AlcaliNObacter

In a collaborative project focused on enhancing the well-being of rural populations in Colombia, thorough observations and interviews were conducted. Medical centers like Profamilia and the Juan N Corpas clinic were examined, along with interviews with healthcare professionals. Additionally, individ...

Full description

Autores:
Acosta Corredor, Laura Valentina
Ardila Rueda, Juan Felipe
Corredor Alzate, Loreana
Ojeda Alonso, Sebastián
Puentes Mozo, Juanita
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2023
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/69110
Acceso en línea:
http://hdl.handle.net/1992/69110
Palabra clave:
AlcaliNObacter
Primary care
Colombia
Detecting and treating infections
Rural populations
Hydrogel
Waterproof dressing
Biocompatible adhesive
Broad-spectrum antibiotic
Antimicrobial properties
Tissue healing
Quality of life
Preventing infections
Chitosan
Bacterial infections
Wound infections
Ingeniería
Rights
openAccess
License
Atribución 4.0 Internacional
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network_acronym_str UNIANDES2
network_name_str Séneca: repositorio Uniandes
repository_id_str
dc.title.none.fl_str_mv AlcaliNObacter
title AlcaliNObacter
spellingShingle AlcaliNObacter
AlcaliNObacter
Primary care
Colombia
Detecting and treating infections
Rural populations
Hydrogel
Waterproof dressing
Biocompatible adhesive
Broad-spectrum antibiotic
Antimicrobial properties
Tissue healing
Quality of life
Preventing infections
Chitosan
Bacterial infections
Wound infections
Ingeniería
title_short AlcaliNObacter
title_full AlcaliNObacter
title_fullStr AlcaliNObacter
title_full_unstemmed AlcaliNObacter
title_sort AlcaliNObacter
dc.creator.fl_str_mv Acosta Corredor, Laura Valentina
Ardila Rueda, Juan Felipe
Corredor Alzate, Loreana
Ojeda Alonso, Sebastián
Puentes Mozo, Juanita
dc.contributor.advisor.none.fl_str_mv Morales Pinzón, Paula Andrea
Bigio Roitman, David
dc.contributor.author.none.fl_str_mv Acosta Corredor, Laura Valentina
Ardila Rueda, Juan Felipe
Corredor Alzate, Loreana
Ojeda Alonso, Sebastián
Puentes Mozo, Juanita
dc.subject.keyword.none.fl_str_mv AlcaliNObacter
Primary care
Colombia
Detecting and treating infections
Rural populations
Hydrogel
Waterproof dressing
Biocompatible adhesive
Broad-spectrum antibiotic
Antimicrobial properties
Tissue healing
Quality of life
Preventing infections
Chitosan
Bacterial infections
Wound infections
topic AlcaliNObacter
Primary care
Colombia
Detecting and treating infections
Rural populations
Hydrogel
Waterproof dressing
Biocompatible adhesive
Broad-spectrum antibiotic
Antimicrobial properties
Tissue healing
Quality of life
Preventing infections
Chitosan
Bacterial infections
Wound infections
Ingeniería
dc.subject.themes.es_CO.fl_str_mv Ingeniería
description In a collaborative project focused on enhancing the well-being of rural populations in Colombia, thorough observations and interviews were conducted. Medical centers like Profamilia and the Juan N Corpas clinic were examined, along with interviews with healthcare professionals. Additionally, individuals living near the La Copa dam in Boyaca were interviewed to validate the need for a product. The team identified a pressing need for improving primary care for sharp wounds in rural areas. Wound infections contribute significantly to the delayed healing of chronic open wounds and increase hospital costs. Detecting and treating these infections can lead to a 10% to 20% rise in expenses and extended hospital stays. While complete elimination of wound infections is not feasible, reducing the infection rate to a minimum level can greatly benefit patients' comfort and efficient use of medical resources. Therefore, offering a temporary solution to seal sharp wounds becomes crucial for preventing infections and improving people's quality of life in rural areas of Colombia. The product developed for addressing this pressing need is called AlcaliNObacter. It is a biocompatible adhesive and waterproof dressing that contains a hydrogel. AlcaliNObacter is designed to be included in Type A first aid kits as an immediate solution for isolating wounds when suturing is not available. The inclusion of a pH indicator allows for the identification of bacterial infections, while the hydrogel, composed of chitosan and 1% acetic acid, promotes tissue healing and provides antimicrobial properties. Additionally, the product incorporates a broad-spectrum antibiotic to minimize the risk of infections from various bacteria. AlcaliNObacter effectively shields the wound from the environment and prevents infection until a trained healthcare professional is able to suture the patient.
