Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts

Due to the high mortality associated with cardiovascular diseases (CD) and alterations in the peripheral circulatory system, tissue engineering for the development of new treatments is presented as a very attractive approach. Tissue engineering seeks the development of new devices to improve current...

Full description

Autores:
Sánchez Puccini, Paolo Francisco
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2018
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/38691
Acceso en línea:
http://hdl.handle.net/1992/38691
Palabra clave:
Ingeniería de tejidos - Investigaciones - Estudio de casos
Medicina regenerativa - Investigaciones - Estudio de casos
Materiales biomédicos - Investigaciones
Trasplantes de órganos, tejidos, etc - Investigaciones
Modelado tridimensional - Investigaciones
Ingeniería
Rights
openAccess
License
https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
id UNIANDES2_958d9faefd088cd7d2e1a570acd14d5e
oai_identifier_str oai:repositorio.uniandes.edu.co:1992/38691
network_acronym_str UNIANDES2
network_name_str Séneca: repositorio Uniandes
repository_id_str
dc.title.es_CO.fl_str_mv Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
title Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
spellingShingle Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
Ingeniería de tejidos - Investigaciones - Estudio de casos
Medicina regenerativa - Investigaciones - Estudio de casos
Materiales biomédicos - Investigaciones
Trasplantes de órganos, tejidos, etc - Investigaciones
Modelado tridimensional - Investigaciones
Ingeniería
title_short Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
title_full Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
title_fullStr Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
title_full_unstemmed Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
title_sort Computational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular grafts
dc.creator.fl_str_mv Sánchez Puccini, Paolo Francisco
dc.contributor.advisor.none.fl_str_mv Brey, Eric M.
Briceño Triana, Juan Carlos
dc.contributor.author.none.fl_str_mv Sánchez Puccini, Paolo Francisco
dc.contributor.jury.none.fl_str_mv Marañón León, Edgar Alejandro
Suárez Venegas, Daniel Ricardo
dc.subject.keyword.es_CO.fl_str_mv Ingeniería de tejidos - Investigaciones - Estudio de casos
Medicina regenerativa - Investigaciones - Estudio de casos
Materiales biomédicos - Investigaciones
Trasplantes de órganos, tejidos, etc - Investigaciones
Modelado tridimensional - Investigaciones
topic Ingeniería de tejidos - Investigaciones - Estudio de casos
Medicina regenerativa - Investigaciones - Estudio de casos
Materiales biomédicos - Investigaciones
Trasplantes de órganos, tejidos, etc - Investigaciones
Modelado tridimensional - Investigaciones
Ingeniería
dc.subject.themes.none.fl_str_mv Ingeniería
description Due to the high mortality associated with cardiovascular diseases (CD) and alterations in the peripheral circulatory system, tissue engineering for the development of new treatments is presented as a very attractive approach. Tissue engineering seeks the development of new devices to improve current solutions and in the process increase our knowledge about the physiology of the human body to be able to obtain the greatest impact in the use of this technology in patients. This thesis is aimed at the study of the regeneration of arteries through the use of a porcine intestinal submucosa graft (SIS). Previous studies have shown the potential of this material for its use as a cardiovascular graft. In this thesis, we sought to understand the effect of the physical properties of SIS on tissue regeneration. In order to fulfill this objective, mechanical characterization, multi-scale simulation and in vivo experimentation were combined in order to understand the biomechanical environment provided by this material. Among the results obtained, it was possible to characterize the fatigue of the SIS under specific conditions of a vascular graft and to identify the effect of the orientation of the fibers in the transmission of stresses to the cells
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2020-06-10T14:27:58Z
dc.date.available.none.fl_str_mv 2020-06-10T14:27:58Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/doctoralThesis
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TD
format http://purl.org/coar/resource_type/c_db06
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/1992/38691
dc.identifier.doi.none.fl_str_mv 10.57784/1992/38691
dc.identifier.pdf.none.fl_str_mv u807597.pdf
dc.identifier.instname.spa.fl_str_mv instname:Universidad de los Andes
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Séneca
dc.identifier.repourl.spa.fl_str_mv repourl:https://repositorio.uniandes.edu.co/
url http://hdl.handle.net/1992/38691
identifier_str_mv 10.57784/1992/38691
u807597.pdf
instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
repourl:https://repositorio.uniandes.edu.co/
dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.rights.uri.*.fl_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.es_CO.fl_str_mv 120 hojas
dc.format.mimetype.es_CO.fl_str_mv application/pdf
dc.publisher.es_CO.fl_str_mv Uniandes
dc.publisher.program.es_CO.fl_str_mv Doctorado en Ingeniería
dc.publisher.faculty.es_CO.fl_str_mv Facultad de Ingeniería
