Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116
El cáncer colorrectal es una enfermedad de alta incidencia y una de las principales causas de muerte por cáncer en todo el mundo. La doxorrubicina, un fármaco comúnmente utilizado en quimioterapia, tiene efectos secundarios graves a altas dosis, lo que ha impulsado la búsqueda de terapias combinadas...
- Autores:
-
Castellanos Aldana, Camila
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/68852
- Acceso en línea:
- http://hdl.handle.net/1992/68852
- Palabra clave:
- Losartán
Doxorrubicina
Ciclo celular
Migración
Proliferación
Cáncer colorrectal
Química
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| title |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| spellingShingle |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 Losartán Doxorrubicina Ciclo celular Migración Proliferación Cáncer colorrectal Química |
| title_short |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| title_full |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| title_fullStr |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| title_full_unstemmed |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| title_sort |
Análisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116 |
| dc.creator.fl_str_mv |
Castellanos Aldana, Camila |
| dc.contributor.advisor.none.fl_str_mv |
Jiménez Díaz, Elizabeth |
| dc.contributor.author.none.fl_str_mv |
Castellanos Aldana, Camila |
| dc.contributor.researchgroup.es_CO.fl_str_mv |
Grupo de investigación en Bioquímica Aplicada |
| dc.subject.keyword.none.fl_str_mv |
Losartán Doxorrubicina Ciclo celular Migración Proliferación Cáncer colorrectal |
| topic |
Losartán Doxorrubicina Ciclo celular Migración Proliferación Cáncer colorrectal Química |
| dc.subject.themes.es_CO.fl_str_mv |
Química |
| description |
El cáncer colorrectal es una enfermedad de alta incidencia y una de las principales causas de muerte por cáncer en todo el mundo. La doxorrubicina, un fármaco comúnmente utilizado en quimioterapia, tiene efectos secundarios graves a altas dosis, lo que ha impulsado la búsqueda de terapias combinadas para mejorar su eficacia. Estudios previos han demostrado que la combinación de doxorrubicina con el fármaco hipertensivo Losartán muestra sinergia en el tratamiento. Este estudio se centró en caracterizar molecular y fenotípicamente esta terapia combinada en células de cáncer colorrectal, revelando que la combinación aumenta el arresto celular en la fase S, disminuye la proliferación y la formación de tumores debido al daño en el ADN irreparable, y mejora los efectos secundarios de la doxorrubicina. Además, la terapia combinatoria reduce la movilidad celular mediante la disminución de la expresión de TGF-B1, asociada a la metástasis y la invasión del cáncer. Se sugiere futuros estudios para analizar la expresión de proteínas de la vía PI3K/AKT y TGF-B1 para comprender mejor los mecanismos afectados por la terapia combinada. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-07-28T15:08:26Z |
| dc.date.available.none.fl_str_mv |
2023-07-28T15:08:26Z |
| dc.date.issued.none.fl_str_mv |
2023-07-24 |
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Trabajo de grado - Pregrado |
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info:eu-repo/semantics/bachelorThesis |
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D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. Angiotensin Inhibition Enhances Drug Delivery and Potentiates Chemotherapy by Decompressing Tumour Blood Vessels. Nat Commun 2013, 4 (1), 2516. https://doi.org/10.1038/ncomms3516. Bishop, N.; Kalajzic, I.; Arshad, F.; Lefley, D.; Gossiel, F.; Ottewell, P. Losartan Reduces Circulating TGFb and CTX and Increases Vertebral Bone Mass in the OIM Mouse. BA 2019. https://doi.org/10.1530/boneabs.7.P133. Pallasch, F. B.; Schumacher, U. Angiotensin Inhibition, TGF-B and EMT in Cancer. Cancers 2020, 12 (10), 2785. https://doi.org/10.3390/cancers12102785. |
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Repositorio institucional Séneca |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Jiménez Díaz, Elizabethvirtual::4680-1Castellanos Aldana, Camilaba061df7-a77c-44f9-a289-f953fe122212600Grupo de investigación en Bioquímica Aplicada2023-07-28T15:08:26Z2023-07-28T15:08:26Z2023-07-24http://hdl.handle.net/1992/68852instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/El cáncer colorrectal es una enfermedad de alta incidencia y una de las principales causas de muerte por cáncer en todo el mundo. La doxorrubicina, un fármaco comúnmente utilizado en quimioterapia, tiene efectos secundarios graves a altas dosis, lo que ha impulsado la búsqueda de terapias combinadas para mejorar su eficacia. Estudios previos han demostrado que la combinación de doxorrubicina con el fármaco hipertensivo Losartán muestra sinergia en el tratamiento. Este estudio se centró en caracterizar molecular y fenotípicamente esta terapia combinada en células de cáncer colorrectal, revelando que la combinación aumenta el arresto celular en la fase S, disminuye la proliferación y la formación de tumores debido al daño en el ADN irreparable, y mejora los efectos secundarios de la doxorrubicina. Además, la terapia combinatoria reduce la movilidad celular mediante la disminución de la expresión de TGF-B1, asociada a la metástasis y la invasión del cáncer. Se sugiere futuros estudios para analizar la expresión de proteínas de la vía PI3K/AKT y TGF-B1 para comprender mejor los mecanismos afectados por la terapia combinada.QuímicoPregradoBioquímica42 páginasapplication/pdfspaUniversidad de los AndesQuímicaFacultad de CienciasDepartamento de QuímicaAnálisis del efecto de la terapia doxorrubicina-losartán sobre el ciclo celular, la proliferación y la migración en células de cáncer colorrectal HCT116Trabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPLosartánDoxorrubicinaCiclo celularMigraciónProliferaciónCáncer colorrectalQuímicaMarley, A. R.; Nan, H. Epidemiology of Colorectal Cancer. Int J Mol Epidemiol Genet 2016, 7 (3), 105-114.Mármol, I.; Sánchez-de-Diego, C.; Pradilla Dieste, A.; Cerrada, E.; Rodriguez Yoldi, M. Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer. 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Toxicology and Applied Pharmacology 2022, 440, 115951. https://doi.org/10.1016/j.taap.2022.115951.Hashemzehi, M.; Rahmani, F.; Khoshakhlagh, M.; Avan, A.; Asgharzadeh, F.; Barneh, F.; Moradi-Marjaneh, R.; Soleimani, A.; Fiuji, H.; Ferns, G. A.; Ryzhikov, M.; Jafari, M.; Khazaei, M.; Hassanian, S. M. Angiotensin Receptor Blocker Losartan Inhibits Tumor Growth of Colorectal Cancer. EXCLI Journal; 20:Doc506; ISSN 1611-2156 2021. https://doi.org/10.17179/EXCLI2020-3083.Khoshghamat, N.; Jafari, N.; Toloue-pouya, V.; Azami, S.; Mirnourbakhsh, S. H.; Khazaei, M.; Ferns, G. A.; Rajabian, M.; Avan, A. The Therapeutic Potential of Renin-Angiotensin System Inhibitors in the Treatment of Pancreatic Cancer. Life Sciences 2021, 270, 119118. https://doi.org/10.1016/j.lfs.2021.119118.Melo Torres, C. P. Rational Approach to Evaluate Interaction Effect on Combination Therapy for Cancer Treatment with Doxorubicin and Non- Traditional Chemotherapeutic Drugs (Metformin, Losartan, Taurine and Salicylic Acid ), Universidad de los andes, 2021.Tallarida, R. J. Quantitative Methods for Assessing Drug Synergism. Genes Cancer 2011, 2 (11), 1003-1008. https://doi.org/10.1177/1947601912440575.Hashemzehi, M.; Naghibzadeh, N.; Asgharzadeh, F.; Mostafapour, A.; Hassanian, S. M.; Ferns, G. A.; Cho, W. C.; Avan, A.; Khazaei, M. The Therapeutic Potential of Losartan in Lung Metastasis of Colorectal Cancer. EXCLI Journal; 19:Doc927; ISSN 1611-2156 2020. https://doi.org/10.17179/EXCLI2020-2093.Godugu, C.; Patel, A. R.; Doddapaneni, R.; Marepally, S.; Jackson, T.; Singh, M. Inhalation Delivery of Telmisartan Enhances Intratumoral Distribution of Nanoparticles in Lung Cancer Models. Journal of Controlled Release 2013, 172 (1), 86-95. https://doi.org/10.1016/j.jconrel.2013.06.036.Smith, G. 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