Defining a core genome for the herpesvirales and elucidating their evolutionary relationship with the caudovirales

The order Herpesvirales encompasses a wide variety of important and widely distributed human pathogens, including the Varicella-Zoster Virus, Human Cytomegalovirus and Epstein-Barr virus. During the last decades, similarities in the viral cycle and the structure of some of their proteins with those of the tailed phages have brought speculation regarding the existence of an evolutionary relationship between the two clades. To evaluate such hypothesis, we used over 700 Herpesvirales and 2000 Caudovirales genomes downloaded from the NCBI genome and nucleotide databases, which were first de-replicated both at the nucleotide and amino acid level. Following this, they were screened for the presence or absence of clusters of orthologous viral proteins, and a dendrogram was constructed based on their compositional similarities. The results obtained strongly suggest that the Herpesvirales have an evolutionary relationship with the Caudovirales, and allow putting forth hypotheses concerning the specific details of such relationship...

• Autores: Andrade Martínez, Juan Sebastián
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2018
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: eng
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/60896
• Acceso en línea: http://hdl.handle.net/1992/60896
• Palabra clave: Caudovirales; Herpesvirus; Virus
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/