Aplicaciones de la tecnología de aptámeros en los últimos 15 años
Reseña bibliográfica en la que se muestran las aplicaciones de la tecnología de aptámeros en los últimos 15 años, en donde se exponen sus ventajas, limitaciones y perspectivas futuras.
- Autores:
-
Rodríguez Ramírez, Ana María
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2022
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/64559
- Acceso en línea:
- http://hdl.handle.net/1992/64559
- Palabra clave:
- Aptámeros
Aplicaciones
SELEX
Reguladores moleculares
Nanoestructuras de ADN
Liberación de drogas
Agentes diagnósticos de enfermedades
Sensores
Agentes terapeúticos
Química
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| title |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| spellingShingle |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años Aptámeros Aplicaciones SELEX Reguladores moleculares Nanoestructuras de ADN Liberación de drogas Agentes diagnósticos de enfermedades Sensores Agentes terapeúticos Química |
| title_short |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| title_full |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| title_fullStr |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| title_full_unstemmed |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| title_sort |
Aplicaciones de la tecnología de aptámeros en los últimos 15 años |
| dc.creator.fl_str_mv |
Rodríguez Ramírez, Ana María |
| dc.contributor.advisor.none.fl_str_mv |
Jiménez Díaz, Elizabeth |
| dc.contributor.author.none.fl_str_mv |
Rodríguez Ramírez, Ana María |
| dc.contributor.researchgroup.es_CO.fl_str_mv |
Grupo de Investigación de Bioquímica Aplicada |
| dc.subject.keyword.none.fl_str_mv |
Aptámeros Aplicaciones SELEX Reguladores moleculares Nanoestructuras de ADN Liberación de drogas Agentes diagnósticos de enfermedades Sensores Agentes terapeúticos |
| topic |
Aptámeros Aplicaciones SELEX Reguladores moleculares Nanoestructuras de ADN Liberación de drogas Agentes diagnósticos de enfermedades Sensores Agentes terapeúticos Química |
| dc.subject.themes.es_CO.fl_str_mv |
Química |
| description |
Reseña bibliográfica en la que se muestran las aplicaciones de la tecnología de aptámeros en los últimos 15 años, en donde se exponen sus ventajas, limitaciones y perspectivas futuras. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022-12 |
| dc.date.accessioned.none.fl_str_mv |
2023-02-02T20:04:22Z |
| dc.date.available.none.fl_str_mv |
2023-02-02T20:04:22Z |
| dc.type.es_CO.fl_str_mv |
Trabajo de grado - Pregrado |
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info:eu-repo/semantics/bachelorThesis |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_7a1f |
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Text |
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http://purl.org/redcol/resource_type/TP |
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http://purl.org/coar/resource_type/c_7a1f |
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acceptedVersion |
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http://hdl.handle.net/1992/64559 |
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instname:Universidad de los Andes |
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repourl:https://repositorio.uniandes.edu.co/ |
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Animal Biotechnology: Models in Discovery and Translation 2014, 265-287. https://doi.org/10.1016/B978-0-12-416002-6.00015-8. Tuerk, C.; Gold, L. Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase. Science 1990, 249 (4968), 505-510. https://doi.org/10.1126/SCIENCE.2200121. Ellington, A. D.; Szostak, J. W. In Vitro Selection of RNA Molecules That Bind Specific Ligands. Nature 1990 346:6287 1990, 346 (6287), 818-822. https://doi.org/10.1038/346818a0. Ospina, J. D. Los Aptámeros Como Novedosa Herramienta Diagnóstica y Terapéutica y Su Potencial Uso En Parasitología. Biomédica 2020, 40 (Suppl 1), 148. https://doi.org/10.7705/BIOMEDICA.4765. Hernández, F. J.; Andrea, J.; Hincapié, B.; Clave, P. Aptámeros: Agentes Diagnósticos y Terapéuticos. Iatreia 2012, 25 (2), 159-168. Conrad, R.; Keranen, L. M.; Ellington, A. D.; Newton, A. C. Isozyme-Specific Inhibition of Protein Kinase C by RNA Aptamers. 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Ni, S.; Zhuo, Z.; Pan, Y.; Yu, Y.; Li, F.; Liu, J.; Wang, L.; Wu, X.; Li, D.; Wan, Y.; Zhang, L.; Yang, Z.; Zhang, B. T.; Lu, A.; Zhang, G. Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. ACS Appl Mater Interfaces 2021, 13 (8), 9500-9519. https://doi.org/10.1021/ACSAMI.0C05750/ASSET/IMAGES/LARGE/AM0C05750_0017.JPEG. Zhou, J.; Rossi, J. Aptamers as Targeted Therapeutics: Current Potential and Challenges. Nat Rev Drug Discov 2017, 16 (3), 181-202. https://doi.org/10.1038/NRD.2016.199. Xuan, W.; Peng, Y.; Deng, Z.; Peng, T.; Kuai, H.; Li, Y.; He, J.; Jin, C.; Liu, Y.; Wang, R.; Tan, W. A Basic Insight into Aptamer-Drug Conjugates (ApDCs). Biomaterials 2018, 182, 216-226. https://doi.org/10.1016/J.BIOMATERIALS.2018.08.021. Bruno, J. G. A Review of Therapeutic Aptamer Conjugates with Emphasis on New Approaches. Pharmaceuticals 2013, Vol. 6, Pages 340-357 2013, 6 (3), 340-357. https://doi.org/10.3390/PH6030340. Cho, E. J.; Lee, J. W.; Ellington, A. D. 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B.; Dirkzwager, R. M.; Zhou, C.; Kuzuya, A.; Tanner, J. A.; Heddle, J. G. A DNA Aptamer Recognising a Malaria Protein Biomarker Can Function as Part of a DNA Origami Assembly. Sci Rep 2016, 6. https://doi.org/10.1038/SREP21266. Ding, T.; Yang, J.; Wang, J.; Pan, V.; Lu, Z.; Ke, Y.; Zhang, C. Shaped DNA Origami Carrier Nanopore Translocation Influenced by Aptamer Based Surface Modification. Biosens Bioelectron 2022, 195, 113658. https://doi.org/10.1016/J.BIOS.2021.113658. Liu, X.; Yan, H.; Liu, Y.; Chang, Y. Targeted Cell-Cell Interactions by DNA NanoscaffoldTemplated Multivalent Bispecific Aptamers. Small 2011, 7 (12), 1673-1682. https://doi.org/10.1002/SMLL.201002292. Li, J.; Xun, K.; Pei, K.; Liu, X.; Peng, X.; Du, Y.; Qiu, L.; Tan, W. Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions. J Am Chem Soc 2019, 141 (45), 18013-18020. https://doi.org/10.1021/JACS.9B04725/ASSET/IMAGES/LARGE/JA9B04725_0005.JPEG. Platella, C.; Riccardi, C.; Montesarchio, D.; Roviello, G. N.; Musumeci, D. G-Quadruplex-Based Aptamers against Protein Targets in Therapy and Diagnostics. Biochimica et Biophysica Acta (BBA) - General Subjects 2017, 1861 (5), 1429-1447. https://doi.org/10.1016/J.BBAGEN.2016.11.027. Roxo, C.; Kotkowiak, W.; Pasternak, A. G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives. Molecules 2019, Vol. 24, Page 3781 2019, 24 (20), 3781. https://doi.org/10.3390/MOLECULES24203781. Reyes-Reyes, E. M.; Salipur, F. R.; Shams, M.; Forsthoefel, M. K.; Bates, P. J. Mechanistic Studies of Anticancer Aptamer AS1411 Reveal a Novel Role for Nucleolin in Regulating Rac1 Activation. Mol Oncol 2015, 9 (7), 1392-1405. https://doi.org/10.1016/J.MOLONC.2015.03.012. Wang, J.; Wei, Y.; Hu, X.; Fang, Y. Y.; Li, X.; Liu, J.; Wang, S.; Yuan, Q. Protein Activity Regulation: Inhibition by Closed-Loop Aptamer-Based Structures and Restoration by Near-IR Stimulation. 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Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Jiménez Díaz, Elizabethvirtual::5966-1Rodríguez Ramírez, Ana Maríad7a36dc6-248f-4cf4-a2ed-c50ea6d4557c600Grupo de Investigación de Bioquímica Aplicada2023-02-02T20:04:22Z2023-02-02T20:04:22Z2022-12http://hdl.handle.net/1992/64559instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Reseña bibliográfica en la que se muestran las aplicaciones de la tecnología de aptámeros en los últimos 15 años, en donde se exponen sus ventajas, limitaciones y perspectivas futuras.Los aptámeros son cadenas de oligonucleótidos de ARN o ADN elaborados sintéticamente, que tienen la propiedad de unirse a moléculas objetivo con alta afinidad y especificidad. Estos han sido utilizados como análogos a anticuerpos debido a sus ventajas de producción y detección, tomando el nombre de anticuerpos sintéticos. Aunque presentan desventajas a la hora de utilizarse in vivo, a lo largo de los años se han mejorado sus propiedades, ya que su estructura es fácilmente modificable. De hecho, gracias a su versatilidad y capacidad de reconocer específicamente objetivos moleculares, los aptámeros han sido objeto de estudio, por lo que se han derivado nuevas aplicaciones, más allá de actuar como análogos de anticuerpos. En el presente trabajo se presentarán las aplicaciones de la tecnología de aptámeros en los últimos 15 años. Entre las aplicaciones se encuentra su uso como agentes terapéuticos, sistemas de liberación de drogas, agentes diagnósticos de enfermedades o infecciones, sensores, nanoestructuras de ADN y reguladores moleculares. Además de exponer perspectivas futuras para el desarrollo de esta tecnología en los campos anteriormente mencionados.QuímicoPregradoBioquímica, tecnología36 páginasapplication/pdfspaUniversidad de los AndesQuímicaFacultad de CienciasDepartamento de QuímicaAplicaciones de la tecnología de aptámeros en los últimos 15 añosTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPAptámerosAplicacionesSELEXReguladores molecularesNanoestructuras de ADNLiberación de drogasAgentes diagnósticos de enfermedadesSensoresAgentes terapeúticosQuímicaSun, H.; Zu, Y. A Highlight of Recent Advances in Aptamer Technology and Its Application. Molecules 2015, 20 (7), 11959-11980. https://doi.org/10.3390/MOLECULES200711959.Sefah, K.; Shangguan, D.; Xiong, X.; O'Donoghue, M. B.; Tan, W. Development of DNA Aptamers Using Cell-SELEX. 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