Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos
Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con...
- Autores:
-
Cárdenas Palacio, Carlos Andrés
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/74621
- Acceso en línea:
- https://hdl.handle.net/1992/74621
- Palabra clave:
- Enfermedad de Parkinson
Hipofonía
Desórdenes de la voz
FMRI
Disartria
Psicología
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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| dc.title.none.fl_str_mv |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| dc.title.alternative.none.fl_str_mv |
Feedback mechanisms sensitive to voice intensity in Parkinson’s disease. Neurophysiological correlates |
| title |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| spellingShingle |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria Psicología |
| title_short |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_full |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_fullStr |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_full_unstemmed |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_sort |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| dc.creator.fl_str_mv |
Cárdenas Palacio, Carlos Andrés |
| dc.contributor.advisor.none.fl_str_mv |
Cárdenas Parra, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Cárdenas Palacio, Carlos Andrés |
| dc.contributor.jury.none.fl_str_mv |
López Velásquez, Norman Darío Strange, Bryan Andrew Báez Buitrago, Sandra Jimena Monsalve Duarte, Guillermo Alfonso |
| dc.contributor.researchgroup.none.fl_str_mv |
Facultad de Ciencias Sociales::Neurociencia y Comportamiento |
| dc.subject.keyword.none.fl_str_mv |
Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria |
| topic |
Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria Psicología |
| dc.subject.themes.none.fl_str_mv |
Psicología |
| description |
Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con Enfermedad de Parkinson. Para tal fin, se ha realizado un análisis comparativo en las variables de intensidad de la voz, percepción del volumen del habla y conectividad funcional, en las redes neurales mencionadas, entre 13 pacientes con enfermedad de Parkinson y 15 controles sanos. De manera complementaria, se ha analizado una posible relación de la intensidad de la voz con las variables clínicas de nivel de severidad, tiempo de evolución, medicación y lado afectado en los pacientes evaluados. La intensidad de la voz ha sido valorada a través de la Consensus Auditory-Perceptual Evaluation of Voice; el nivel de percepción del volumen del habla se ha obtenido mediante un protocolo consistente en tres tareas: magnitud de la estimación, imitación y magnitud de la producción; la magnitud de conectividad funcional ha sido calculada a partir de un registro de resonancia magnética funcional en estado de reposo. Los resultados han permitido entender la hipofonía como un desorden de integración sensoriomotora. De manera complementaria, se han observado alteraciones adicionales de la voz relacionadas con la aspereza, el escape y la tensión. Con base en tales hallazgos se propone incluir elementos sensoriales auditivos y propioceptivos como parte de la evaluación y el tratamiento de las alteraciones de la voz y el habla secundarias a la enfermedad de Parkinson. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-22T13:06:21Z |
| dc.date.available.none.fl_str_mv |
2024-07-22T13:06:21Z |
| dc.date.issued.none.fl_str_mv |
2024-06-21 |
| dc.type.none.fl_str_mv |
Trabajo de grado - Doctorado |
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info:eu-repo/semantics/doctoralThesis |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_db06 |
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Text |
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https://purl.org/redcol/resource_type/TD |
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http://purl.org/coar/resource_type/c_db06 |
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acceptedVersion |
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https://hdl.handle.net/1992/74621 |
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10.57784/1992/74621 |
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instname:Universidad de los Andes |
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reponame:Repositorio Institucional Séneca |
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Abur, D., Lupiani, A. A., Hickox, A. E., Shinn-Cunningham, B. G., & Stepp, C. E. (2018). Loudness perception of pure tones in Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 61(6), 1487–1496. https://doi.org/10.1044/2018_JSLHR-H-17-0382 Abur, D., Subaciute, A., Daliri, A., Lester-Smith, R. A., Lupiani, A. A., Cilento, D., Enos, N. M., Weerathunge, H. R., Tardif, M. C., & Stepp, C. E. (2021). Feedback and feedforward auditory-motor processes for voice and articulation in parkinson’s disease. Journal of Speech, Language, and Hearing Research, 64(12), 4682-4694. https://doi.org/10.1044/2021_JSLHR-21-00153 Acosta, S. A., Tajiri, N., de la Pena, I., Bastawrous, M., Sanberg, P. R., Kaneko, Y., & Borlongan, C. V. (2015). Alpha-Synuclein as a pathological link between chronic traumatic brain injury and parkinson’s disease. Journal of Cellular Physiology, 230(5), 1024-1032. https://doi.org/10.1002/jcp.24830 Agüero, P., Tulli, J., Moscardi, G., González, E., & Uriz, A. (28 a 30 de septiembre de 2011). Estimating RASATI scores using acoustical parameters. Journal of Physics: Conference Series (JPCS), 332(012050), Mar del Plata, Argentina. Akünal Türel, C., & Arıcan, M. (2023). Deep brain stimulation in idiopathic Parkinson’s disease. Northwestern Medical Journal, 3(1) 56-61. https://doi.org/10.54307/nwmj.2023.96967 Andersson, J. L. R., Hutton, C., Ashburner, J., Turner, R., & Friston, K. (2001). Modeling geometric deformations in EPI time series. NeuroImage, 13(5), 903-919. https://doi.org/10.1006/nimg.2001.0746 Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and Treatment of Parkinson Disease: A Review. JAMA - Journal of the American Medical Association, 323(6), 548–560. https://doi.org/10.1001/jama.2019.22360 Arnold, C., Gehrig, J., Gispert, S., Seifried, C., & Kell, C. A. (2014). Pathomechanisms and compensatory efforts related to Parkinsonian speech. NeuroImage: Clinical, 4, 82–97. https://doi.org/10.1016/j.nicl.2013.10.016 Ashburner, J., & Friston, K. J. (2005). Unified segmentation. NeuroImage, 26(3), 839-851. https://doi.org/10.1016/j.neuroimage.2005.02.018 Aslan, S. N., & Karahalil, B. (2019). Oxidative stress and Parkinson disease. Ankara Universitesi Eczacilik Fakultesi Dergisi, 43(1), 94-116. https://doi.org/10.33483/jfpau.519964 Baumann, A., Nebel, A., Granert, O., Giehl, K., Wolff, S., Schmidt, W., Baasch, C., Schmidt, G., Witt, K., Deuschl, G., Hartwigsen, G., Zeuner, K. E., & van Eimeren, T. (2018). Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease. Neurorehabilitation and Neural Repair, 32(12), 1055–1066. https://doi.org/10.1177/1545968318812726 Bayram, E., Aslanbaba, E., & Akbostanci, M. C. (2019). Levodopa effect on spontaneous speech in Parkinson’s disease. Journal of Neurolinguistics, 51, 194–198. https://doi.org/10.1016/j.jneuroling.2019.03.001 Behroozmand, R., Phillip, L., Johari, K., Bonilha, L., Rorden, C., Hickok, G., & Fridriksson, J. (2018). Sensorimotor impairment of speech auditory feedback processing in aphasia. NeuroImage, 165, 102–111. https://doi.org/10.1016/j.neuroimage.2017.10.014 Behroozmand, R., Shebek, R., Hansen, D. R., Oya, H., Robin, D. A., Howard, M. A., & Greenlee, J. D. W. (2015). Sensory-motor networks involved in speech production and motor control: An fMRI study. NeuroImage, 109, 418–428. https://doi.org/10.1016/j.neuroimage.2015.01.040 Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007). A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. NeuroImage, 37(1), 90-101. https://doi.org/10.1016/j.neuroimage.2007.04.042 Bellomo, G., Paciotti, S., Gatticchi, L., & Parnetti, L. (2020). The vicious cycle between α-synuclein aggregation and autophagic-lysosomal dysfunction. In Movement Disorders, 35(1), 34-44. https://doi.org/10.1002/mds.27895 Bhidayasiri, R., Chaudhuri, K. R., LeWitt, P., Martin, A., Boonpang, K., & Van Laar, T. (2015). Effective delivery of apomorphine in the management of parkinson disease: Practical considerations for clinicians and parkinson nurses. Clinical Neuropharmacology, 38(3), 89-103. https://doi.org/10.1097/WNF.0000000000000082 Biundo R, Weis L, Bostantjopoulou S, Stefanova E, Falup-Pecurariu C, Kramberger MG, Geurtsen GJ, Antonini A, Weintraub D, Aarsland D. MMSE and MoCA in Parkinsons disease and dementia with Lewy bodies: a multicenter 1-year follow-up study (2016). Journal of Neural Transmission (Vienna), 123(4), 431-438. doi: 10.1007/s00702-016-1517-6. Boersma, P. (2002). Praat, a system for doing phonetics by computer. Glot International, 5(9/10), 341-347. Broadfoot, C. K., Abur, D., Hoffmeister, J. D., Stepp, C. E., & Ciucci, M. R. (2019). Research-Based Updates in Swallowing and Communication Dysfunction in Parkinson Disease: Implications for Evaluation and Management. Perspectives of the ASHA Special Interest Groups, 4(5), 825–841. https://doi.org/10.1044/2019_pers-sig3-2019-0001 Bronstein, J. M., Tagliati, M., Alterman, R. L., Lozano, A. M., Volkmann, J., Stefani, A., Horak, F. B., Okun, M. S., Foote, K. D., Krack, P., Pahwa, R., Henderson, J. M., Hariz, M. I., Bakay, R. A., Rezai, A., Marks, W. J., Moro, E., Vitek, J. L., Weaver, F. M., … DeLong, M. R. (2011). Deep brain stimulation for Parkinson disease an expert consensus and review of key issues. Archives of Neurology,68(2), 165. https://doi.org/10.1001/archneurol.2010.260 Brown, S., Laird, A. R., Pfordresher, P. Q., Thelen, S. M., Turkeltaub, P., & Liotti, M. (2009). The somatotopy of speech: Phonation and articulation in the human motor cortex. Brain and Cognition, 70(1), 31–41. https://doi.org/10.1016/j.bandc.2008.12.006 Calhoun, V. D., Wager, T. D., Krishnan, A., Rosch, K. S., Seymour, K. E., Nebel, M. B., Mostofsky, S. H., Nyalakanai, P., & Kiehl, K. (2017). The impact of T1 versus EPI spatial normalization templates for fMRI data analyses. Human Brain Mapping, 38(11), 5331-5342. https://doi.org/10.1002/hbm.23737 Carlson, N. R. (2017). Physiology of behavior. Pearson Education. Chai, X. J., Castañán, A. N., Öngür, D., & Whitfield-Gabrieli, S. (2012). Anticorrelations in resting state networks without global signal regression. NeuroImage, 59(2), 1420-1428. https://doi.org/10.1016/j.neuroimage.2011.08.048 Chaudhuri, K. R., Odin, P., Ferreira, J. J., Antonini, A., Rascol, O., Kurtis, M. M., Storch, A., Bannister, K., Soares-da-Silva, P., Costa, R., Magalhães, D., & Rocha, J. F. (2022). Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial. BMC Neurology, 22(1), 88. https://doi.org/10.1186/s12883-022-02602-8 Chen, H., O’Reilly, E., McCullough, M. L., Rodriguez, C., Schwarzschild, M. A., Calle, E. E., Thun, M. J., & Ascherio, A. (2007). Consumption of dairy products and risk of parkinson’s disease. American Journal of Epidemiology, 165(9), 998-1006. https://doi.org/10.1093/aje/kwk089 Chen, J., Guan, Z., Wang, L., Song, G., Ma, B., & Wang, Y. (2014). Meta-analysis: Overweight, obesity, and Parkinson’s disease. International Journal of Endocrinology,2014, 203930. https://doi.org/10.1155/2014/203930 Chen, J., Zhang, C., Wu, Y., & Zhang, D. (2019). Association between Hypertension and the Risk of Parkinson’s Disease: A Meta-Analysis of Analytical Studies. Neuroepidemiology, 52(3-4), 181-192. https://doi.org/10.1159/000496977 Clark, J. P., Adams, S. G., Dykstra, A. D., Moodie, S., & Jog, M. (2014). Loudness perception and speech intensity control in Parkinson’s disease. Journal of Communication Disorders, 51, 1–12. https://doi.org/10.1016/j.jcomdis.2014.08.001 Clarke CE, Patel S, Ives N, et al. (2016). Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB). Southampton (UK): NIHR Journals Library. (Health Technology Assessment, No. 20.63.