Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts

Cordyceps is a genus of fungal entomopathogens, which is currently studied because of its potential in pharmaceutic applications. Cordyceps nidus (Hypocreales: Cordycipitaceae) is a parasite of young trapdoor spiders (Mygalomorpha) in rainforests from Neotropics. This species is phylogenetically rel...

Full description

Autores:
Figueroa Morales, María Alejandra
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2018
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/60826
Acceso en línea:
http://hdl.handle.net/1992/60826
Palabra clave:
Cordyceps nidus
Cordyceps
Hongos entomopatógenos
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.title.spa.fl_str_mv Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
title Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
spellingShingle Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
Cordyceps nidus
Cordyceps
Hongos entomopatógenos
title_short Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
title_full Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
title_fullStr Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
title_full_unstemmed Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
title_sort Inhibitory activity and toxicity of Cordyceps nidus lyophilized extracts
dc.creator.fl_str_mv Figueroa Morales, María Alejandra
dc.contributor.advisor.none.fl_str_mv Chiriví Salomón, Juan Sebastián
Groot de Restrepo, Helena
Narváez Noguera, Diana María
Restrepo Restrepo, Silvia
dc.contributor.author.none.fl_str_mv Figueroa Morales, María Alejandra
dc.subject.keyword.spa.fl_str_mv Cordyceps nidus
Cordyceps
Hongos entomopatógenos
topic Cordyceps nidus
Cordyceps
Hongos entomopatógenos
description Cordyceps is a genus of fungal entomopathogens, which is currently studied because of its potential in pharmaceutic applications. Cordyceps nidus (Hypocreales: Cordycipitaceae) is a parasite of young trapdoor spiders (Mygalomorpha) in rainforests from Neotropics. This species is phylogenetically related to Cordyceps militaris and Cordyceps pruinosa, which are traditionally used because of their medicinal properties. Previous metabolomics assays and some biological activity analyses have shown unique biochemical characteristics of C. nidus. Although, this species has a strong potential in the industry of natural products, the toxicity of its extracts has to be deeply determined in order to understand the safety of its application. So, we aimed to evaluate the cytotoxicity and genotoxicity of C. nidus methanolic extracts. Additionally, we also aimed to prove the bactericidal effect with a different method than the one used before, due to its reported activity against several gram-positive bacteria. Results showed that there is a negative...
publishDate 2018
dc.date.issued.spa.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2022-09-26T22:02:46Z
dc.date.available.none.fl_str_mv 2022-09-26T22:02:46Z
dc.type.spa.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.language.iso.spa.fl_str_mv eng
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dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.extent.spa.fl_str_mv 14 hojas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad de los Andes
dc.publisher.program.spa.fl_str_mv Biología
Microbiología
dc.publisher.faculty.spa.fl_str_mv Facultad de Ciencias
dc.publisher.department.spa.fl_str_mv Departamento de Ciencias Biológicas
institution Universidad de los Andes
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spelling Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Chiriví Salomón, Juan Sebastián77904129-a65e-4497-b17e-40e88f255114500Groot de Restrepo, Helena22da896e-781a-4a3b-a149-e88f7b93cf10400Narváez Noguera, Diana María9f5cce59-93b7-44de-a4ac-b1066e9aded1400Restrepo Restrepo, Silviavirtual::11261-1Figueroa Morales, María Alejandra1f6f7399-5c48-46bf-8237-47a8b56709355002022-09-26T22:02:46Z2022-09-26T22:02:46Z2018http://hdl.handle.net/1992/60826instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/795748-1001Cordyceps is a genus of fungal entomopathogens, which is currently studied because of its potential in pharmaceutic applications. Cordyceps nidus (Hypocreales: Cordycipitaceae) is a parasite of young trapdoor spiders (Mygalomorpha) in rainforests from Neotropics. This species is phylogenetically related to Cordyceps militaris and Cordyceps pruinosa, which are traditionally used because of their medicinal properties. Previous metabolomics assays and some biological activity analyses have shown unique biochemical characteristics of C. nidus. Although, this species has a strong potential in the industry of natural products, the toxicity of its extracts has to be deeply determined in order to understand the safety of its application. So, we aimed to evaluate the cytotoxicity and genotoxicity of C. nidus methanolic extracts. Additionally, we also aimed to prove the bactericidal effect with a different method than the one used before, due to its reported activity against several gram-positive bacteria. Results showed that there is a negative...Cordyceps es un género de hongos entomopatógenos, que actualmente es estudiado debido a su potencial en aplicaciones farmacúuticas. Cordyceps nidus (Hypocreales: Cordycipitaceae) es un parásito de arañas tramperas jóvenes (Mygalomorpha) en selvas tropicales del Neotropico. Esta especie está relacionada filogenéticamente con Cordyceps militaris y Cordyceps pruinosa, los cuales han sido utilizados tradicionalmente debido a sus propiedades medicinales. Anteriores estudios de metabolómica y algunos análisis de su actividad biológica han demostrado características bioquímicas únicas de C. nidus. Aunque, esta especie tiene un fuerte potencial en la industria de productos naturales, la toxicidad de sus extractos tiene que ser profundamente determinada para entender la seguridad de su aplicación. Por lo tanto, nuestro objetivo fue evaluar la citotoxicidad y la genotoxicidad de los extractos metanólicos de Cordyceps nidus. Adicionalmente, también pretendimos probar el efecto bactericida con un método diferente al utilizado anteriormente, debido a su actividad reportada contra varias bacterias gram-positivas. Los resultados...BiólogoMicrobiólogoPregrado14 hojasapplication/pdfengUniversidad de los AndesBiologíaMicrobiologíaFacultad de CienciasDepartamento de Ciencias BiológicasInhibitory activity and toxicity of Cordyceps nidus lyophilized extractsTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPCordyceps nidusCordycepsHongos entomopatógenos201213440Publicationhttps://scholar.google.es/citations?user=7_dVIeAAAAAJvirtual::11261-10000-0001-9016-1040virtual::11261-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000468800virtual::11261-1d7d594d1-aae9-471e-be1d-fc6bbcabef5cvirtual::11261-1d7d594d1-aae9-471e-be1d-fc6bbcabef5cvirtual::11261-1ORIGINAL13212.pdfapplication/pdf16533083https://repositorio.uniandes.edu.co/bitstreams/95124198-f3b5-4eb9-949e-651f6974b8a4/downloade84aa3f6af08431e0577d39bf9a1b67eMD51TEXT13212.pdf.txt13212.pdf.txtExtracted texttext/plain32694https://repositorio.uniandes.edu.co/bitstreams/b7eb79d9-4301-4947-afd0-220c0edc9560/downloadd9e9292f775abe58297944a8f624d2f2MD52THUMBNAIL13212.pdf.jpg13212.pdf.jpgIM Thumbnailimage/jpeg26403https://repositorio.uniandes.edu.co/bitstreams/ab9e3013-71a1-41ec-937a-68147a7e4b43/download9fe062a255826f6896163f78a3e71328MD531992/60826oai:repositorio.uniandes.edu.co:1992/608262024-03-13 14:23:24.866http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co

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