Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis
ABSTRACT TITLE: Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis. OBJECTIVE: To identify the available scientific evidence regarding the benefits a...
- Autores:
-
Ocampo Salgado, Carolina
Ochoa Montero, Hansel
Naranjo Vanegas, Melisa Sofía
Sierra Barbosa, Diego Orlando
Sadeghirad, Behnam
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/56505
- Acceso en línea:
- http://hdl.handle.net/1992/56505
- Palabra clave:
- COPD
Alpha 1 Antitrypsin
Alpha 1 Antitrypsin deficiency
Medicina
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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|
dc.title.eng.fl_str_mv |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
title |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
spellingShingle |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis COPD Alpha 1 Antitrypsin Alpha 1 Antitrypsin deficiency Medicina |
title_short |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
title_full |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
title_fullStr |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
title_full_unstemmed |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
title_sort |
Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis |
dc.creator.fl_str_mv |
Ocampo Salgado, Carolina Ochoa Montero, Hansel Naranjo Vanegas, Melisa Sofía Sierra Barbosa, Diego Orlando Sadeghirad, Behnam |
dc.contributor.advisor.spa.fl_str_mv |
Yepes Nuñez, Juan Jose Ortega Jaramillo, Hector José |
dc.contributor.author.spa.fl_str_mv |
Ocampo Salgado, Carolina |
dc.contributor.author.none.fl_str_mv |
Ochoa Montero, Hansel Naranjo Vanegas, Melisa Sofía Sierra Barbosa, Diego Orlando Sadeghirad, Behnam |
dc.contributor.jury.spa.fl_str_mv |
Yepes Nuñez, Juan Jose Ortega Jaramillo, Hector José García Morales, Olga Milena |
dc.subject.keyword.none.fl_str_mv |
COPD Alpha 1 Antitrypsin Alpha 1 Antitrypsin deficiency |
topic |
COPD Alpha 1 Antitrypsin Alpha 1 Antitrypsin deficiency Medicina |
dc.subject.themes.none.fl_str_mv |
Medicina |
description |
ABSTRACT TITLE: Benefits and harms of replacement therapy with Alpha 1 Antitrypsin in patients with documented enzyme deficiency and Chronic Obstructive Pulmonary Disease: A systematic review and network meta-analysis. OBJECTIVE: To identify the available scientific evidence regarding the benefits and safety of replacement therapy with Alpha 1-Antitrypsin compared with endobronchial or surgical management for reduction of lung volume, lung transplantation, standard of care for chronic obstructive pulmonary disease, and placebo or control/no treatment in patients with documented enzyme deficiency, presenting with chronic obstructive pulmonary disease. METHODS: A systematic review and meta-analysis was conducted. MEDLINE-PubMed (via Ovid), EMBASE (via Elsevier), LILACS and the Cochrane Library of Controlled Register of Trials (CENTRAL) were assessed for randomized controlled trials (RCT); cluster, factorial, parallel-design and cross-over designs were included, from inception to May of 2021. Any restrictions regarding language, setting, report status or date of publication were included. Non-published articles in clinicaltrials.gov, and grey literature in ProQuest were also considered. Trials studying adult patients with documented Alpha-1 Antitrypsin Deficiency (A1AD) and diagnosed with Chronic Obstructive Pulmonary Disease (COPD), treated with A1A augmentation therapy or other standard care interventions (according to current guidelines for COPD treatment1) such as inhaled corticosteroids, phosphodiesterase 4 inhibitors, antibiotics, inhaled anticholinergic or beta 2 agents, anti-oxidant, lung volume reduction interventions or lung transplant were included. Patient important outcomes as well as surrogate outcomes were assessed. Risk of bias (ROB) for each included trial was independently assessed, using the Cochrane Risk of Bias tool (ROB2). DerSimonian-Laird random-effects models for all pairwise comparisons were used. Heterogeneity was calculated with Q statistic |
publishDate |
2021 |
dc.date.issued.none.fl_str_mv |
2021 |
dc.date.accessioned.none.fl_str_mv |
2022-03-23T21:50:07Z |
dc.date.available.none.fl_str_mv |
2022-03-23T21:50:07Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/masterThesis |
dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/acceptedVersion |
dc.type.content.spa.fl_str_mv |
Text |
dc.type.redcol.spa.fl_str_mv |
http://purl.org/redcol/resource_type/TM |
status_str |
acceptedVersion |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/1992/56505 |
dc.identifier.pdf.none.fl_str_mv |
26579.pdf |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad de los Andes |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Séneca |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repositorio.uniandes.edu.co/ |
url |
http://hdl.handle.net/1992/56505 |
identifier_str_mv |
26579.pdf instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
dc.language.iso.spa.fl_str_mv |
spa |
language |
spa |
dc.rights.license.spa.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
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rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.spa.fl_str_mv |
52 páginas |
dc.format.mimetype.spa.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidad de los Andes |
dc.publisher.program.spa.fl_str_mv |
Maestría en Epidemiología |
dc.publisher.faculty.spa.fl_str_mv |
Facultad de Medicina |
institution |
Universidad de los Andes |
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