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK379760/ doi: 10.3310/hta20630. Cófreces, P., Ofman, S. D., Estay, J. A., & Hermida, P. D. (2022). Enfermedad de Parkinson: una actualización bibliográfica de los aspectos psicosociales. Revista de La Facultad de Ciencias Médicas de Córdoba, 79(2), 181-187. https://doi.org/10.31053/1853.0605.v79.n2.33610 Conte, A., Khan, N., Defazio, G., Rothwell, J. C., & Berardelli, A. (2013). Pathophysiology of somatosensory abnormalities in Parkinson disease. Nature Reviews Neurology, 9(12), 687–697. https://doi.org/10.1038/nrneurol.2013.224 Dalrymple-Alford JC, MacAskill MR, Nakas CT, Livingston L, Graham C, Crucian GP, Melzer TR, Kirwan J, Keenan R, Wells S, Porter RJ, Watts R, Anderson TJ. (2010). The MoCA: well-suited screen for cognitive impairment in Parkinson disease. Neurology, 9, 75(19),1717-25. doi: 10.1212/WNL.0b013e3181fc29c9. Darainy, M., Vahdat, S., & Ostry, D. J. (2019). Neural Basis of Sensorimotor Plasticity in Speech Motor Adaptation. Cerebral Cortex, 29(7), 2876-2889. https://doi.org/10.1093/cercor/bhy153 Dashtipour, K., Tafreshi, A., Lee, J., & Crawley, B. (2018). Speech disorders in Parkinson’s disease: pathophysiology, medical management and surgical approaches. Neurodegenerative disease management 8(5), 337–348. https://doi.org/10.2217/nmt-2018-0021 Dauer, W., Przedborski, S., Schulz, J. B., & Falkenburger, B. H. (2003). Parkinson’s disease: mechanisms and models\rNeuronal pathology in Parkinson’s disease. Neuron, 39(6), 889–909. De Keyser, K., Santens, P., Bockstael, A., Botteldooren, D., Talsma, D., De Vos, S., Van Cauwenberghe, M., Verheugen, F., Corthals, P., & De Letter, M. (2016). The relationship between speech production and speech perception deficits in Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 59(5), 915–931. https://doi.org/10.1044/2016_JSLHR-S-15-0197 De Lau, L. M. L., Giesbergen, P. C. L. M., De Rijk, M. C., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2004). Incidence of parkinsonism and Parkinson disease in a general population: The Rotterdam Study. Neurology, 63(7), 1240-1244. https://doi.org/10.1212/01.WNL.0000140706.52798.BE Delic, V., Beck, K. D., Pang, K. C. H., & Citron, B. A. (2020). Biological links between traumatic brain injury and Parkinson’s disease. Acta Neuropathologica Communications, 8(1), 45. https://doi.org/10.1186/s40478-020-00924-7 Despotović I, Goossens B, Philips W. (2015). MRI segmentation of the human brain: challenges, methods, and applications. Computational and Mathematical Methods in Medicine, 450341. doi: 10.1155/2015/450341. Dromey, C., & Adams, S. (2000). Loudness perception and hypophonia in Parkinson disease. Journal of Medical Speech-Language Pathology, 8(4), 255–259. Dykstra, A. D., Adams, S. G., & Jog, M. (2012). Examining the conversational speech intelligibility of individuals with hypophonia associated with Parkinson’s disease. Journal of Medical Speech-Language Pathology, 20(4), 53. Elangovan, N., Tuite, P. J., & Konczak, J. (2018). Somatosensory Training Improves Proprioception and Untrained Motor Function in Parkinson’s Disease. Frontiers in Neurology, 9, 1053. https://doi.org/10.3389/fneur.2018.01053 Elfmarková, N., Gajdoš, M., Mračková, M., Mekyska, J., Mikl, M., & Rektorová, I. (2016). Impact of Parkinson’s disease and levodopa on resting state functional connectivity related to speech prosody control. Parkinsonism and Related Disorders, 22(Suppl 1), S52-5. https://doi.org/10.1016/j.parkreldis.2015.09.006 Erekat, N. S. (2022). Autophagy and Its Association with Genetic Mutations in Parkinson Disease. Medical Science Monitor, 28, e938519. https://doi.org/10.12659/MSM.938519 Espay, A. J., Pagan, F. L., Walter, B. L., Morgan, J. C., Elmer, L. W., Waters, C. H., Agarwal, P., Dhall, R., Ondo, W. G., Klos, K. J., & Silver, D. E. (2017). Optimizing extended-release carbidopa/levodopa in Parkinson disease. Neurology: Clinical Practice, 7(1), 86-93. https://doi.org/10.1212/CPJ.0000000000000316 Espay, A. J., Stocchi, F., Pahwa, R., Albanese, A., Ellenbogen, A., Ferreira, J. J., Giladi, N., Gurevich, T., Hassin-Baer, S., Hernandez-Vara, J., Isaacson, S. H., Kieburtz, K., LeWitt, P. A., Lopez-Manzanares, L., Olanow, C. W., Poewe, W., Sarva, H., Yardeni, T., Adar, L., … Zhukova, I. (2024). Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson’s disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial. The Lancet Neurology, 23(5), 465-476. https://doi.org/10.1016/S1474-4422(24)00052-8 Fabbri, M., Guimarães, I., Cardoso, R., Coelho, M., Guedes, L. C., Rosa, M. M., Godinho, C., Abreu, D., Gonçalves, N., Antonini, A., & Ferreira, J. J. (2017). Speech and voice response to a levodopa challenge in late-stage Parkinson’s disease. Frontiers in Neurology, 8, 432. https://doi.org/10.3389/fneur.2017.00432 Fahn, S., & Elton, R. L. (1987). UPDRS DEVELOPMENT COMMITTEE. Unified Parkinson’s Disease Rating Scale. Recent developments in Parkinson’s disease, 2, 153–163, 293–304. Fernández-Santiago, R., & Sharma, M. (2022). What have we learned from genome-wide association studies (GWAS) in Parkinson’s disease? Ageing Research Reviews,79, 101648. https://doi.org/10.1016/j.arr.2022.101648 Ferreira, J. J., Katzenschlager, R., Bloem, B. R., Bonuccelli, U., Burn, D., Deuschl, G., Dietrichs, E., Fabbrini, G., Friedman, A., Kanovsky, P., Kostic, V., Nieuwboer, A., Odin, P., Poewe, W., Rascol, O., Sampaio, C., Schüpbach, M., Tolosa, E., Trenkwalder, C., … Oertel, W. H. (2013). Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson’s disease. European Journal of Neurology, 20(1), 5-15. https://doi.org/10.1111/j.1468-1331.2012.03866.x Fox, C. M., Morrison, C. E., Ramig, L. O., & Sapir, S. (2002). Current perspectives on the Lee Silverman voice treatment (LSVT) for individuals with idiopathic Parkinson disease. American Journal of Speech-Language Pathology, 11(2), 111-123. https://doi.org/10.1044/1058-0360(2002/012) Friston, K. J., Ashburner, J., Frith, C. D., Poline, J. ‐B, Heather, J. D., & Frackowiak, R. S. J. (1995). Spatial registration and normalization of images. Human Brain Mapping, 3(3) 165-189. https://doi.org/10.1002/hbm.460030303 Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3) 346-355. https://doi.org/10.1002/mrm.1910350312 Gan-Or, Z., Dion, P. A., & Rouleau, G. A. (2015). Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease. Autophagy,11(9) 1443-1457. https://doi.org/10.1080/15548627.2015.1067364 Goetz, C. G., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stebbins, G. T., Stern, M. B., Tilley, B. C., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., … LaPelle, N. (2007). Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 22(1), 41–47. https://doi.org/10.1002/mds.21198 Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., … Zweig, R. M. (2008). Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129–2170. https://doi.org/10.1002/mds.22340 Gong, S., Xu, M., Tao, Y., Jin, H., Liu, Y., Sun, X., Wang, S., Yang, X., Wang, Y., Yuan, L., & Song, W. (2020). Comparison of Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation Surgery on Parkinson Disease–Related Pain. World Neurosurgery, 135, e94-e99. https://doi.org/10.1016/j.wneu.2019.11.026 Haas, B. M., Trew, M., & Castle, P. C. (2004). Effects of respiratory muscle weakness on daily living function, quality of life, activity levels, and exercise capacity in mild to moderate Parkinson’s disease. American Journal of Physical Medicine and Rehabilitation, 83(8), 601-607. https://doi.org/10.1097/01.PHM.0000133436.61009.02 Hallquist, M. N., Hwang, K., & Luna, B. (2013). The nuisance of nuisance regression: Spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity. NeuroImage, 82, 208-225. https://doi.org/10.1016/j.neuroimage.2013.05.116 Hariz, M., Lees, A. J., Blomstedt, Y., & Blomstedt, P. (2022). Serendipity and Observations in Functional Neurosurgery: From James Parkinson’s Stroke to Hamani’s & Lozano’s Flashbacks. Stereotactic and Functional Neurosurgery,100(4), 201-209. https://doi.org/10.1159/000525794 Hayes, M. T. (2019). Parkinson’s Disease and Parkinsonism. American Journal of Medicine, 132(7), 802–807. https://doi.org/10.1016/j.amjmed.2019.03.001 Henchcliffe, C., & Beal, F. M. (2008). Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice Neurology,4(11), 600-609. https://doi.org/10.1038/ncpneuro0924 Hickok, G. (2014). The architecture of speech production and the role of the phoneme in speech processing. Language, Cognition and Neuroscience, 29(1), 2–20. https://doi.org/10.1080/01690965.2013.834370 Hirano, M. (1981). Psycho-acoustic evaluation of voice: GRBAS scale for evaluating the hoarse voice. Clinical examination of voice. Hlavnika, J., Cmejla, R., Tykalová, T., Šonka, K., Ruzicka, E., & Rusz, J. (2017). Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder. Scientific Reports, 7(1), 12. https://doi.org/10.1038/s41598-017-00047-5 Ho, A. K., Bradshaw, J. L., & Iansek, R. (2000). Volume perception in Parkinsonian speech. Movement Disorders, 15(6), 1125–1131. https://doi.org/10.1002/1531-8257(200011)15:6<1125::AID-MDS1010>3.0.CO;2-R Ho, A. K., Bradshaw, J. L., & Iansek, R. (2008). For better or worse: The effect of Levodopa on speech in Parkinson’s disease. Movement Disorders, 23(4), 574–580. https://doi.org/10.1002/mds.21899 Ho, A. K., Bradshaw, J. L., Iansek, R., & Alfredson, R. (1999). Speech volume regulation in Parkinson’s disease: Effects of implicit cues and explicit instructions. Neuropsychologia, 37(13), 1453-1460. https://doi.org/10.1016/S0028-3932(99)00067-6 Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: Onset, progression, and mortality. Neurology, 17(5), 427-442. https://doi.org/10.1212/wnl.17.5.427 Hong, C. T., Chan, L., & Bai, C. H. (2020). The effect of caffeine on the risk and progression of Parkinson’s disease: A meta-analysis. Nutrients, 12(6), 1860. https://doi.org/10.3390/nu12061860 Houde, J. F., & Nagarajan, S. S. (2011). Speech production as state feedback control. Frontiers in Human Neuroscience, 5(82), 1-14. https://doi.org/10.3389/fnhum.2011.00082 Huang, X., Chen, X., Yan, N., Jones, J. A., Wang, E. Q., Chen, L., Guo, Z., Li, W., Liu, P., & Liu, H. (2016). The impact of Parkinson’s disease on the cortical mechanisms that support auditory–motor integration for voice control. Human Brain Mapping, 37(12), 4248–4261. https://doi.org/10.1002/hbm.23306 Hubsher, G., Haider, M., & Okun, M. S. (2012). Amantadine: The journey from fighting flu to treating Parkinson disease. Neurology, 78(14), 1096-1099. https://doi.org/10.1212/WNL.0b013e31824e8f0d Im, H., Adams, S., Abeysekera, A., Pieterman, M., Gilmore, G., & Jog, M. (2019). Effect of Levodopa on Speech Dysfluency in Parkinson’s Disease. Movement Disorders Clinical Practice, 6(2), 150–154. https://doi.org/10.1002/mdc3.12714 Jenkinson, C., Fitzpatrick, R., Peto, V., Greenhall, R., & Hyman, N. (1997). The Parkinson’s disease questionnaire (PDQ-39): Development and validation of a Parkinson’s disease summary index score. Age and Ageing, 26(5), 353-357. https://doi.org/10.1093/ageing/26.5.353 Karine, R., Luc, N. J., & Nadine, V. (2010). The effect of levodopa on speech in Parkinson’s disease: Musical’ scale study. Proceedings of the International Conference on Speech Prosody, 1-4. https://doi.org/10.21437/speechprosody.2010-244 Kaut, O., Schmitt, I., Stahl, F., Fröhlich, H., Hoffmann, P., Gonzalez, F. J., & Wüllner, U. (2022). Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex. Life, 12(4), 502. https://doi.org/10.3390/life12040502 Kempster, G. B., Gerratt, B. R., Abbott, K. V., Barkmeier-Kraemer, J., & Hillman, R. E. (2009). Consensus auditory-perceptual evaluation of voice: Development of a standardized clinical protocol. American Journal of Speech-Language Pathology, 18(2), 124–132. https://doi.org/10.1044/1058-0360(2008/08-0017) Keus, S. H. J., Munneke, M., Nijkrake, M. J., Kwakkel, G., & Bloem, B. R. (2009). Physical therapy in Parkinson’s disease: Evolution and future challenges. Movement Disorders, 24(1), 1-14. https://doi.org/10.1002/mds.22141 Kim, J. J., Vitale, D., Veliz-Otani, D., Lian, M., Heilbron, K., Team, the 23andMe R., Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E.