Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans

Nowadays, the principle on which the distribution of the pulmonary ventilation (V) perfusion (Q) index is based and proposed states the main force that determines this rate is gravity. From this, it was established that the behavior of this index is modified depending on how close the lung lobe of i...

Full description

Autores:
Franco Burgos, Eva Isabella
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2021
Institución:
Universidad de los Andes
Repositorio:
Séneca: repositorio Uniandes
Idioma:
eng
OAI Identifier:
oai:repositorio.uniandes.edu.co:1992/59038
Acceso en línea:
http://hdl.handle.net/1992/59038
Palabra clave:
Ventilation
Perfusion
Gas exchange
Mathematical model
Lung architecture
Ingeniería
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.title.none.fl_str_mv Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
title Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
spellingShingle Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
Ventilation
Perfusion
Gas exchange
Mathematical model
Lung architecture
Ingeniería
title_short Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
title_full Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
title_fullStr Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
title_full_unstemmed Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
title_sort Development of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scans
dc.creator.fl_str_mv Franco Burgos, Eva Isabella
dc.contributor.advisor.none.fl_str_mv Cordovez Alvarez, Juan Manuel
Bravo Vega, Carlos Andrés
dc.contributor.author.none.fl_str_mv Franco Burgos, Eva Isabella
dc.contributor.jury.none.fl_str_mv Cifuentes de la Portilla, Christian Javier
dc.subject.keyword.none.fl_str_mv Ventilation
Perfusion
Gas exchange
Mathematical model
Lung architecture
topic Ventilation
Perfusion
Gas exchange
Mathematical model
Lung architecture
Ingeniería
dc.subject.themes.es_CO.fl_str_mv Ingeniería
description Nowadays, the principle on which the distribution of the pulmonary ventilation (V) perfusion (Q) index is based and proposed states the main force that determines this rate is gravity. From this, it was established that the behavior of this index is modified depending on how close the lung lobe of interest is to the lung base. However, there is compelling evidence to consider that the behavior of this variable is not governed solely by these laws and that within the lung volume there are random regions with ideal values to carry out gas exchange effectively and these do not obey the previously established trends. A real threedimensional model of the lung airway architecture was obtained from CT-scans and a computational flow dynamics study was performed through these meshed geometries with the objective of determining an in-silico approximation to the real volumetric air flow values in the different lung regions or determined lung lobes, which have a direct repercussion on the index of interest. These values are meant to be parameters inputs to be used in a previously proposed mathematical model whose result illustrates this V / Q index zoning for ideal gas exchange.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021-12-13
dc.date.accessioned.none.fl_str_mv 2022-07-22T17:37:28Z
dc.date.available.none.fl_str_mv 2022-07-22T17:37:28Z
dc.type.es_CO.fl_str_mv Trabajo de grado - Maestría
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
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dc.identifier.instname.es_CO.fl_str_mv instname:Universidad de los Andes
dc.identifier.reponame.es_CO.fl_str_mv reponame:Repositorio Institucional Séneca
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url http://hdl.handle.net/1992/59038
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dc.language.iso.es_CO.fl_str_mv eng
language eng
dc.rights.license.spa.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.format.extent.es_CO.fl_str_mv 11 páginas
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dc.publisher.es_CO.fl_str_mv Universidad de los Andes
dc.publisher.program.es_CO.fl_str_mv Maestría en Ingeniería Biomédica
dc.publisher.faculty.es_CO.fl_str_mv Facultad de Ingeniería
dc.publisher.department.es_CO.fl_str_mv Departamento de Ingeniería Biomédica
institution Universidad de los Andes
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However, there is compelling evidence to consider that the behavior of this variable is not governed solely by these laws and that within the lung volume there are random regions with ideal values to carry out gas exchange effectively and these do not obey the previously established trends. A real threedimensional model of the lung airway architecture was obtained from CT-scans and a computational flow dynamics study was performed through these meshed geometries with the objective of determining an in-silico approximation to the real volumetric air flow values in the different lung regions or determined lung lobes, which have a direct repercussion on the index of interest. These values are meant to be parameters inputs to be used in a previously proposed mathematical model whose result illustrates this V / Q index zoning for ideal gas exchange.Magíster en Ingeniería BiomédicaMaestría11 páginasapplication/pdfengUniversidad de los AndesMaestría en Ingeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería BiomédicaDevelopment of a methodology to determine ventilation parameters with CFD simulations in airway tree geometry obtained from CT scansTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttps://purl.org/redcol/resource_type/TMVentilationPerfusionGas exchangeMathematical modelLung architectureIngeniería201425701PublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81810https://repositorio.uniandes.edu.co/bitstreams/d9e30c81-0986-4074-ab04-81a46f0065aa/download5aa5c691a1ffe97abd12c2966efcb8d6MD51ORIGINALThesisEvaFrancoBurgos.pdfThesisEvaFrancoBurgos.pdfMain Textapplication/pdf8240489https://repositorio.uniandes.edu.co/bitstreams/86aa92a7-cfc1-4beb-a928-b7c3a9c9d25e/downloadc205d4d519e52cb8372c4b428a399fc3MD52Autorizacio¿nRepo.pdfAutorizacio¿nRepo.pdfHIDEapplication/pdf206465https://repositorio.uniandes.edu.co/bitstreams/70aaf21b-5df8-4b97-90ec-214b73fa6248/download4ada65db04af5a2a7bebc1cfc159ed5dMD53THUMBNAILThesisEvaFrancoBurgos.pdf.jpgThesisEvaFrancoBurgos.pdf.jpgIM Thumbnailimage/jpeg29038https://repositorio.uniandes.edu.co/bitstreams/cfc4e1ec-e5c7-4d89-95fe-d296e5cb0d90/download29b37dc994108dea52d2807264d1bb78MD55Autorizacio¿nRepo.pdf.jpgAutorizacio¿nRepo.pdf.jpgIM Thumbnailimage/jpeg16597https://repositorio.uniandes.edu.co/bitstreams/5c6bd7dc-0f19-4626-adff-33e029643377/downloada8353eb19a8899330fbf52feb16df001MD57TEXTThesisEvaFrancoBurgos.pdf.txtThesisEvaFrancoBurgos.pdf.txtExtracted texttext/plain37591https://repositorio.uniandes.edu.co/bitstreams/af02d685-3341-4d44-a143-d8b305462e0f/download177487565d8080e50c78b0ec360e5cb4MD54Autorizacio¿nRepo.pdf.txtAutorizacio¿nRepo.pdf.txtExtracted texttext/plain1163https://repositorio.uniandes.edu.co/bitstreams/7e26262f-e0e6-4b82-80fe-1690f6165178/download4491fe1afb58beaaef41a73cf7ff2e27MD561992/59038oai:repositorio.uniandes.edu.co:1992/590382023-10-10 19:34:47.819http://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.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