Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática
La respuesta de sobresalto acústico e inhibición prepulso ha sido ampliamente estudiada en esquizofrenia, pues es una medida usada para evaluar alteraciones en el filtrado sensoriomotor. Sin embargo, en pacientes con Enfermedad de Parkinson también se ha encontrado evidencia que indica que estas res...
- Autores:
-
Rivera López, Juan Manuel
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2023
- Institución:
- Universidad de los Andes
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- Séneca: repositorio Uniandes
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- Acceso en línea:
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- Palabra clave:
- Substantia nigra
Sobresalto acústico
Startle
Prepulse inhibition
Pars compacta
Pars reticulata
Núcleo subtalámico
Inhibición prepulso
Parkinson
Subthalamic nucleus
Psicología
- Rights
- openAccess
- License
- Attribution-NoDerivatives 4.0 Internacional
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Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
| title |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
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Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática Substantia nigra Sobresalto acústico Startle Prepulse inhibition Pars compacta Pars reticulata Núcleo subtalámico Inhibición prepulso Parkinson Subthalamic nucleus Psicología |
| title_short |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
| title_full |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
| title_fullStr |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
| title_full_unstemmed |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
| title_sort |
Rol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemática |
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Rivera López, Juan Manuel |
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Cárdenas Parra, Luis Fernando |
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Rivera López, Juan Manuel |
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Laboratorio de Neurociencia y Comportamiento |
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Substantia nigra Sobresalto acústico Startle Prepulse inhibition Pars compacta Pars reticulata Núcleo subtalámico Inhibición prepulso Parkinson Subthalamic nucleus |
| topic |
Substantia nigra Sobresalto acústico Startle Prepulse inhibition Pars compacta Pars reticulata Núcleo subtalámico Inhibición prepulso Parkinson Subthalamic nucleus Psicología |
| dc.subject.themes.es_CO.fl_str_mv |
Psicología |
| description |
La respuesta de sobresalto acústico e inhibición prepulso ha sido ampliamente estudiada en esquizofrenia, pues es una medida usada para evaluar alteraciones en el filtrado sensoriomotor. Sin embargo, en pacientes con Enfermedad de Parkinson también se ha encontrado evidencia que indica que estas respuestas pueden estar alteradas. Para validar esto, se realizó una revisión sistemática del rol que tienen la substantia nigra pars compacta, la substantia nigra pars reticulata y el núcleo subtalámico en la respuesta de sobresalto acústico y la inhibición prepulso en ratas. Estos núcleos se eligieron debido a que en la Enfermedad de Parkinson se da una pérdida de neuronas dopaminérgicas en la substantia nigra pars compacta, las cuáles proyectan a la substantia nigra pars reticulata, el núcleo subtalámico y el estriado. Se eligieron estudios que realizaran intervenciones focalizadas en estas estructuras, ya fueran lesiones crónicas (p.ej.: lesiones con 6-hidroxidopamina) o intervenciones temporales agudas (p.ej.: inoculación intracerebral de muscimol). Los resultados encontrados sugieren que la lesión de la substantia nigra pars compacta afectaría la inhibición prepulso y podría afectar la respuesta de sobresalto en etapas avanzadas. Asimismo, la substantia nigra pars reticulata podría regular la inhibición prepulso, pero este efecto no sería mediado por la substantia nigra pars compacta. Finalmente, la lesión del núcleo subtalámico no afecta ninguna de las dos respuestas, pero una estimulación contínua prolongada podría afectar la inhibición prepulso. |