-K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Blauwendraat, C., Nalls, M. A., Foo, J. N., & Mata, I. (2024). Multi-ancestry genome-wide meta-analysis in Parkinson’s disease. Nature Genetics, 56(1), 27-36. Kim, K. S., Gaines, J. L., Parrell, B., Ramanarayanan, V., Nagarajan, S. S., & Houde, J. F. (2023). Mechanisms of sensorimotor adaptation in a hierarchical state feedback control model of speech. PLoS Computational Biology, 19(7), e1011244. https://doi.org/10.1371/journal.pcbi.1011244 Knight, E. J., Testini, P., Min, H. K., Gibson, W. S., Gorny, K. R., Favazza, C. P., Felmlee, J. P., Kim, I., Welker, K. M., Clayton, D. A., Klassen, B. T., Chang, S. Y., & Lee, K. H. (2015). Motor and nonmotor circuitry activation induced by subthalamic nucleus deep brain stimulation in patients with Parkinson disease: Intraoperative functional magnetic resonance imaging for deep brain stimulation. Mayo Clinic Proceedings, 90(6), 773-785. https://doi.org/10.1016/j.mayocp.2015.03.022 Kobayashi, S., Maki, T., & Kunimoto, M. (2011). Clinical symptoms of bilateral anterior cerebral artery territory infarction. Journal of Clinical Neuroscience, 18(2), 218-222. https://doi.org/10.1016/j.jocn.2010.05.013 Kolb, B., & Whishaw, I. (2014). An Introduction to Brain and Behavior (4th ed.). Worth Publishers. Konczak, J., Corcos, D. M., Horak, F., Poizner, H., Shapiro, M., Tuite, P., Volkmann, J., & Maschke, M. (2009). Proprioception and Motor Control in Parkinson’s Disease. Journal of Motor Behavior, 41(6), 543–552. https://doi.org/10.3200/35-09-002 Kreiman, J., & Gerratt, B. R. (2000). Sources of listener disagreement in voice quality assessment. The Journal of the Acoustical Society of America, 108(4), 1867-1876. https://doi.org/10.1121/1.1289362 Lechien, J. R., Delsaut, B., Abderrakib, A., Huet, K., Delvaux, V., Piccaluga, M., Khalife, M., Harmegnies, B., Saussez, S., & Blecic, S. (2020). Orofacial Strength and Voice Quality as Outcome of Levodopa Challenge Test in Parkinson Disease. Laryngoscope, 130(12), E896-E903. https://doi.org/10.1002/lary.28645 Lees, A. J., Hardy, J., & Revesz, T. (2009). Parkinson’s disease. The Lancet, 373(9680), 2055–2066. https://doi.org/10.1016/S0140-6736(09)60492-X Li, S. H., Chen, H. B., Wang, Z. F., Tang, R. H., Zhang, X. Y., Yang, J. S., Zhao, W. Q., Sun, X. R., & Ma, J. (2013). Efficacy and safety of ropinirole in the treatment of Parkinson disease: a multi-center, randomized, double-blind and bromocriptine-controlled trial. National Medical Journal of China, 93(25), 1952-1957. https://doi.org/10.3760/cma.j.issn.0376-2491.2013.25.005 Lieberman, A. N., & Goldstein, M. (1985). Bromocriptine in Parkinson disease. Pharmacological Reviews, 37(2), 217-227. https://doi.org/10.1212/wnl.29.3.363 Lin, M. T., Cantuti-Castelvetri, I., Zheng, K., Jackson, K. E., Tan, Y. B., Arzberger, T., Lees, A. J., Betensky, R. A., Beal, M. F., & Simon, D. K. (2012). Somatic mitochondrial DNA mutations in early Parkinson and incidental lewy body disease. Annals of Neurology, 71(6), 850-854. https://doi.org/10.1002/ana.23568 Lombard, E. (1911). Le signe de l’élévation de la voix (translated from French). Annales Des Maladies de l’oreille et Du Larynx, 37(2), 101-119. Lukos, J. R., Snider, J., Hernandez, M. E., Tunik, E., Hillyard, S., & Poizner, H. (2013). Parkinson’s disease patients show impaired corrective grasp control and eye-hand coupling when reaching to grasp virtual objects. Neuroscience, 254, 205-221. https://doi.org/10.1016/j.neuroscience.2013.09.026 Manes, J. L., Kurani, A. S., Herschel, E., Roberts, A. C., Tjaden, K., Parrish, T., & Corcos, D. M. (2023). Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson’s disease and hypophonia. Frontiers in Human Neuroscience, 17, 1250114. https://doi.org/10.3389/fnhum.2023.1250114 Manes, J. L., Parkinson, A. L., Larson, C. R., Greenlee, J. D., Eickhoff, S. B., Corcos, D. M., & Robin, D. A. (2014). Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta-analytic connectivity study. Human Brain Mapping, 35(7), 3499–3516. https://doi.org/10.1002/hbm.22417 Manes, J. L., Tjaden, K., Parrish, T., Simuni, T., Roberts, A., Greenlee, J. D., Corcos, D. M., & Kurani, A. S. (2018). Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson’s disease. Brain and Behavior, 8(9), e01073. https://doi.org/10.1002/brb3.1073 Margolesky, J., & Singer, C. (2018). Extended-release oral capsule of carbidopa-levodopa in parkinson disease. Therapeutic Advances in Neurological Disorders, 11, 1756285617737728. https://doi.org/10.1177/1756285617737728 Marín-M, D. S., Carmona-V, H., Ibarra-Q, M., & Gámez-C, M. (2022). Enfermedad de Parkinson: fisiopatología, diagnóstico y tratamiento. Revista de la Universidad Industrial de Santander Salud, 50(1), 79-92. Marín-Medina, D. S., Quintero-Moreno, J. F., Valencia-Vásquez, A., Duque-Salazar, C., Gil-Restrepo, A. F., Castaño-Montoya, J. P., García-Rodríguez, D., & Carmona-Villada, H. (2018). Deep brain stimulation in parkinson disease. Iatreia, 31(3), 262–273. https://doi.org/10.17533/udea.iatreia.v31n3a04 Martínez-Fernández, R., Gasca-Salas, C., Sánchez-Ferro, Á., & Obeso, J. Á. (2016). Actualización en la enfermedad de Parkinson. Revista Médica Clínica Las Condes, 27(3), 363–379. Martínez-Fernández, R., Máñez-Miró, J. U., Rodríguez-Rojas, R., del Álamo, M., Shah, B. B., Hernández-Fernández, F., Pineda-Pardo, J. A., Monje, M. H. G., Fernández-Rodríguez, B., Sperling, S. A., Mata-Marín, D., Guida, P., Alonso-Frech, F., Obeso, I., Gasca-Salas, C., Vela-Desojo, L., Elias, W. J., & Obeso, J. A. (2020). Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease. New England Journal of Medicine, 383(26), 2501-2513. https://doi.org/10.1056/nejmoa2016311 Mata-Marín, D., Pineda-Pardo, J. A., Molina, J. A., Vela, L., Alonso-Frech, F., & Obeso, I. (2021). Aberrant Salient and Corticolimbic Connectivity in Hypersexual Parkinson’s Disease. Brain Connectivity, 11(8), 639-650. https://doi.org/10.1089/brain.2020.0868 McDonnell, M. N., Rischbieth, B., Schammer, T. T., Seaforth, C., Shaw, A. J., & Phillips, A. C. (2018). Lee Silverman Voice Treatment (LSVT)-BIG to improve motor function in people with Parkinson’s disease: a systematic review and meta-analysis. Clinical Rehabilitation, 32(5), 607-618. https://doi.org/10.1177/0269215517734385 Meléndez Flores, J. D., Castillo Torres, S. A., Cerda Contreras, C., Chávez Luévanos, B. E., & Estrada Bellmann, I. (2021). Características clínicas del síndrome metabólico en pacientes con enfermedad de Parkinson. Revista de Neurología, 72(1), 9-15. https://doi.org/10.33588/rn.7201.2020323 Miller, N., Noble, E., Jones, D., & Burn, D. (2006). Life with communication changes in Parkinson’s disease. Age and Ageing, 35(3), 235–239. https://doi.org/10.1093/ageing/afj053 Morato-Galán, M. (2014). Análisis perceptual de la disfonía: adaptación y validación del método CAPE-V al español. Universidad de Oviedo. Moreau, C., & Pinto, S. (2019). Misconceptions about speech impairment in Parkinson’s disease. Movement Disorders, 34(10), 1471–1475. https://doi.org/10.1002/mds.27791 Nagaratnam, N., Nagaratnam, K., Ng, K., & Diu, P. (2004). Akinetic mutism following stroke. Journal of Clinical Neuroscience, 11(1), 