Autonomous Regulator of Tremor (ART)

Essential tremor (ET) stands as one of the most prevalent neurological disorders globally, affecting over 400 million individuals. Typically impacting those aged 20 to 60, ET significantly diminishes the quality of life, particularly in fine motor skills control, notably within the upper limbs. This...

Full description

Autores:
Castelblanco García, Mateo Alejandro
Reyes Marín, Germán Raúl
Martínez Hernández, Andrés Santiago
Chaparro Ríos, Laura Verónica
Rodríguez Márquez, Sebastián
Cadena Parra, Andrés Felipe
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/73317
Acceso en línea:
https://hdl.handle.net/1992/73317
Palabra clave:
Essential Tremor
Microvibrations
Compression
Orthosis
Glove
Ingeniería
Rights
openAccess
License
https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
id UNIANDES2_f8cf1ca57e2260d6887aa7327153a93c
oai_identifier_str oai:repositorio.uniandes.edu.co:1992/73317
network_acronym_str UNIANDES2
network_name_str Séneca: repositorio Uniandes
repository_id_str
dc.title.eng.fl_str_mv Autonomous Regulator of Tremor (ART)
dc.title.alternative.spa.fl_str_mv ART: regulador autónomo del temblor
title Autonomous Regulator of Tremor (ART)
spellingShingle Autonomous Regulator of Tremor (ART)
Essential Tremor
Microvibrations
Compression
Orthosis
Glove
Ingeniería
title_short Autonomous Regulator of Tremor (ART)
title_full Autonomous Regulator of Tremor (ART)
title_fullStr Autonomous Regulator of Tremor (ART)
title_full_unstemmed Autonomous Regulator of Tremor (ART)
title_sort Autonomous Regulator of Tremor (ART)
dc.creator.fl_str_mv Castelblanco García, Mateo Alejandro
Reyes Marín, Germán Raúl
Martínez Hernández, Andrés Santiago
Chaparro Ríos, Laura Verónica
Rodríguez Márquez, Sebastián
Cadena Parra, Andrés Felipe
dc.contributor.advisor.none.fl_str_mv Bigio Roitman, David
dc.contributor.author.none.fl_str_mv Castelblanco García, Mateo Alejandro
Reyes Marín, Germán Raúl
Martínez Hernández, Andrés Santiago
Chaparro Ríos, Laura Verónica
Rodríguez Márquez, Sebastián
Cadena Parra, Andrés Felipe
dc.contributor.jury.none.fl_str_mv Henríquez Martínez, Angie
Alvarado Rueda, Sarai Ilian
Gómez Bonilla, José Fernando
dc.subject.keyword.none.fl_str_mv Essential Tremor
Microvibrations
Compression
Orthosis
Glove
topic Essential Tremor
Microvibrations
Compression
Orthosis
Glove
Ingeniería
dc.subject.themes.spa.fl_str_mv Ingeniería
description Essential tremor (ET) stands as one of the most prevalent neurological disorders globally, affecting over 400 million individuals. Typically impacting those aged 20 to 60, ET significantly diminishes the quality of life, particularly in fine motor skills control, notably within the upper limbs. This impairment hinders everyday tasks like writing, drawing, and eating, often leading to complications and an increased susceptibility to Parkinson's disease. Traditional approaches for tremor reduction involve invasive measures such as medication, deep brain stimulation, and focused ultrasound via magnetic resonance, alongside emerging electrotherapy treatments. However, these solutions tend to be either invasive or expensive, with even the most cost-effective innovations facing availability challenges, especially in countries like Colombia. Recognizing the need for accessible, low-cost solutions, we introduce ART: Autonomous Regulator of Tremor.
publishDate 2023
dc.date.issued.none.fl_str_mv 2023-12-05
dc.date.accessioned.none.fl_str_mv 2024-01-18T13:14:20Z
dc.date.available.none.fl_str_mv 2024-01-18T13:14:20Z
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.content.none.fl_str_mv Text
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/TP
format http://purl.org/coar/resource_type/c_7a1f
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/1992/73317
dc.identifier.instname.none.fl_str_mv instname:Universidad de los Andes
dc.identifier.reponame.none.fl_str_mv reponame:Repositorio Institucional Séneca
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.uniandes.edu.co/
url https://hdl.handle.net/1992/73317
identifier_str_mv instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
repourl:https://repositorio.uniandes.edu.co/
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.references.none.fl_str_mv [1] S. Agarwal and M. Biagioni, “Essential Tremor,” National Library of Medicine. Accessed: Aug. 31, 2023. [Online]. Available: https://https://www.ncbi.nlm.nih.gov/books/NBK499986/www.ncbi.nlm.nih.gov/books/NBK499986/
​[2] X. Zheng, A. Vieira Campos, J. Ordieres-Meré, J. Balseiro, S. Labrador Marcos, and Y. Aladro, “Continuous Monitoring of Essential Tremor Using a Portable System Based on Smartwatch,” Front Neurol, vol. 8, Mar. 2017, doi: 10.3389/fneur.2017.00096.
​[3] S. Prasad, K. S. Bhalsing, K. Jhunjhunwala, A. Lenka, V. Binu, and P. K. Pal, “Phenotypic Variability of Essential Tremor Based on the Age at Onset,” Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol. 46, no. 2, pp. 192–198, Mar. 2019, doi: 10.1017/cjn.2018.384.
​[4] M.-K. Pan and S.-H. Kuo, “Essential tremor: Clinical perspectives and pathophysiology,” J Neurol Sci, vol. 435, p. 120198, Apr. 2022, doi: 10.1016/j.jns.2022.120198.
​[5] H. B. Delier, Z. I. Katirci Kirmaci, H. Adiguzel, and A. Demirguc, “The relationship of tremor severity with proximal and distal muscle strength and upper extremity functional skills in older adults with essential tremor,” Eur Geriatr Med, vol. 14, no. 2, pp. 381–387, Mar. 2023, doi: 10.1007/s41999-023-00766-1.
