Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line

Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the curren...

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Autores:
Suesca Sánchez, Elizabeth
Tipo de recurso:
Doctoral thesis
Fecha de publicación:
2017
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/7752
Acceso en línea:
http://hdl.handle.net/1992/7752
Palabra clave:
Glioblastoma multiforme - Investigaciones
Liposomas - Investigaciones
Astrocitos - Investigaciones
Física
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-sa/4.0/
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spelling Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2González, John Marioec14c351-2407-437b-a7a4-170770d38229500Leidy, Chad2b60d701-94f4-4ef0-8e4c-e38fc520e479500Pérez Gil, Jesús171f6a71-7d0c-4362-b670-fcef8db24222500Forero Shelton, Antonio Manuvirtual::14854-1Pedraza Leal, Juan Manuelvirtual::14855-1Suesca Sánchez, Elizabeth106375002018-09-27T16:37:43Z2018-09-27T16:37:43Z2017http://hdl.handle.net/1992/775210.57784/1992/7752u754524.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the current therapeutic strategies, chemotherapy is the most frequently used alone or in combination with other therapies. However drawbacks related with an eficient delivery of the therapeutic agent to the tumor cells limit their success. A promising approach is to implement novel delivery systems using carriers which transport molecules in the body and across barriers such as the blood brain barrier, ensuring drug accumulation in tumor tissue. Among these carners, liposomes have received special attention since their physicochemical properties may be modifiable for specific targets while minimizing side effects. GBM tumors over-express Iow-density lipoprotein receptor (LDLR), so targeting this receptor is a rational avenue for potential therapiesDoctor en Ciencias - FísicaDoctorado142 hojasapplication/pdfengUniandesDoctorado en Ciencias - FísicaFacultad de CienciasDepartamento de Físicainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaSulfatides regulate specific uptake of liposomes by an astrocytoma cell lineTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesishttp://purl.org/coar/resource_type/c_db06http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TDGlioblastoma multiforme - InvestigacionesLiposomas - InvestigacionesAstrocitos - InvestigacionesFísicaPublicationhttps://scholar.google.es/citations?user=0_jvORsAAAAJvirtual::14854-1https://scholar.google.es/citations?user=x8-YWMsAAAAJvirtual::14855-10000-0002-1802-3337virtual::14855-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001289730virtual::14854-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000001817virtual::14855-1d8390b22-58d0-4d8c-9abb-d88e0327611dvirtual::14854-1a4c0056f-ab75-4234-9297-925380d7633avirtual::14855-1d8390b22-58d0-4d8c-9abb-d88e0327611dvirtual::14854-1a4c0056f-ab75-4234-9297-925380d7633avirtual::14855-1TEXTu754524.pdf.txtu754524.pdf.txtExtracted texttext/plain210910https://repositorio.uniandes.edu.co/bitstreams/d4d85ad5-f8b2-4bbf-a5d1-a39ff7017718/downloadff61aa15539d48e109dc69852107ece5MD54ORIGINALu754524.pdfapplication/pdf58158833https://repositorio.uniandes.edu.co/bitstreams/b9f2746e-47f9-4e7e-81c4-9f3936e26949/download95d89db23868fd3c7030dd2ead9d431dMD51THUMBNAILu754524.pdf.jpgu754524.pdf.jpgIM Thumbnailimage/jpeg6777https://repositorio.uniandes.edu.co/bitstreams/676e8621-4f20-4e25-990a-db53502f9096/downloadfeb8efaa6ece5c9183f382ab7a3e0a88MD551992/7752oai:repositorio.uniandes.edu.co:1992/77522024-08-26 15:25:49.855http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co
dc.title.es_CO.fl_str_mv Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
title Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
spellingShingle Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
Glioblastoma multiforme - Investigaciones
Liposomas - Investigaciones
Astrocitos - Investigaciones
Física
title_short Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
title_full Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
title_fullStr Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
title_full_unstemmed Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
title_sort Sulfatides regulate specific uptake of liposomes by an astrocytoma cell line
dc.creator.fl_str_mv Suesca Sánchez, Elizabeth
dc.contributor.advisor.none.fl_str_mv González, John Mario
Leidy, Chad
Pérez Gil, Jesús
Forero Shelton, Antonio Manu
Pedraza Leal, Juan Manuel
dc.contributor.author.none.fl_str_mv Suesca Sánchez, Elizabeth
dc.subject.keyword.es_CO.fl_str_mv Glioblastoma multiforme - Investigaciones
Liposomas - Investigaciones
Astrocitos - Investigaciones
topic Glioblastoma multiforme - Investigaciones
Liposomas - Investigaciones
Astrocitos - Investigaciones
Física
dc.subject.themes.none.fl_str_mv Física
description Glioblastoma multiforme (GBM) is one of the most aggressive forms of central nervous System (CNS) neoplasm, and corresponds to 77% of brain tumors. Despite substantial advances in the development of new cancer treatments, GBM remains a tumor of dificult treatment and poor prognosis. Among the current therapeutic strategies, chemotherapy is the most frequently used alone or in combination with other therapies. However drawbacks related with an eficient delivery of the therapeutic agent to the tumor cells limit their success. A promising approach is to implement novel delivery systems using carriers which transport molecules in the body and across barriers such as the blood brain barrier, ensuring drug accumulation in tumor tissue. Among these carners, liposomes have received special attention since their physicochemical properties may be modifiable for specific targets while minimizing side effects. GBM tumors over-express Iow-density lipoprotein receptor (LDLR), so targeting this receptor is a rational avenue for potential therapies
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2018-09-27T16:37:43Z
dc.date.available.none.fl_str_mv 2018-09-27T16:37:43Z
dc.type.spa.fl_str_mv Trabajo de grado - Doctorado
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dc.format.extent.es_CO.fl_str_mv 142 hojas
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dc.publisher.es_CO.fl_str_mv Uniandes
dc.publisher.program.es_CO.fl_str_mv Doctorado en Ciencias - Física
dc.publisher.faculty.es_CO.fl_str_mv Facultad de Ciencias
dc.publisher.department.es_CO.fl_str_mv Departamento de Física
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