BioBrain ColSolutions

Deep brain tumors generate risks such as seizures, memory loss, balance, and can even lead to death. One of the treatments to solve this problem is surgical extraction. This is an invasive procedure that makes use of a cerebral tubular retractor, an instrument that generates an access channel for the other surgical instruments to the tumor. The use of this retractor has been identified as causing damage to the cerebral cortex and loss of brain mass, as it does not allow the brain tissue to be displaced when inserting it. For this reason, BioBrain ColSolutions has focused on a solution to the need to provide a way to make the neurosurgical procedure less damaging to the cerebral cortex in patients with deep tumors to reduce the risk of brain injury. This need was addressed from the analysis of the state of the art, a solution proposal, and a prototyping process. As a result, the final BrainSafe prototype was reached, which consists of the use of a nitinol stent, as a body of variable diameter, guided by a functional structure and a pressure safety device. This allows to reduce the damage in the cerebral cortex by displacing the tissue, as well as satisfying the requirements that were identified in the initial process. This prototype was validated through tests that simulated the context of the human brain, for which materials such as gelatin and brain from a porcine animal model were used. A feasibility analysis, market potential, risk analysis and regulatory strategies were carried out on the proposed device. Thanks to this, the value proposition of the product was determined and that it would impact the Colombian health system. Likewise, technical aspects to improve in the design of the presented prototype were identified, such as: the use of a biocompatible membrane that protects the tissue against friction and mechanical stress.

• Autores: Ardila Gil, Laura Camila; Bonilla León, Juan Sebastián Felipe; Castro Escandón, Daniela; Dussán Delvasto, Laura María; Gantiva Díaz, Mónica Rocío; Gutiérrez Gamboa, Manuela Margarita
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2020
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: spa
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/51423
• Acceso en línea: http://hdl.handle.net/1992/51423
• Palabra clave: Neurocirugía; Ingeniería biomédica; Medicina; Diseño de productos; Ingeniería
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/