Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors
The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron...
- Autores:
-
Quintero Escobar, María Carolina
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2016
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/7711
- Acceso en línea:
- http://hdl.handle.net/1992/7711
- Palabra clave:
- Tronco cerebral - Investigaciones - Simulación por computador
Quimiorreceptores - Investigaciones - Simulación por computador
Quimiorrecepción - Investigaciones - Simulación por computador
Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador
Ingeniería
- Rights
- openAccess
- License
- https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
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Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cordovez Alvarez, Juan Manuelbcc44a60-316b-4acc-83ed-7231956ec30f400Putnam, Robert W.0efddafa-5c6d-4ead-a6e6-9b747ea7c63a500Toporikova, Natalia39e6bcc1-1fcd-485f-ace5-fa57a2a02efb500Valderrama Manrique, Mario Andrés4fb75d66-99e5-4e76-b591-d5b65f89abbf400Hartzler, Lynnc015b212-cd94-49d3-af49-2681a7343462500Quintero Escobar, María Carolinae9d3e2ab-6001-4dc1-86a3-1c47d8a1787c5002018-09-27T16:36:45Z2018-09-27T16:36:45Z2016http://hdl.handle.net/1992/771110.57784/1992/7711u729325.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron model was developed following a Hodgkin-Huxley formulation characterized by a set of eleven mammalian C02/H+-sensitive ion currents: a voltage-sensitive Na+ current (INa), three Ca2+ currents (IL, IN, IT), inward and delayed rectifier K+ (Iir, Idr), two additional K+ currents (IA, IM), two Ca2+-sensitive K+ currents (ISK, IBK), and a hyperpolarization activated current (IH). We used the model to (i) simulate the general electrophysiological behavior of spontaneous chemosensitive neurons and their response to hypercapnic acidotic stimuli, (ii) to compute firing frequencies in response to different acidotic conditions, (iii) to study the effect of each ionic current on the firing rate, and (iv) to establish the role of the currents on the chemosensitive response. The results of this model give insights into the cellular mechanisms acting together to activate and modulate the C02/H* response of central chemoreceptors and argue in favor of additional braking pathways limiting the firing frequency by means of Ca2+-sensitive K+ current activationDoctor en IngenieríaDoctorado79 hojasapplication/pdfspaUniandesDoctorado en IngenieríaFacultad de Ingenieríainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaTheoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptorsTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TDTronco cerebral - Investigaciones - Simulación por computadorQuimiorreceptores - Investigaciones - Simulación por computadorQuimiorrecepción - Investigaciones - Simulación por computadorDióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computadorIngenieríaPublicationTEXTu729325.pdf.txtu729325.pdf.txtExtracted texttext/plain155794https://repositorio.uniandes.edu.co/bitstreams/64cad367-e464-441f-80ff-f8c58ebd3787/download7daa2170c2c5559951711e1da92c74bdMD54THUMBNAILu729325.pdf.jpgu729325.pdf.jpgIM Thumbnailimage/jpeg6001https://repositorio.uniandes.edu.co/bitstreams/339f00f3-0d32-4476-a97e-b872e45a9116/download77bf45cdee63ceb2df5fda062227046aMD55ORIGINALu729325.pdfapplication/pdf7195968https://repositorio.uniandes.edu.co/bitstreams/cdeee3d2-3b19-4546-ad22-d3c9ffff17b1/download8a5c9ec3060486679a02b83d3bb7ac0fMD511992/7711oai:repositorio.uniandes.edu.co:1992/77112024-08-26 15:22:45.886https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |
dc.title.es_CO.fl_str_mv |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
title |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
spellingShingle |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors Tronco cerebral - Investigaciones - Simulación por computador Quimiorreceptores - Investigaciones - Simulación por computador Quimiorrecepción - Investigaciones - Simulación por computador Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador Ingeniería |
title_short |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
title_full |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
title_fullStr |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
title_full_unstemmed |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
title_sort |
Theoretical perspectives on central chemoreception - intrinsic excitation-inhibition mechanisms in brainstem chemoreceptors |
dc.creator.fl_str_mv |
Quintero Escobar, María Carolina |
dc.contributor.advisor.none.fl_str_mv |
Cordovez Alvarez, Juan Manuel Putnam, Robert W. Toporikova, Natalia Valderrama Manrique, Mario Andrés Hartzler, Lynn |
dc.contributor.author.none.fl_str_mv |
Quintero Escobar, María Carolina |
dc.subject.keyword.es_CO.fl_str_mv |
Tronco cerebral - Investigaciones - Simulación por computador Quimiorreceptores - Investigaciones - Simulación por computador Quimiorrecepción - Investigaciones - Simulación por computador Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador |
topic |
Tronco cerebral - Investigaciones - Simulación por computador Quimiorreceptores - Investigaciones - Simulación por computador Quimiorrecepción - Investigaciones - Simulación por computador Dióxido de carbono - Efectos fisiológicos - Investigaciones - Simulación por computador Ingeniería |
dc.subject.themes.none.fl_str_mv |
Ingeniería |
description |
The aim of this work was to investigate intrinsic mechanisms of activation and inhibition of the C02 response in central chemoreceptors. We employed computational single neuron modeling to simulate the basic electrochemical behavior of individual chemoreceptors from the brainstem. The single-neuron model was developed following a Hodgkin-Huxley formulation characterized by a set of eleven mammalian C02/H+-sensitive ion currents: a voltage-sensitive Na+ current (INa), three Ca2+ currents (IL, IN, IT), inward and delayed rectifier K+ (Iir, Idr), two additional K+ currents (IA, IM), two Ca2+-sensitive K+ currents (ISK, IBK), and a hyperpolarization activated current (IH). We used the model to (i) simulate the general electrophysiological behavior of spontaneous chemosensitive neurons and their response to hypercapnic acidotic stimuli, (ii) to compute firing frequencies in response to different acidotic conditions, (iii) to study the effect of each ionic current on the firing rate, and (iv) to establish the role of the currents on the chemosensitive response. The results of this model give insights into the cellular mechanisms acting together to activate and modulate the C02/H* response of central chemoreceptors and argue in favor of additional braking pathways limiting the firing frequency by means of Ca2+-sensitive K+ current activation |
publishDate |
2016 |
dc.date.issued.none.fl_str_mv |
2016 |
dc.date.accessioned.none.fl_str_mv |
2018-09-27T16:36:45Z |
dc.date.available.none.fl_str_mv |
2018-09-27T16:36:45Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Doctorado |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TD |
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http://purl.org/coar/resource_type/c_db06 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/1992/7711 |
dc.identifier.doi.none.fl_str_mv |
10.57784/1992/7711 |
dc.identifier.pdf.none.fl_str_mv |
u729325.pdf |
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reponame:Repositorio Institucional Séneca |
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repourl:https://repositorio.uniandes.edu.co/ |
url |
http://hdl.handle.net/1992/7711 |
identifier_str_mv |
10.57784/1992/7711 u729325.pdf instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
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info:eu-repo/semantics/openAccess |
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79 hojas |
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Doctorado en Ingeniería |
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Facultad de Ingeniería |
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