​[6] P. Song et al., “The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis,” J Glob Health, vol. 11, p. 04028, Apr. 2021, doi: 10.7189/jogh.11.04028.
​[7] J. García Gil, D. Mendoza Mantilla, and P. Navarro Gil, “Análisis semiológico de las manifestaciones atípicas de temblor en pacientes con enfermedad de Parkinson y temblor esencial,” Acta Neurológica Colombiana, vol. 35, no. 1, pp. 9–14, Mar. 2019, doi: 10.22379/24224022227.
​[8] J. Benito León and M. León Ruiz, “Epidemiología del temblor esencial,” Rev Neurol, vol. 70, no. 04, p. 139, 2020, doi: 10.33588/rn.7004.2019316.
​[9] F. Hopfner and G. Deuschl, “Managing Essential Tremor,” Neurotherapeutics, vol. 17, no. 4, pp. 1603–1621, Oct. 2020, doi: 10.1007/s13311-020-00899-2.
​[10] V. Shanker, “Essential tremor: diagnosis and management,” BMJ, p. l4485, Aug. 2019, doi: 10.1136/bmj.l4485.
​[11] H. J. H. Geesink and D. K. F. Meijer, “Mathematical Structure for Electromagnetic Frequencies that May Reflect Pilot Waves of Bohm’s Implicate Order,” Journal of Modern Physics, vol. 09, no. 05, pp. 851–897, 2018, doi: 10.4236/jmp.2018.95055.
​[12] R. J. Páez Salgado, “Development of a device for the treatment of tremors in patients with Parkinson’s disease through inverse vibrations,” instname:Universidad de los Andes, 2019, Accessed: Sep. 01, 2023. [Online]. Available: http://hdl.handle.net/1992/34066
​[13] Tracy and Tyrone, “Vibration reducing pen for people with tremors.”
​[14] Inc. Cala Health, “Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors,” Justia Patents. Accessed: Aug. 31, 2023. [Online]. Available: https://patents.justia.com/patent/11596785
​[15] Cala, “This is Cala kIQTM.” Accessed: Sep. 01, 2023. [Online]. Available: https://calahealth.com/
​[16] P. Pal, “Guidelines for management of essential tremor,” Ann Indian Acad Neurol, vol. 14, no. 5, p. 25, 2011, doi: 10.4103/0972-2327.83097.
​[17] J. Pilitsis, O. Khazen, and S. Patel, “Deep Brain Stimulation,” American Association of Neurological Surgeons. Accessed: Sep. 01, 2023. [Online]. Available: https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Deep-Brain-Stimulation
​[18] L. C. Mancipe Garcia, Y. M. Rodriguez Mojica, A. M. Rodríguez Lozano, D. M. Chaustre Ruiz, J. M. Tolosa Cubillos, and F. Barragán Noriega, “Situación laboral de los especialistas en Medicina Física y Rehabilitación Colombia, antes y durante la pandemia por Covid-19,” Revista Colombiana de Médicina Física y Rehabilitación, vol. 30, no. Supl, p. 16, Jul. 2020, doi: 10.28957/rcmfr.v30spa3.
​[19] I. Tzinis, “Technology Readiness Level,” National Aeronautics and Space Administration. Accessed: Sep. 01, 2023. [Online]. Available: https://www.nasa.gov/directorates/heo/scan/engineering/technology/technology_readiness_level
​[20] J. Mo and R. Priefer, “Medical Devices for Tremor Suppression: Current Status and Future Directions,” Biosensors (Basel), vol. 11, no. 4, p. 99, Mar. 2021, doi: 10.3390/bios11040099.
​[21] “The Emma Watch: A Wearable Device to Ease PD Tremors.” Accessed: Sep. 01, 2023. [Online]. Available: https://parkinsonsdisease.net/news/emma-watch-wearable-device-tremors
​[22] E. Rocon, J. M. Belda-Lois, A. F. Ruiz, M. Manto, J. C. Moreno, and J. L. Pons, “Design and Validation of a Rehabilitation Robotic Exoskeleton for Tremor Assessment and Suppression,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 15, no. 3, pp. 367–378, Sep. 2007, doi: 10.1109/TNSRE.2007.903917.
​[23] D. Huen, J. Liu, and B. Lo, “An integrated wearable robot for tremor suppression with context aware sensing,” in 2016 IEEE 13th International Conference on Wearable and Implantable Body Sensor Networks (BSN), IEEE, Jun. 2016, pp. 312–317. doi: 10.1109/BSN.2016.7516280.
​[24] Y. Matsumoto et al., “Development of an elbow-forearm interlock joint mechanism toward an exoskeleton for patients with essential tremor,” in 2014 IEEE/RSJ International Conference on Intelligent Robots and Systems, IEEE, Sep. 2014, pp. 2055–2062. doi: 10.1109/IROS.2014.6942837.
​[25] M. Manto, E. Rocon, J. Pons, J. M. Belda, and S. Camut, “Evaluation of a wearable orthosis and an associated algorithm for tremor suppression,” Physiol Meas, vol. 28, no. 4, pp. 415–425, Apr. 2007, doi: 10.1088/0967-3334/28/4/007.
​[26] A. Zahedi, B. Zhang, A. Yi, and D. Zhang, “A Soft Exoskeleton for Tremor Suppression Equipped with Flexible Semiactive Actuator,” Soft Robot, vol. 8, no. 4, pp. 432–447, Aug. 2021, doi: 10.1089/soro.2019.0194.
​[27] S. Rudraraju and T. Nguyen, “Wearable Tremor Reduction Device (TRD) for Human Hands and Arms,” in 2018 Design of Medical Devices Conference, American Society of Mechanical Engineers, Apr. 2018. doi: 10.1115/DMD2018-6918.
​[28] M. Takanokura, R. Sugahara, N. Miyake, K. Ishiguro, T. Muto, and K. Sakamoto, “UPPER-LIMB ORTHOSES IMPLEMENTED WITH AIR DASHPOTS FOR SUPPRESSION OF PATHOLOGICAL TREMOR IN DAILY ACTIVITES.” Accessed: Sep. 01, 2023. [Online]. Available: https://isbweb.org/images/conf/2011/ScientificProgram/ISB2011_ScientificProgram_files/447.pdf
​[29] M. Valderrama, E. Gonzalez, and F. Garcia, “Development of a low-cost surface EMG acquisition system device for wearable applications,” in 2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI), IEEE, Oct. 2021, pp. 1–4. doi: 10.1109/CI-IBBI54220.2021.9626100.
​[30] R. D. Castillo Ayala, “Caracterización y control del temblor de pacientes con Parkinson a través de vibraciones mecánicas inversas,” instname:Universidad de los Andes, 2019, Accessed: Sep. 02, 2023. [Online]. Available: http://hdl.handle.net/1992/44659
​[31] R. J. Páez Salgado, “Development of a device for the treatment of tremors in patients with Parkinson’s disease through inverse vibrations,” instname:Universidad de los Andes, 2019, Accessed: Sep. 02, 2023. [Online]. Available: http://hdl.handle.net/1992/34066
​[32] S. Abramavičius, M. Venslauskas, A. Vaitkus, V. Gudžiūnas, O. Laucius, and E. Stankevičius, “Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study,” Medicina 2020, Vol. 56, Page 552, vol. 56, no. 10, p. 552, Oct. 2020, doi: 10.3390/MEDICINA56100552.
​[33] “Chapter 14 Interference and Diffraction.” Accessed: Sep. 01, 2023. [Online]. Available: https://web.mit.edu/8.02t/www/802TEAL3D/visualizations/coursenotes/modules/guide14.pdf
​[34] Cambridge Dictionary, “DESTRUCTIVE INTERFERENCE - Cambridge English Dictionary.” Accessed: Sep. 01, 2023. [Online]. Available: https://dictionary.cambridge.org/dictionary/english/destructive-interference
​[35] Vybronics, “Coin type vibration motor.” Jul. 01, 2020. Accessed: Aug. 31, 2023. [Online]. Available: https://www.vybronics.com/wp-content/uploads/datasheet-files/Vybronics-VC0720B001F-datasheet.pdf
​[36] J. S. Lora-Millán, R. López-Blanco, J. Á. Gallego, A. Méndez-Guerrero, J. González de la Aleja, and E. Rocon, “Mechanical vibration does not systematically reduce the tremor in essential tremor patients,” Sci Rep, vol. 9, no. 1, p. 16476, Nov. 2019, doi: 10.1038/s41598-019-52988-8.
​[37] European Comission, “Low Voltage Directive (LVD).” Accessed: Sep. 01, 2023. [Online]. Available: https://single-market-economy.ec.europa.eu/sectors/electrical-and-electronic-engineering-industries-eei/low-voltage-directive-lvd_en
​[38] INVIMA, “ABC de Dispositivos Médicos.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.invima.gov.co/documents/20143/442916/abc_dispositivos-medicos.pdf/d32f6922-0c50-bcaa-6b53-066edfb98274
​[39] INVIMA, “Dispositivos Médicos y Equipos Biomédicos”, Accessed: Sep. 01, 2023. [Online]. Available: https://www.invima.gov.co/dispositivos-medicos-y-equipos-biomedicos
​[40] “IEC 60601-1: Medical electrical equipment—Part 1: General requirements for basic safety and essential performance,” International Electrotechnical Commission, 2006.
​[41] “IEC 60601-2-57: Medical electrical equipment - Part 2-57: Particular requirements for the basic safety and essential performance of non-laser light source equipment intended for therapeutic, diagnostic, monitoring, and cosmetic/aesthetic use,” International Electrotechnical Commission.
​[42] “ISO 14971: Medical Device Risk Management,” International Organization for Standardization.
​[43] “ISO 10993-10: Biological evaluation of medical devices — Part 10: Tests for skin sensitization,” International Organization for Standardization.
​[44] D. Nacopoulos, “Compression Therapy: A Treatment of Rubral Tremor,” International Parkinson and Movement Disorder Society. 2019. Accessed: Sep. 01, 2023. [Online]. Available: https://www.mdsabstracts.org/abstract/compression-therapy-a-treatment-of-rubral-tremor/
​[45] J. E. Becerra et al., “Economic Analysis of Deep Brain Stimulation in Parkinson Disease: Systematic Review of the Literature,” World Neurosurg, vol. 93, pp. 44–49, Sep. 2016, doi: 10.1016/j.wneu.2016.05.028.
​[46] C. Li et al., “Cost‐Effectiveness of Magnetic Resonance‐Guided Focused Ultrasound for Essential Tremor,” Movement Disorders, vol. 34, no. 5, pp. 735–743, May 2019, doi: 10.1002/mds.27587.
​[47] J. S. Perlmutter and J. W. Mink, “DEEP BRAIN STIMULATION,” Annu Rev Neurosci, vol. 29, no. 1, pp. 229–257, Jul. 2006, doi: 10.1146/annurev.neuro.29.051605.112824.
​[48] C. Li et al., “Cost‐Effectiveness of Magnetic Resonance‐Guided Focused Ultrasound for Essential Tremor,” Movement Disorders, vol. 34, no. 5, pp. 735–743, May 2019, doi: 10.1002/mds.27587.
​[49] Cruz Verde, “Propranolol 40Mg Tabla Caja X 30.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.cruzverde.com.co/propranolol-40mg-tabla-caja-x-30/COCV_385085.html
​[50] M. H. Morgan, R. L. Hewer, and R. Cooper, “Effect of the beta adrenergic blocking agent propranolol on essential tremor,” J Neurol Neurosurg Psychiatry, vol. 36, no. 4, pp. 618–624, Aug. 1973, doi: 10.1136/jnnp.36.4.618.