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-08-02T18:51:05Z
dc.date.available.none.fl_str_mv 2023-08-02T18:51:05Z
dc.date.issued.none.fl_str_mv 2023-06-02
dc.type.es_CO.fl_str_mv Trabajo de grado - Pregrado
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/1992/69110
dc.identifier.instname.es_CO.fl_str_mv instname:Universidad de los Andes
dc.identifier.reponame.es_CO.fl_str_mv reponame:Repositorio Institucional Séneca
dc.identifier.repourl.es_CO.fl_str_mv repourl:https://repositorio.uniandes.edu.co/
url http://hdl.handle.net/1992/69110
identifier_str_mv instname:Universidad de los Andes
reponame:Repositorio Institucional Séneca
repourl:https://repositorio.uniandes.edu.co/
dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.relation.references.es_CO.fl_str_mv Abedi-Firoozjah, R., Yousefi, S., Heydari, M., Seyedfatehi, F., Jafarzadeh, S., Mohammadi, R., ... Garavand, F. (2022). Application of red cabbage anthocyanins as ph-sensitive pigments in smart food packaging and sensors. Polymers, 14 (8), 1629.
Acelity. (2020). NU-DERMTM Hydrocolloid Wound Dressings. https://www.acelity.com/healthcare-professionals/ global-product-catalog/catalog/nu-derm-hydrocolloid-wound-dressing. (Accessed: June 1, 2023)
AD Surgical. (2023). Silicone foam dressings. https://ad-surgical.com/wound-free-silicone-foam-dressings/. (Accessed: June 1, 2023)
All Health. (2021). All health advanced healing antibacterial heavy duty adhesive bandages, regular. https://www.amazon.com/ All-Health-Advanced-Healing-Regular/dp/B07D3VH658?th=1. ([Accessed: April 20, 2023])
Anaya, D. A., Quintero, G. A., Garda-Herreros, L. G., Vanegas, B. S., Vera, A., Nassar, R., & Sotomayor, J. (2021, sep.). Epidemiología de las heridas de tratamiento hospitalario en Colombia. Revista Colombiana de Cirugía, 13 (3), 181-184. Retrieved from https://www.revistacirugia.org/index.php/cirugia/article/view/1575
Arafa, A. A., Nada, A. A., Ibrahim, A. Y., Sajkiewicz, P., Zahran, M. K., & Hakeim, O. A. (2021). Preparation and characterization of smart therapeutic ph-sensitive wound dressing from red cabbage extract and chitosan hydrogel. International Journal of Biological Macromolecules, 182 , 1820-1831.
Biological evaluation of medical devices - part 10: Tests for irritation and skin sensitization. (2010). Retrieved from https://nhiso.com/wp-content/uploads/2018/05/ISO-10993-10-2010.pdf
Biological evaluation of medical devices - part 5: Tests for in vitro cytotoxicity. (2009). Retrieved from https://nhiso.com/wp-content/uploads/2018/05/ISO-10993-5-2009.pdf
Bowler, P., Duerden, B., & Armstrong, D. (2001, April). Wound microbiology and associated approaches to wound management. Clinical Microbiology Reviews, 14 , 244-269. doi: 10.1128/CMR.14.2.244-269.2001
Bruns, T. B., & Worthington, J. M. (2000). Using tissue adhesive for wound repair: a practical guide to dermabond. , 61 (5),1383-1388.
Dabiri, S. M. H., Sefat, F., Nasiri, M., Ebrahimi-Barough, S., & Shirazi, R. (2020). A review of biocompatible dressings and coatings for wound healing applications: state-of-the-art. Journal of Materials Science: Materials in Medicine, 31 (5), 43. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111237/ doi: 10.1007/s10856-020-06390-6
Edwards, P. (2017). Hydrocolloid dressing testing - surgical materials testing laboratory. http://www.smtl.co.uk/testing -services/54-wound-dressings-testing-services/103-hydrocolloids.html. (Accessed: June 1, 2023)
ESTEVA, E. (2006). El tratamiento de las heridas. , 25 (8), 54-60. Retrieved from https://www.elsevier.es/es-revista -offarm-4-articulo-el-tratamiento-heridas-13094127
FDA. (2020). Classify your medical device. https://www.fda.gov/medical-devices/overview-device-regulation/ classify-your-medical-device. (Accessed: June 1, 2023)
Freedman, B., & Mooney, D. (2021). Tough gel adhesives for wound healing. Retrieved 2022-12-11, from https://wyss.harvard .edu/technology/tough-gel-adhesives-for-wound-healing/
Goldman, A. H., & Kates, S. (2017). Pay-for-performance in orthopedics: how we got here and where we are going. Current Reviews in Musculoskeletal Medicine, 10 , 212-217.
