Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study
Background Adiponectin and leptin are pivotal in the regulation of metabolism. Pediatric lupus nephritis (pLN), a manifestation of childhood systemic lupus erythematosus (SLE) affecting the kidneys, is associated with impaired adipokine levels, suggesting a role in pLN pathogenesis. The aim of this...
- Autores:
-
Garavito De Egea, Gloria
Domínguez‑Vargas, Alex
Fang, Luis
Pereira‑Sanandrés, Nicole
Rodríguez, Jonathan
Aroca‑Martinez, Gustavo
Espítatela, Zilac
Malagón, Clara
Iglesias‑Gamarra, Antonio
Moreno‑Woo, Ana
López‑Lluch, Guillermo
Egea, Eduardo
- Tipo de recurso:
- Fecha de publicación:
- 2024
- Institución:
- Universidad Simón Bolívar
- Repositorio:
- Repositorio Digital USB
- Idioma:
- eng
- OAI Identifier:
- oai:bonga.unisimon.edu.co:20.500.12442/14374
- Acceso en línea:
- https://hdl.handle.net/20.500.12442/14374
https://doi.org/10.1186/s43042-024-00507-4
https://jmhg.springeropen.com/articles/10.1186/s43042-024-00507-4
- Palabra clave:
- Pediatric lupus nephritis
Adiponectin
Leptin
MTHFR
FGG
Polymorphism
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| title |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| spellingShingle |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study Pediatric lupus nephritis Adiponectin Leptin MTHFR FGG Polymorphism |
| title_short |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| title_full |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| title_fullStr |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| title_full_unstemmed |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| title_sort |
Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study |
| dc.creator.fl_str_mv |
Garavito De Egea, Gloria Domínguez‑Vargas, Alex Fang, Luis Pereira‑Sanandrés, Nicole Rodríguez, Jonathan Aroca‑Martinez, Gustavo Espítatela, Zilac Malagón, Clara Iglesias‑Gamarra, Antonio Moreno‑Woo, Ana López‑Lluch, Guillermo Egea, Eduardo |
| dc.contributor.author.none.fl_str_mv |
Garavito De Egea, Gloria Domínguez‑Vargas, Alex Fang, Luis Pereira‑Sanandrés, Nicole Rodríguez, Jonathan Aroca‑Martinez, Gustavo Espítatela, Zilac Malagón, Clara Iglesias‑Gamarra, Antonio Moreno‑Woo, Ana López‑Lluch, Guillermo Egea, Eduardo |
| dc.subject.eng.fl_str_mv |
Pediatric lupus nephritis Adiponectin Leptin MTHFR FGG Polymorphism |
| topic |
Pediatric lupus nephritis Adiponectin Leptin MTHFR FGG Polymorphism |
| description |
Background Adiponectin and leptin are pivotal in the regulation of metabolism. Pediatric lupus nephritis (pLN), a manifestation of childhood systemic lupus erythematosus (SLE) affecting the kidneys, is associated with impaired adipokine levels, suggesting a role in pLN pathogenesis. The aim of this study was to explore the potential relationship between specific single-nucleotide polymorphisms (SNPs)—methylenetetrahydrofolate reductase (MTHFR) rs1801131 and fibrinogen gamma chain (FGG) rs2066865—and the serum levels of leptin and adiponectin in patients with pLN. Methods Ninety-eight pLN patients and one hundred controls were enrolled in the study. Serum leptin and adiponectin levels were measured using ELISA. DNA extraction and real-time PCR genotyping were performed for MTHFR rs1801131 and FGG rs2066865 SNPs. Results Compared to healthy controls, pLN patients exhibited significantly greater serum leptin (11.3 vs. 18.2 ng/ mL, p < 0.001) and adiponectin (18.2 vs. 2.7 ug/mL, p < 0.001). Adiponectin levels were positively correlated with proteinuria (p < 0.05), while leptin levels positively correlated with proteinuria, SLE disease activity index-2000 (SLEDAI-2K), and cyclophosphamide usage (all p < 0.05). There was no significant association between MTHFR rs1801131 or FGG rs2066865 SNPs and pLN in either codominant or allelic models (all p > 0.05). However, the AG genotype of FGG gene rs2066865 SNP was significantly associated with high leptin levels (> 15 ng/mL) (p = 0.01). Conclusion Serum adiponectin and leptin levels are associated with pathological manifestations of pLN. High leptin levels are associated with the AG genotype of FGG rs2066865 SNP in pLN patients, suggesting direct involvement in disease progression and potential utility as a disease biomarker. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-03-15T20:31:19Z |
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2024-03-15T20:31:19Z |
| dc.date.issued.none.fl_str_mv |
2024 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Artículo científico |
| dc.identifier.citation.eng.fl_str_mv |
De Egea, G.G., Domínguez-Vargas, A., Fang, L. et al. Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study. Egypt J Med Hum Genet 25, 34 (2024). https://doi.org/10.1186/s43042-024-00507-4 |
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20902441 (electrónico) |
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https://hdl.handle.net/20.500.12442/14374 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1186/s43042-024-00507-4 |
| dc.identifier.url.none.fl_str_mv |
https://jmhg.springeropen.com/articles/10.1186/s43042-024-00507-4 |
| identifier_str_mv |
De Egea, G.G., Domínguez-Vargas, A., Fang, L. et al. Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study. Egypt J Med Hum Genet 25, 34 (2024). https://doi.org/10.1186/s43042-024-00507-4 20902441 (electrónico) |
| url |
https://hdl.handle.net/20.500.12442/14374 https://doi.org/10.1186/s43042-024-00507-4 https://jmhg.springeropen.com/articles/10.1186/s43042-024-00507-4 |
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eng |
