Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo
Maintenance of the microcirculatory function has been proposed as a key factor for the positive outcome of the performance of artificial oxygen carriers and plasma expanders. Such products are used to restore blood volume and oxygen carrying capacity in cases of hemorrhagic shock. The majority of th...
- Autores:
-
Ortiz Vélez, Daniel
- Tipo de recurso:
- Fecha de publicación:
- 2012
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/11630
- Acceso en línea:
- http://hdl.handle.net/1992/11630
- Palabra clave:
- Ingeniería biomédica - Investigaciones
Sustitutos sanguíneos - Investigaciones
Microcirculación sanguínea - Investigaciones
Ingeniería
- Rights
- openAccess
- License
- https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf
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Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| title |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| spellingShingle |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo Ingeniería biomédica - Investigaciones Sustitutos sanguíneos - Investigaciones Microcirculación sanguínea - Investigaciones Ingeniería |
| title_short |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| title_full |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| title_fullStr |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| title_full_unstemmed |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| title_sort |
Implementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivo |
| dc.creator.fl_str_mv |
Ortiz Vélez, Daniel |
| dc.contributor.advisor.none.fl_str_mv |
Briceño Triana, Juan Carlos |
| dc.contributor.author.none.fl_str_mv |
Ortiz Vélez, Daniel |
| dc.contributor.jury.none.fl_str_mv |
González Mancera, Andrés Leonardo |
| dc.subject.keyword.es_CO.fl_str_mv |
Ingeniería biomédica - Investigaciones Sustitutos sanguíneos - Investigaciones Microcirculación sanguínea - Investigaciones |
| topic |
Ingeniería biomédica - Investigaciones Sustitutos sanguíneos - Investigaciones Microcirculación sanguínea - Investigaciones Ingeniería |
| dc.subject.themes.none.fl_str_mv |
Ingeniería |
| description |
Maintenance of the microcirculatory function has been proposed as a key factor for the positive outcome of the performance of artificial oxygen carriers and plasma expanders. Such products are used to restore blood volume and oxygen carrying capacity in cases of hemorrhagic shock. The majority of the experimental data in which all this theory is based was obtained from a skin fold window chamber preparation that allows the direct visualization of the muscle and connective tissue microvessels. This vessels are thought to be the first tissues to be shot down during severe bleeding due to control mechanisms. For this reason the visualization and measurements should be done in the microcirculation of the main organs whose survival is highly compromised during hypoxia such as the brain, to contrast with the existing data. In this document a summary of a year of work for the implementation of a methodology for the direct visualization and quantification of microcirculatory parameters in cerebral tissue of a swine model is presented. |
| publishDate |
2012 |
| dc.date.issued.none.fl_str_mv |
2012 |
| dc.date.accessioned.none.fl_str_mv |
2018-09-28T08:06:21Z |
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2018-09-28T08:06:21Z |
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Trabajo de grado - Maestría |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/masterThesis |
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Text |
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http://purl.org/redcol/resource_type/TM |
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http://hdl.handle.net/1992/11630 |
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u608741.pdf |
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repourl:https://repositorio.uniandes.edu.co/ |
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http://hdl.handle.net/1992/11630 |
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u608741.pdf instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/ |
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eng |
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eng |
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https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdf |
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info:eu-repo/semantics/openAccess |
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openAccess |
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39 hojas |
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application/pdf |
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Uniandes |
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Maestría en Ingeniería Mecánica |
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Facultad de Ingeniería |
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Departamento de Ingeniería Mecánica |
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Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Briceño Triana, Juan Carlosvirtual::15614-1Ortiz Vélez, Daniel0accf1b5-a209-4737-8f46-df6541a7ba23600González Mancera, Andrés Leonardo2018-09-28T08:06:21Z2018-09-28T08:06:21Z2012http://hdl.handle.net/1992/11630u608741.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Maintenance of the microcirculatory function has been proposed as a key factor for the positive outcome of the performance of artificial oxygen carriers and plasma expanders. Such products are used to restore blood volume and oxygen carrying capacity in cases of hemorrhagic shock. The majority of the experimental data in which all this theory is based was obtained from a skin fold window chamber preparation that allows the direct visualization of the muscle and connective tissue microvessels. This vessels are thought to be the first tissues to be shot down during severe bleeding due to control mechanisms. For this reason the visualization and measurements should be done in the microcirculation of the main organs whose survival is highly compromised during hypoxia such as the brain, to contrast with the existing data. In this document a summary of a year of work for the implementation of a methodology for the direct visualization and quantification of microcirculatory parameters in cerebral tissue of a swine model is presented.La preservación de la función microvascular ha sido establecida como un factor clave en el desempeño final de cualquier transportador de oxigeno o expansor de plasma que pretenda ser usado para el restablecimiento del volumen sanguíneo y el transporte de oxígeno en casos de choque hemorrágico. La mayoría de los datos experimentales con los que se cuenta para soportar esta teoría han sido obtenidos mediante la visualización de la microvasculatura del tejido cutáneo, conectivo y muscular de pequeños animales implantados con una ventana cutánea dorsal, estos tejidos se conoce que son los primeros en ser apagados durante el progreso de un choque hemorrágico debido a los mecanismos de control homeostático, por esta razón se ha propuesto que la visualización y cuantificación de parámetros se debe hacer en los órganos principales como el cerebro. En este trabajo se presenta el resumen de un año de trabajo dedicado a la implementación de una metodología para la visualización directa y la cuantificación de parámetros microcirculatorios en el tejido cerebral de un modelo animal porcino.Magíster en Ingeniería MecánicaMaestría39 hojasapplication/pdfengUniandesMaestría en Ingeniería MecánicaFacultad de IngenieríaDepartamento de Ingeniería Mecánicainstname:Universidad de los Andesreponame:Repositorio Institucional SénecaImplementation of a methodology to quantify microcirculatory parameters in cerebral tissue of a swine model in vivoTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesishttp://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TMIngeniería biomédica - InvestigacionesSustitutos sanguíneos - InvestigacionesMicrocirculación sanguínea - InvestigacionesIngenieríaPublicationa1afa9bf-acfa-4fd4-b002-806fa86cc367virtual::15614-1a1afa9bf-acfa-4fd4-b002-806fa86cc367virtual::15614-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000008320virtual::15614-1ORIGINALu608741.pdfapplication/pdf2399769https://repositorio.uniandes.edu.co/bitstreams/e42ec587-39e0-436e-ad2c-ce6d78a0031d/downloaddbcaa395b2e865e82b21370ff524aad3MD51THUMBNAILu608741.pdf.jpgu608741.pdf.jpgIM Thumbnailimage/jpeg9340https://repositorio.uniandes.edu.co/bitstreams/b5139c17-71e0-4d29-b243-f72a2d5c3aa9/download3911bfddb39a4e3d355f2b3548c8b55eMD55TEXTu608741.pdf.txtu608741.pdf.txtExtracted texttext/plain90366https://repositorio.uniandes.edu.co/bitstreams/b80037fb-9104-4c3f-9e5f-862ec1e0384a/downloadf8ed4f5f05214986bc95fff164ac6aa1MD541992/11630oai:repositorio.uniandes.edu.co:1992/116302024-03-13 15:30:34.639https://repositorio.uniandes.edu.co/static/pdf/aceptacion_uso_es.pdfopen.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |