Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
The extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system...
- Autores:
-
Ruiz Rojas, Lina Marcela
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/1150
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/1150
- Palabra clave:
- acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
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Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| dc.title.alternative.spa.fl_str_mv |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| title |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| spellingShingle |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication |
| title_short |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| title_full |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| title_fullStr |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| title_full_unstemmed |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| title_sort |
Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide |
| dc.creator.fl_str_mv |
Ruiz Rojas, Lina Marcela |
| dc.contributor.author.none.fl_str_mv |
Ruiz Rojas, Lina Marcela |
| dc.contributor.other.none.fl_str_mv |
Valencia Zapata, Mayra Eliana Gordillo Suarez, Marisol Advincula, Rigoberto Grande-Tovar, Carlos David Mina Hernández, José Herminsul |
| dc.subject.keywords.spa.fl_str_mv |
acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication |
| topic |
acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication |
| description |
The extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system and a decrease in the patient’s quality of life due to the prosthesis’s loosening. Materials such as graphene oxide (GO) have a reinforcing effect on ABC’s mechanical and setting properties. This article shows for the first time the interactions present between the factors sonication time and GO percentage in the liquid phase, together with the percentage of benzoyl peroxide (BPO) in the solid phase, on the mechanical and setting properties established for cements in the ISO 5833-02 standard. Optimization of the factors using a completely randomized experimental design with a factorial structure resulted in selecting nine combinations that presented an increase in compression, flexion, and the setting time and decreased the maximum temperature reached during the polymerization. All of these characteristics are desirable for improving the clinical performance of cement. Those containing 0.3 wt.% of GO were highlighted from the selected formulations because all the possible combinations of the studied factors generate desirable properties for the ABC. |
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2021 |
| dc.date.issued.none.fl_str_mv |
2021-06-03 |
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2021-04-28 |
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2022-12-19T21:07:39Z |
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2022-12-19T21:07:39Z |
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info:eu-repo/semantics/publishedVersion |
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Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185 |
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https://hdl.handle.net/20.500.12834/1150 |
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10.3390/app11115185 |
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Universidad del Atlántico |
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Repositorio Universidad del Atlántico |
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Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185 10.3390/app11115185 Universidad del Atlántico Repositorio Universidad del Atlántico |
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https://hdl.handle.net/20.500.12834/1150 |
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Ruiz Rojas, Lina Marcelac99ad2ec-1349-464d-882b-15cf7c66d690Valencia Zapata, Mayra ElianaGordillo Suarez, MarisolAdvincula, RigobertoGrande-Tovar, Carlos DavidMina Hernández, José Herminsul2022-12-19T21:07:39Z2022-12-19T21:07:39Z2021-06-032021-04-28Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185https://hdl.handle.net/20.500.12834/115010.3390/app11115185Universidad del AtlánticoRepositorio Universidad del AtlánticoThe extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system and a decrease in the patient’s quality of life due to the prosthesis’s loosening. Materials such as graphene oxide (GO) have a reinforcing effect on ABC’s mechanical and setting properties. This article shows for the first time the interactions present between the factors sonication time and GO percentage in the liquid phase, together with the percentage of benzoyl peroxide (BPO) in the solid phase, on the mechanical and setting properties established for cements in the ISO 5833-02 standard. Optimization of the factors using a completely randomized experimental design with a factorial structure resulted in selecting nine combinations that presented an increase in compression, flexion, and the setting time and decreased the maximum temperature reached during the polymerization. All of these characteristics are desirable for improving the clinical performance of cement. Those containing 0.3 wt.