Gonzalez, A., & Roddick, J. (2018). Open wound: Types, treatments, and complications. Retrieved 2022-12-12, from https://www.healthline.com/health/open-wound
[hot item] máquina de mezclador químico precio/ mezclador químico. (n.d.). Retrieved 2023-04-21, from https://es.made-in-china.com/co yalian/product Chemical-Mixer-Machine-Price-Mixer-Chemical uouorrgneg.html
Invima. (n.d.). Dispositivos médicos y equipos biomédicos. Retrieved from https://www.invima.gov.co/dispositivos -medicos-y-equipos-biomedicos
Laurano, R., Boffito, M., Ciardelli, G., & Chiono, V. (2022). Wound dressing products: A translational investigation from the bench to the market. Engineered Regeneration, 3 (2), 182-200. Retrieved from https://www.sciencedirect.com/ science/article/pii/S2666138122000287 doi: https://doi.org/10.1016/j.engreg.2022.04.002
Leaper, D., Assadian, O., & Edmiston, C. E. (2015). Approach to chronic wound infections. British Journal of Dermatology, 173 (2), 351-358.
Mostafalu, P., Tamayol, A., Rahimi, R., Ochoa, M., Khalilpour, A., Kiaee, G., ... others (2018). Smart bandage for monitoring and treatment of chronic wounds. Small , 14 (33), 1703509.
Máquina cortadora junior de tela KM vertical KM-JNR-10 | 10 pulgadas - macoser. (n.d.). Retrieved 2023-04-21, from https://www.macoser-sa.com/maquina-cortadora-junior-de-tela-km-vertical-km-jnr-10-10-pulgadas/p
Negut, I., Grumezescu, V., & Grumezescu, A. (2018). Treatment strategies for infected wounds. Molecules, 23 , 2392. doi:10.3390/molecules23092392
Neosporin. (2023). NEOSPORIN® Original Ointment. https://www.neosporin.com/products/topical-antibiotics/ original-antibiotic-ointment.
Nga, N. K., Tam, L., Ha, N., Viet, P., & Huy, T. (2020, 11). Enhanced biomineralization and protein adsorption capacity of 3d chitosan/hydroxyapatite biomimetic scaffolds applied for bone-tissue engineering. RSC Advances, 10 , 43045-43057. doi:10.1039/D0RA09432C
O'Donnell, A. N., Williams, M., & Kilbourne, A. M. (2013). Overcoming roadblocks: current and emerging reimbursement strategies for integrated mental health services in primary care. Journal of general internal medicine, 28 , 1667-1672.
Pan, N., Qin, J., Feng, P., Li, Z., & Song, B. (2019). Color-changing smart fibrous materials for naked eye real-time monitoring of wound pH. , 7 (16), 2626-2633. Retrieved 2022-11-07, from http://xlink.rsc.org/?DOI=C9TB00195F doi: 10.1039/ C9TB00195F
Pusta, A., Tertis, , M., Cristea, C., & Mirel, S. (2022). Wearable sensors for the detection of biomarkers for wound infection. Biosensors, 12 (1). Retrieved from https://www.mdpi.com/2079-6374/12/1/1
Safetec of America. (2023, April 10). Bacitracin single antibiotic ointment. https://safetec.com/product/single-antibiotic-ointment-bacitracin/
Santalla, A., López-Criado, M., Ruiz, M., Fernández-Parra, J., Gallo, J., & Montoya, F. (2007). Infección de la herida quirúrgica. prevención y tratamiento. Clínica e investigación en ginecología y obstetricia, 34 (5), 189-196.
Sen, C. K. (2019). Human wounds and its burden: An updated compendium of estimates. , 8 (2), 39-48. Retrieved 2022-12-12, from https://www.liebertpub.com/doi/10.1089/wound.2019.0946 doi: 10.1089/wound.2019.0946
Seton.co.uk. (2019). Jsp® visilite® safety helmet light. https://www.seton.co.uk/jsp-reg-visilite-reg-safety-helmet -light.html. (Accessed: June 1, 2023)
Soliman, M., & Leonard, J. (2022). Infected wound: Recognition, causes, symptoms, treatment. Retrieved 2022-12-12, from https://www.medicalnewstoday.com/articles/325040
Sun, Y., Zhao, C., Niu, J., Ren, J., & Qu, X. (2020). Colorimetric band-aids for point-of-care sensing and treating bacterial infection. ACS Central Science, 6 (2), 207-212. Retrieved from https://doi.org/10.1021/acscentsci.9b01104 (PMID:32123738) doi: 10.1021/acscentsci.9b01104
Winner Medical. (2022). Alginate dressing in roll with high quality. https://www.winnermedical.com/alginate-dressing-in -roll.html. (Accessed: June 1, 2023)
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spelling Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Morales Pinzón, Paula Andreaf408db13-a9b0-4f5b-bc18-5ea4b6df0cc6600Bigio Roitman, Davidvirtual::6203-1Acosta Corredor, Laura Valentina3d7c1c0f-236a-423d-aa02-a8886d061d79600Ardila Rueda, Juan Felipea9fb4f18-f33c-4eb4-b68b-b3ef3f941b20600Corredor Alzate, Loreana580f6552-fa74-472f-a3c3-b3ceb7cf18fd600Ojeda Alonso, Sebastiánc82ef619-12d9-403e-bda4-5b0d74ec00c9600Puentes Mozo, Juanita1657a7f0-234b-46c3-af12-bfb10c694e256002023-08-02T18:51:05Z2023-08-02T18:51:05Z2023-06-02http://hdl.handle.net/1992/69110instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/In a collaborative project focused on enhancing the well-being of rural populations in Colombia, thorough observations and interviews were conducted. Medical centers like Profamilia and the Juan N Corpas clinic were examined, along with interviews with healthcare professionals. Additionally, individuals living near the La Copa dam in Boyaca were interviewed to validate the need for a product. The team identified a pressing need for improving primary care for sharp wounds in rural areas. Wound infections contribute significantly to the delayed healing of chronic open wounds and increase hospital costs. Detecting and treating these infections can lead to a 10% to 20% rise in expenses and extended hospital stays. While complete elimination of wound infections is not feasible, reducing the infection rate to a minimum level can greatly benefit patients' comfort and efficient use of medical resources. Therefore, offering a temporary solution to seal sharp wounds becomes crucial for preventing infections and improving people's quality of life in rural areas of Colombia. The product developed for addressing this pressing need is called AlcaliNObacter. It is a biocompatible adhesive and waterproof dressing that contains a hydrogel. AlcaliNObacter is designed to be included in Type A first aid kits as an immediate solution for isolating wounds when suturing is not available. The inclusion of a pH indicator allows for the identification of bacterial infections, while the hydrogel, composed of chitosan and 1% acetic acid, promotes tissue healing and provides antimicrobial properties. Additionally, the product incorporates a broad-spectrum antibiotic to minimize the risk of infections from various bacteria. AlcaliNObacter effectively shields the wound from the environment and prevents infection until a trained healthcare professional is able to suture the patient.Ingeniero BiomédicoPregrado30 páginasapplication/pdfengUniversidad de los AndesIngeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería BiomédicaAlcaliNObacterTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPAlcaliNObacterPrimary careColombiaDetecting and treating infectionsRural populationsHydrogelWaterproof dressingBiocompatible adhesiveBroad-spectrum antibioticAntimicrobial propertiesTissue healingQuality of lifePreventing infectionsChitosanBacterial infectionsWound infectionsIngenieríaAbedi-Firoozjah, R., Yousefi, S., Heydari, M., Seyedfatehi, F., Jafarzadeh, S., Mohammadi, R., ... Garavand, F. (2022). Application of red cabbage anthocyanins as ph-sensitive pigments in smart food packaging and sensors. Polymers, 14 (8), 1629.Acelity. (2020). NU-DERMTM Hydrocolloid Wound Dressings. https://www.acelity.com/healthcare-professionals/ global-product-catalog/catalog/nu-derm-hydrocolloid-wound-dressing. (Accessed: June 1, 2023)AD Surgical. (2023). Silicone foam