​[51] Cala, “New patients.” Accessed: Sep. 01, 2023. [Online]. Available: https://calahealth.com/patients/
​[52] Readi-Steadi, “Readi-Steadi Anti- Tremor Orthotic Glove System - Readi-Steadi® | Anti-Tremor Orthotic Glove System.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.readi-steadi.com/
​[53] GyroGear, “GyroGloveTM.” Accessed: Sep. 01, 2023. [Online]. Available: https://gyrogear.co/gyroglove
​[54] Steadiwear, “Steadi-Two: Tremor Reducing Glove.” Accessed: Sep. 01, 2023. [Online]. Available: https://steadiwear.com/products/steadi-two
​[55] Vilimed, “VILIM ball.” Accessed: Sep. 01, 2023. [Online]. Available: https://vilimed.com/es/produktas/vilim-ball-3/
​[56] FisioAyudas, “Manilla Antitemblor.” Accessed: Sep. 01, 2023. [Online]. Available: https://tienda.fisioayudas.com/item-manilla_antitemblor-240186
​[57] Verily, “Liftware.” Accessed: Sep. 02, 2023. [Online]. Available: https://www.liftware.com/
[58] Rudraraju S., Nguyen T. Wearable Tremor Reduction Device (TRD) for Human Hands and Arms; Proceedings of the 2018 Design of Medical Devices Conference; Minneapolis, MI, USA. 9–12 April 2018
[59] Takanokura M., Sugahara R., Miyake N., Ishiguro K., Muto T., Sakamoto K. Upper-limb orthoses implemented with air dashpots for suppression of pathological tremor in daily activities; Proceedings of the 23rd Congress of International Society of Biomechanics; Brussels, Belgium. 2–3 July 2011
[60] M. Valderrama, E. González and F. García, "Development of a low-cost surface EMG acquisition system device for wearable applications," 2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI), Bogota D.C., Colombia, 2021, pp. 1-4, doi: 10.1109/CI-IBBI54220.2021.9626100.”
[61] Castillo Ayala, R. (2019). Caracterización y control del temblor de pacientes con Parkinson a través de vibraciones mecánicas inversas. Universidad de los Andes.
[62] Páez Salgado, R. (2019). Development of a device for the treatment of tremors in patients with Parkinson's disease through inverse vibrations. Uniandes.
[63] MASSACHUSETTS INSTITUTE OF TECHNOLOGY, “Interference and Diffraction,” Mit.edu. [Online]. Available: https://web.mit.edu/8.02t/www/802TEAL3D/visualizations/coursenotes/modules/guide14.pdf. [Accessed: 28-May-2023].
[64] “Destructive interference,” Cambridge.org. [Online]. Available: https://dictionary.cambridge.org/dictionary/english/destructive-interference. [Accessed: 28-May-2023].
[65] J. S. Lora-Millán, R. López-Blanco, J. Á. Gallego, A. Méndez-Guerrero, J. González de la Aleja, and E. Rocon, “Mechanical vibration does not systematically reduce the tremor in essential tremor patients,” Sci. Rep., vol. 9, no. 1, p. 16476, 2019.
[66] Low Voltage Directive (LVD). (n.d.). Single-Market-Economy.ec.europa.eu. https://single-market- economy.ec.europa.eu/sectors/electrical-and-electronic-engineering-industries-eei/low-voltage-directive- lvd_en
[67] Ministerio de la Protección Social, “Decreto 4725 de 2005”, 2005, Accessed: May 21, 2023. [Online]. Available: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/Decreto-4725-de- 2005.pdf
[68] INVIMA, “ABC de Dispositivos Médicos”, 2023, Accessed: May 21, 2023. [Online]. Available: https://www.invima.gov.co/documents/20143/442916/abc_dispositivos-medicos.pdf/d32f6922-0c50-bcaa- 6b53-066edfb98274
[69] INVIMA, “Dispósitivos Médicos y Equipos Biomédicos”. Accessed: May 21, 2023. [Online]. Available: https://www.invima.gov.co/dispositivos-medicos-y-equipos-biomedicos
[70] IEEE. “IEC 60601-1: Medical electrical equipment—Part 1: General requirements for basic safety and essential performance,” 2006, International Electrotechnical Commission.
[71] IEC, "IEC 60601-2-57: Medical electrical equipment - Part 2-57: Particular requirements for the basic safety and essential performance of non-laser light source equipment intended for therapeutic, diagnostic, monitoring, and cosmetic/aesthetic use," International Electrotechnical Commission.
[72] ISO, "ISO 14971: Medical Device Risk Management," International Organization for Standardization.
[73] ISO, "ISO 10993-10: Biological evaluation of medical devices — Part 10: Tests for skin sensitization", International Organization for Standardization.