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eng |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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pdf |
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Springer Nature |
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Egyptian Journal of Medical Human Genetics |
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Vol. 25 N° 34, (2024) |
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Universidad Simón Bolívar |
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Garavito De Egea, Gloria34fc0524-219a-4a6e-9228-1d16b3fd9729Domínguez‑Vargas, Alex0da310b3-e1d1-48bc-bbcc-6a05320b6269Fang, Luis3961d770-1b6f-4b7f-8d1f-0697a762197bPereira‑Sanandrés, Nicole7fd1c71b-9187-4f25-bd94-312ab6d179ccRodríguez, Jonathaned5e074c-037e-498e-883c-1d85d785336dAroca‑Martinez, Gustavo8af8cd86-1c1c-4521-a728-2cd6e7b33274Espítatela, Zilacbcafc965-ff4f-4189-8e59-d71690ccc0baMalagón, Clarad06dc5ae-3c16-499b-a6f7-d98262f14f76Iglesias‑Gamarra, Antoniof70483bb-4ced-47b5-8f5d-17ffba211bd1Moreno‑Woo, Anac59070d0-aa51-486e-9ba9-41b3b2198249López‑Lluch, Guillermo9c5e2442-2ba7-4415-b071-5239459308c3Egea, Eduardo4f89b318-81b2-4eff-af87-ea8302a1d8672024-03-15T20:31:19Z2024-03-15T20:31:19Z2024De Egea, G.G., Domínguez-Vargas, A., Fang, L. et al. Exploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot study. Egypt J Med Hum Genet 25, 34 (2024). https://doi.org/10.1186/s43042-024-00507-420902441 (electrónico)https://hdl.handle.net/20.500.12442/14374https://doi.org/10.1186/s43042-024-00507-4https://jmhg.springeropen.com/articles/10.1186/s43042-024-00507-4Background Adiponectin and leptin are pivotal in the regulation of metabolism. Pediatric lupus nephritis (pLN), a manifestation of childhood systemic lupus erythematosus (SLE) affecting the kidneys, is associated with impaired adipokine levels, suggesting a role in pLN pathogenesis. The aim of this study was to explore the potential relationship between specific single-nucleotide polymorphisms (SNPs)—methylenetetrahydrofolate reductase (MTHFR) rs1801131 and fibrinogen gamma chain (FGG) rs2066865—and the serum levels of leptin and adiponectin in patients with pLN. Methods Ninety-eight pLN patients and one hundred controls were enrolled in the study. Serum leptin and adiponectin levels were measured using ELISA. DNA extraction and real-time PCR genotyping were performed for MTHFR rs1801131 and FGG rs2066865 SNPs. Results Compared to healthy controls, pLN patients exhibited significantly greater serum leptin (11.3 vs. 18.2 ng/ mL, p < 0.001) and adiponectin (18.2 vs. 2.7 ug/mL, p < 0.001). Adiponectin levels were positively correlated with proteinuria (p < 0.05), while leptin levels positively correlated with proteinuria, SLE disease activity index-2000 (SLEDAI-2K), and cyclophosphamide usage (all p < 0.05). There was no significant association between MTHFR rs1801131 or FGG rs2066865 SNPs and pLN in either codominant or allelic models (all p > 0.05). However, the AG genotype of FGG gene rs2066865 SNP was significantly associated with high leptin levels (> 15 ng/mL) (p = 0.01). Conclusion Serum adiponectin and leptin levels are associated with pathological manifestations of pLN. High leptin levels are associated with the AG genotype of FGG rs2066865 SNP in pLN patients, suggesting direct involvement in disease progression and potential utility as a disease biomarker.pdfengSpringer NatureAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Egyptian Journal of Medical Human GeneticsVol. 25 N° 34, (2024)Pediatric lupus nephritisAdiponectinLeptinMTHFRFGGPolymorphismExploring the interplay of MTHFR and FGG polymorphisms with serum levels of adiponectin and leptin in pediatric lupus nephritis: a pilot studyinfo:eu-repo/semantics/articleArtículo científicohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC (2017) Pathogenesis of human systemic lupus erythematosus: a cellular perspective. Trends Mol Med 23(7):615–635. https://doi.org/10.1016/j.molmed.2017.05.006Valdivielso JM, Rodríguez-Puyol D, Pascual J et al (2019) Atherosclerosis in chronic kidney disease. Arterioscler Thromb Vasc Biol 39(10):1938–1966. https://doi.org/10.1161/ATVBAHA.119.312705Selzer F, Sutton-Tyrrell K, Fitzgerald SG et al (2004) Comparison of risk factors for vascular disease in the carotid artery and aorta in women with systemic lupus erythematosus. Arthritis Rheum 50(1):151–159. https://doi.org/10.1002/art.11418Bruce IN, Urowitz MB, Gladman DD, Ibañez D, Steiner G (2003) Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto risk factor study. Arthritis Rheum 48(11):3159–3167. https://doi.org/10.1002/art.11296Doria A (2003) Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus. 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J Phys Conf Ser 1246(1):012046. https://doi.org/10.1088/1742-6596/1246/1/012046Wisłowska M, Rok M, Stępień K, Kuklo-Kowalska A (2008) Serum leptin in systemic lupus erythematosus. Rheumatol Int 28(5):467–473. https://doi.org/10.1007/s00296-008-0526-7Lee YH, Song GG (2018) Association between circulating leptin levels and systemic lupus erythematosus: an updated meta-analysis. Lupus 27(3):428–435. https://doi.org/10.1177/0961203317725587McMahon M, Skaggs BJ, Sahakian L et al (2011) High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis 70(9):1619–1624. https://doi.org/10.1136/ard.2010.142737Vadacca M, Zardi EM, Margiotta D et al (2013) Leptin, adiponectin and vascular stiffness parameters in women with systemic lupus erythematosus. 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