Synthesis of 3-Aroyl-4-heteroarylpyrrole Derivatives by the Van Leusen Method
The synthesis and structural diversification of N-heterocycles systems have attracted much attention because of their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4- b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen– Schmidt c...
- Autores:
-
Trilleras, Jorge
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/843
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/843
https://www.scopus.com/record/display.uri?eid=2-s2.0-85124887565&doi=10.3390%2fM1341&origin=inward&txGid=5618b897dc3d8c383a4dd756255f557e
- Palabra clave:
- 3,4-substituted pyrrole synthesis
TosMIC
Van Leusen reaction
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
| Summary: | The synthesis and structural diversification of N-heterocycles systems have attracted much attention because of their potential applications. Three 6-aryl-3-methyl-1-phenyl-1H-pyrazolo[3,4- b]pyridine-5-carbaldehyde 4 derivatives, in reaction with acetophenones 5, via conventional Claisen– Schmidt condensation reactions, generated the respective enones. The enones were used as electrondeficient olefins in a “formal” [2+3] cycloaddition reaction using p-tosylmethyl isocyanide—TosMIC 7. This protocol allows access to 3-(substituted aroyl)-4-heteroaryl pyrrole derivatives by the Van Leusen method. |
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