Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide

The extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system...

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Autores:
Ruiz Rojas, Lina Marcela
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad del Atlántico
Repositorio:
Repositorio Uniatlantico
Idioma:
eng
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oai:repositorio.uniatlantico.edu.co:20.500.12834/1150
Acceso en línea:
https://hdl.handle.net/20.500.12834/1150
Palabra clave:
acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication
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openAccess
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http://creativecommons.org/licenses/by-nc/4.0/
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dc.title.spa.fl_str_mv Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
dc.title.alternative.spa.fl_str_mv Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
title Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
spellingShingle Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication
title_short Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
title_full Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
title_fullStr Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
title_full_unstemmed Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
title_sort Optimization of mechanical and setting properties in acrylic bone cements added with graphene oxide
dc.creator.fl_str_mv Ruiz Rojas, Lina Marcela
dc.contributor.author.none.fl_str_mv Ruiz Rojas, Lina Marcela
dc.contributor.other.none.fl_str_mv Valencia Zapata, Mayra Eliana
Gordillo Suarez, Marisol
Advincula, Rigoberto
Grande-Tovar, Carlos David
Mina Hernández, José Herminsul
dc.subject.keywords.spa.fl_str_mv acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication
topic acrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonication
description The extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system and a decrease in the patient’s quality of life due to the prosthesis’s loosening. Materials such as graphene oxide (GO) have a reinforcing effect on ABC’s mechanical and setting properties. This article shows for the first time the interactions present between the factors sonication time and GO percentage in the liquid phase, together with the percentage of benzoyl peroxide (BPO) in the solid phase, on the mechanical and setting properties established for cements in the ISO 5833-02 standard. Optimization of the factors using a completely randomized experimental design with a factorial structure resulted in selecting nine combinations that presented an increase in compression, flexion, and the setting time and decreased the maximum temperature reached during the polymerization. All of these characteristics are desirable for improving the clinical performance of cement. Those containing 0.3 wt.% of GO were highlighted from the selected formulations because all the possible combinations of the studied factors generate desirable properties for the ABC.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-06-03
dc.date.submitted.none.fl_str_mv 2021-04-28
dc.date.accessioned.none.fl_str_mv 2022-12-19T21:07:39Z
dc.date.available.none.fl_str_mv 2022-12-19T21:07:39Z
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dc.identifier.citation.spa.fl_str_mv Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12834/1150
dc.identifier.doi.none.fl_str_mv 10.3390/app11115185
dc.identifier.instname.spa.fl_str_mv Universidad del Atlántico
dc.identifier.reponame.spa.fl_str_mv Repositorio Universidad del Atlántico
identifier_str_mv Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185
10.3390/app11115185
Universidad del Atlántico
Repositorio Universidad del Atlántico
url https://hdl.handle.net/20.500.12834/1150
dc.language.iso.spa.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.place.spa.fl_str_mv Barranquilla
dc.publisher.discipline.spa.fl_str_mv Ingeniería Química
dc.publisher.sede.spa.fl_str_mv Sede Norte
dc.source.spa.fl_str_mv applied sciences
institution Universidad del Atlántico
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spelling Ruiz Rojas, Lina Marcelac99ad2ec-1349-464d-882b-15cf7c66d690Valencia Zapata, Mayra ElianaGordillo Suarez, MarisolAdvincula, RigobertoGrande-Tovar, Carlos DavidMina Hernández, José Herminsul2022-12-19T21:07:39Z2022-12-19T21:07:39Z2021-06-032021-04-28Ruiz Rojas, L. M., Valencia Zapata, M. E., Gordillo Suarez, M., Advincula, R., Grande-Tovar, C. D., & Mina Hernández, J. H. (2021). Optimization of Mechanical and Setting Properties in Acrylic Bone Cements Added with Graphene Oxide. Applied Sciences, 11(11), 5185. https://doi.org/10.3390/app11115185https://hdl.handle.net/20.500.12834/115010.3390/app11115185Universidad del AtlánticoRepositorio Universidad del AtlánticoThe extended use of acrylic bone cements (ABC) in orthopedics presents some disadvantages related to the generation of high temperatures during methyl methacrylate polymerization, thermal tissue necrosis, and low mechanical properties. Both weaknesses cause an increase in costs for the health system and a decrease in the patient’s quality of life due to the prosthesis’s loosening. Materials such as graphene oxide (GO) have a reinforcing effect on ABC’s mechanical and setting properties. This article shows for the first time the interactions present between the factors sonication time and GO percentage in the liquid phase, together with the percentage of benzoyl peroxide (BPO) in the solid phase, on the mechanical and setting properties established for cements in the ISO 5833-02 standard. Optimization of the factors using a completely randomized experimental design with a factorial structure resulted in selecting nine combinations that presented an increase in compression, flexion, and the setting time and decreased the maximum temperature reached during the polymerization. All of these characteristics are desirable for improving the clinical performance of cement. Those containing 0.3 wt.% of GO were highlighted from the selected formulations because all the possible combinations of the studied factors generate desirable properties for the ABC.application/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2applied sciencesOptimization of mechanical and setting properties in acrylic bone cements added with graphene oxideOptimization of mechanical and setting properties in acrylic bone cements added with graphene oxidePúblico generalacrylic bone cement; benzoyl peroxide; completely randomized factorial design; graphene oxide; mechanical properties; PMMA; setting properties; sonicationinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaIngeniería QuímicaSede NorteHasenwinkel, J.M.; Lautenschlager, E.P.; Wixson, R.L.; Gilbert, J.L. 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