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Aguilar, B. L., Forcelli, P. A., & Malkova, L. (2018). Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-27577-w Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and Treatment of Parkinson Disease: A Review. JAMA, 323(6), 548-560. https://doi.org/10.1001/JAMA.2019.22360 Braak, H., del Tredici, K., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003). Staging of brain pathology related to sporadic Parkinson's disease. Neurobiology of Aging, 24(2), 197-211. https://doi.org/10.1016/S0197-4580(02)00065-9 Camacho-Abrego, I., Tellez-Merlo, G., Melo, A. I., Rodríguez-Moreno, A., Garcés, L., de La Cruz, F., Zamudio, S., & Flores, G. (2014). Rearrangement of the dendritic morphology of the neurons from prefrontal cortex and hippocampus after subthalamic lesion in Sprague-Dawley rats. Synapse (New York, N.Y.), 68(3), 114-126. https://doi.org/10.1002/SYN.21722 Crawley, J. N. (2007). Short protocols in neuroscience : systems and behavioral methods : a compendium of methods from Current protocols in neuroscience. John Wiley. Davis, M. (1986). Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm. Behavioral Neuroscience, 100(6), 814-824. https://doi.org/10.1037//0735-7044.100.6.814 Dudman, J. T., & Gerfen, C. R. (2015). The Basal Ganglia. En The Rat Nervous System: Fourth Edition (pp. 391-440). https://doi.org/10.1016/B978-0-12-374245-2.00017-6 Gómez-Nieto, R., de Horta-Júnior, J. de A. C., Castellano, O., Millian-Morell, L., Rubio, M. E., & López, D. E. (2014). Origin and function of short-latency inputs to the neural substrates underlying the acoustic startle reflex. Frontiers in Neuroscience, 8(8 JUL). https://doi.org/10.3389/fnins.2014.00216 Haß, K., Bak, N., Szycik, G. R., Glenthøj, B. Y., & Oranje, B. (2017). Deficient prepulse inhibition of the startle reflex in schizophrenia using a cross-modal paradigm. Biological Psychology, 128, 112-116. https://doi.org/10.1016/j.biopsycho.2017.07.016 Heyes, M. P., Saito, K., Crowley, J. S., Davis, L. E., Demitrack, M. A., Der, M., Dilling, L. A., Elia, J., Kruesi, M. J. P., Lackner, A., Larsen, S. A., Lee, K., Leonard, H. L., Markey, S. P., Martin, A., Milstein, S., Mouradian, M. M., Pranzatelli, M. R., Quearry, B. J., Tourtellotte, W. W. (1992). Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain : a journal of neurology, 115 ( Pt 5)(5), 1249-1273. https://doi.org/10.1093/BRAIN/115.5.1249 Hitchcock, J. M., & Davis, M. (1991). Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm. Behavioral neuroscience, 105(6), 826-842. https://doi.org/10.1037//0735-7044.105.6.826 Hormigo, S., López, D. E., Cardoso, A., Zapata, G., Sepúlveda, J., & Castellano, O. (2018). Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex. Brain Structure and Function, 223(6), 2733-2751. https://doi.org/10.1007/s00429-018-1654-9 Issy, A. C., Padovan-Neto, F. E., Lazzarini, M., Bortolanza, M., & Del-Bel, E. (2015). Disturbance of sensorimotor filtering in the 6-OHDA rodent model of Parkinson's disease. Life Sciences, 125, 71-78. https://doi.org/10.1016/j.lfs.2015.01.022 Klein, J., Hadar, R., Götz, T., Männer, A., Eberhardt, C., Baldassarri, J., Schmidt, T. T., Kupsch, A., Heinz, A., Morgenstern, R., Schneider, M., Weiner, I., & Winter, C. (2013). Mapping Brain Regions in Which Deep Brain Stimulation Affects Schizophrenia-Like Behavior in Two Rat Models of Schizophrenia. Brain Stimulation, 6(4), 490-499. https://doi.org/10.1016/J.BRS.2012.09.004 Koch, M. (1999). The neurobiology of startle. En Progress in Neurobiology (Vol. 59, Número 2, pp. 107-128). Prog Neurobiol. https://doi.org/10.1016/S0301-0082(98)00098-7 Koch, M., Fendt, M., & Kretschmer, B. D. (2000). Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats. Behavioural Brain Research, 117(1-2), 153-162. https://doi.org/10.1016/S0166-4328(00)00299-0 Kodsi, M. H., & Swerdlow, N. R. (1997). Regulation of prepulse inhibition by ventral pallidal projections. Brain Research Bulletin. https://doi.org/10.1016/S0361-9230(96)00440-6 Kofler, M., Müller, J., & Valls-Solè, J. (2006). Chapter 19 Auditory startle responses as a probe of brainstem function in healthy subjects and patients with movement disorders. Supplements to Clinical Neurophysiology, 58(C), 232-248. https://doi.org/10.1016/S1567-424X(09)70072-8 Kofler, M., Müller, J., Wenning, G. K., Reggiani, L., Hollosi, P., Bösch, S., Ransmayr, G., Valls-Solé, J., & Poewe, W. (2001). The auditory startle reaction in parkinsonian disorders. Movement Disorders, 16(1), 62-71. https://doi.org/10.1002/1531-8257(200101)16:1<62::AID-MDS1002>3.0.CO;2-V Kohl, S., Heekeren, K., Klosterkötter, J., & Kuhn, J. (2013). Prepulse inhibition in psychiatric disorders - Apart from schizophrenia. En Journal of Psychiatric Research (Vol. 47, Número 4, pp. 445-452). Elsevier Ltd. https://doi.org/10.1016/j.jpsychires.2012.11.018 Lindemann, C., Krauss, J. K., & Schwabe, K. (2012). Deep brain stimulation of the subthalamic nucleus in the 6-hydroxydopamine rat model of Parkinson's disease: Effects on sensorimotor gating. Behavioural Brain Research, 230(1), 243-250. https://doi.org/10.1016/j.bbr.2012.02.009 Lozza, A., Pepin, J. L., Rapisarda, G., Moglia, A., & Delwaide, P. J. (1997). Functional changes of brainstem reflexes in Parkinson's disease Conditioning of the blink reflex R2 component by paired and index finger stimulation. Journal of Neural Transmission, 104(6-7), 679-687. https://doi.org/10.1007/BF01291885 McFarland, K., Price, D. L., & Bonhaus, D. W. (2011). Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson's disease. Behavioural Pharmacology, 22(7), 681-692. https://doi.org/10.1097/FBP.0B013E32834AFF98 McFarland, K., Price, D. L., Davis, C. N., Ma, J. N., Bonhaus, D. W., Burstein, E. S., & Olsson, R. (2013). AC-186, a selective nonsteroidal estrogen receptor - agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS chemical neuroscience, 4(9), 1249-1255. https://doi.org/10.1021/CN400132U Meloni, E. G., & Davis, M. (2000). Enhancement of the acoustic startle response by dopamine agonists after 6-hydroxydopamine lesions of the substantia nigra pars compacta: corresponding changes in c-Fos expression in the caudate-putamen. Brain research, 879(1-2), 93-104. https://doi.org/10.1016/S0006-8993(00)02753-0 Meloni, E. G., & Davis, M. (2004). The substancia nigra pars reticulata mediates the enhancement of startle by the dopamine D1 receptor agonist SKF 82958 in rats. Psychopharmacology, 174(2), 228-236. https://doi.org/10.1007/s00213-003-1728-z Potter, M., Herzog, J., Siebner, H. R., Kopper, F., Steigerwald, F., Deuschl, G., & Volkmann, J. (2008). Subthalamic nucleus stimulation modulates audiospinal reactions in Parkinson disease. Neurology, 70(Issue 16, Part 2), 1445-1451. https://doi.org/10.1212/01.wnl.0000310422.49977.ea Purves, D. (2016). Neurociencia. (Quinta edi). Editorial Médica Panamericana. Rodrigues, S., & Ferreira, T. L. (2020). Muscimol injection into the substantia nigra but not globus pallidus affects prepulse inhibition and startle reflex. Neuropharmacology, 162(April 2019), 107796. https://doi.org/10.1016/j.neuropharm.2019.107796 Schicatano, E. J., Peshori, K. R., Gopalaswamy, R., Sahay, E., & Evinger, C. (2000). Reflex excitability regulates prepulse inhibition. Journal of Neuroscience, 20(11), 4240-4247. https://doi.org/10.1523/jneurosci.20-11-04240.2000 Shimozawa, A., Ono, M., Takahara, D., Tarutani, A., Imura, S., Masuda-Suzukake, M., Higuchi, M., Yanai, K., Hisanaga, S. I., & Hasegawa, M. (2017). Propagation of pathological [alfa]-synuclein in marmoset brain. Acta neuropathologica communications, 5(1), 12. https://doi.org/10.1186/S40478-017-0413-0 Simon, D. K., Tanner, C. M., & Brundin, P. (2020). Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in geriatric medicine, 36(1), 1-12. https://doi.org/10.1016/J.CGER.2019.08.002 Swerdlow, N. R., Braff, D. L., Taaid, N., & Geyer, M. A. (1994). Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Archives of general psychiatry, 51(2), 139-154. https://doi.org/10.1001/ARCHPSYC.1994.03950020063007 Szmidt-Salkowska, E., Gawel, M., Jamrozik, Z., Salkowska-Wanat, J., Gawel, D., & Kaminska, A. (2016). Diagnostic value of blink reflex in multisystem atrophy, progressive supranuclear palsy and Parkinson disease. Neurologia i Neurochirurgia Polska, 50(5), 336-341. https://doi.org/10.1016/j.pjnns.2016.06.001 Tupper, D. E., & Wallace, R. B. (1980). Utility of the neurological examination in rats. Acta Neurobiologiae Experimentalis, 40(6), 999-1003. Tysnes, O. B., & Storstein, A. (2017). Epidemiology of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 124(8), 901-905. https://doi.org/10.1007/S00702-017-1686-Y Valsamis, B., & Schmid, S. (2011). Habituation and Prepulse Inhibition of Acoustic Startle in Rodents. Journal of Visualized Experiments : JoVE, 55, 3446. https://doi.org/10.3791/3446 Vidailhet, M., Rothwelll, J. C., Thompson, P. D., Lees, A. J., & Marsden, C. D. (1992). The auditory startle response in the steele-richardson-olszewski syndrome and parkinson's disease. Brain, 115(4), 1181-1192. https://doi.org/10.1093/brain/115.4.1181 Yeomans, J. S., Lee, J., Yeomans, M. H., Steidl, S., & Li, L. (2006). Midbrain pathways for prepulse inhibition and startle activation in rat. Neuroscience, 142(4), 921-929. https://doi.org/10.1016/j.neuroscience.2006.06.025 Zinkand, W. C., Moore, W. C., Thompson, C., Salama, A. I., & Patel, J. (1992). Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptor mechanisms. Molecular and Chemical Neuropathology, 16(1-2), 1-10. https://doi.org/10.1007/BF03159956 Zoetmulder, M., Biernat, H. B., Nikolic, M., Korbo, L., Friberg, L., & Jennum, P. J. (2014). Prepulse inhibition is associated with attention, processing speed, and 123I-FP-CIT SPECT in Parkinson's disease. Journal of Parkinson's disease, 4(1), 77-87. https://doi.org/10.3233/JPD-130307 |
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Attribution-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cárdenas Parra, Luis Fernandovirtual::9287-1Rivera López, Juan Manuel6200de20-29b7-4bab-b5c6-d7d761c9e0d8600Laboratorio de Neurociencia y Comportamiento2023-02-09T21:56:40Z2023-02-09T21:56:40Z2023-02-09http://hdl.handle.net/1992/64855instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/La respuesta de sobresalto acústico e inhibición prepulso ha sido ampliamente estudiada en esquizofrenia, pues es una medida usada para evaluar alteraciones en el filtrado sensoriomotor. Sin embargo, en pacientes con Enfermedad de Parkinson también se ha encontrado evidencia que indica que estas respuestas pueden estar alteradas. Para validar esto, se realizó una revisión sistemática del rol que tienen la substantia nigra pars compacta, la substantia nigra pars reticulata y el núcleo subtalámico en la respuesta de sobresalto acústico y la inhibición prepulso en ratas. Estos núcleos se eligieron debido a que en la Enfermedad de Parkinson se da una pérdida de neuronas dopaminérgicas en la substantia nigra pars compacta, las cuáles proyectan a la substantia nigra pars reticulata, el núcleo subtalámico y el estriado. Se eligieron estudios que realizaran intervenciones focalizadas en estas estructuras, ya fueran lesiones crónicas (p.ej.: lesiones con 6-hidroxidopamina) o intervenciones temporales agudas (p.ej.: inoculación intracerebral de muscimol). Los resultados encontrados sugieren que la lesión de la substantia nigra pars compacta afectaría la inhibición prepulso y podría afectar la respuesta de sobresalto en etapas avanzadas. Asimismo, la substantia nigra pars reticulata podría regular la inhibición prepulso, pero este efecto