Efect of two pore domain potassium channel

The aim of this Project is to do a research in the nerve system of the Lymnaea Stagnalis specifically the study of the 2-Pore domain potassium channel in order to find its mammalian counterpart. To be able to make a comparison between the snail's channel and the human one, it was necessary to applied the concepts given in an article published in 2004 by Marco Gruss and his group titled 'the two pore domain K+ channels TREK-I and TASK-3 are differentially modulated by copper and zinc". By following the above method we started modulating the lymnaea's channel by making two separate solutions, one of copper and another one of zinc. We wanted to see if the behaviour of the channel in the Lymnaea had the same features as in the human ones explained in the article. For example: If the lymnaea's channel was TREK-I we were expecting to see an inhibition when a high concentration of zinc (i.e. 200uM)...

• Autores: Martínez Vega, Diana del Pilar
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2006
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: eng
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/22845
• Acceso en línea: http://hdl.handle.net/1992/22845
• Palabra clave: Canales iónicos - Investigaciones; Canales de potasio - Investigaciones; Anestésicos - Investigaciones; Física
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/