ADHD Endophenotypes in Caribbean Families
Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The geneti...
- Autores:
-
Cervantes-Henríquez, M. L.
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/933
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/933
- Palabra clave:
- ADHD, endophenotypes, attention, memory, genetics, heritability
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families ADHD, endophenotypes, attention, memory, genetics, heritability |
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families |
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ADHD Endophenotypes in Caribbean Families |
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Cervantes-Henríquez, M. L. |
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Cervantes-Henríquez, M. L. |
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Acosta-López, J. E. Martínez-Banfi, M. L. Vélez, J. I. Mejía-Segura, , E. Lozano-Gutiérrez, S. G. Sánchez-Rojas1, M. Zurbarán, M. A. Zurek, E. E. Arcos-Burgos, M. Pineda, D. A. Puentes-Rozo, P. J. |
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ADHD, endophenotypes, attention, memory, genetics, heritability |
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ADHD, endophenotypes, attention, memory, genetics, heritability |
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Objective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. (J. of Att. Dis. XXXX; XX(X) XX-XX |
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2018 |
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2018-03-28 |
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2018-03-28 |
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2022-11-15T21:03:45Z |
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2022-11-15T21:03:45Z |
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https://hdl.handle.net/20.500.12834/933 |
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10.1177/1087054718763741 |
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Universidad del Atlántico |
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Repositorio Universidad del Atlántico |
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Cervantes-Henríquez, M. L.98ea6aa0-12ed-4265-91cd-e201817fc5eeAcosta-López, J. E.Martínez-Banfi, M. L.Vélez, J. I.Mejía-Segura, , E.Lozano-Gutiérrez, S. G.Sánchez-Rojas1, M.Zurbarán, M. A.Zurek, E. E.Arcos-Burgos, M.Pineda, D. A.Puentes-Rozo, P. J.2022-11-15T21:03:45Z2022-11-15T21:03:45Z2018-03-282018-03-28https://hdl.handle.net/20.500.12834/93310.1177/1087054718763741Universidad del AtlánticoRepositorio Universidad del AtlánticoObjective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. (J. of Att. Dis. XXXX; XX(X) XX-XXapplication/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Journal of Attention DisordersADHD Endophenotypes in Caribbean FamiliesPúblico generalADHD, endophenotypes, attention, memory, genetics, heritabilityinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaSede NorteAcosta, M. T., Arcos-Burgos, M., & Muenke, M. (2004). Attention deficit/hyperactivity disorder (ADHD): Complex phenotype, simple genotype? Genetics in Medicine, 6, 1-15. doi:10.1097/01.GIM.0000110413.07490.0BAcosta, M. T., Velez, J. I., Bustamante, M. L., Balog, J. Z., ArcoBurgos, M., & Muenke, M. (2011). A two-locus geneticinteraction between LPHN3 and 11q predicts ADHD severity and long-term outcome. Translational Psychiatry, 1, Article e17Acosta-Lopez, J., Cervantes-Henriquez, M. L., Jiménez-Figueroa, G., Núñez-Barragán, M., Sánchez-Rojas, M., & Puentes Rozo, P. (2013). Uso de una escala comportamental Wender Utah para evaluar en retrospectiva trastorno de atención-hiperactividad en adultos de la ciudad de Barranquilla [Using a Wender Utah behavioral scale to assess with hindsight adults suffering from attention-hyperactivity disorder in the city of Barranquilla]. Revista Universidad Y Salud, 15, 45-61.Acosta-López, J., Cervantes-Henríquez, M. L., Sánchez-Rojas, M., Núñez-Barragán, M., Puentes Rozo, P., Aguirre-Acevedo, D., & Pineda, D. (2010). Alteraciones del Control Inhibitorio Conductual en Niños de 6 A 11 Años Con TDAH Familiar de Barranquilla [Alterations of Inhibitory Control in Children 6-11 years with ADHD from Barranquilla]. Psicogente, 13(24), 274-291American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). 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