Efectos de la estimulación transcraneal con corriente directa anódica y catódica sobre la corteza prefrontal en la reconsolidación y extinción de memorias de miedo en ratas

Despite the therapeutically advantage that represent the reconsolidation for pathological memories underpinning a wide range of neuropsychiatric diseases, most of the pharmacological agents interfering with the reconsolidation are not approved for human testing. Additionally, extinction provides an...

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Autores:
Durán Molina, Johanna Marcela
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2020
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
spa
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/51265
Acceso en línea:
http://hdl.handle.net/1992/51265
Palabra clave:
Estimulación cerebral
Estimulación magnética del cerebro
Estimulación nerviosa
Campos electromagnéticos
Memoria
Corteza prefrontal
Ratas como animales de laboratorio
Psicología
Rights
openAccess
License
http://creativecommons.org/licenses/by/4.0/
Description
Summary:Despite the therapeutically advantage that represent the reconsolidation for pathological memories underpinning a wide range of neuropsychiatric diseases, most of the pharmacological agents interfering with the reconsolidation are not approved for human testing. Additionally, extinction provides an effective and practical, but not permanent, method of addressing pathogenic emotional responses. Transcranial direct current stimulation (tDCS) is a non-invasive neurostimulation technique used to alter cortical neuronal excitability via externally applied electric fields. However, there is a lack of evidence about the effect of these technology to modify memory traces via reactivation/reconsolidation mechanism. In this study, we evaluate the effect of cathodal and anodal transcranial direct current stimulation applied after memory reactivation and extinction in rats...