Cognitive function using event-related potentials (P300) on epileptic patients : a colombian study

Cognitive function for thirteen patients with epilepsy was evaluated through auditory and visual P300 elicited using oddball-paradigm for recording electrodes Cz and Pz. Twelve healthy subjects were selected as control group in order to evaluate the effect of disease on normal cognitive function. Significant prolonged P300 latencies were found in patient group for auditory (p = 0:005) and visual (p = 0:048) P300 compared with control group. P300 amplitude was found to be lower in patients than in controls but no significant differences were found. Clinical variables such as age, age at onset epilepsy, duration of disease, seizure frequency, Antiepileptic Drugs (AEDs) therapy and epilepsy lesion characteristics were correlated with P300 wave (amplitude and latency). Patients medicated with more than one AED had prolonged P300 latencies and lower amplitudes than the ones with only one AED for both auditory and visual P300, but significant differences were just found for auditory P300 latency (p = 0:02). significant differences were found just for auditory P300 latency. Lateralization and location of highest P300 latency was evaluated based on epileptic lesion in patients with focal epilepsy. General tendencies were found for some patients but due to the small sample size no significant results were reported.

• Autores: Barbosa Rondon, Lina María; Espinosa Jovel, Camilo; Le Van Quyen, Michel
• Fecha de publicación: 2019
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: eng
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/44340
• Acceso en línea: http://hdl.handle.net/1992/44340
• Palabra clave: Potenciales evocados auditivos - Investigaciones; Potenciales evocados visuales; Cerebro - Investigaciones; Epilepsia - Investigaciones; Electroencefalografía - Investigaciones; Ingeniería
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/