dc.source.es_CO.fl_str_mv instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
instname_str Universidad de los Andes
institution Universidad de los Andes
reponame_str Repositorio Institucional Séneca
collection Repositorio Institucional Séneca
bitstream.url.fl_str_mv https://repositorio.uniandes.edu.co/bitstreams/4323d2ce-f44e-4887-abc7-9c2b4ab904e4/download
https://repositorio.uniandes.edu.co/bitstreams/159fcf0f-2ddc-4d33-bb59-1a802dc50229/download
https://repositorio.uniandes.edu.co/bitstreams/20e7fe86-53e0-4b09-b250-b4c976cf0d07/download
bitstream.checksum.fl_str_mv e18f9d2c26b72d7d3594e29bff8e9844
e786ce08e087eada117946cf987a7f38
2d7649b75c5910a8b667d1409a4b742c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio institucional Séneca
repository.mail.fl_str_mv adminrepositorio@uniandes.edu.co
_version_ 1812134030514061312
spelling Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Brey, Eric M.03c494ac-e8db-4912-9759-435015bfa2bd600Briceño Triana, Juan Carlosvirtual::14536-1Sánchez Puccini, Paolo Francisco11416600Marañón León, Edgar AlejandroSuárez Venegas, Daniel Ricardo2020-06-10T14:27:58Z2020-06-10T14:27:58Z2018http://hdl.handle.net/1992/3869110.57784/1992/38691u807597.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Due to the high mortality associated with cardiovascular diseases (CD) and alterations in the peripheral circulatory system, tissue engineering for the development of new treatments is presented as a very attractive approach. Tissue engineering seeks the development of new devices to improve current solutions and in the process increase our knowledge about the physiology of the human body to be able to obtain the greatest impact in the use of this technology in patients. This thesis is aimed at the study of the regeneration of arteries through the use of a porcine intestinal submucosa graft (SIS). Previous studies have shown the potential of this material for its use as a cardiovascular graft. In this thesis, we sought to understand the effect of the physical properties of SIS on tissue regeneration. In order to fulfill this objective, mechanical characterization, multi-scale simulation and in vivo experimentation were combined in order to understand the biomechanical environment provided by this material. Among the results obtained, it was possible to characterize the fatigue of the SIS under specific conditions of a vascular graft and to identify the effect of the orientation of the fibers in the transmission of stresses to the cellsDada la alta mortalidad asociada a enfermedades cardiovasculares (EC) y a alteraciones en el sistema circulatorio periférico, el uso de la ingeniería de tejidos para el desarrollo de nuevos tratamientos se presenta como una alternativa muy atractiva. La ingeniería de tejidos busca en el desarrollo de nuevos dispositivos mejorar las soluciones actuales y en el proceso aumentar nuestro conocimiento sobre la fisiología del cuerpo humano para poder llegar a obtener el mayor impacto en el uso de esta tecnología en pacientes. La presente tesis está encaminada al estudio de la regeneración de arterias mediante el uso de un injerto de submucosa intestinal porcina (SIS por sus siglas en inglés). Estudios previos han demostrado el potencial de este material para su uso como injerto cardiovascular. En esta tesis se buscó entender el efecto de las propiedades físicas de la SIS en la regeneración tisular. Para esto se combinaron técnicas de caracterización mecánica, simulación multi-escala y experimentación in vivo, con el fin de entender el entorno biomecánico proveído por este material. Entre los resultados obtenidos, se pudo caracterizar la fatiga de la SIS bajo condiciones propias de un injerto vascular e identificar el efecto de la orientación de las fibras en la transmisión de esfuerzos a las célulasDoctor en IngenieríaDoctorado120 hojasapplication/pdfengUniandesDoctorado en IngenieríaFacultad de Ingenieríainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaComputational and in vivo modeling of small intestinal submucosa (SIS) as a 3D scaffold for tissue-engineered vascular graftsTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TDIngeniería de tejidos - Investigaciones - Estudio de casosMedicina regenerativa - Investigaciones - Estudio de casosMateriales biomédicos - InvestigacionesTrasplantes de órganos, tejidos, etc - InvestigacionesModelado tridimensional - InvestigacionesIngenieríaPublicationa1afa9bf-acfa-4fd4-b002-806fa86cc367virtual::14536-1a1afa9bf-acfa-4fd4-b002-806fa86cc367virtual::14536-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000008320virtual::14536-1THUMBNAILu807597.pdf.jpgu807597.pdf.jpgIM Thumbnailimage/jpeg8242https://repositorio.uniandes.edu.co/bitstreams/4323d2ce-f44e-4887-abc7-9c2b4ab904e4/downloade18f9d2c26b72d7d3594e29bff8e9844MD55TEXTu807597.pdf.txtu807597.pdf.txtExtracted texttext/plain247176https://repositorio.uniandes.edu.co/bitstreams/159fcf0f-2ddc-4d33-bb59-1a802dc50229/downloade786ce08e087eada117946cf987a7f38MD54ORIGINALu807597.pdfapplication/pdf31346272https://repositorio.uniandes.edu.co/bitstreams/20e7fe86-53e0-4b09-b250-b4c976cf0d07/download2d7649b75c5910a8b667d1409a4b742cMD511992/38691oai:repositorio.uniandes.edu.co:1992/386912024-08-26 15:25:43.001https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co

Publicaciones similares