dc.rights.uri.none.fl_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.none.fl_str_mv 36 páginas
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad de los Andes
dc.publisher.program.none.fl_str_mv Ingeniería Biomédica
dc.publisher.faculty.none.fl_str_mv Facultad de Ingeniería
dc.publisher.department.none.fl_str_mv Departamento de Ingeniería Biomédica
publisher.none.fl_str_mv Universidad de los Andes
institution Universidad de los Andes
bitstream.url.fl_str_mv https://repositorio.uniandes.edu.co/bitstreams/913d4261-548b-427f-a630-8e52b1646cd3/download
https://repositorio.uniandes.edu.co/bitstreams/e09884ed-1548-407a-aa43-363f3eb11b71/download
https://repositorio.uniandes.edu.co/bitstreams/bae18967-35c6-4428-8289-6a93251a4118/download
https://repositorio.uniandes.edu.co/bitstreams/95853b26-7037-4906-9365-1db01e4ad58b/download
https://repositorio.uniandes.edu.co/bitstreams/4000a69b-589f-4565-8d76-a2776be5390a/download
https://repositorio.uniandes.edu.co/bitstreams/f79957c6-29be-48a7-82cc-9e55211e412c/download
https://repositorio.uniandes.edu.co/bitstreams/766ded47-48d3-48b9-b962-5a26c823785c/download
https://repositorio.uniandes.edu.co/bitstreams/5290dd89-4ea5-44dd-94c6-29fa4ffd2e2d/download
https://repositorio.uniandes.edu.co/bitstreams/a3e63fd4-b6cd-4f23-bb2a-cec7af8dbb6f/download
https://repositorio.uniandes.edu.co/bitstreams/bbc9f259-270b-413b-b89f-927f6798f6c6/download
bitstream.checksum.fl_str_mv ae9e573a68e7f92501b6913cc846c39f
48303f7ab0fff50e08c6717d2bf7bc2c
0ed81741202ac47be01b6ac772573d52
6aaf26ad0934c88b72d68044b519dd8b
356d9eab3ca69904af586c76a54ca31a
517510758a2fd981287e3e1b942ae504
6fc73fd563e8df7a442d5d073dc98172
5a00c65ee6e4811bcc5551c55708de70
e20c8bfff216574fc7e4554146882640
22a257e5991dc71b52681de0ff279844
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional Séneca
repository.mail.fl_str_mv adminrepositorio@uniandes.edu.co
_version_ 1812133954971500544
spelling Bigio Roitman, DavidCastelblanco García, Mateo AlejandroReyes Marín, Germán RaúlMartínez Hernández, Andrés SantiagoChaparro Ríos, Laura VerónicaRodríguez Márquez, SebastiánCadena Parra, Andrés FelipeHenríquez Martínez, AngieAlvarado Rueda, Sarai IlianGómez Bonilla, José Fernando2024-01-18T13:14:20Z2024-01-18T13:14:20Z2023-12-05https://hdl.handle.net/1992/73317instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Essential tremor (ET) stands as one of the most prevalent neurological disorders globally, affecting over 400 million individuals. Typically impacting those aged 20 to 60, ET significantly diminishes the quality of life, particularly in fine motor skills control, notably within the upper limbs. This impairment hinders everyday tasks like writing, drawing, and eating, often leading to complications and an increased susceptibility to Parkinson's disease. Traditional approaches for tremor reduction involve invasive measures such as medication, deep brain stimulation, and focused ultrasound via magnetic resonance, alongside emerging electrotherapy treatments. However, these solutions tend to be either invasive or expensive, with even the most cost-effective innovations facing availability challenges, especially in countries like Colombia. Recognizing the need for accessible, low-cost solutions, we introduce ART: Autonomous Regulator of Tremor.Ingeniero BiomédicoPregrado36 páginasapplication/pdfengUniversidad de los AndesIngeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería Biomédicahttps://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Autonomous Regulator of Tremor (ART)ART: regulador autónomo del temblorTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPEssential TremorMicrovibrationsCompressionOrthosisGloveIngeniería[1] S. Agarwal and M. Biagioni, “Essential Tremor,” National Library of Medicine. Accessed: Aug. 31, 2023. [Online]. Available: https://https://www.ncbi.nlm.nih.gov/books/NBK499986/www.ncbi.nlm.nih.gov/books/NBK499986/​[2] X. Zheng, A. Vieira Campos, J. Ordieres-Meré, J. Balseiro, S. Labrador Marcos, and Y. Aladro, “Continuous Monitoring of Essential Tremor Using a Portable System Based on Smartwatch,” Front Neurol, vol. 8, Mar. 2017, doi: 10.3389/fneur.2017.00096.​[3] S. Prasad, K. S. Bhalsing, K. Jhunjhunwala, A. Lenka, V. Binu, and P. K. Pal, “Phenotypic Variability of Essential Tremor Based on the Age at Onset,” Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol. 46, no. 2, pp. 192–198, Mar. 2019, doi: 10.1017/cjn.2018.384.​[4] M.-K. Pan and S.-H. Kuo, “Essential tremor: Clinical perspectives and pathophysiology,” J Neurol Sci, vol. 435, p. 120198, Apr. 2022, doi: 10.1016/j.jns.2022.120198.​[5] H. B. Delier, Z. I. Katirci Kirmaci, H. Adiguzel, and A. Demirguc, “The relationship of tremor severity with proximal and distal muscle strength and upper extremity functional skills in older adults with essential tremor,” Eur Geriatr Med, vol. 14, no. 2, pp. 381–387, Mar. 2023, doi: 10.1007/s41999-023-00766-1.​[6] P. Song et al., “The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis,” J Glob Health, vol. 11, p. 04028, Apr. 2021, doi: 10.7189/jogh.11.04028.​[7] J. García Gil, D. Mendoza Mantilla, and P. Navarro Gil, “Análisis semiológico de las manifestaciones atípicas de temblor en pacientes con enfermedad de Parkinson y temblor esencial,” Acta Neurológica Colombiana, vol. 35, no. 1, pp. 9–14, Mar. 2019, doi: 10.22379/24224022227.​[8] J. Benito León and M. León Ruiz, “Epidemiología del temblor esencial,” Rev Neurol, vol. 70, no. 04, p. 139, 2020, doi: 10.33588/rn.7004.2019316.​[9] F. Hopfner and G. Deuschl, “Managing Essential Tremor,” Neurotherapeutics, vol. 17, no. 4, pp. 1603–1621, Oct. 2020, doi: 10.1007/s13311-020-00899-2.​[10] V. Shanker, “Essential tremor: diagnosis and management,” BMJ, p. l4485, Aug. 2019, doi: 10.1136/bmj.l4485.​[11] H. J. H. Geesink and D. K. F. Meijer, “Mathematical Structure for Electromagnetic Frequencies that May Reflect Pilot Waves of Bohm’s Implicate Order,” Journal of Modern Physics, vol. 09, no. 05, pp. 851–897, 2018, doi: 10.4236/jmp.2018.95055.​[12] R. J. Páez Salgado, “Development of a device for the treatment of tremors in patients with Parkinson’s disease through inverse vibrations,” instname:Universidad de los Andes, 2019, Accessed: Sep. 01, 2023. [Online]. Available: http://hdl.handle.net/1992/34066​[13] Tracy and Tyrone, “Vibration reducing pen for people with tremors.”​[14] Inc. Cala Health, “Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors,” Justia Patents. Accessed: Aug. 31, 2023. [Online]. Available: https://patents.justia.com/patent/11596785​[15] Cala, “This is Cala kIQTM.” Accessed: Sep. 01, 2023. [Online]. Available: https://calahealth.com/​[16] P. Pal, “Guidelines for management of essential tremor,” Ann Indian Acad Neurol, vol. 14, no. 5, p. 25, 2011, doi: 10.4103/0972-2327.83097.​[17] J. Pilitsis, O. Khazen, and S. Patel, “Deep Brain Stimulation,” American Association of Neurological Surgeons. Accessed: Sep. 01, 2023. [Online]. Available: https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Deep-Brain-Stimulation​[18] L. C. Mancipe Garcia, Y. M. Rodriguez Mojica, A. M. Rodríguez Lozano, D. M. Chaustre Ruiz, J. M. Tolosa Cubillos, and F. Barragán Noriega, “Situación laboral de los especialistas en Medicina Física y Rehabilitación Colombia, antes y durante la pandemia por Covid-19,” Revista Colombiana de Médicina Física y Rehabilitación, vol. 30, no. Supl, p. 16, Jul. 2020, doi: 10.28957/rcmfr.v30spa3.​[19] I. Tzinis, “Technology Readiness Level,” National Aeronautics and Space Administration. Accessed: Sep. 01, 2023. [Online]. Available: https://www.nasa.gov/directorates/heo/scan/engineering/technology/technology_readiness_level​[20] J. Mo and R. Priefer, “Medical Devices for Tremor Suppression: Current Status and Future Directions,” Biosensors (Basel), vol. 11, no. 4, p. 99, Mar. 2021, doi: 10.3390/bios11040099.​[21] “The Emma Watch: A Wearable Device to Ease PD Tremors.” Accessed: Sep. 01, 2023. [Online]. Available: https://parkinsonsdisease.net/news/emma-watch-wearable-device-tremors​[22] E. Rocon, J. M. Belda-Lois, A. F. Ruiz, M. Manto, J. C. Moreno, and J. L. Pons, “Design and Validation of a Rehabilitation Robotic Exoskeleton for Tremor Assessment and Suppression,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 15, no. 3, pp. 367–378, Sep. 2007, doi: 10.1109/TNSRE.2007.903917.​[23] D. Huen, J. Liu, and B. Lo, “An integrated wearable robot for tremor suppression with context aware sensing,” in 2016 IEEE 13th International Conference on Wearable and Implantable Body Sensor Networks (BSN), IEEE, Jun. 2016, pp. 312–317. doi: 10.1109/BSN.2016.7516280.​[24] Y. Matsumoto et al., “Development of an elbow-forearm interlock joint mechanism toward an exoskeleton for patients with essential tremor,” in 2014 IEEE/RSJ International Conference on Intelligent Robots and Systems, IEEE, Sep. 2014, pp. 2055–2062. doi: 10.1109/IROS.2014.6942837.​[25] M. Manto, E. Rocon, J. Pons, J. M. Belda, and S. Camut, “Evaluation of a wearable orthosis and an associated algorithm for tremor suppression,” Physiol Meas, vol. 28, no. 4, pp. 415–425, Apr. 2007, doi: 10.1088/0967-3334/28/4/007.​[26] A. Zahedi, B. Zhang, A. Yi, and D. Zhang, “A Soft Exoskeleton for Tremor Suppression Equipped with Flexible Semiactive Actuator,” Soft Robot, vol. 8, no. 4, pp. 432–447, Aug. 2021, doi: 10.1089/soro.2019.0194.​[27] S. Rudraraju and T. Nguyen, “Wearable Tremor Reduction Device (TRD) for Human Hands and Arms,” in 2018 Design of Medical Devices Conference, American Society of Mechanical Engineers, Apr. 2018. doi: 10.1115/DMD2018-6918.​[28] M. Takanokura, R. Sugahara, N. Miyake, K. Ishiguro, T. Muto, and K. Sakamoto, “UPPER-LIMB ORTHOSES IMPLEMENTED WITH AIR DASHPOTS FOR SUPPRESSION OF PATHOLOGICAL TREMOR IN DAILY ACTIVITES.” Accessed: Sep. 01, 2023. [Online]. Available: https://isbweb.org/images/conf/2011/ScientificProgram/ISB2011_ScientificProgram_files/447.pdf​[29] M. Valderrama, E. Gonzalez, and F. Garcia, “Development of a low-cost surface EMG acquisition system device for wearable applications,” in 2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI), IEEE, Oct. 2021, pp. 1–4. doi: 10.1109/CI-IBBI54220.2021.9626100.​[30] R. D. Castillo Ayala, “Caracterización y control del temblor de pacientes con Parkinson a través de vibraciones mecánicas inversas,” instname:Universidad de los Andes, 2019, Accessed: Sep. 02, 2023. [Online]. Available: http://hdl.handle.net/1992/44659​[31] R. J. Páez Salgado, “Development of a device for the treatment of tremors in patients with Parkinson’s disease through inverse vibrations,” instname:Universidad de los Andes, 2019, Accessed: Sep. 02, 2023. [Online]. Available: http://hdl.handle.net/1992/34066​[32] S. Abramavičius, M. Venslauskas, A. Vaitkus, V. Gudžiūnas, O. Laucius, and E. Stankevičius, “Local Vibrational Therapy for Essential Tremor Reduction: A Clinical Study,” Medicina 2020, Vol. 56, Page 552, vol. 56, no. 10, p. 552, Oct. 2020, doi: 10.3390/MEDICINA56100552.​[33] “Chapter 14 Interference and Diffraction.” Accessed: Sep. 01, 2023. [Online]. Available: https://web.mit.edu/8.02t/www/802TEAL3D/visualizations/coursenotes/modules/guide14.pdf​[34] Cambridge Dictionary, “DESTRUCTIVE INTERFERENCE - Cambridge English Dictionary.” Accessed: Sep. 01, 2023. [Online]. Available: https://dictionary.cambridge.org/dictionary/english/destructive-interference​[35] Vybronics, “Coin type vibration motor.” Jul. 01, 2020. Accessed: Aug. 31, 2023. [Online]. Available: https://www.vybronics.com/wp-content/uploads/datasheet-files/Vybronics-VC0720B001F-datasheet.pdf​[36] J. S. Lora-Millán, R. López-Blanco, J. Á. Gallego, A. Méndez-Guerrero, J. González de la Aleja, and E. Rocon, “Mechanical vibration does not systematically reduce the tremor in essential tremor patients,” Sci Rep, vol. 9, no. 1, p. 16476, Nov. 2019, doi: 10.1038/s41598-019-52988-8.​[37] European Comission, “Low Voltage Directive (LVD).” Accessed: Sep. 01, 2023. [Online]. Available: https://single-market-economy.ec.europa.eu/sectors/electrical-and-electronic-engineering-industries-eei/low-voltage-directive-lvd_en​[38] INVIMA, “ABC de Dispositivos Médicos.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.invima.gov.co/documents/20143/442916/abc_dispositivos-medicos.pdf/d32f6922-0c50-bcaa-6b53-066edfb98274​[39] INVIMA, “Dispositivos Médicos y Equipos Biomédicos”, Accessed: Sep. 01, 2023. [Online]. Available: https://www.invima.gov.co/dispositivos-medicos-y-equipos-biomedicos​[40] “IEC 60601-1: Medical electrical equipment—Part 1: General requirements for basic safety and essential performance,” International Electrotechnical Commission, 2006.​[41] “IEC 60601-2-57: Medical electrical equipment - Part 2-57: Particular requirements for the basic safety and essential performance of non-laser light source equipment intended for therapeutic, diagnostic, monitoring, and cosmetic/aesthetic use,” International Electrotechnical Commission.​[42] “ISO 14971: Medical Device Risk Management,” International Organization for Standardization.​[43] “ISO 10993-10: Biological evaluation of medical devices — Part 10: Tests for skin sensitization,” International Organization for Standardization.​[44] D. Nacopoulos, “Compression Therapy: A Treatment of Rubral Tremor,” International Parkinson and Movement Disorder Society. 2019. Accessed: Sep. 01, 2023. [Online]. Available: https://www.mdsabstracts.org/abstract/compression-therapy-a-treatment-of-rubral-tremor/​[45] J. E. Becerra et al., “Economic Analysis of Deep Brain Stimulation in Parkinson Disease: Systematic Review of the Literature,” World Neurosurg, vol. 93, pp. 44–49, Sep. 2016, doi: 10.1016/j.wneu.2016.05.028.​[46] C. Li et al., “Cost‐Effectiveness of Magnetic Resonance‐Guided Focused Ultrasound for Essential Tremor,” Movement Disorders, vol. 34, no. 5, pp. 735–743, May 2019, doi: 10.1002/mds.27587.​[47] J. S. Perlmutter and J. W. Mink, “DEEP BRAIN STIMULATION,” Annu Rev Neurosci, vol. 29, no. 1, pp. 229–257, Jul. 2006, doi: 10.1146/annurev.neuro.29.051605.112824.​[48] C. Li et al., “Cost‐Effectiveness of Magnetic Resonance‐Guided Focused Ultrasound for Essential Tremor,” Movement Disorders, vol. 34, no. 5, pp. 735–743, May 2019, doi: 10.1002/mds.27587.​[49] Cruz Verde, “Propranolol 40Mg Tabla Caja X 30.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.cruzverde.com.co/propranolol-40mg-tabla-caja-x-30/COCV_385085.html​[50] M. H. Morgan, R. L. Hewer, and R. Cooper, “Effect of the beta adrenergic blocking agent propranolol on essential tremor,” J Neurol Neurosurg Psychiatry, vol. 36, no. 4, pp. 618–624, Aug. 1973, doi: 10.1136/jnnp.36.4.618.​[51] Cala, “New patients.” Accessed: Sep. 01, 2023. [Online]. Available: https://calahealth.com/patients/​[52] Readi-Steadi, “Readi-Steadi Anti- Tremor Orthotic Glove System - Readi-Steadi® | Anti-Tremor Orthotic Glove System.” Accessed: Sep. 01, 2023. [Online]. Available: https://www.readi-steadi.com/​[53] GyroGear, “GyroGloveTM.” Accessed: Sep. 01, 2023. [Online]. Available: https://gyrogear.co/gyroglove​[54] Steadiwear, “Steadi-Two: Tremor Reducing Glove.” Accessed: Sep. 01, 2023. [Online]. Available: https://steadiwear.com/products/steadi-two​[55] Vilimed, “VILIM ball.” Accessed: Sep. 01, 2023. [Online]. Available: https://vilimed.com/es/produktas/vilim-ball-3/​[56] FisioAyudas, “Manilla Antitemblor.” Accessed: Sep. 01, 2023. [Online]. Available: https://tienda.fisioayudas.com/item-manilla_antitemblor-240186​[57] Verily, “Liftware.” Accessed: Sep. 02, 2023. [Online]. Available: https://www.liftware.com/[58] Rudraraju S., Nguyen T. Wearable Tremor Reduction Device (TRD) for Human Hands and Arms; Proceedings of the 2018 Design of Medical Devices Conference; Minneapolis, MI, USA. 9–12 April 2018[59] Takanokura M., Sugahara R., Miyake N., Ishiguro K., Muto T., Sakamoto K. Upper-limb orthoses implemented with air dashpots for suppression of pathological tremor in daily activities; Proceedings of the 23rd Congress of International Society of Biomechanics; Brussels, Belgium. 