.
Acosta-López, J. E.
Martínez-Banfi, M. L.
Vélez, J. I.
Mejía-Segura, E.
Lozano-Gutiérrez, S. G.
Sánchez-Rojas, M.
Zurbarán, M. A.
Zurek, E. E.
Arcos-Burgos, M.
Pineda, D. A.
Puentes-Rozo, P. J.
Tipo de recurso:
Fecha de publicación:
2018
Institución:
Universidad Simón Bolívar
Repositorio:
Repositorio Digital USB
Idioma:
eng
OAI Identifier:
oai:bonga.unisimon.edu.co:20.500.12442/2088
Acceso en línea:
http://hdl.handle.net/20.500.12442/2088
Palabra clave:
ADHD
Endophenotypes
Attention
Memory
Genetics
Heritability
Rights
License
Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
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oai_identifier_str oai:bonga.unisimon.edu.co:20.500.12442/2088
network_acronym_str USIMONBOL2
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dc.title.eng.fl_str_mv ADHD Endophenotypes in Caribbean Families
title ADHD Endophenotypes in Caribbean Families
spellingShingle ADHD Endophenotypes in Caribbean Families
ADHD
Endophenotypes
Attention
Memory
Genetics
Heritability
title_short ADHD Endophenotypes in Caribbean Families
title_full ADHD Endophenotypes in Caribbean Families
title_fullStr ADHD Endophenotypes in Caribbean Families
title_full_unstemmed ADHD Endophenotypes in Caribbean Families
title_sort ADHD Endophenotypes in Caribbean Families
dc.creator.fl_str_mv Cervantes-Henríquez, M. L.
Acosta-López, J. E.
Martínez-Banfi, M. L.
Vélez, J. I.
Mejía-Segura, E.
Lozano-Gutiérrez, S. G.
Sánchez-Rojas, M.
Zurbarán, M. A.
Zurek, E. E.
Arcos-Burgos, M.
Pineda, D. A.
Puentes-Rozo, P. J.
dc.contributor.author.none.fl_str_mv Cervantes-Henríquez, M. L.
Acosta-López, J. E.
Martínez-Banfi, M. L.
Vélez, J. I.
Mejía-Segura, E.
Lozano-Gutiérrez, S. G.
Sánchez-Rojas, M.
Zurbarán, M. A.
Zurek, E. E.
Arcos-Burgos, M.
Pineda, D. A.
Puentes-Rozo, P. J.
dc.subject.eng.fl_str_mv ADHD
Endophenotypes
Attention
Memory
Genetics
Heritability
topic ADHD
Endophenotypes
Attention
Memory
Genetics
Heritability
description Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2018-05-09T14:49:05Z
dc.date.available.none.fl_str_mv 2018-05-09T14:49:05Z
dc.date.issued.none.fl_str_mv 2018-03
dc.type.eng.fl_str_mv article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 10870547
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12442/2088
identifier_str_mv 10870547
url http://hdl.handle.net/20.500.12442/2088
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.rights.license.spa.fl_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
rights_invalid_str_mv Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacional
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dc.publisher.eng.fl_str_mv Sage publising
dc.source.eng.fl_str_mv Journal of Attention Disorders
institution Universidad Simón Bolívar
dc.source.uri.eng.fl_str_mv http://journals.sagepub.com/doi/pdf/10.1177/1087054718763741
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spelling Licencia de Creative Commons Reconocimiento-NoComercial-CompartirIgual 4.0 Internacionalhttp://purl.org/coar/access_right/c_abf2Cervantes-Henríquez, M. L.c1f25e55-e364-44ca-8c26-b97fa24c24bc-1Acosta-López, J. E.ff40b394-e47a-47f7-845e-58b2aabcdcda-1Martínez-Banfi, M. L.8babd59b-c451-4731-aad6-1904f94f89d0-1Vélez, J. I.b000bbde-cbc2-4359-b420-2d49843aa62c-1Mejía-Segura, E.16af9fbe-8626-439a-9167-382d40e2cb53-1Lozano-Gutiérrez, S. G.8423c260-f138-41b8-9a50-ce5e849f7e7d-1Sánchez-Rojas, M.095a9d38-010a-42a0-97a9-a93977d3111c-1Zurbarán, M. A.00bf9deb-8aeb-4360-8fd2-0b6dd541c254-1Zurek, E. E.d72a1d7b-2d14-41ec-95d5-7bb82b280fea-1Arcos-Burgos, M.296bdafe-583e-4867-8af4-fa0e6a39f376-1Pineda, D. A.04c55104-9413-41e3-92f7-c1b86600e779-1Puentes-Rozo, P. J.983a42b1-36a0-49b5-904c-098fbb535731-12018-05-09T14:49:05Z2018-05-09T14:49:05Z2018-0310870547http://hdl.handle.net/20.500.12442/2088Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD.engSage publisingJournal of Attention Disordershttp://journals.sagepub.com/doi/pdf/10.1177/1087054718763741ADHDEndophenotypesAttentionMemoryGeneticsHeritabilityADHD Endophenotypes in Caribbean Familiesarticlehttp://purl.org/coar/resource_type/c_6501Acosta, M. T., Arcos-Burgos, M., & Muenke, M. (2004). Attention deficit/hyperactivity disorder (ADHD): Complex phenotype, simple genotype? Genetics in Medicine, 6, 1-15. doi:10.1097/01.GIM.0000110413.07490.0BAcosta, M. T., Velez, J. I., Bustamante, M. L., Balog, J. Z., ArcoBurgos, M., & Muenke, M. (2011). A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. Translational Psychiatry, 1, Article e17Acosta-Lopez, J., Cervantes-Henriquez, M. L., Jiménez-Figueroa, G., Núñez-Barragán, M., Sánchez-Rojas, M., & Puentes Rozo, P. (2013). Uso de una escala comportamental Wender Utah para evaluar en retrospectiva trastorno de atención-hiperactividad en adultos de la ciudad de Barranquilla [Using a Wender Utah behavioral scale to assess with hindsight adults suffering from attention-hyperactivity disorder in the city of Barranquilla]. Revista Universidad Y Salud, 15, 45-61.Acosta-López, J., Cervantes-Henríquez, M. L., Sánchez-Rojas, M., Núñez-Barragán, M., Puentes Rozo, P., Aguirre-Acevedo, D., & Pineda, D. (2010). Alteraciones del Control Inhibitorio Conductual en Niños de 6 A 11 Años Con TDAH Familiar de Barranquilla [Alterations of Inhibitory Control in Children 6-11 years with ADHD from Barranquilla]. Psicogente, 13(24), 274-291.American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). 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