Análisis in silico de la interacción de variantes virales de la proteína NS3 de la familia Flaviviridae con antivirale

Hepatitis C virus, dengue virus, and Zika virus belong to the Flaviviridae family. Unlike HCV, these viruses are transmitted mostly by vectors, are distributed worldwide and are pathogens that cause various diseases. Additionally, they present a conserved genome that encodes a polyprotein that is then cleaved by cellular and viral proteases into structural and non-structural proteins. NS3 protease is a key target for antiviral treatment, since it is essential during the viral cycle. Therefore, antivirals that inhibit this protease have been evaluated for the treatment against viruses of the Flaviviridae family. However, polymorphisms could cause a decrease in the effectiveness of treatment and even prevent inhibition. Therefore, using bioinformatics tools, the interaction of simeprevir and narlaprevir with the NS3 protein with polymorphisms in Colombia was evaluated.

• Autores: Hernández Sánchez, Karla Vanessa
• Tipo de recurso: Trabajo de grado de pregrado
• Fecha de publicación: 2021
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: spa
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/51318
• Acceso en línea: http://hdl.handle.net/1992/51318
• Palabra clave: Flavivirus; Agentes antivirales; Enzimas proteolíticas; Microbiología
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/4.0/