A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation
In many neurodegenerative diseases, such as Dementia and Alzheimer's, the accumulation of amyloid plaques and tau proteins has shown to be correlated with the neurodegeneration of neurons. Based on some recent studies, in which was demonstrated a stimulation at 40 Hz might enhance gamma oscilla...
- Autores:
-
Reyes Torres, Julio Nicolás
- Tipo de recurso:
- Fecha de publicación:
- 2021
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/53420
- Acceso en línea:
- http://hdl.handle.net/1992/53420
- Palabra clave:
- Enfermedad de Alzheimer
Fotobiomodulación
Ingeniería
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/4.0/
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A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| title |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| spellingShingle |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation Enfermedad de Alzheimer Fotobiomodulación Ingeniería |
| title_short |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| title_full |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| title_fullStr |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| title_full_unstemmed |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| title_sort |
A non-invasive device for induction of cerebral rhythms based on near-infrared light stimulation |
| dc.creator.fl_str_mv |
Reyes Torres, Julio Nicolás |
| dc.contributor.advisor.none.fl_str_mv |
Le Van Quyen, Michel Valderrama Manrique, Mario Andrés |
| dc.contributor.author.none.fl_str_mv |
Reyes Torres, Julio Nicolás |
| dc.contributor.jury.none.fl_str_mv |
Gómez Martínez, Rodrigo Segura Quijano, Fredy Enrique |
| dc.subject.armarc.none.fl_str_mv |
Enfermedad de Alzheimer Fotobiomodulación |
| topic |
Enfermedad de Alzheimer Fotobiomodulación Ingeniería |
| dc.subject.themes.none.fl_str_mv |
Ingeniería |
| description |
In many neurodegenerative diseases, such as Dementia and Alzheimer's, the accumulation of amyloid plaques and tau proteins has shown to be correlated with the neurodegeneration of neurons. Based on some recent studies, in which was demonstrated a stimulation at 40 Hz might enhance gamma oscillations, activating a series of endogenous mechanism to "clean" the brain and get rid of those proteins related with neurodegenerative diseases, it was designed a noninvasive stimulation device, named NIRCo-Stimulator, it was developed with the goal of being efficient enough to modulate a cerebral activity in the Gamma band. This thesis document describes the theoretical foundations and electrical features to build the device with the proficiency to modulate cerebral rhythms in the gamma band at 40 Hz. EEG digital signal analysis implemented tools to check if there was evidence to demonstrate this device is able to stimulate cerebral rhythms. Results showed NIRCo-Stimulator seems to achieve modulating this brain activity. An optional but not mandatory requirement in this thesis was to check whether, could brain stimulation due to pulses in the NIR spectrum, enhance cognitive abilities in healthy subjects?. Though in this research, it was implemented a cognitive experiment, this is still fairly away to get an answer. |
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2021 |
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2021-11-03T16:21:51Z |
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2021-11-03T16:21:51Z |
| dc.date.issued.none.fl_str_mv |
2021 |
| dc.type.spa.fl_str_mv |
Trabajo de grado - Maestría |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Text |
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http://hdl.handle.net/1992/53420 |
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24379.pdf |
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reponame:Repositorio Institucional Séneca |
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repourl:https://repositorio.uniandes.edu.co/ |
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http://hdl.handle.net/1992/53420 |
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eng |
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eng |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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19 páginas |
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Universidad de los Andes |
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Maestría en Ingeniería Biomédica |
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Facultad de Ingeniería |
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Departamento de Ingeniería Biomédica |
