Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications
Scaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs)...
- Autores:
-
Castro, Jorge Iván
- Tipo de recurso:
- Fecha de publicación:
- 2022
- Institución:
- Universidad del Atlántico
- Repositorio:
- Repositorio Uniatlantico
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniatlantico.edu.co:20.500.12834/807
- Acceso en línea:
- https://hdl.handle.net/20.500.12834/807
- Palabra clave:
- antimicrobial
biocompatibility
cell viability
histology
nanobioglass
nanocomposites
polylactic acid
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc/4.0/
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Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| title |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| spellingShingle |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications antimicrobial biocompatibility cell viability histology nanobioglass nanocomposites polylactic acid |
| title_short |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| title_full |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| title_fullStr |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| title_full_unstemmed |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| title_sort |
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications |
| dc.creator.fl_str_mv |
Castro, Jorge Iván |
| dc.contributor.author.none.fl_str_mv |
Castro, Jorge Iván |
| dc.contributor.other.none.fl_str_mv |
Valencia Llano, Carlos Humberto López Tenorio, Diego Saavedra, Marcela Zapata, Paula Navia Porras, Diana Paola Delgado Ospina, Johannes N. Chaur, Manuel Mina Hernández, José Hermínsul Grande Tovar, Carlos David |
| dc.subject.keywords.spa.fl_str_mv |
antimicrobial biocompatibility cell viability histology nanobioglass nanocomposites polylactic acid |
| topic |
antimicrobial biocompatibility cell viability histology nanobioglass nanocomposites polylactic acid |
| description |
Scaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs) were prepared using a sol–gel methodology with a size of ca. 24.87 6.26 nm. In addition, they showed the ability to inhibit bacteria such as Escherichia coli (ATCC 11775), Vibrio parahaemolyticus (ATCC 17802), Staphylococcus aureus subsp. aureus (ATCC 55804), and Bacillus cereus (ATCC 13061) at concentrations of 20 w/v%. The analysis of the nanocomposite microstructures exhibited a heterogeneous sponge-like morphology. The mechanical properties showed that the addition of 5 wt.% n-BG increased the elastic modulus of PLA by ca. 91.3% (from 1.49 0.44 to 2.85 0.99 MPa) and influenced the resorption capacity, as shown by histological analyses in biomodels. The incorporation of n-BGs decreased the PLA crystallinity (from 7.1% to 4.98%) and increased the glass transition temperature (Tg) from 53 C to 63 C. In addition, the n-BGs increased the thermal stability due to the nanoparticle’s intercalation between the polymeric chains and the reduction in their movement. The histological implantation of the nanocomposites and the cell viability with HeLa cells higher than 80% demonstrated their biocompatibility character with a greater resorption capacity than PLA. These results show the potential of PLA/n-BGs nanocomposites for biomedical applications, especially for long healing processes such as bone tissue repair and avoiding microbial contamination. |
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2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-11-15T19:24:53Z |
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2022-11-15T19:24:53Z |
| dc.date.issued.none.fl_str_mv |
2022-06-06 |
| dc.date.submitted.none.fl_str_mv |
2022-03-17 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Castro, J.I.; Valencia Llano, C.H.; Tenorio, D.L.; Saavedra, M.; Zapata, P.; Navia-Porras, D.P.; Delgado-Ospina, J.; Chaur, M.N.; Hernández, J.H.M.; Grande-Tovar, C.D. Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications. Molecules 2022, 27, 3640. https://doi.org/10.3390/ molecules27113640 |
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https://hdl.handle.net/20.500.12834/807 |
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10.3390/ molecules27113640 |
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Universidad del Atlántico |
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Repositorio Universidad del Atlántico |
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Castro, J.I.; Valencia Llano, C.H.; Tenorio, D.L.; Saavedra, M.; Zapata, P.; Navia-Porras, D.P.; Delgado-Ospina, J.; Chaur, M.N.; Hernández, J.H.M.; Grande-Tovar, C.D. Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications. Molecules 2022, 27, 3640. https://doi.org/10.3390/ molecules27113640 10.3390/ molecules27113640 Universidad del Atlántico Repositorio Universidad del Atlántico |
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https://hdl.handle.net/20.500.12834/807 |
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Castro, Jorge Iván1e9148aa-03c6-48ae-951a-2cba30f0c017Valencia Llano, Carlos HumbertoLópez Tenorio, DiegoSaavedra, MarcelaZapata, PaulaNavia Porras, Diana PaolaDelgado Ospina, JohannesN. Chaur, ManuelMina Hernández, José HermínsulGrande Tovar, Carlos David2022-11-15T19:24:53Z2022-11-15T19:24:53Z2022-06-062022-03-17Castro, J.I.; Valencia Llano, C.H.; Tenorio, D.L.; Saavedra, M.; Zapata, P.; Navia-Porras, D.P.; Delgado-Ospina, J.; Chaur, M.N.; Hernández, J.H.M.; Grande-Tovar, C.D. Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications. Molecules 2022, 27, 3640. https://doi.org/10.3390/ molecules27113640https://hdl.handle.net/20.500.12834/80710.3390/ molecules27113640Universidad del AtlánticoRepositorio Universidad del AtlánticoScaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs) were prepared using a sol–gel methodology with a size of ca. 24.87 6.26 nm. In addition, they showed the ability to inhibit bacteria such as Escherichia coli (ATCC 11775), Vibrio parahaemolyticus (ATCC 17802), Staphylococcus aureus subsp. aureus (ATCC 55804), and Bacillus cereus (ATCC 13061) at concentrations of 20 w/v%. The analysis of the nanocomposite microstructures exhibited a heterogeneous sponge-like morphology. The mechanical properties showed that the addition of 5 wt.% n-BG increased the elastic modulus of PLA by ca. 91.3% (from 1.49 0.44 to 2.85 0.99 MPa) and influenced the resorption capacity, as shown by histological analyses in biomodels. The incorporation of n-BGs decreased the PLA crystallinity (from 7.1% to 4.98%) and increased the glass transition temperature (Tg) from 53 C to 63 C. In addition, the n-BGs increased the thermal stability due to the nanoparticle’s intercalation between the polymeric chains and the reduction in their movement. The histological implantation of the nanocomposites and the cell viability with HeLa cells higher than 80% demonstrated their biocompatibility character with a greater resorption capacity than PLA. These results show the potential of PLA/n-BGs nanocomposites for biomedical applications, especially for long healing processes such as bone tissue repair and avoiding microbial contamination.application/pdfenghttp://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2MoleculesBiocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical ApplicationsPúblico generalantimicrobialbiocompatibilitycell viabilityhistologynanobioglassnanocompositespolylactic acidinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1BarranquillaQuímicaSede NorteChristy, P.N.; Basha, S.K.; Kumari, V.S.; Bashir, A.K.H.; Maaza, M.; Kaviyarasu, K.; Arasu, M.V.; Al-Dhabi, N.A.; Ignacimuthu, S. 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