Galleria mellonella como un modelo novedoso para el estudio de Malassezia furfur cbs 1878

Malassezia furfur is a lipid dependent yeast, that is part of the microbiota of animals and humans skin. M. furfur has been identified as a pathogen causing systemic infection in immunosuppressed patients and neonatal with lipid parental nutrition. However, the interaction of the pathogen with its host is currently unknown. That is the reason we propose Galleria mellonella as a new infection model that allows us to evaluate the virulence of this pathogen in interaction with the host. This insect tolerates a wide range of temperatures, including human temperature 37?C, and the immune response against pathogens is similar to the innate immune response in humans. This model has allowed scientists to the study of virulence and the activity of drugs in some yeast of medical importance such as Candida sp. and Cryptococcus sp. The aim of this study is to establish G. mellonella as infection model of M. furfur.

• Autores: Pinzón Pineda, Elkin Nicolás
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2021
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: spa
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/51304
• Acceso en línea: http://hdl.handle.net/1992/51304
• Palabra clave: Malassezia furfur; Hongos patógenos; Levaduras; Polilla de la cera; Lípidos; Relación huésped-virus; Virulencia (Microbiología); Microbiología
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/