Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides
The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In this article, we present the synthesis of four...
- Autores:
-
González-López, Edwin
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/923
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/923
- Palabra clave:
- agrochemicals, antifungal agent, Colletotrichum gloeosporioides, nitrogen heterocycles, pyrazole carboxamide
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
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| dc.title.spa.fl_str_mv |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| title |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| spellingShingle |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides agrochemicals, antifungal agent, Colletotrichum gloeosporioides, nitrogen heterocycles, pyrazole carboxamide |
| title_short |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| title_full |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| title_fullStr |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| title_full_unstemmed |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| title_sort |
Synthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioides |
| dc.creator.fl_str_mv |
González-López, Edwin |
| dc.contributor.author.none.fl_str_mv |
González-López, Edwin |
| dc.contributor.other.none.fl_str_mv |
León-Jaramillo, Jhair Trilleras, Jorge Grande-Tovar, Carlos D. Peralta-Ruiz, Yeimmy Quiroga, Jairo |
| dc.subject.keywords.spa.fl_str_mv |
agrochemicals, antifungal agent, Colletotrichum gloeosporioides, nitrogen heterocycles, pyrazole carboxamide |
| topic |
agrochemicals, antifungal agent, Colletotrichum gloeosporioides, nitrogen heterocycles, pyrazole carboxamide |
| description |
The pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In this article, we present the synthesis of four new pyrazol-4-carboxamide 8a-8d derivatives (PCD), through a four-step synthetic protocol, starting with edaravone 1 and primary amines like benzo-fused, aliphatic, and hydrazines, through a process of low environmental impact. Synthesized derivatives were evaluated against one fungal strain of Colletotrichum gloeosporioides BA3, fungus that causes several losses to farmers around the world, through in vitro sensitivity tests. The compound 8c showed better inhibiting behavior against Colletotrichum gloeosporioides BA3, inducing a lag phase of almost 2.77 days. These results were obtained via Gompertz modeling, for the first time reported for biological evaluation of pyrazole-carboxamide derivatives against Colletotrichum gloeosporioides. |
| publishDate |
2020 |
| dc.date.issued.none.fl_str_mv |
2020-05-19 |
| dc.date.submitted.none.fl_str_mv |
2020-01-31 |
| dc.date.accessioned.none.fl_str_mv |
2022-11-15T21:01:48Z |
| dc.date.available.none.fl_str_mv |
2022-11-15T21:01:48Z |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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Artículo |
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publishedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12834/923 |
| dc.identifier.doi.none.fl_str_mv |
10.21577/0103-5053.20200092 |
| dc.identifier.instname.spa.fl_str_mv |
Universidad del Atlántico |
| dc.identifier.reponame.spa.fl_str_mv |
Repositorio Universidad del Atlántico |
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https://hdl.handle.net/20.500.12834/923 |
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10.21577/0103-5053.20200092 Universidad del Atlántico Repositorio Universidad del Atlántico |
| dc.language.iso.spa.fl_str_mv |
eng |
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eng |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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Attribution-NonCommercial 4.0 International |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc/4.0/ Attribution-NonCommercial 4.0 International http://purl.org/coar/access_right/c_abf2 |
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Química |
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Sede Norte |
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Sociedade Brasileira de Química |
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Universidad del Atlántico |
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González-López, Edwin603c75f6-10fe-40e9-bd5b-3157cd0b8074León-Jaramillo, JhairTrilleras, JorgeGrande-Tovar, Carlos D.Peralta-Ruiz, YeimmyQuiroga, Jairo2022-11-15T21:01:48Z2022-11-15T21:01:48Z2020-05-192020-01-31https://hdl.handle.net/20.500.12834/92310.21577/0103-5053.20200092Universidad del AtlánticoRepositorio Universidad del AtlánticoThe pyrazole core has been recognized by their biological properties and included in the synthesis of modern agrochemicals. Part of these studies consists of making structural modifications to pesticides for commercial purposes to increase efficacy. In this article, we present the synthesis of four new pyrazol-4-carboxamide 8a-8d derivatives (PCD), through a four-step synthetic protocol, starting with edaravone 1 and primary amines like benzo-fused, aliphatic, and hydrazines, through a process of low environmental impact. Synthesized derivatives were evaluated against one fungal strain of Colletotrichum gloeosporioides BA3, fungus that causes several losses to farmers around the world, through in vitro sensitivity tests. The compound 8c showed better inhibiting behavior against Colletotrichum gloeosporioides BA3, inducing a lag phase of almost 2.77 days. These results were obtained via Gompertz modeling, for the first time reported for biological evaluation of pyrazole-carboxamide derivatives against Colletotrichum gloeosporioides.application/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Sociedade Brasileira de QuímicaSynthesis and Evaluation of the Fungal Activity of New Pyrazole-Carboxamides against Colletotrichum gloeosporioidesPúblico generalagrochemicals, antifungal agent, Colletotrichum gloeosporioides, nitrogen heterocycles, pyrazole carboxamideinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaQuímicaSede Norte1. Thuy, G. L.; Abhijit, K.; Atanu, G.; Nghi, H.; Nguyen, S. P.; Yaqing, J.; Banfeng, R.; Lian, X.; Fei, H.; Keiser, J.; Hofmann, A.; Chang, B. C. 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