2–3 July 2011[60] M. Valderrama, E. González and F. García, "Development of a low-cost surface EMG acquisition system device for wearable applications," 2021 IEEE 2nd International Congress of Biomedical Engineering and Bioengineering (CI-IB&BI), Bogota D.C., Colombia, 2021, pp. 1-4, doi: 10.1109/CI-IBBI54220.2021.9626100.”[61] Castillo Ayala, R. (2019). Caracterización y control del temblor de pacientes con Parkinson a través de vibraciones mecánicas inversas. Universidad de los Andes.[62] Páez Salgado, R. (2019). Development of a device for the treatment of tremors in patients with Parkinson's disease through inverse vibrations. Uniandes.[63] MASSACHUSETTS INSTITUTE OF TECHNOLOGY, “Interference and Diffraction,” Mit.edu. [Online]. Available: https://web.mit.edu/8.02t/www/802TEAL3D/visualizations/coursenotes/modules/guide14.pdf. [Accessed: 28-May-2023].[64] “Destructive interference,” Cambridge.org. [Online]. Available: https://dictionary.cambridge.org/dictionary/english/destructive-interference. [Accessed: 28-May-2023].[65] J. S. Lora-Millán, R. López-Blanco, J. Á. Gallego, A. Méndez-Guerrero, J. González de la Aleja, and E. Rocon, “Mechanical vibration does not systematically reduce the tremor in essential tremor patients,” Sci. Rep., vol. 9, no. 1, p. 16476, 2019.[66] Low Voltage Directive (LVD). (n.d.). Single-Market-Economy.ec.europa.eu. https://single-market- economy.ec.europa.eu/sectors/electrical-and-electronic-engineering-industries-eei/low-voltage-directive- lvd_en[67] Ministerio de la Protección Social, “Decreto 4725 de 2005”, 2005, Accessed: May 21, 2023. [Online]. Available: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/DE/DIJ/Decreto-4725-de- 2005.pdf[68] INVIMA, “ABC de Dispositivos Médicos”, 2023, Accessed: May 21, 2023. [Online]. Available: https://www.invima.gov.co/documents/20143/442916/abc_dispositivos-medicos.pdf/d32f6922-0c50-bcaa- 6b53-066edfb98274[69] INVIMA, “Dispósitivos Médicos y Equipos Biomédicos”. Accessed: May 21, 2023. [Online]. Available: https://www.invima.gov.co/dispositivos-medicos-y-equipos-biomedicos[70] IEEE. “IEC 60601-1: Medical electrical equipment—Part 1: General requirements for basic safety and essential performance,” 2006, International Electrotechnical Commission.[71] IEC, "IEC 60601-2-57: Medical electrical equipment - Part 2-57: Particular requirements for the basic safety and essential performance of non-laser light source equipment intended for therapeutic, diagnostic, monitoring, and cosmetic/aesthetic use," International Electrotechnical Commission.[72] ISO, "ISO 14971: Medical Device Risk Management," International Organization for Standardization.[73] ISO, "ISO 10993-10: Biological evaluation of medical devices — Part 10: Tests for skin sensitization", International Organization for Standardization.201911933201922991201921006201912022201921696201915031PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-82535https://repositorio.uniandes.edu.co/bitstreams/913d4261-548b-427f-a630-8e52b1646cd3/downloadae9e573a68e7f92501b6913cc846c39fMD51ORIGINALAutonomous Regulator of Tremor (ART).pdfAutonomous Regulator of Tremor (ART).pdfapplication/pdf1512750https://repositorio.uniandes.edu.co/bitstreams/e09884ed-1548-407a-aa43-363f3eb11b71/download48303f7ab0fff50e08c6717d2bf7bc2cMD52Autonomous Regulator of Tremor (ART) ProtocoloLab.pdfAutonomous Regulator of Tremor (ART) ProtocoloLab.pdfapplication/pdf381163https://repositorio.uniandes.edu.co/bitstreams/bae18967-35c6-4428-8289-6a93251a4118/download0ed81741202ac47be01b6ac772573d52MD53autorizacion tesis (1).pdfautorizacion tesis (1).pdfHIDEapplication/pdf769577https://repositorio.uniandes.edu.co/bitstreams/95853b26-7037-4906-9365-1db01e4ad58b/download6aaf26ad0934c88b72d68044b519dd8bMD54TEXTAutonomous Regulator of Tremor (ART).pdf.txtAutonomous Regulator of Tremor (ART).pdf.txtExtracted texttext/plain100569https://repositorio.uniandes.edu.co/bitstreams/4000a69b-589f-4565-8d76-a2776be5390a/download356d9eab3ca69904af586c76a54ca31aMD55Autonomous Regulator of Tremor (ART) ProtocoloLab.pdf.txtAutonomous Regulator of Tremor (ART) ProtocoloLab.pdf.txtExtracted texttext/plain8633https://repositorio.uniandes.edu.co/bitstreams/f79957c6-29be-48a7-82cc-9e55211e412c/download517510758a2fd981287e3e1b942ae504MD57autorizacion tesis (1).pdf.txtautorizacion tesis (1).pdf.txtExtracted texttext/plain1721https://repositorio.uniandes.edu.co/bitstreams/766ded47-48d3-48b9-b962-5a26c823785c/download6fc73fd563e8df7a442d5d073dc98172MD59THUMBNAILAutonomous Regulator of Tremor (ART).pdf.jpgAutonomous Regulator of Tremor (ART).pdf.jpgGenerated Thumbnailimage/jpeg8125https://repositorio.uniandes.edu.co/bitstreams/5290dd89-4ea5-44dd-94c6-29fa4ffd2e2d/download5a00c65ee6e4811bcc5551c55708de70MD56Autonomous Regulator of Tremor (ART) ProtocoloLab.pdf.jpgAutonomous Regulator of Tremor (ART) ProtocoloLab.pdf.jpgGenerated Thumbnailimage/jpeg11234https://repositorio.uniandes.edu.co/bitstreams/a3e63fd4-b6cd-4f23-bb2a-cec7af8dbb6f/downloade20c8bfff216574fc7e4554146882640MD58autorizacion tesis (1).pdf.jpgautorizacion tesis (1).pdf.jpgGenerated Thumbnailimage/jpeg11881https://repositorio.uniandes.edu.co/bitstreams/bbc9f259-270b-413b-b89f-927f6798f6c6/download22a257e5991dc71b52681de0ff279844MD5101992/73317oai:repositorio.uniandes.edu.co:1992/733172024-01-20 03:07:33.825https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.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