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Al consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Le Van Quyen, Michelfea924f6-91bb-444f-af77-fec4be8484bc500Valderrama Manrique, Mario Andrésvirtual::11232-1Reyes Torres, Julio Nicolás2fdb339f-db1f-463f-8a59-0cec73103335500Gómez Martínez, RodrigoSegura Quijano, Fredy Enrique2021-11-03T16:21:51Z2021-11-03T16:21:51Z2021http://hdl.handle.net/1992/5342024379.pdfinstname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/In many neurodegenerative diseases, such as Dementia and Alzheimer's, the accumulation of amyloid plaques and tau proteins has shown to be correlated with the neurodegeneration of neurons. Based on some recent studies, in which was demonstrated a stimulation at 40 Hz might enhance gamma oscillations, activating a series of endogenous mechanism to "clean" the brain and get rid of those proteins related with neurodegenerative diseases, it was designed a noninvasive stimulation device, named NIRCo-Stimulator, it was developed with the goal of being efficient enough to modulate a cerebral activity in the Gamma band. This thesis document describes the theoretical foundations and electrical features to build the device with the proficiency to modulate cerebral rhythms in the gamma band at 40 Hz. EEG digital signal analysis implemented tools to check if there was evidence to demonstrate this device is able to stimulate cerebral rhythms. Results showed NIRCo-Stimulator seems to achieve modulating this brain activity. An optional but not mandatory requirement in this thesis was to check whether, could brain stimulation due to pulses in the NIR spectrum, enhance cognitive abilities in healthy subjects?. Though in this research, it was implemented a cognitive experiment, this is still fairly away to get an answer.En varias enfermedades neurodegenerativas como es el caso de la demencia y el Alzheimer, se ha demostrado que la acumulación de placas beta-amiloide y proteínas tau está correlacionada con la neurodegeneración de neuronas. Con base en algunos estudios recientes, en los que se demostró que una estimulación a 40 Hz podría potenciar las oscilaciones gamma, activando una serie de mecanismos endógenos para "limpiar" el cerebro y deshacerse de aquellas proteínas relacionadas con enfermedades neurodegenerativas, se diseñó un dispositivo de estimulación no invasiva llamado NIRCo-Stimulator, fue desarrollado con el objetivo de ser lo suficientemente eficiente como para modular una actividad cerebral en la banda Gamma. Este documento de tesis describe los fundamentos teóricos y las características eléctricas para construir el dispositivo con la habilidad de modular los ritmos cerebrales en la banda gamma a 40 Hz. El análisis de señales digitales de EEG implementó herramientas para verificar si había evidencia que demostrara que este dispositivo fuese capaz de estimular los ritmos cerebrales. Los resultados mostraron que NIRCo-Stimulator parece lograr modular esta actividad cerebral. Un requisito opcional pero no obligatorio en esta tesis fue comprobar si, ¿podría la estimulación cerebral debida a pulsos en el espectro NIR mejorar las capacidades cognitivas en sujetos sanos?. Aunque en esta investigación se implementó un experimento cognitivo, aún queda bastante lejos para obtener una respuesta.Magíster en Ingeniería BiomédicaMaestría19 páginasapplication/pdfengUniversidad de los AndesMaestría en Ingeniería BiomédicaFacultad de IngenieríaDepartamento de Ingeniería BiomédicaA non-invasive device for induction of cerebral rhythms based on near-infrared light stimulationTrabajo de grado - Maestríainfo:eu-repo/semantics/masterThesishttp://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/TMEnfermedad de AlzheimerFotobiomodulaciónIngeniería201318551Publication036bf7e3-a4e3-40cc-b3a3-fa2effe4b3aevirtual::11232-1036bf7e3-a4e3-40cc-b3a3-fa2effe4b3aevirtual::11232-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000344079virtual::11232-1TEXT24379.pdf.txt24379.pdf.txtExtracted texttext/plain60723https://repositorio.uniandes.edu.co/bitstreams/0eae02aa-475e-498b-8bc3-aae87d0e158e/download067b7b98890e58ecbea2b3bc17ba1951MD54THUMBNAIL24379.pdf.jpg24379.pdf.jpgIM Thumbnailimage/jpeg30307https://repositorio.uniandes.edu.co/bitstreams/ab37f3d3-4a4d-4921-8bd6-5bbf083ec8a8/download885651194373a9026dc55b9f9ef922a6MD55ORIGINAL24379.pdfapplication/pdf14882517https://repositorio.uniandes.edu.co/bitstreams/5d9fbced-c9d9-466b-b27b-746cb5a6d8d9/download14aea17c736c8f68f16a1a645820555fMD511992/53420oai:repositorio.uniandes.edu.co:1992/534202024-03-13 14:23:00.043http://creativecommons.org/licenses/by-nc-nd/4.0/open.accesshttps://repositorio.uniandes.edu.coRepositorio institucional Sénecaadminrepositorio@uniandes.edu.co |