dressings. https://ad-surgical.com/wound-free-silicone-foam-dressings/. (Accessed: June 1, 2023)All Health. (2021). All health advanced healing antibacterial heavy duty adhesive bandages, regular. https://www.amazon.com/ All-Health-Advanced-Healing-Regular/dp/B07D3VH658?th=1. ([Accessed: April 20, 2023])Anaya, D. A., Quintero, G. A., Garda-Herreros, L. G., Vanegas, B. S., Vera, A., Nassar, R., & Sotomayor, J. (2021, sep.). Epidemiología de las heridas de tratamiento hospitalario en Colombia. Revista Colombiana de Cirugía, 13 (3), 181-184. Retrieved from https://www.revistacirugia.org/index.php/cirugia/article/view/1575Arafa, A. A., Nada, A. A., Ibrahim, A. Y., Sajkiewicz, P., Zahran, M. K., & Hakeim, O. A. (2021). Preparation and characterization of smart therapeutic ph-sensitive wound dressing from red cabbage extract and chitosan hydrogel. International Journal of Biological Macromolecules, 182 , 1820-1831.Biological evaluation of medical devices - part 10: Tests for irritation and skin sensitization. (2010). Retrieved from https://nhiso.com/wp-content/uploads/2018/05/ISO-10993-10-2010.pdfBiological evaluation of medical devices - part 5: Tests for in vitro cytotoxicity. (2009). Retrieved from https://nhiso.com/wp-content/uploads/2018/05/ISO-10993-5-2009.pdfBowler, P., Duerden, B., & Armstrong, D. (2001, April). Wound microbiology and associated approaches to wound management. Clinical Microbiology Reviews, 14 , 244-269. doi: 10.1128/CMR.14.2.244-269.2001Bruns, T. B., & Worthington, J. M. (2000). Using tissue adhesive for wound repair: a practical guide to dermabond. , 61 (5),1383-1388.Dabiri, S. M. H., Sefat, F., Nasiri, M., Ebrahimi-Barough, S., & Shirazi, R. (2020). A review of biocompatible dressings and coatings for wound healing applications: state-of-the-art. Journal of Materials Science: Materials in Medicine, 31 (5), 43. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111237/ doi: 10.1007/s10856-020-06390-6Edwards, P. (2017). Hydrocolloid dressing testing - surgical materials testing laboratory. http://www.smtl.co.uk/testing -services/54-wound-dressings-testing-services/103-hydrocolloids.html. (Accessed: June 1, 2023)ESTEVA, E. (2006). El tratamiento de las heridas. , 25 (8), 54-60. Retrieved from https://www.elsevier.es/es-revista -offarm-4-articulo-el-tratamiento-heridas-13094127FDA. (2020). Classify your medical device. https://www.fda.gov/medical-devices/overview-device-regulation/ classify-your-medical-device. (Accessed: June 1, 2023)Freedman, B., & Mooney, D. (2021). Tough gel adhesives for wound healing. Retrieved 2022-12-11, from https://wyss.harvard .edu/technology/tough-gel-adhesives-for-wound-healing/Goldman, A. H., & Kates, S. (2017). Pay-for-performance in orthopedics: how we got here and where we are going. Current Reviews in Musculoskeletal Medicine, 10 , 212-217.Gonzalez, A., & Roddick, J. (2018). Open wound: Types, treatments, and complications. Retrieved 2022-12-12, from https://www.healthline.com/health/open-wound[hot item] máquina de mezclador químico precio/ mezclador químico. (n.d.). Retrieved 2023-04-21, from https://es.made-in-china.com/co yalian/product Chemical-Mixer-Machine-Price-Mixer-Chemical uouorrgneg.htmlInvima. (n.d.). Dispositivos médicos y equipos biomédicos. Retrieved from https://www.invima.gov.co/dispositivos -medicos-y-equipos-biomedicosLaurano, R., Boffito, M., Ciardelli, G., & Chiono, V. (2022). Wound dressing products: A translational investigation from the bench to the market. Engineered Regeneration, 3 (2), 182-200. Retrieved from https://www.sciencedirect.com/ science/article/pii/S2666138122000287 doi: https://doi.org/10.1016/j.engreg.2022.04.002Leaper, D., Assadian, O., & Edmiston, C. E. (2015). Approach to chronic wound infections. British Journal of Dermatology, 173 (2), 351-358.Mostafalu, P., Tamayol, A., Rahimi, R., Ochoa, M., Khalilpour, A., Kiaee, G., ... others (2018). Smart bandage for monitoring and treatment of chronic wounds. Small , 14 (33), 1703509.Máquina cortadora junior de tela KM vertical KM-JNR-10 | 10 pulgadas - macoser. (n.d.). Retrieved 2023-04-21, from https://www.macoser-sa.com/maquina-cortadora-junior-de-tela-km-vertical-km-jnr-10-10-pulgadas/pNegut, I., Grumezescu, V., & Grumezescu, A. (2018). Treatment strategies for infected wounds. Molecules, 23 , 2392. doi:10.3390/molecules23092392Neosporin. (2023). NEOSPORIN® Original Ointment. https://www.neosporin.com/products/topical-antibiotics/ original-antibiotic-ointment.Nga, N. K., Tam, L., Ha, N., Viet, P., & Huy, T. 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