In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori
Helicobacter pylori is a bacterium that has been associated to a diverse range of pathologies that varies from gastritis to gastric cancer. Due to its clinical an evolutionary importance, there has been extensive research focused on the population genetics among different H. pylori isolates worldwid...
- Autores:
-
Ulloa Guerrero, Cindy Pamela
- Tipo de recurso:
- Fecha de publicación:
- 2018
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/35000
- Acceso en línea:
- http://hdl.handle.net/1992/35000
- Palabra clave:
- Helicobacter pylori - Investigaciones
Secuencia de nucleótidos - Investigaciones
Helicobacter pylori - Análisis - Investigaciones
Genética de población - Investigaciones - Estudio de casos
Biología
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/4.0/
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In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| title |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| spellingShingle |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori Helicobacter pylori - Investigaciones Secuencia de nucleótidos - Investigaciones Helicobacter pylori - Análisis - Investigaciones Genética de población - Investigaciones - Estudio de casos Biología |
| title_short |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| title_full |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| title_fullStr |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| title_full_unstemmed |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| title_sort |
In silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pylori |
| dc.creator.fl_str_mv |
Ulloa Guerrero, Cindy Pamela |
| dc.contributor.advisor.none.fl_str_mv |
Reyes Muñoz, Alejandro |
| dc.contributor.author.none.fl_str_mv |
Ulloa Guerrero, Cindy Pamela |
| dc.contributor.jury.none.fl_str_mv |
Trespalacios Rangel, Alba Alicia |
| dc.subject.keyword.es_CO.fl_str_mv |
Helicobacter pylori - Investigaciones Secuencia de nucleótidos - Investigaciones Helicobacter pylori - Análisis - Investigaciones Genética de población - Investigaciones - Estudio de casos |
| topic |
Helicobacter pylori - Investigaciones Secuencia de nucleótidos - Investigaciones Helicobacter pylori - Análisis - Investigaciones Genética de población - Investigaciones - Estudio de casos Biología |
| dc.subject.themes.none.fl_str_mv |
Biología |
| description |
Helicobacter pylori is a bacterium that has been associated to a diverse range of pathologies that varies from gastritis to gastric cancer. Due to its clinical an evolutionary importance, there has been extensive research focused on the population genetics among different H. pylori isolates worldwide. Until now Multilocus Sequence Typing (MSLT) has been the main method used for the determination of ancestry. However, this technique has certain limitations regarding consistency in clusterization and has been generating conflicting results. Due to the fact that a bacterium like H. pylori has a high recombination rate, a more versatile technique with a whole genome approach is desirable. Recently, with decreasing sequencing costs, full genome sequencing of small microbial genomes is becoming a viable approach. However, when typing hundreds of strains, the cost is still prohibitive. In this sense, Restriction site-associated DNA sequencing (RAD-Seq) is a cost-effective method that is suitable for phylogenetic inferences, especially in non-model organisms... |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2020-06-10T09:30:32Z |
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2020-06-10T09:30:32Z |
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Trabajo de grado - Maestría |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/masterThesis |
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Text |
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http://purl.org/redcol/resource_type/TM |
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http://hdl.handle.net/1992/35000 |
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u821134.pdf |
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instname:Universidad de los Andes |
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reponame:Repositorio Institucional Séneca |
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repourl:https://repositorio.uniandes.edu.co/ |
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http://hdl.handle.net/1992/35000 |
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u821134.pdf instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
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eng |
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eng |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ |
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info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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25 hojas |
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application/pdf |
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Uniandes |
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Maestría en Biología Computacional |
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Facultad de Ciencias |
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Departamento de Biología |
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Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Reyes Muñoz, Alejandrovirtual::3315-1Ulloa Guerrero, Cindy Pamela065a5994-848f-4fc7-8c4d-3973a7c51a35500Trespalacios Rangel, Alba Alicia2020-06-10T09:30:32Z2020-06-10T09:30:32Z2018http://hdl.handle.net/1992/35000u821134.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Helicobacter pylori is a bacterium that has been associated to a diverse range of pathologies that varies from gastritis to gastric cancer. Due to its clinical an evolutionary importance, there has been extensive research focused on the population genetics among different H. pylori isolates worldwide. Until now Multilocus Sequence Typing (MSLT) has been the main method used for the determination of ancestry. However, this technique has certain limitations regarding consistency in clusterization and has been generating conflicting results. Due to the fact that a bacterium like H. pylori has a high recombination rate, a more versatile technique with a whole genome approach is desirable. Recently, with decreasing sequencing costs, full genome sequencing of small microbial genomes is becoming a viable approach. However, when typing hundreds of strains, the cost is still prohibitive. In this sense, Restriction site-associated DNA sequencing (RAD-Seq) is a cost-effective method that is suitable for phylogenetic inferences, especially in non-model organisms...Helicobacter pylori es una bacteria que se ha asociado a una amplia gama de patologías que varían desde la gastritis hasta el cáncer gástrico. Debido a su importancia clínica y evolutiva, ha habido una amplia investigación centrada en la genética de poblaciones entre diferentes aislados de H. pylori en todo el mundo. Hasta ahora, Multilocus Sequence Typing (MSLT) ha sido el método principal utilizado para la determinación de la ascendencia. Sin embargo, esta técnica tiene ciertas limitaciones con respecto a la consistencia en la agrupación y ha generado resultados conflictivos. Debido a que H. pylori tiene una alta tasa de recombinación, es deseable una técnica más versátil con un enfoque de genoma completo. Recientemente, con la disminución de los costos de secuenciación, la secuenciación de genomas microbianos pequeños son fácilmente realizables. Sin embargo, al tipificar cientos de cepas, el costo sigue siendo alto. En este sentido, la secuenciación del ADN asociada a sitios de restricción (RAD-Seq)...Magíster en Biología ComputacionalMaestría25 hojasapplication/pdfengUniandesMaestría en Biología ComputacionalFacultad de CienciasDepartamento de Biologíainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaIn silico RAD-Seq as a possible tool for ancestry determination : an application in helicobacter pyloriTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesishttp://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TMHelicobacter pylori - InvestigacionesSecuencia de nucleótidos - InvestigacionesHelicobacter pylori - Análisis - InvestigacionesGenética de población - Investigaciones - Estudio de casosBiologíaPublicationhttps://scholar.google.es/citations?user=hbXF8UEAAAAJvirtual::3315-10000-0003-2907-3265virtual::3315-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000395927virtual::3315-1f71489e5-69f6-4e6b-90a6-c6b1d3fecec7virtual::3315-1f71489e5-69f6-4e6b-90a6-c6b1d3fecec7virtual::3315-1THUMBNAILu821134.pdf.jpgu821134.pdf.jpgIM Thumbnailimage/jpeg7745https://repositorio.uniandes.edu.co/bitstreams/75025e88-d176-41ea-b447-be2e93f4de4b/download458b17f378831a80e389c6286c919d26MD55ORIGINALu821134.pdfapplication/pdf4070918https://repositorio.uniandes.edu.co/bitstreams/22db0f42-93a8-456f-b605-09afd37f6bdc/download373dff9dc66154a0a09a5a4ccffacd0dMD51TEXTu821134.pdf.txtu821134.pdf.txtExtracted texttext/plain69750https://repositorio.uniandes.edu.co/bitstreams/2422519d-0014-4fb1-bcaf-5fddfc719ee4/downloadf97f34c2a082b3b5356c85ea26973cdfMD541992/35000oai:repositorio.uniandes.edu.co:1992/350002024-03-13 12:24:29.385http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |