Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects
Autologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability of hom...
- Autores:
-
Valencia Llano, Carlos Humberto
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/768
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/768
- Palabra clave:
- bone substitutes
collagen membranes
critical size defects
xenografts
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
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Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| title |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| spellingShingle |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects bone substitutes collagen membranes critical size defects xenografts |
| title_short |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| title_full |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| title_fullStr |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| title_full_unstemmed |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| title_sort |
Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects |
| dc.creator.fl_str_mv |
Valencia Llano, Carlos Humberto |
| dc.contributor.author.none.fl_str_mv |
Valencia Llano, Carlos Humberto |
| dc.contributor.other.none.fl_str_mv |
López Tenorio, Diego Saavedra, Marcela Zapata, Paula A. Grande Tovar, Carlos David |
| dc.subject.keywords.spa.fl_str_mv |
bone substitutes collagen membranes critical size defects xenografts |
| topic |
bone substitutes collagen membranes critical size defects xenografts |
| description |
Autologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability of homologous tissue donors. Bone neoformation was studied in critical-size defects created in the parietal bone of 40 adult maleWistar rats, implanted with xenografts composed of particulate bovine hydroxyapatite (HA) and with blocks of bovine hydroxyapatite (HA) and Collagen, which introduces crystallinity to the materials. The Fourier-transform infrared spectroscopy (FTIR) analysis demonstrated the carbonate and phosphate groups of the hydroxyapatite and the amide groups of the collagen structure, while the thermal transitions for HA and HA/collagen composites established mainly dehydration endothermal processes, which increased (from 79 C to 83 C) for F2 due to the collagen presence. The xenograft’s X-ray powder diffraction (XRD) analysis also revealed the bovine HA crystalline structure, with a prominent peak centered at 32 . We observed macroporosity and mesoporosity in the xenografts from the morphology studies with heterogeneous distribution. The two xenografts induced neoformation in defects of critical size. Histological, histochemical, and scanning electron microscopy (SEM) analyses were performed 30, 60, and 90 days after implantation. The empty defects showed signs of neoformation lower than 30% in the three periods, while the defects implanted with the material showed partial regeneration. InterOss Collagen material temporarily induced osteon formation during the healing process. The results presented here are promising for bone regeneration, demonstrating a beneficial impact in the biomedical field. |
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2022 |
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2022-11-15T19:11:34Z |
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2022-11-15T19:11:34Z |
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2022-09-06 |
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2022-08-01 |
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http://purl.org/coar/version/c_b1a7d7d4d402bcce |
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info:eu-repo/semantics/draft |
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Artículo |
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Valencia-Llano, C.H.; López-Tenorio, D.; Saavedra, M.; Zapata, P.A.; Grande-Tovar, C.D. Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects. Molecules 2022, 27, 5745. https://doi.org/10.3390/ molecules27185745 |
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https://hdl.handle.net/20.500.12834/768 |
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10.3390/ molecules27185745 |
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Universidad del Atlántico |
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Repositorio Universidad del Atlántico |
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Valencia-Llano, C.H.; López-Tenorio, D.; Saavedra, M.; Zapata, P.A.; Grande-Tovar, C.D. Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects. Molecules 2022, 27, 5745. https://doi.org/10.3390/ molecules27185745 10.3390/ molecules27185745 Universidad del Atlántico Repositorio Universidad del Atlántico |
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https://hdl.handle.net/20.500.12834/768 |
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eng |
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eng |
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Sede Norte |
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Valencia Llano, Carlos Humberto5001100c-6436-4cba-b693-132c254d6451López Tenorio, DiegoSaavedra, MarcelaZapata, Paula A.Grande Tovar, Carlos DavidColombia2022-11-15T19:11:34Z2022-11-15T19:11:34Z2022-09-062022-08-01Valencia-Llano, C.H.; López-Tenorio, D.; Saavedra, M.; Zapata, P.A.; Grande-Tovar, C.D. Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial Defects. Molecules 2022, 27, 5745. https://doi.org/10.3390/ molecules27185745https://hdl.handle.net/20.500.12834/76810.3390/ molecules27185745Universidad del AtlánticoRepositorio Universidad del AtlánticoAutologous bone is the gold standard in regeneration processes. However, there is an endless search for alternative materials in bone regeneration. Xenografts can act as bone substitutes given the difficulty of obtaining bone tissue from patients and before the limitations in the availability of homologous tissue donors. Bone neoformation was studied in critical-size defects created in the parietal bone of 40 adult maleWistar rats, implanted with xenografts composed of particulate bovine hydroxyapatite (HA) and with blocks of bovine hydroxyapatite (HA) and Collagen, which introduces crystallinity to the materials. The Fourier-transform infrared spectroscopy (FTIR) analysis demonstrated the carbonate and phosphate groups of the hydroxyapatite and the amide groups of the collagen structure, while the thermal transitions for HA and HA/collagen composites established mainly dehydration endothermal processes, which increased (from 79 C to 83 C) for F2 due to the collagen presence. The xenograft’s X-ray powder diffraction (XRD) analysis also revealed the bovine HA crystalline structure, with a prominent peak centered at 32 . We observed macroporosity and mesoporosity in the xenografts from the morphology studies with heterogeneous distribution. The two xenografts induced neoformation in defects of critical size. Histological, histochemical, and scanning electron microscopy (SEM) analyses were performed 30, 60, and 90 days after implantation. The empty defects showed signs of neoformation lower than 30% in the three periods, while the defects implanted with the material showed partial regeneration. InterOss Collagen material temporarily induced osteon formation during the healing process. The results presented here are promising for bone regeneration, demonstrating a beneficial impact in the biomedical field.Universidad del Atlánticoapplication/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Comparison of Two Bovine Commercial Xenografts in the Regeneration of Critical Cranial DefectsPúblico generalbone substitutescollagen membranescritical size defectsxenograftsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/draftArtículohttp://purl.org/coar/version/c_b1a7d7d4d402bccehttp://purl.org/coar/resource_type/c_2df8fbb1BarranquillaIngeniería QuímicaSede NorteChen, M.-Y.; Fang, J.-J.; Lee, J.-N.; Periasamy, S.; Yen, K.-C.; Wang, H.-C.; Hsieh, D.-J. Supercritical Carbon Dioxide Decellularized Xenograft-3D CAD/CAM Carved Bone Matrix Personalized for Human Bone Defect Repair. Genes 2022, 13, 1–14. 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[CrossRef]http://purl.org/coar/resource_type/c_2df8fbb1ORIGINALmolecules-27-05745.pdfmolecules-27-05745.pdfapplication/pdf7979422https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/768/1/molecules-27-05745.pdf795246569b6dbd8e3a2875a4898f178eMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/768/2/license_rdf24013099e9e6abb1575dc6ce0855efd5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81306https://repositorio.uniatlantico.edu.co/bitstream/20.500.12834/768/3/license.txt67e239713705720ef0b79c50b2ececcaMD5320.500.12834/768oai:repositorio.uniatlantico.edu.co:20.500.12834/7682022-11-15 14:11:35.771DSpace de la Universidad de Atlánticosysadmin@mail.uniatlantico.edu.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 |