Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors

The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron...

Full description

Autores:
Quintero Escobar, María Carolina
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2016
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
spa
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/7711
Acceso en línea:
http://hdl.handle.net/1992/7711
Palabra clave:
Tronco cerebral - Investigaciones - Simulación por computador
Quimiorreceptores - Investigaciones - Simulación por computador
Quimiorrecepción - Investigaciones - Simulación por computador
Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador
Ingeniería
Rights
openAccess
License
https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
id UNIANDES2_ccd28eb2e9bb948fc5180d76a7f7fe52
oai_identifier_str oai:repositorio.uniandes.edu.co:1992/7711
network_acronym_str UNIANDES2
network_name_str Séneca: repositorio Uniandes
repository_id_str
spelling Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cordovez Alvarez, Juan Manuelbcc44a60-316b-4acc-83ed-7231956ec30f400Putnam, Robert W.0efddafa-5c6d-4ead-a6e6-9b747ea7c63a500Toporikova, Natalia39e6bcc1-1fcd-485f-ace5-fa57a2a02efb500Valderrama Manrique, Mario Andrés4fb75d66-99e5-4e76-b591-d5b65f89abbf400Hartzler, Lynnc015b212-cd94-49d3-af49-2681a7343462500Quintero Escobar, María Carolinae9d3e2ab-6001-4dc1-86a3-1c47d8a1787c5002018-09-27T16:36:45Z2018-09-27T16:36:45Z2016http://hdl.handle.net/1992/771110.57784/1992/7711u729325.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron model was developed following a Hodgkin-Huxley formulation characterized by a set of eleven mammalian C02/H+-sensitive ion currents: a voltage-sensitive Na+ current (INa), three Ca2+ currents (IL, IN, IT), inward and delayed rectifier K+ (Iir, Idr), two additional K+ currents (IA, IM), two Ca2+-sensitive K+ currents (ISK, IBK), and a hyperpolarization activated current (IH). We used the model to (i) simulate the general electrophysiological behavior of spontaneous chemosensitive neurons and their response to hypercapnic acidotic stimuli, (ii) to compute firing frequencies in response to different acidotic conditions, (iii) to study the effect of each ionic current on the firing rate, and (iv) to establish the role of the currents on the chemosensitive response. The results of this model give insights into the cellular mechanisms acting together to activate and modulate the C02/H* response of central chemoreceptors and argue in favor of additional braking pathways limiting the firing frequency by means of Ca2+-sensitive K+ current activationDoctor en IngenieríaDoctorado79 hojasapplication/pdfspaUniandesDoctorado en IngenieríaFacultad de Ingenieríainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaTheoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptorsTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TDTronco cerebral - Investigaciones - Simulación por computadorQuimiorreceptores - Investigaciones - Simulación por computadorQuimiorrecepción - Investigaciones - Simulación por computadorDióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computadorIngenieríaPublicationTEXTu729325.pdf.txtu729325.pdf.txtExtracted texttext/plain155794https://repositorio.uniandes.edu.co/bitstreams/64cad367-e464-441f-80ff-f8c58ebd3787/download7daa2170c2c5559951711e1da92c74bdMD54THUMBNAILu729325.pdf.jpgu729325.pdf.jpgIM Thumbnailimage/jpeg6001https://repositorio.uniandes.edu.co/bitstreams/339f00f3-0d32-4476-a97e-b872e45a9116/download77bf45cdee63ceb2df5fda062227046aMD55ORIGINALu729325.pdfapplication/pdf7195968https://repositorio.uniandes.edu.co/bitstreams/cdeee3d2-3b19-4546-ad22-d3c9ffff17b1/download8a5c9ec3060486679a02b83d3bb7ac0fMD511992/7711oai:repositorio.uniandes.edu.co:1992/77112024-08-26 15:22:45.886https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co
dc.title.es_CO.fl_str_mv Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
title Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
spellingShingle Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
Tronco cerebral - Investigaciones - Simulación por computador
Quimiorreceptores - Investigaciones - Simulación por computador
Quimiorrecepción - Investigaciones - Simulación por computador
Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador
Ingeniería
title_short Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
title_full Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
title_fullStr Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
title_full_unstemmed Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
title_sort Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
dc.creator.fl_str_mv Quintero Escobar, María Carolina
dc.contributor.advisor.none.fl_str_mv Cordovez Alvarez, Juan Manuel
Putnam, Robert W.
Toporikova, Natalia
Valderrama Manrique, Mario Andrés
Hartzler, Lynn
dc.contributor.author.none.fl_str_mv Quintero Escobar, María Carolina
dc.subject.keyword.es_CO.fl_str_mv Tronco cerebral - Investigaciones - Simulación por computador
Quimiorreceptores - Investigaciones - Simulación por computador
Quimiorrecepción - Investigaciones - Simulación por computador
Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador
topic Tronco cerebral - Investigaciones - Simulación por computador
Quimiorreceptores - Investigaciones - Simulación por computador
Quimiorrecepción - Investigaciones - Simulación por computador
Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador
Ingeniería
dc.subject.themes.none.fl_str_mv Ingeniería
description The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron model was developed following a Hodgkin-Huxley formulation characterized by a set of eleven mammalian C02/H+-sensitive ion currents: a voltage-sensitive Na+ current (INa), three Ca2+ currents (IL, IN, IT), inward and delayed rectifier K+ (Iir, Idr), two additional K+ currents (IA, IM), two Ca2+-sensitive K+ currents (ISK, IBK), and a hyperpolarization activated current (IH). We used the model to (i) simulate the general electrophysiological behavior of spontaneous chemosensitive neurons and their response to hypercapnic acidotic stimuli, (ii) to compute firing frequencies in response to different acidotic conditions, (iii) to study the effect of each ionic current on the firing rate, and (iv) to establish the role of the currents on the chemosensitive response. The results of this model give insights into the cellular mechanisms acting together to activate and modulate the C02/H* response of central chemoreceptors and argue in favor of additional braking pathways limiting the firing frequency by means of Ca2+-sensitive K+ current activation
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2018-09-27T16:36:45Z
dc.date.available.none.fl_str_mv 2018-09-27T16:36:45Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/1992/7711
dc.identifier.doi.none.fl_str_mv 10.57784/1992/7711
dc.identifier.pdf.none.fl_str_mv u729325.pdf
dc.identifier.instname.spa.fl_str_mv instname:Universidad de los Andes
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Séneca
dc.identifier.repourl.spa.fl_str_mv repourl:https://repositorio.uniandes.edu.co/
url http://hdl.handle.net/1992/7711
identifier_str_mv 10.57784/1992/7711
u729325.pdf
instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
repourl:https://repositorio.uniandes.edu.co/
dc.language.iso.es_CO.fl_str_mv spa
language spa
dc.rights.uri.*.fl_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.es_CO.fl_str_mv 79 hojas
dc.format.mimetype.es_CO.fl_str_mv application/pdf
dc.publisher.es_CO.fl_str_mv Uniandes
dc.publisher.program.es_CO.fl_str_mv Doctorado en Ingeniería
dc.publisher.faculty.es_CO.fl_str_mv Facultad de Ingeniería
dc.source.es_CO.fl_str_mv instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
instname_str Universidad de los Andes
institution Universidad de los Andes
reponame_str Repositorio Institucional Séneca
collection Repositorio Institucional Séneca
bitstream.url.fl_str_mv https://repositorio.uniandes.edu.co/bitstreams/64cad367-e464-441f-80ff-f8c58ebd3787/download
https://repositorio.uniandes.edu.co/bitstreams/339f00f3-0d32-4476-a97e-b872e45a9116/download
https://repositorio.uniandes.edu.co/bitstreams/cdeee3d2-3b19-4546-ad22-d3c9ffff17b1/download
bitstream.checksum.fl_str_mv 7daa2170c2c5559951711e1da92c74bd
77bf45cdee63ceb2df5fda062227046a
8a5c9ec3060486679a02b83d3bb7ac0f
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional Séneca
repository.mail.fl_str_mv adminrepositorio@uniandes.edu.co
_version_ 1812133895112491008