Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the curren...
- Autores:
-
Suesca Sánchez, Elizabeth
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2017
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/7752
- Acceso en línea:
- http://hdl.handle.net/1992/7752
- Palabra clave:
- Glioblastoma multiforme - Investigaciones
Liposomas - Investigaciones
Astrocitos - Investigaciones
Física
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/4.0/
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Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2González, John Marioec14c351-2407-437b-a7a4-170770d38229500Leidy, Chad2b60d701-94f4-4ef0-8e4c-e38fc520e479500Pérez Gil, Jesús171f6a71-7d0c-4362-b670-fcef8db24222500Forero Shelton, Antonio Manuvirtual::14854-1Pedraza Leal, Juan Manuelvirtual::14855-1Suesca Sánchez, Elizabeth106375002018-09-27T16:37:43Z2018-09-27T16:37:43Z2017http://hdl.handle.net/1992/775210.57784/1992/7752u754524.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the current therapeutic strategies, chemotherapy is the most frequently used alone or in combination with other therapies. However drawbacks related with an eficient delivery of the therapeutic agent to the tumor cells limit their success. A promising approach is to implement novel delivery systems using carriers which transport molecules in the body and across barriers such as the blood brain barrier, ensuring drug accumulation in tumor tissue. Among these carners, liposomes have received special attention since their physicochemical properties may be modifiable for specific targets while minimizing side effects. GBM tumors over-express Iow-density lipoprotein receptor (LDLR), so targeting this receptor is a rational avenue for potential therapiesDoctor en Ciencias - FísicaDoctorado142 hojasapplication/pdfengUniandesDoctorado en Ciencias - FísicaFacultad de CienciasDepartamento de Físicainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaSulfatides regulate specific uptake of liposomes by an astrocytoma cell lineTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TDGlioblastoma multiforme - InvestigacionesLiposomas - InvestigacionesAstrocitos - InvestigacionesFísicaPublicationhttps://scholar.google.es/citations?user=0_jvORsAAAAJvirtual::14854-1https://scholar.google.es/citations?user=x8-YWMsAAAAJvirtual::14855-10000-0002-1802-3337virtual::14855-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001289730virtual::14854-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000001817virtual::14855-1d8390b22-58d0-4d8c-9abb-d88e0327611dvirtual::14854-1a4c0056f-ab75-4234-9297-925380d7633avirtual::14855-1d8390b22-58d0-4d8c-9abb-d88e0327611dvirtual::14854-1a4c0056f-ab75-4234-9297-925380d7633avirtual::14855-1TEXTu754524.pdf.txtu754524.pdf.txtExtracted texttext/plain210910https://repositorio.uniandes.edu.co/bitstreams/d4d85ad5-f8b2-4bbf-a5d1-a39ff7017718/downloadff61aa15539d48e109dc69852107ece5MD54ORIGINALu754524.pdfapplication/pdf58158833https://repositorio.uniandes.edu.co/bitstreams/b9f2746e-47f9-4e7e-81c4-9f3936e26949/download95d89db23868fd3c7030dd2ead9d431dMD51THUMBNAILu754524.pdf.jpgu754524.pdf.jpgIM Thumbnailimage/jpeg6777https://repositorio.uniandes.edu.co/bitstreams/676e8621-4f20-4e25-990a-db53502f9096/downloadfeb8efaa6ece5c9183f382ab7a3e0a88MD551992/7752oai:repositorio.uniandes.edu.co:1992/77522024-08-26 15:25:49.855http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |
dc.title.es_CO.fl_str_mv |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
title |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
spellingShingle |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line Glioblastoma multiforme - Investigaciones Liposomas - Investigaciones Astrocitos - Investigaciones Física |
title_short |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
title_full |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
title_fullStr |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
title_full_unstemmed |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
title_sort |
Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line |
dc.creator.fl_str_mv |
Suesca Sánchez, Elizabeth |
dc.contributor.advisor.none.fl_str_mv |
González, John Mario Leidy, Chad Pérez Gil, Jesús Forero Shelton, Antonio Manu Pedraza Leal, Juan Manuel |
dc.contributor.author.none.fl_str_mv |
Suesca Sánchez, Elizabeth |
dc.subject.keyword.es_CO.fl_str_mv |
Glioblastoma multiforme - Investigaciones Liposomas - Investigaciones Astrocitos - Investigaciones |
topic |
Glioblastoma multiforme - Investigaciones Liposomas - Investigaciones Astrocitos - Investigaciones Física |
dc.subject.themes.none.fl_str_mv |
Física |
description |
Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the current therapeutic strategies, chemotherapy is the most frequently used alone or in combination with other therapies. However drawbacks related with an eficient delivery of the therapeutic agent to the tumor cells limit their success. A promising approach is to implement novel delivery systems using carriers which transport molecules in the body and across barriers such as the blood brain barrier, ensuring drug accumulation in tumor tissue. Among these carners, liposomes have received special attention since their physicochemical properties may be modifiable for specific targets while minimizing side effects. GBM tumors over-express Iow-density lipoprotein receptor (LDLR), so targeting this receptor is a rational avenue for potential therapies |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2018-09-27T16:37:43Z |
dc.date.available.none.fl_str_mv |
2018-09-27T16:37:43Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Doctorado |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/doctoralThesis |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_db06 |
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Text |
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http://purl.org/redcol/resource_type/TD |
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http://purl.org/coar/resource_type/c_db06 |
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http://hdl.handle.net/1992/7752 |
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10.57784/1992/7752 |
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u754524.pdf |
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repourl:https://repositorio.uniandes.edu.co/ |
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http://hdl.handle.net/1992/7752 |
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eng |
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eng |
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openAccess |
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142 hojas |
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Facultad de Ciencias |
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Departamento de Física |
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