Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations
Multilevel selection is a mechanism that enables natural selection to establish cooperation when competition happens at various levels of the population. Such mechanism can be observed in the system of plasmids in bacteria. Therefore, for this research the cost of altruism will be calculated under t...
- Autores:
-
Ramírez Ramírez, María Alejandra
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2020
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/49156
- Acceso en línea:
- http://hdl.handle.net/1992/49156
- Palabra clave:
- Plásmidos bacterianos
Altruismo
Selección multinivel
Cooperación (Evolución)
Física
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.title.es_CO.fl_str_mv |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
title |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
spellingShingle |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations Plásmidos bacterianos Altruismo Selección multinivel Cooperación (Evolución) Física |
title_short |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
title_full |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
title_fullStr |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
title_full_unstemmed |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
title_sort |
Cost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulations |
dc.creator.fl_str_mv |
Ramírez Ramírez, María Alejandra |
dc.contributor.advisor.none.fl_str_mv |
Pedraza Leal, Juan Manuel |
dc.contributor.author.none.fl_str_mv |
Ramírez Ramírez, María Alejandra |
dc.contributor.jury.none.fl_str_mv |
Forero Shelton, Antonio Manu |
dc.subject.armarc.es_CO.fl_str_mv |
Plásmidos bacterianos Altruismo Selección multinivel Cooperación (Evolución) |
topic |
Plásmidos bacterianos Altruismo Selección multinivel Cooperación (Evolución) Física |
dc.subject.themes.none.fl_str_mv |
Física |
description |
Multilevel selection is a mechanism that enables natural selection to establish cooperation when competition happens at various levels of the population. Such mechanism can be observed in the system of plasmids in bacteria. Therefore, for this research the cost of altruism will be calculated under the multilevel selection framework for this particular system. In general terms, cooperation can be evidenced in this system when a given plasmid type adopts a relatively low replication rate compared to its contenders. Such strategy inherently translates into a disadvantage at an individual level. However, it represents a benefit at the collective level, since a lower metabolic burden is exerted on the bacterial host. Consequently, to reduce the replication rate can be interpreted as an altruistic act. In particular, for this project an approach based on probabilistic simulations is used to calculate the cost of this act, because it allows to analyze the competition happening between plasmids at an intracellular level. As part of the results, it was found that the cost of an altruistic act depends on the degree of selfishness of the direct contender. Also, it was discovered that the cost paid by a selfish type is negative, which allows for the cost to be interpreted as a benefit in this case. Additionally, a phenomenological expression for the cost of an altruistic act was derived from the results obtained. Such expression shows that the cost is equal to the logarithmic difference between the repression coefficients (or steady-states) of the competing plasmids, multiplied by a constant that is directly proportional to the Hill coefficient. Therefore, this research provides a powerful tool to obtain the cost of an altruistic act through information that can be readily measured on the biological system |
publishDate |
2020 |
dc.date.issued.none.fl_str_mv |
2020 |
dc.date.accessioned.none.fl_str_mv |
2021-02-18T12:42:59Z |
dc.date.available.none.fl_str_mv |
2021-02-18T12:42:59Z |
dc.type.spa.fl_str_mv |
Trabajo de grado - Pregrado |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
dc.type.content.spa.fl_str_mv |
Text |
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http://purl.org/redcol/resource_type/TP |
format |
http://purl.org/coar/resource_type/c_7a1f |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/1992/49156 |
dc.identifier.pdf.none.fl_str_mv |
u833901.pdf |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad de los Andes |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Séneca |
dc.identifier.repourl.spa.fl_str_mv |
repourl:https://repositorio.uniandes.edu.co/ |
url |
http://hdl.handle.net/1992/49156 |
identifier_str_mv |
u833901.pdf instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
dc.language.iso.es_CO.fl_str_mv |
eng |
language |
eng |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.extent.es_CO.fl_str_mv |
97 hojas |
dc.format.mimetype.es_CO.fl_str_mv |
application/pdf |
dc.publisher.es_CO.fl_str_mv |
Universidad de los Andes |
dc.publisher.program.es_CO.fl_str_mv |
Física |
dc.publisher.faculty.es_CO.fl_str_mv |
Facultad de Ciencias |
dc.publisher.department.es_CO.fl_str_mv |
Departamento de Física |
dc.source.es_CO.fl_str_mv |
instname:Universidad de los Andes reponame:Repositorio Institucional Séneca |
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Universidad de los Andes |
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Universidad de los Andes |
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Repositorio Institucional Séneca |
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Repositorio Institucional Séneca |
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spelling |
Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Pedraza Leal, Juan Manuelvirtual::15258-1Ramírez Ramírez, María Alejandraac1ca718-f3be-45ab-8669-af6bafc2d4d3500Forero Shelton, Antonio Manu2021-02-18T12:42:59Z2021-02-18T12:42:59Z2020http://hdl.handle.net/1992/49156u833901.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Multilevel selection is a mechanism that enables natural selection to establish cooperation when competition happens at various levels of the population. Such mechanism can be observed in the system of plasmids in bacteria. Therefore, for this research the cost of altruism will be calculated under the multilevel selection framework for this particular system. In general terms, cooperation can be evidenced in this system when a given plasmid type adopts a relatively low replication rate compared to its contenders. Such strategy inherently translates into a disadvantage at an individual level. However, it represents a benefit at the collective level, since a lower metabolic burden is exerted on the bacterial host. Consequently, to reduce the replication rate can be interpreted as an altruistic act. In particular, for this project an approach based on probabilistic simulations is used to calculate the cost of this act, because it allows to analyze the competition happening between plasmids at an intracellular level. As part of the results, it was found that the cost of an altruistic act depends on the degree of selfishness of the direct contender. Also, it was discovered that the cost paid by a selfish type is negative, which allows for the cost to be interpreted as a benefit in this case. Additionally, a phenomenological expression for the cost of an altruistic act was derived from the results obtained. Such expression shows that the cost is equal to the logarithmic difference between the repression coefficients (or steady-states) of the competing plasmids, multiplied by a constant that is directly proportional to the Hill coefficient. Therefore, this research provides a powerful tool to obtain the cost of an altruistic act through information that can be readily measured on the biological system"El mecanismo conocido como selección multinivel permite el surgimiento de estrategias altruistas, en la naturaleza, cuando existe competencia en varios niveles de la población. Tal mecanismo se puede observar en el sistema de plásmidos en bacterias. Por lo tanto, para esta investigación, el costo de ser altruista se calculará bajo el marco de selección multinivel para este sistema en particular. En términos generales, la cooperación se puede evidenciar en este sistema cuando un tipo de plásmido adopta una tasa de replicación relativamente baja en comparación con sus contendientes. Esta estrategia se traduce en una desventaja a nivel individual. Sin embargo, representa un beneficio a nivel colectivo, ya que se ejerce una menor carga metabólica sobre el huésped bacteriano. En consecuencia, reducir la tasa de replicación puede interpretarse como un acto altruista. En particular, para esta investigación se utiliza un enfoque basado en simulaciones probabilísticas para calcular el costo de este acto, ya que permite analizar la competencia que ocurre entre plásmidos a nivel intracelular. Como parte de los resultados, se encontró que el costo de un acto altruista depende del grado de egoísmo del contendiente directo. Asimismo, se descubrió que el costo pagado por plásmidos tipo egoísta es negativo, lo que permite interpretar el costo, en este caso, como un beneficio. Adicionalmente, con base en los resultados obtenidos se derivó una expresión fenomenológica del costo de un acto altruista. Tal expresión muestra que el costo es igual a la diferencia logarítmica entre los coeficientes de represión (o estados estacionarios) de los plásmidos en competencia, multiplicada por una constante que es directamente proporcional al coeficiente de Hill. Por lo tanto, esta investigación proporciona una poderosa herramienta para obtener el costo de un acto altruista a través de información que se puede medir fácilmente en el sistema biológico."--Tomado del Formato de Documento de GradoFísicoPregrado97 hojasapplication/pdfengUniversidad de los AndesFísicaFacultad de CienciasDepartamento de Físicainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaCost calculation of an altruistic act for the plasmids-in-bacteria system through probabilistic simulationsTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesishttp://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TPPlásmidos bacterianosAltruismoSelección multinivelCooperación (Evolución)FísicaPublicationhttps://scholar.google.es/citations?user=x8-YWMsAAAAJvirtual::15258-10000-0002-1802-3337virtual::15258-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000001817virtual::15258-1a4c0056f-ab75-4234-9297-925380d7633avirtual::15258-1a4c0056f-ab75-4234-9297-925380d7633avirtual::15258-1ORIGINALu833901.pdfapplication/pdf5738534https://repositorio.uniandes.edu.co/bitstreams/32a1d1fb-5317-40c0-9696-42d55212d87e/download96902d255b22d672d10f16487c4dfc52MD51THUMBNAILu833901.pdf.jpgu833901.pdf.jpgIM Thumbnailimage/jpeg8280https://repositorio.uniandes.edu.co/bitstreams/a81b45cc-f298-4e85-985a-1b216e26412d/download638d5a2988b8b044e4f924382a6240edMD55TEXTu833901.pdf.txtu833901.pdf.txtExtracted texttext/plain221797https://repositorio.uniandes.edu.co/bitstreams/52717688-9649-4270-aced-f49c560be827/download709183340fac1c54cbc9785f5fd5036cMD541992/49156oai:repositorio.uniandes.edu.co:1992/491562024-03-13 15:24:47.915http://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |