Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis

ABSTRACT TITLE: Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis. OBJECTIVE: To identify the available scientific evidence regarding the benefits a...

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Autores:
Ocampo Salgado, Carolina
Ochoa Montero, Hansel
Naranjo Vanegas, Melisa Sofía
Sierra Barbosa, Diego Orlando
Sadeghirad, Behnam
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
spa
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/56505
Acceso en línea:
http://hdl.handle.net/1992/56505
Palabra clave:
COPD
Alpha 1 Antitrypsin
Alpha 1 Antitrypsin deficiency
Medicina
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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network_name_str Séneca: repositorio Uniandes
repository_id_str
dc.title.eng.fl_str_mv Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
title Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
spellingShingle Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
COPD
Alpha 1 Antitrypsin
Alpha 1 Antitrypsin deficiency
Medicina
title_short Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
title_full Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
title_fullStr Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
title_full_unstemmed Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
title_sort Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
dc.creator.fl_str_mv Ocampo Salgado, Carolina
Ochoa Montero, Hansel
Naranjo Vanegas, Melisa Sofía
Sierra Barbosa, Diego Orlando
Sadeghirad, Behnam
dc.contributor.advisor.spa.fl_str_mv Yepes Nuñez, Juan Jose
Ortega Jaramillo, Hector José
dc.contributor.author.spa.fl_str_mv Ocampo Salgado, Carolina
dc.contributor.author.none.fl_str_mv Ochoa Montero, Hansel
Naranjo Vanegas, Melisa Sofía
Sierra Barbosa, Diego Orlando
Sadeghirad, Behnam
dc.contributor.jury.spa.fl_str_mv Yepes Nuñez, Juan Jose
Ortega Jaramillo, Hector José
García Morales, Olga Milena
dc.subject.keyword.none.fl_str_mv COPD
Alpha 1 Antitrypsin
Alpha 1 Antitrypsin deficiency
topic COPD
Alpha 1 Antitrypsin
Alpha 1 Antitrypsin deficiency
Medicina
dc.subject.themes.none.fl_str_mv Medicina
description ABSTRACT TITLE: Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis. OBJECTIVE: To identify the available scientific evidence regarding the benefits and safety of replacement therapy with Alpha 1-Antitrypsin compared with endobronchial or surgical management for reduction of lung volume, lung transplantation, standard of care for chronic obstructive pulmonary disease, and placebo or control/no treatment in patients with documented enzyme deficiency, presenting with chronic obstructive pulmonary disease. METHODS: A systematic review and meta-analysis was conducted. MEDLINE-PubMed (via Ovid), EMBASE (via Elsevier), LILACS and the Cochrane Library of Controlled Register of Trials (CENTRAL) were assessed for randomized controlled trials (RCT); cluster, factorial, parallel-design and cross-over designs were included, from inception to May of 2021. Any restrictions regarding language, setting, report status or date of publication were included. Non-published articles in clinicaltrials.gov, and grey literature in ProQuest were also considered. Trials studying adult patients with documented Alpha-1 Antitrypsin Deficiency (A1AD) and diagnosed with Chronic Obstructive Pulmonary Disease (COPD), treated with A1A augmentation therapy or other standard care interventions (according to current guidelines for COPD treatment1) such as inhaled corticosteroids, phosphodiesterase 4 inhibitors, antibiotics, inhaled anticholinergic or beta 2 agents, anti-oxidant, lung volume reduction interventions or lung transplant were included. Patient important outcomes as well as surrogate outcomes were assessed. Risk of bias (ROB) for each included trial was independently assessed, using the Cochrane Risk of Bias tool (ROB2). DerSimonian-Laird random-effects models for all pairwise comparisons were used. Heterogeneity was calculated with Q statistic
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-03-23T21:50:07Z
dc.date.available.none.fl_str_mv 2022-03-23T21:50:07Z
dc.type.spa.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/1992/56505
dc.identifier.pdf.none.fl_str_mv 26579.pdf
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dc.format.extent.spa.fl_str_mv 52 páginas
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dc.publisher.spa.fl_str_mv Universidad de los Andes
dc.publisher.program.spa.fl_str_mv Maestría en Epidemiología
dc.publisher.faculty.spa.fl_str_mv Facultad de Medicina
institution Universidad de los Andes
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