Desarrollo de una metodología para la endotelización in-vitro de injertos cardiovasculares de diámetro pequeño hechos a base de submucosa intestinal porcina (SIS)

"The lack of success of small diameter vascular grafts (< 6mm) has driven biomedical engineers to develop multiple strategies for their improvement. One of the most promising proposals involves the formation of a healthy and uniform endothelial layer. The early formation of this tissue on the lumen of the graft, prevents thrombosis and excessive proliferation of smooth muscle cells which can lead to intimal hyperplasia... With this purpose in mind, it is necessary to study the adhesion of endothelial cells to the biomaterial not only in a static cell culture but also under dynamic conditions which can better simulate the cell?s physiological environment in vivo. This project develops a methodology to implant cells in cardiovascular grafts under perfusion conditions in vitro, through the design of a bioreactor and the standardization of a static cell culture protocol on SIS sheets and a dynamic culture protocol in SIS grafts." -- Tomado del Formato de Documento de Grado.

• Autores: Cuellar Entrena, Mónica
• Fecha de publicación: 2017
• Institución: Universidad de los Andes
• Repositorio: Séneca: repositorio Uniandes
• Idioma: spa
• OAI Identifier: oai:repositorio.uniandes.edu.co:1992/61744
• Acceso en línea: http://hdl.handle.net/1992/61744
• Palabra clave: Cerdos; Cirugia experimental; Ingeniería biomédica; Ingeniería de tejidos; Materiales biomédicos; Trasplantes de órganos, tejidos, etc.
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/