Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties

Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents i...

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Autores:
Valencia Zapata, Mayra Eliana
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad del Atlántico
Repositorio:
Repositorio Uniatlantico
Idioma:
eng
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oai:repositorio.uniatlantico.edu.co:20.500.12834/849
Acceso en línea:
https://hdl.handle.net/20.500.12834/849
Palabra clave:
acrylic bone cement; antibacterial activity; graphene oxide; mechanical properties; physical properties
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openAccess
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http://creativecommons.org/licenses/by-nc/4.0/
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network_acronym_str UNIATLANT2
network_name_str Repositorio Uniatlantico
repository_id_str
dc.title.spa.fl_str_mv Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
spellingShingle Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
acrylic bone cement; antibacterial activity; graphene oxide; mechanical properties; physical properties
title_short Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_full Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_fullStr Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_full_unstemmed Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_sort Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
dc.creator.fl_str_mv Valencia Zapata, Mayra Eliana
dc.contributor.author.none.fl_str_mv Valencia Zapata, Mayra Eliana
dc.contributor.other.none.fl_str_mv Ruiz Rojas, Lina Marcela
Mina Hernández, José Herminsul
Delgado-Ospina, Johannes
Grande Tovar, Carlos David
dc.subject.keywords.spa.fl_str_mv acrylic bone cement; antibacterial activity; graphene oxide; mechanical properties; physical properties
topic acrylic bone cement; antibacterial activity; graphene oxide; mechanical properties; physical properties
description Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents in acrylic bone cements (ABCs) is open. In this study, the antibacterial effect of formulations of ABCs loaded with graphene oxide (GO) between 0 and 0.5 wt.% was evaluated against Gram-positive bacteria: Bacillus cereus and Staphylococcus aureus, and Gram-negative ones: Salmonella enterica and Escherichia coli. It was found that the effect of GO was dependent on the concentration and type of bacteria: GO loadings ≥0.2 wt.% presented total inhibition of Gram-negative bacteria, while GO loadings ≥0.3 wt.% was necessary to achieve the same effect with Gram-positives bacteria. Additionally, the evaluation of some physical and mechanical properties showed that the presence of GO in cement formulations increased wettability by 17%, reduced maximum temperature during polymerization by 19%, increased setting time by 40%, and increased compressive and flexural mechanical properties by up to 17%, all of which are desirable behaviors in ABCs. The formulation of ABC loading with 0.3 wt.% GO showed great potential for use as a bone cement with antibacterial properties.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020-08-07
dc.date.submitted.none.fl_str_mv 2020-07-22
dc.date.accessioned.none.fl_str_mv 2022-11-15T19:44:40Z
dc.date.available.none.fl_str_mv 2022-11-15T19:44:40Z
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dc.type.spa.spa.fl_str_mv Artículo
status_str publishedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12834/849
dc.identifier.doi.none.fl_str_mv 10.3390/polym12081773
dc.identifier.instname.spa.fl_str_mv Universidad del Atlántico
dc.identifier.reponame.spa.fl_str_mv Repositorio Universidad del Atlántico
url https://hdl.handle.net/20.500.12834/849
identifier_str_mv 10.3390/polym12081773
Universidad del Atlántico
Repositorio Universidad del Atlántico
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.publisher.place.spa.fl_str_mv Barranquilla
dc.publisher.sede.spa.fl_str_mv Sede Norte
dc.source.spa.fl_str_mv Polymers
institution Universidad del Atlántico
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spelling Valencia Zapata, Mayra Elianac9423aa9-8912-4a7c-82d7-d8e4335d733eRuiz Rojas, Lina MarcelaMina Hernández, José HerminsulDelgado-Ospina, JohannesGrande Tovar, Carlos David2022-11-15T19:44:40Z2022-11-15T19:44:40Z2020-08-072020-07-22https://hdl.handle.net/20.500.12834/84910.3390/polym12081773Universidad del AtlánticoRepositorio Universidad del AtlánticoBacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents in acrylic bone cements (ABCs) is open. In this study, the antibacterial effect of formulations of ABCs loaded with graphene oxide (GO) between 0 and 0.5 wt.% was evaluated against Gram-positive bacteria: Bacillus cereus and Staphylococcus aureus, and Gram-negative ones: Salmonella enterica and Escherichia coli. It was found that the effect of GO was dependent on the concentration and type of bacteria: GO loadings ≥0.2 wt.% presented total inhibition of Gram-negative bacteria, while GO loadings ≥0.3 wt.% was necessary to achieve the same effect with Gram-positives bacteria. Additionally, the evaluation of some physical and mechanical properties showed that the presence of GO in cement formulations increased wettability by 17%, reduced maximum temperature during polymerization by 19%, increased setting time by 40%, and increased compressive and flexural mechanical properties by up to 17%, all of which are desirable behaviors in ABCs. The formulation of ABC loading with 0.3 wt.% GO showed great potential for use as a bone cement with antibacterial properties.application/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PolymersAcrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial PropertiesPúblico generalacrylic bone cement; antibacterial activity; graphene oxide; mechanical properties; physical propertiesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaSede Norte1. Eil Bakhtiari, S.S.; Bakhsheshi-Rad, H.R.; Karbasi, S.; Tavakoli, M.; Razzaghi, M.; Fauzi Ismail, A.; Ramakrishna, S.; Berto, F. 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Nano 2017, 4, 1808–1816http://purl.org/coar/resource_type/c_6501ORIGINALpolymers-12-01773.pdfpolymers-12-01773.pdfapplication/pdf4478821https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/849/1/polymers-12-01773.pdf249feba951f18fc8c53da43da4e8fe37MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/849/2/license_rdf24013099e9e6abb1575dc6ce0855efd5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81306https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/849/3/license.txt67e239713705720ef0b79c50b2ececcaMD5320.500.12834/849oai:repositorio.uniatlantico.edu.co:20.500.12834/8492022-11-15 14:44:41.877DSpace de la Universidad de Atlánticosysadmin@mail.uniatlantico.edu.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