no sería mediado por la substantia nigra pars compacta. Finalmente, la lesión del núcleo subtalámico no afecta ninguna de las dos respuestas, pero una estimulación contínua prolongada podría afectar la inhibición prepulso.Acoustic startle response and prepulse inhibition have been studied mainly in schizophrenia as a measure of sensorimotor gating. Nevertheless, evidence in Parkinson's Disease patients indicates that these responses may also be affected. To validate this, a systematic review of the role of the substantia nigra pars compacta, the substantia nigra pars reticulata, and the subthalamic nucleus in rats was performed. These nuclei were chosen because in Parkinson's Disease there is a loss of dopaminergic neurons in the substantia nigra pars compacta, which project to substantia nigra pars reticulata, subthalamic nucleus, and striatum. Studies that did a focal intervention on these nuclei were chosen. Chronic lesions (e.g., 6-hydroxidopamine lesions) and acute temporal interventions (e.g., intracerebral Muscimol injections) were included. Results suggest that a lesion in the substantia nigra pars compacta would affect prepulse inhibition and could affect startle response, but only in an advanced stage. Likewise, substantia nigra pars reticulata would regulate prepulse inhibition, but this effect wouldn't be mediated by the substantia nigra pars compacta. Finally, subthalamic lesions wouldn't affect either startle or prepulse inhibition, but continuous long-term stimulation could affect prepulse inhibition.PsicólogoPregrado26 páginasapplication/pdfspaUniversidad de los AndesPsicologíaFacultad de Ciencias SocialesDepartamento de PsicologíaRol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en ratas: una revisión sistemáticaTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPSubstantia nigraSobresalto acústicoStartlePrepulse inhibitionPars compactaPars reticulataNúcleo subtalámicoInhibición prepulsoParkinsonSubthalamic nucleusPsicologíaAguilar, B. L., Forcelli, P. A., & Malkova, L. (2018). Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys. 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Journal of Parkinson's disease, 4(1), 77-87. https://doi.org/10.3233/JPD-130307201534131Publicationhttps://scholar.google.com/citations?hl=es&user=YfNeJIAAAAAJvirtual::9287-10000-0002-8826-6211virtual::9287-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000699195virtual::9287-163debca4-c66a-465e-a43f-72049a27497avirtual::9287-163debca4-c66a-465e-a43f-72049a27497avirtual::9287-1TEXTRol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en rata, una revisión sistemática.pdf.txtRol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en rata, una revisión sistemática.pdf.txtExtracted texttext/plain61887https://repositorio.uniandes.edu.co/bitstreams/01f49e4d-dbd4-4826-9567-babf240d00ed/download2355c6186a8a3c13737c7dc00ceed546MD57Formato autorizacion tesis juan manuel - biblioteca.pdf.txtFormato autorizacion tesis juan manuel - biblioteca.pdf.txtExtracted texttext/plain1163https://repositorio.uniandes.edu.co/bitstreams/6fdafad0-fad0-434a-96c1-8448e88b93f6/download4491fe1afb58beaaef41a73cf7ff2e27MD59THUMBNAILRol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en rata, una revisión sistemática.pdf.jpgRol de la substantia nigra y el núcleo subtalámico en la respuesta de sobresalto acústico e inhibición prepulso en rata, una revisión sistemática.pdf.jpgIM Thumbnailimage/jpeg8262https://repositorio.uniandes.edu.co/bitstreams/3fdd3602-0ce4-4b42-aa50-bc6b58a70de5/downloadd5808243aef3c0c3c22a344adf9106d2MD58Formato autorizacion tesis juan manuel - biblioteca.pdf.jpgFormato autorizacion tesis juan manuel - biblioteca.pdf.jpgIM Thumbnailimage/jpeg16353https://repositorio.uniandes.edu.co/bitstreams/f076a967-861e-4bf3-a808-812134946194/downloadf1604f97699570f039a13893ced1f2f7MD510CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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