Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water
In order to address water quality control difficulties in remote locations, an electrochemical sensor is designed, manufactured and characterized to detect acetaminophen on aqueous solutions. CAD (Shapr3D) and PCB (Altium Designer) software tools were used in the design of the sensing electrodes. Th...
- Autores:
-
Arias Castrillón, Juan Camilo
- Tipo de recurso:
- Trabajo de grado de pregrado
- Fecha de publicación:
- 2022
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/64154
- Acceso en línea:
- http://hdl.handle.net/1992/64154
- Palabra clave:
- Electrochemical sensor
Microfluidic systems
Cyclic voltammetry
Acetaminophen
Ingeniería
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| title |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| spellingShingle |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water Electrochemical sensor Microfluidic systems Cyclic voltammetry Acetaminophen Ingeniería |
| title_short |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| title_full |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| title_fullStr |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| title_full_unstemmed |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| title_sort |
Design and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in water |
| dc.creator.fl_str_mv |
Arias Castrillón, Juan Camilo |
| dc.contributor.advisor.none.fl_str_mv |
Rodríguez Toro, Víctor Osma Cruz, Johann Faccelo |
| dc.contributor.author.none.fl_str_mv |
Arias Castrillón, Juan Camilo |
| dc.contributor.jury.none.fl_str_mv |
Sotelo Briceño, Diana Camila |
| dc.contributor.researchgroup.es_CO.fl_str_mv |
Biomicrosystems |
| dc.subject.keyword.none.fl_str_mv |
Electrochemical sensor Microfluidic systems Cyclic voltammetry Acetaminophen |
| topic |
Electrochemical sensor Microfluidic systems Cyclic voltammetry Acetaminophen Ingeniería |
| dc.subject.themes.es_CO.fl_str_mv |
Ingeniería |
| description |
In order to address water quality control difficulties in remote locations, an electrochemical sensor is designed, manufactured and characterized to detect acetaminophen on aqueous solutions. CAD (Shapr3D) and PCB (Altium Designer) software tools were used in the design of the sensing electrodes. The characterization of the sensor was done by exposing the electrode to acetaminophen diluted in purified water and then measured the change in the output electrical signal through cyclic voltammetry. |
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2022 |
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2022-12-13 |
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2023-01-25T16:55:43Z |
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2023-01-25T16:55:43Z |
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Trabajo de grado - Pregrado |
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B. Marine Environment Protection Commission, "Productos farmacéuticos en el medio acuático de la región del mar Báltico: informe, principales recomendaciones y datos; 2017," 2017. Accessed: Jun. 26, 2022. [Online]. Available: https://unesdoc.unesco.org/ark:/48223/pf0000260743_spa W. J. L et al., "Pharmaceutical pollution of the world's rivers," Proceedings of the National Academy of Sciences, vol. 119, no. 8, p. e2113947119, Feb. 2022, doi: 10.1073/pnas.2113947119. O. Gutiérrez Álvarez, W. F. Montaña Chaparro, and F. R. Nates Solano, "Análisis de las Prescripciones de Tecnologías en Salud no financiadas con recursos de la UPC realizadas a través del Módulo General de la herramienta tecnológica MIPRES durante 2020," Bogotá D.C, Feb. 2021. Accessed: Jul. 04, 2022. [Online]. Available: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VP/RBC/informe-mipres-2020.pdf L. L. Mazaleuskaya, K. Sangkuhl, C. F. Thorn, G. A. Fitzgerald, R. B. Altman, and T. E. Klein, "PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses," Pharmacogenet Genomics, vol. 25, no. 8, pp. 416-426, Jul. 2015, doi: 10.1097/FPC.0000000000000150. E. Choi, D. Alsop, and J. Y. Wilson, "The effects of chronic acetaminophen exposure