% of GO were highlighted from the selected formulations because all the possible combinations of the studied factors generate desirable properties for the ABC.application/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2applied sciencesOptimization of mechanical and setting properties in acrylic bone cements added with graphene oxideOptimization of mechanical and setting properties in acrylic bone cements added with graphene oxidePúblico generalacrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonicationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaIngeniería QuímicaSede NorteHasenwinkel, J.M.; Lautenschlager, E.P.; Wixson, R.L.; Gilbert, J.L. A novel high-viscosity, two-solution acrylic bone cement: Effect of chemical composition on properties. J. Biomed. Mater. Res. 1999, 47, 36–45. [CrossRef]Brauer, G.M.; Steinberger, D.R.; Stansbury, J.W. Dependence of curing time, peak temperature, and mechanical properties on the composition of bone cement. J. Biomed. Mater. Res. 1986, 20, 839–852. [CrossRef] [PubMed]Paz, E.; Forriol, F.; del Real, J.C.; Dunne, N. Graphene oxide versus graphene for optimisation of PMMA bone cement for orthopaedic applications. Mater. Sci. Eng. C 2017, 77, 1003–1011. [CrossRef] [PubMed]Rusu, M.C.; Ichim, I.C.; Popa, M.; Rusu, M. New radiopaque acrylic bone cement. II. Acrylic bone cement with bromine-containing monomer. J. Mater. Sci. Mater. Med. 2008, 19, 2609–2617. [CrossRef] [PubMed]Nussbaum, D.A.; Gailloud, P.; Murphy, K. The Chemistry of Acrylic Bone Cements and Implications for Clinical Use in Image-guided Therapy. J. Vasc. Interv. Radiol. 2004, 15, 121–126. [CrossRef] [PubMed]Madigan, S.; Towler, M.R.; Lewis, G. Influence of two changes in the composition of an acrylic bone cement on some of its properties: The case of Surgical Simplex® P. J. Mater. Sci. 2006, 41, 5758–5759. [CrossRef]Madigan, S.; Towler, M.R.; Lewis, G. Optimisation of the composition of an acrylic bone cement: Application to relative amounts of the initiator and the activator/co-initiator in Surgical Simplex® P. J. Mater. Sci. Mater. Med. 2006, 17, 307–311. [CrossRef] [PubMed]Sharma, R.; Kapusetti, G.; Bhong, S.Y.; Roy, P.; Singh, S.K.; Singh, S.; Balavigneswaran, C.K.; Mahato, K.K.; Ray, B.; Maiti, P.; et al. Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization. Bioconjug. Chem. 2017, 28, 2254–2265. [CrossRef] [PubMed]Kuehn, K.-D.; Ege, W.; Gopp, U. Acrylic bone cements: Composition and properties. Orthop. Clin. N. Am. 2005, 36, 17–28. [CrossRef] [PubMed]IMAI, Y.; OHYAMA, A. Characterization of Powder Components of Commercial Bone Cements. Dent. Mater. J. 2001, 20, 345–352. [CrossRef]Kühn, K.-D. Bone Cements; Springer: Berlin, Germany, 2000; ISBN 9783642641152.Yang, D.H.; Yoon, G.H.; Kim, S.H.; Rhee, J.M.; Kim, Y.S.; Khang, G. Surface and chemical properties of surface-modified UHMWPE powder and mechanical and thermal properties of it impregnated PMMA bone cement, III: Effect of various ratios of initiator/inhibitor on the surface modification of UHMWPE powder. J. Biomater. Sci. Polym. Ed. 2005, 16, 1121–1138. [CrossRef] [PubMed]Dunne, N.; Ormsby, R.; Mitchell, C. Carbon Nanotubes in Acrylic Bone Cement; Springer Series in Biomaterials Science and Engineering; Antoniac, I., Wang, M., Eds.; Springer: New York, NY, USA, 2013; pp. 173–200. ISBN 9781461443278.Dalby, M.J.; Di Silvio, L.; Harper, E.J.; Bonfield, W. In vitro evaluation of a new polymethylmethacrylate cement reinforced with hydroxyapatite. J. Mater. Sci. Mater. Med. 1999, 10, 793–796. [CrossRef] [PubMed]Espigares, I.; Elvira, C.; Mano, J.F.; Vázquez, B.; San Román, J.; Reis, R.L. New partially degradable and bioactive acrylic bone cements based on starch blends and ceramic fillers. Biomaterials 2002, 23, 1883–1895. [CrossRef]Lozano, K.; Mina, J.; Zuluaga, F.; Valencia, C.; Valencia, M. Influencia de la incorporación de un co-monómero alcalino e hidroxiapatita en las propiedades de cementos óseos acrílicos. DYNA 2013, 80, 153–162.Heikkilä, J.T.; Aho, A.J.; Kangasniemi, I.; Yli-Urpo, A. Polymethylmethacrylate composites: Disturbed bone formation at the surface of bioactive glass and hydroxyapatite. Biomaterials 1996, 17, 1755–1760. [CrossRef]Fernández, M.; Méndez, J.A.; Vázquez, B.; San Román, J.; Ginebra, M.P.; Gil, F.J.; Manero, J.M.; Planell, J.A. Acrylic-phosphate glasses composites as self-curing controlled delivery systems of antibiotics. J. Mater. Sci. Mater. Med. 2002, 13, 1251–1257. 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