on the kidney, gill and liver in rainbow trout (Oncorhynchus mykiss)," Aquatic Toxicology, vol. 198, pp. 20-29, May 2018, doi: 10.1016/J.AQUATOX.2018.02.007. W. E. Org et al., "ELECTROCHEMICAL SCIENCE Pharmaceutical Electrochemistry: the Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes," 2015. [Online]. Available: www.electrochemsci.org A. Chatterjee, "Different electrodes for paracetamol estimation using cyclic voltammetry technique: A review," Research Journal of Pharmacology and Pharmacodynamics, vol. 9, no. 2, pp. 88-92, 2017, doi: 10.5958/2321-5836.2017.00015.5. D. Nematollahi, H. Shayani-Jam, M. Alimoradi, and S. Niroomand, "Electrochemical oxidation of acetaminophen in aqueous solutions: Kinetic evaluation of hydrolysis, hydroxylation and dimerization processes," Electrochim Acta, vol. 54, no. 28, pp. 7407-7415, Dec. 2009, doi: 10.1016/j.electacta.2009.07.077. D. Ji et al., "Smartphone-based cyclic voltammetry system with graphene modified screen printed electrodes for glucose detection," Biosens Bioelectron, vol. 98, pp. 449-456, Dec. 2017, doi: 10.1016/j.bios.2017.07.027. J. Massah and K. Asefpour Vakilian, "An intelligent portable biosensor for fast and accurate nitrate determination using cyclic voltammetry," Biosyst Eng, vol. 177, pp. 49-58, Jan. 2019, doi: 10.1016/j.biosystemseng.2018.09.007. C. C. Segura Gómez, "A low-cost multi-technique portable electrochemical device for remote Biosensors," Universidad de los Andes, 2022. Accessed: Dec. 03, 2022. [Online]. Available: https://repositorio.uniandes.edu.co/handle/1992/59425 E. F. Peña Porras, "Diseño y construcción de un dispositivo funcional para el pegado de sistemas microfluídicos," Universidad de los Andes, 2020. A. J. Cardona Rojas, "Diseño Estándar de Sensor Electroquímico de Manera Conjunta para el Acople entre micro-reactores y Potenciostatos en Sistemas Micro- Fluídicos," Universidad de los Andes, 2022. [Online]. Available: http://hdl.handle.net/1992/55200 S. Chen et al., "Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA," Nanoscale Res Lett, vol. 14, no. 1, pp. 1-7, Feb. 2019, doi: 10.1186/S11671-019-2857-6/FIGURES/5. T. Thaweeskulchai and A. Schulte, "Sustainable and Efficient: A Reusable DIY Three-Electrode Base Plate for Microfluidic Electroanalysis and Biosensing," Anal Chem, vol. 93, no. 21, pp. 7557-7561, Jun. 2021, doi: 10.1021/ACS.ANALCHEM.1C00996/SUPPL_FILE/AC1C00996_SI_001.PDF. A. Mohammadzadeh, A. E. F. Robichaud, and P. R. Selvaganapathy, "Rapid and Inexpensive Method for Fabrication and Integration of Electrodes in Microfluidic Devices," Journal of Microelectromechanical Systems, vol. 28, no. 4, pp. 597-605, Aug. 2019, doi: 10.1109/JMEMS.2019.2914110. A. L. Campaña et al., "Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater," 2019, doi: 10.3390/bios9010041. |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Rodríguez Toro, Víctor5f0a70c1-cc0d-444d-8d56-6c8052e458e3600Osma Cruz, Johann Faccelovirtual::7915-1Arias Castrillón, Juan Camilo6aa32c74-0f13-477b-a5d3-dca30d99816d600Sotelo Briceño, Diana CamilaBiomicrosystems2023-01-25T16:55:43Z2023-01-25T16:55:43Z2022-12-13http://hdl.handle.net/1992/64154instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/In order to address water quality control difficulties in remote locations, an electrochemical sensor is designed, manufactured and characterized to detect acetaminophen on aqueous solutions. CAD (Shapr3D) and PCB (Altium Designer) software tools were used in the design of the sensing electrodes. The characterization of the sensor was done by exposing the electrode to acetaminophen diluted in purified water and then measured the change in the output electrical signal through cyclic voltammetry.Ingeniero ElectrónicoPregradoSensores electroquímicos para microfluídica15 páginasapplication/pdfengUniversidad de los AndesIngeniería ElectrónicaFacultad de IngenieríaDepartamento de Ingeniería Eléctrica y ElectrónicaDesign and implementation of an electrochemical sensor, based on a microfluidic system, to determine acetaminophen concentrations in waterTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPElectrochemical sensorMicrofluidic systemsCyclic voltammetryAcetaminophenIngenieríaB. Marine Environment Protection Commission, "Productos farmacéuticos en el medio acuático de la región del mar Báltico: informe, principales recomendaciones y datos; 2017," 2017. Accessed: Jun. 26, 2022. [Online]. Available: https://unesdoc.unesco.org/ark:/48223/pf0000260743_spaW. J. L et al., "Pharmaceutical pollution of the world's rivers," Proceedings of the National Academy of Sciences, vol. 119, no. 8, p. e2113947119, Feb. 2022, doi: 10.1073/pnas.2113947119.O. Gutiérrez Álvarez, W. F. Montaña Chaparro, and F. R. Nates Solano, "Análisis de las Prescripciones de Tecnologías en Salud no financiadas con recursos de la UPC realizadas a través del Módulo General de la herramienta tecnológica MIPRES durante 2020," Bogotá D.C, Feb. 2021. Accessed: Jul. 04, 2022. [Online]. Available: https://www.minsalud.gov.co/sites/rid/Lists/BibliotecaDigital/RIDE/VP/RBC/informe-mipres-2020.pdfL. L. Mazaleuskaya, K. Sangkuhl, C. F. Thorn, G. A. Fitzgerald, R. B. Altman, and T. E. Klein, "PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses," Pharmacogenet Genomics, vol. 25, no. 8, pp. 416-426, Jul. 2015, doi: 10.1097/FPC.0000000000000150.E. Choi, D. Alsop, and J. Y. Wilson, "The effects of chronic acetaminophen exposure on the kidney, gill and liver in rainbow trout (Oncorhynchus mykiss)," Aquatic Toxicology, vol. 198, pp. 20-29, May 2018, doi: 10.1016/J.AQUATOX.2018.02.007.W. E. Org et al., "ELECTROCHEMICAL SCIENCE Pharmaceutical Electrochemistry: the Electrochemical Oxidation of Paracetamol and Its Voltammetric Sensing in Biological Samples Based on Screen Printed Graphene Electrodes," 2015. [Online]. Available: www.electrochemsci.orgA. Chatterjee, "Different electrodes for paracetamol estimation using cyclic voltammetry technique: A review," Research Journal of Pharmacology and Pharmacodynamics, vol. 9, no. 2, pp. 88-92, 2017, doi: 10.5958/2321-5836.2017.00015.5.D. Nematollahi, H. Shayani-Jam, M. Alimoradi, and S. Niroomand, "Electrochemical oxidation of acetaminophen in aqueous solutions: Kinetic evaluation of hydrolysis, hydroxylation and dimerization processes," Electrochim Acta, vol. 54, no. 28, pp. 7407-7415, Dec. 2009, doi: 10.1016/j.electacta.2009.07.077.D. Ji et al., "Smartphone-based cyclic voltammetry system with graphene modified screen printed electrodes for glucose detection," Biosens Bioelectron, vol. 98, pp. 449-456, Dec. 2017, doi: 10.1016/j.bios.2017.07.027.J. Massah and K. Asefpour Vakilian, "An intelligent portable biosensor for fast and accurate nitrate determination using cyclic voltammetry," Biosyst Eng, vol. 177, pp. 49-58, Jan. 2019, doi: 10.1016/j.biosystemseng.2018.09.007.C. C. Segura Gómez, "A low-cost multi-technique portable electrochemical device for remote Biosensors," Universidad de los Andes, 2022. Accessed: Dec. 03, 2022. [Online]. Available: https://repositorio.uniandes.edu.co/handle/1992/59425E. F. Peña Porras, "Diseño y construcción de un dispositivo funcional para el pegado de sistemas microfluídicos," Universidad de los Andes, 2020.A. J. Cardona Rojas, "Diseño Estándar de Sensor Electroquímico de Manera Conjunta para el Acople entre micro-reactores y Potenciostatos en Sistemas Micro- Fluídicos," Universidad de los Andes, 2022. [Online]. Available: http://hdl.handle.net/1992/55200S. Chen et al., "Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA," Nanoscale Res Lett, vol. 14, no. 1, pp. 1-7, Feb. 2019, doi: 10.1186/S11671-019-2857-6/FIGURES/5.T. Thaweeskulchai and A. Schulte, "Sustainable and Efficient: A Reusable DIY Three-Electrode Base Plate for Microfluidic Electroanalysis and Biosensing," Anal Chem, vol. 93, no. 21, pp. 7557-7561, Jun. 2021, doi: 10.1021/ACS.ANALCHEM.1C00996/SUPPL_FILE/AC1C00996_SI_001.PDF.A. Mohammadzadeh, A. E. F. Robichaud, and P. R. Selvaganapathy, "Rapid and Inexpensive Method for Fabrication and Integration of Electrodes in Microfluidic Devices," Journal of Microelectromechanical Systems, vol. 28, no. 4, pp. 597-605, Aug. 2019, doi: 10.1109/JMEMS.2019.2914110.A. L. 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