25-30. https://doi.org/10.1016/j.jocn.2003.04.002 Nagle, K. F. (2022). Clinical Use of the CAPE-V Scales: Agreement, Reliability and Notes on Voice Quality. Journal of Voice, S08921997(22), 00366-6. https://doi.org/10.1016/j.jvoice.2022.11.014 Nakamura, M., Hamamoto, M., Uchida, S., Nagayama, H., Amemiya, S., Okubo, S., & Tanaka, K. (2003). A case of micrographia after subcortical infarction: Possible involvement of frontal lobe function. European Journal of Neurology, 10(5), 593-596. https://doi.org/10.1046/j.1468-1331.2003.00641.x Narea-Veas, M. S., Farías, P. G., & Vázquez Fernández, P. (2023). Consensus Auditory Perceptual Evaluation of Voice (CAPE-V): Systematic Review of Methods Used for Adaptation and Validation. Revista de Investigacion e Innovacion en Ciencias de la Salud, 5(2), 178-204. https://doi.org/10.46634/riics.206 Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x New, A. B., Robin, D. A., Parkinson, A. L., Eickhoff, C. R., Reetz, K., Hoffstaedter, F., Mathys, C., Sudmeyer, M., Grefkes, C., Larson, C. R., Ramig, L. O., Fox, P. T., & Eickhoff, S. B. (2015). The intrinsic resting state voice network in Parkinson’s disease. Human Brain Mapping, 36(5), 1951–1962. https://doi.org/10.1002/hbm.22748 Nieto-Castanon, A. (2020). Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN. Hilbert-Press. https://doi.org/10.56441/hilbertpress.2207.6598 Niziolek, C. A., & Guenther, F. H. (2013). Vowel category boundaries enhance cortical and behavioral responses to speech feedback alterations. Journal of Neuroscience, 33(29), 12090–12098. https://doi.org/10.1523/JNEUROSCI.1008-13.2013 Núñez-Batalla, F., Morato-Galán, M., García-López, I., & Ávila-Menéndez, A. (2015). Adaptación fonética y validación del método de valoración perceptual de la voz CAPE-V al español. Acta Otorrinolaringologica Espanola, 66(5), 249–257. https://doi.org/10.1016/j.otorri.2014.07.007 Obeso, J. A., Marin, C., Rodriguez-Oroz, C., Blesa, J., Benitez-Temiño, B., Mena-Segovia, J., Rodríguez, M., & Olanow, C. W. (2008). The basal ganglia in Parkinson’s disease: Current concepts and unexplained observations. Annals of Neurology, 64(2), S30-46. https://doi.org/10.1002/ana.21481 Obeso, J. A., Rodríguez-Oroz, M. C., Benitez-Temino, B., Blesa, F. J., Guridi, J., Marin, C., & Rodriguez, M. (2008). Functional organization of the basal ganglia: Therapeutic implications for Parkinson’s disease. Movement Disorders, 23(Suppl. 3), S548-559. https://doi.org/10.1002/mds.22062 Ohtomo, R., Iwata, A., & Tsuji, S. (2014). Unilateral opercular infarction presenting with foix-chavany-marie syndrome. Journal of Stroke and Cerebrovascular Diseases, 23(1), 179-181. https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.08.015 Paccosi, E., & Proietti-De-Santis, L. (2023). Parkinson’s Disease: From Genetics and Epigenetics to Treatment, a miRNA-Based Strategy. International Journal of Molecular Sciences,24(11), 9547. https://doi.org/10.3390/ijms24119547 Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., & Logroscino, G. (2019). Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life. Therapeutic Advances in Chronic Disease, 10, 1–17. https://doi.org/10.1177/2040622318811000 Pedraza, O. L., Salazar, A. M., Sierra, F. A., Soler, D., Castro, J., Castillo, P. C., Hernandez, M. A., & Piñeros, C. (2017). Confiabilidad, validez de criterio y discriminante del Montreal Cognitive Assessment (MoCA) test, en un grupo de Adultos de Bogotá. Acta Médica Colombiana, 41(4), 221–228. https://doi.org/10.36104/amc.2016.693 Phokaewvarangkul, O., Boonpang, K., & Bhidayasiri, R. (2019). Subthalamic deep brain stimulation aggravates speech problems in Parkinson’s disease: Objective and subjective analysis of the influence of stimulation frequency and electrode contact location. Parkinsonism and Related Disorders, 66(April), 110–116. https://doi.org/10.1016/j.parkreldis.2019.07.020 Pihlstrøm, L., Shireby, G., Geut, H., Henriksen, S. P., Rozemuller, A. J. M., Tunold, J. A., Hannon, E., Francis, P., Thomas, A. J., Love, S., Mill, J., van de Berg, W. D. J., & Toft, M. (2022). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Nature Communications, 13(1), 4932. https://doi.org/10.1038/s41467-022-32619-z Pinel, J. P. J., & Barnes, S. (2021). Biopsychology (10th Edition). Pearson Education. Pinho, S. R., & Pontes, P. (2002). Escala de evaluación perceptiva de la fuente glótica: RASAT. Vox Brasilis, 8(3), 1-4. Pinto, S., Ozsancak, C., Tripoliti, E., Thobois, S., Limousin-Dowsey, P., & Auzou, P. (2004). Treatments for dysarthria in Parkinson’s disease. Lancet Neurology, 3(9), 547–556. https://doi.org/10.1016/S1474-4422(04)00854-3 Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A. E., & Lang, A. E. (2017). Parkinson disease. Nature Reviews Disease Primers, 3, 17013. Portet, F., Ousset, P. J., Visser, P. J., Frisoni, G. B., Nobili, F., Scheltens, P., Vellas, B., & Touchon, J. (2006). Mild cognitive impairment (MCI) in medical practice: A critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. Journal of Neurology, Neurosurgery and Psychiatry, 77(6), 714-718. https://doi.org/10.1136/jnnp.2005.085332 Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G. (2015). MDS clinical diagnostic criteria for Parkinsons disease. Movement Disorders, 30(12), 1591-601. doi: 10.1002/mds.26424. PMID: 26474316. Power, J. D., Mitra, A., Laumann, T. O., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2014). Methods to detect, characterize, and remove motion artifact in resting state fMRI. NeuroImage, 84, 320–341. https://doi.org/10.1016/j.neuroimage.2013.08.048 Railo, H., Nokelainen, N., Savolainen, S., & Kaasinen, V. (2020). Deficits in monitoring self-produced speech in Parkinson’s disease. Clinical Neurophysiology, 131(9), 2140–2147. https://doi.org/10.1016/j.clinph.2020.05.038 Ramig, L., Fox, C., & Sapir, S. (2008). Speech treatment for Parkinson’s disease. Expert Review of Neurotherapeutics, 8(2), 299–311. https://doi.org/10.1586/14737175.8.2.297 Ray Dorsey, E., Elbaz, A., Nichols, E., Abd-Allah, F., Abdelalim, A., Adsuar, J. C., Ansha, M. G., Brayne, C., Choi, J. Y. J., Collado-Mateo, D., Dahodwala, N., Do, H. P., Edessa, D., Endres, M., Fereshtehnejad, S. M., Foreman, K. J., Gankpe, F. G., Gupta, R., Hankey, G. J., … Murray, C. J. L. (2018). Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939-953. https://doi.org/10.1016/S1474-4422(18)30295-3 Ray, M., Dening, T., & Crosbie, B. (2019). Dementia and hearing loss: A narrative review. Maturitas, 128, 64–69. https://doi.org/10.1016/j.maturitas.2019.08.001 Rektorova, I., Barrett, J., Mikl, M., Rektor, I., & Paus, T. (2007). Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson’s disease. Movement Disorders, 22(14), 2043–2051. https://doi.org/10.1002/mds.21548 Rektorova, I., Mikl, M., Barrett, J., Marecek, R., Rektor, I., & Paus, T. (2012). Functional neuroanatomy of vocalization in patients with Parkinson’s disease. Journal of the Neurological Sciences, 313(1–2), 7–12. https://doi.org/10.1016/j.jns.2011.10.020 Rhonda, J. H., Oates, J. M., Debbie, J. P., & Andrew, J. H. (2000). Voice characteristics in the progression of Parkinson’s disease. International Journal of Language and Communication Disorders, 35(3), 407-418. https://doi.org/10.1080/136828200410654 Ricci-Maccarini, A., Schindler, A., Mozzanica, F., Fantini, M., Murry, T., & Dejonckere, P. (2022, en prensa). Validity, Reliability and Reproducibility of the “Extended GRBAS Scale,” A Comprehensive Perceptual Evaluation of Dysphonia. Journal of Voice. https://doi.org/10.1016/j.jvoice.2022.09.008 Riederer, P., & Müller, T. (2018). Monoamine oxidase-B inhibitors in the treatment of Parkinson’s disease: clinical–pharmacological aspects. Journal of Neural Transmission, 125(11), 1751-1757. https://doi.org/10.1007/s00702-018-1876-2 Rizek, P., Kumar, N., & Jog, M. S. (2016). An update on the diagnosis and treatment of Parkinson disease. CMAJ, 188(16), 1157-1165. https://doi.org/10.1503/cmaj.151179 Rodríguez-López, C., Ayuso García, B., & Moreno García, S. (2018). Hypophonia as a sign of thalamus lesion: a case report. International Journal of Neuroscience, 128(1), 100–101. https://doi.org/10.1080/00207454.2017.1358716 Rodriguez-Sabate, C., Morales, I., Lorenzo, J. N., & Rodriguez, M. (2019). The organization of the basal ganglia functional connectivity network is non-linear in Parkinson’s disease. NeuroImage: Clinical, 22, 101708. https://doi.org/10.1016/j.nicl.2019.101708 Rosqvist, K., Horne, M., Hagell, P., Iwarsson, S., Nilsson, M. H., & Odin, P. (2018). Levodopa effect and motor function in late stage Parkinson’s disease. Journal of Parkinson’s Disease, 8(1), 59–70. https://doi.org/10.3233/JPD-171181 Rughani, A., Schwalb, J. M., Sidiropoulos, C., Pilitsis, J., Ramirez-Zamora, A., Sweet, J. A., Mittal, S., Espay, A. J., Martinez, J. G., Abosch, A., Eskandar, E., Gross, R., Alterman, R., & Hamani, C. (2018). Congress of neurological surgeons systematic review and evidence-based guideline on subthalamic nucleus and globus pallidus internus deep brain stimulation for the treatment of patients with Parkinson’s disease: Executive summary. Neurosurgery, 82(6), 753-756. https://doi.org/10.1093/neuros/nyy037 Sadagopan, N., & Huber, J. E. (2007). Effects of loudness cues on respiration in individuals with Parkinson’s disease. Movement Disorders, 22(5), 651-659. https://doi.org/10.1002/mds.21375 Sapir, S., Ramig, L. O., & Fox, C. M. (2011). Intensive voice treatment in Parkinson’s disease: Lee Silverman Voice Treatment. Expert Review of Neurotherapeutics, 11(6), 815-830. https://doi.org/10.1586/ern.11.43 Scarpa, A., Cassandro, C., Vitale, C., Ralli, M., Policastro, A., Barone, P., Cassandro, E., & Pellecchia, M. T. (2020). A comparison of auditory and vestibular dysfunction in Parkinson’s disease and Multiple System Atrophy. Parkinsonism and Related Disorders, 71, 51–57. https://doi.org/10.1016/j.parkreldis.2020.01.018 Schneider, J. S., Diamond, S. G., & Markham, C. H. (1986). Deficits in orofacial sensorimotor function in Parkinson’s disease. Annals of Neurology, 19(3), 275-282. https://doi.org/10.1002/ana.410190309 Scott, R., Gregory, R., Hines, N., Carroll, C., Hyman, N., Papanasstasiou, V., Leather, C., Rowe, J., Silburn, P., & Aziz, T. (1998). Neuropsychological, neurological and functional outcome following pallidotomy for Parkinson’s disease. A consecutive series of eight simultaneous bilateral and twelve unilateral procedures. Brain, 121(4), 659-675. https://doi.org/10.1093/brain/121.4.659 Senthinathan, A., Adams, S., Page, A. D., & Jog, M. (2021). Speech intensity response to altered intensity feedback in individuals with Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 64(6s), 2261-2275. https://doi.org/10.1044/2021_JSLHR-20-00278 Simon, D. K., Tanner, C. M., & Brundin, P. (2020). Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in Geriatric Medicine, 36(1), 1–12. https://doi.org/10.1016/j.cger.2019.08.002 Smith, K. M., & Caplan, D. N. (2018). Communication impairment in Parkinson’s disease: Impact of motor and cognitive symptoms on speech and language. Brain and Language, 185(July), 38–46. https://doi.org/10.1016/j.bandl.2018.08.002 Smith, L. J., Lee, C. Y., Menozzi, E., & Schapira, A. H. V. (2022). Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease. Frontiers in Neurology, 13, 971252. https://doi.org/10.3389/fneur.2022.971252 Solomon, N. P., & Hixon, T. J. (1993). Speech breathing in Parkinson’s disease. Journal of Speech and Hearing Research, 36(2) 294-310. https://doi.org/10.1044/jshr.3602.294 Sonkaya, Z. Z., Ceylan, M., & Sonkaya, A. R. (2021). Speech characteristics of parkinson disease. Medical Science and Discovery, 8(12), 666-670. https://doi.org/10.36472/msd.v8i12.645 Stathopoulos, E. T., Huber, J. E., Richardson, K., Kamphaus, J., DeCicco, D., Darling, M., Fulcher, K., & Sussman, J. E. (2014). Increased vocal intensity due to the Lombard effect in speakers with Parkinson’s disease: Simultaneous laryngeal and respiratory strategies. Journal of Communication Disorders, 48(1), 1–17. https://doi.org/10.1016/j.jcomdis.2013.12.001 Stathopoulos, E. T., & Sapienza, C. M. (1997). Developmental changes in laryngeal and respiratory function with variations in sound pressure level. Journal of Speech, Language, and Hearing Research, 40(3), 595-614. https://doi.org/10.1044/jslhr.4003.595 Strickland, D. (2012). Rural environment and Parkinson’s disease. En R. F. Pfeiffer, Z. K. Wszolek & M. Ebadi (Eds.) Parkinson’s Disease (2nd Edition) (pp. 63–71). CRC Press. https://doi.org/10.1201/b12948 Suárez Torres, M., Cano Villagrasa, A., & Valles González, B. (2020). Diagnósticos Fonoaudiológicos y Síntomas no Motores en Pacientes con Enfermedad de Parkinson. Areté, 20(2), 63-71. https://doi.org/10.33881/1657-2513.art20207 Thacker, E. L., O’Reilly, E. J., Weisskopf, M. G., Chen, H., Schwarzschild, M. A., McCullough, M. L., Calle, E. E., Thun, M. J., & Ascherio, A. (2007). Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology, 68(10), 764-768. https://doi.org/10.1212/01.wnl.0000256374.50227.4b Tiwari, P. C., & Pal, R. (2017). The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in Clinical Neuroscience, 19(1), 71-80. https://doi.org/10.31887/dcns.2017.19.1/rpal Tsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease. NPJ Parkinson’s Disease, 9(1), 123. https://doi.org/10.1038/s41531-023-00568-z Tursunov, D. (2020). L-Dopa induced dyskinesia. Parkinsonism & Related Disorders, 79, e94. https://doi.org/10.1016/j.parkreldis.2020.06.342 Ulla, M., Bonny, J. M., Ouchchane, L., Rieu, I., Claise, B., & Durif, F. (2013). Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up. PLoS ONE, 8(3), e57904. https://doi.org/10.1371/journal.pone.0057904 Ullah, I., Zhao, L., Hai, Y., Fahim, M., Alwayli, D., Wang, X., & Li, H. (2021). “Metal elements and pesticides as risk factors for Parkinson’s disease - A review.” Toxicology Reports, 8, 607-616. https://doi.org/10.1016/j.toxrep.2021.03.009 Van Den Eeden, S. K., Tanner, C. M., Bernstein, A. L., Fross, R. D., Leimpeter, A., Bloch, D. A., & Nelson, L. M. (2003). Incidence of Parkinson’s disease: Variation by age, gender, and race/ethnicity. American Journal of Epidemiology, 157(11) 1015-1022. https://doi.org/10.1093/aje/kwg068 Vara, A. C., Medeiros, R., & Striebel, V. L. W. (2012). Physical therapy in parkinson’s disease. Revista Neurociencias, 20(2), 266–272. https://doi.org/10.34024/rnc.2012.v20.8281 Venezia, J. H., Fillmore, P., Matchin, W., Lisette Isenberg, A., Hickok, G., & Fridriksson, J. (2016). Perception drives production across sensory modalities: A network for sensorimotor integration of visual speech. NeuroImage, 126, 196–207. https://doi.org/10.1016/j.neuroimage.2015.11.038 Vitale, C., Marcelli, V., Abate, T., Pianese, A., Allocca, R., Moccia, M., Spina, E., Barone, P., Santangelo, G., & Cavaliere, M. (2016). Speech discrimination is impaired in parkinsonian patients: Expanding the audiologic findings of Parkinson’s disease. Parkinsonism and Related Disorders, 22(Suppl 1), S138–S143. https://doi.org/10.1016/j.parkreldis.2015.09.040 Walker, G. M., & Hickok, G. (2016). Bridging computational approaches to speech production: The semantic–lexical–auditory–motor model (SLAM). Psychonomic Bulletin and Review, 23(2), 339–352. https://doi.org/10.3758/s13423-015-0903-7 Walshe, M., & Miller, N. (2011). Living with acquired dysarthria: The speaker’s perspective. Disability and Rehabilitation, 33(3), 195–203. https://doi.org/10.3109/09638288.2010.511685 Yang, W., Liu, B., Huang, B., Huang, R., Wang, L., Zhang, Y., Zhang, X., & Wu, K. (2016). Altered resting-state functional connectivity of the striatum in Parkinson’s disease after levodopa administration. PLoS ONE, 11(9), e0161935. https://doi.org/10.1371/journal.pone.0161935 Yin, H. H. (2017). The Basal Ganglia in Action. Neuroscientist, 23(3), 299-313. https://doi.org/10.1177/1073858416654115 Yu, Q. W., Ye, T. F., & Qian, W. J. (2021). Rare coexistence of multiple manifestations secondary to thalamic hemorrhage: A case report. World Journal of Clinical Cases, 9(18), 4817-4822. https://doi.org/10.12998/wjcc.v9.i18.4817 Yuan, F., Guo, X., Wei, X., Xie, F., Zheng, J., Huang, Y., Huang, Z., Chang, Z., Li, H., Guo, Y., Chen, J., Guo, J., Tang, B., Deng, B., & Wang, Q. (2020). Lee Silverman Voice Treatment for dysarthria in patients with Parkinson’s disease: a systematic review and meta-analysis. European Journal of Neurology, 27(10), 1957-1970. https://doi.org/10.1111/ene.14399 Zarzur, A. P., Duprat, A. C., Shinzato, G., & Eckley, C. A. (2007). Laryngeal electromyography in adults with Parkinson’s disease and voice complaints. Laryngoscope, 117(5), 831-834. https://doi.org/10.1097/MLG.0b013e3180333145 Zegleń, M., Sladowska, K., Kawalec, P., & Brzostek, T. (2022). Opicapone as an add-on to levodopa for reducing end-of-dose motor fluctuations in Parkinson’s disease: a systematic review and meta-analysis. Journal of Comparative Effectiveness Research, 11(12), 889-904. https://doi.org/10.2217/cer-2022-0031 Zeighami, Y., Ulla, M., Iturria-Medina, Y., Dadar, M., Zhang, Y., Larcher, K. M. H., Fonov, V., Evans, A. C., Collins, D. L., & Dagher, A. (2015). Network structure of brain atrophy in de novo Parkinson’s disease. ELife, 4, e08440. https://doi.org/10.7554/eLife.08440 Zhang, K., Paul, K. C., Jacobs, J. P., Chou, H. C. (Lori), Duarte Folle, A., Del Rosario, I., Yu, Y., Bronstein, J. M., Keener, A. M., & Ritz, B. (2022). Parkinson’s Disease and the Gut Microbiome in Rural California. Journal of Parkinson’s Disease, 12(8), 2441-2452. https://doi.org/10.3233/JPD-223500 |
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Cárdenas Parra, Luis Fernandovirtual::19096-1Cárdenas Palacio, Carlos AndrésLópez Velásquez, Norman DaríoStrange, Bryan AndrewBáez Buitrago, Sandra Jimenavirtual::19098-1Monsalve Duarte, Guillermo Alfonsovirtual::19099-1Facultad de Ciencias Sociales::Neurociencia y Comportamiento2024-07-22T13:06:21Z2024-07-22T13:06:21Z2024-06-21https://hdl.handle.net/1992/7462110.57784/1992/74621instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con Enfermedad de Parkinson. Para tal fin, se ha realizado un análisis comparativo en las variables de intensidad de la voz, percepción del volumen del habla y conectividad funcional, en las redes neurales mencionadas, entre 13 pacientes con enfermedad de Parkinson y 15 controles sanos. De manera complementaria, se ha analizado una posible relación de la intensidad de la voz con las variables clínicas de nivel de severidad, tiempo de evolución, medicación y lado afectado en los pacientes evaluados. La intensidad de la voz ha sido valorada a través de la Consensus Auditory-Perceptual Evaluation of Voice; el nivel de percepción del volumen del habla se ha obtenido mediante un protocolo consistente en tres tareas: magnitud de la estimación, imitación y magnitud de la producción; la magnitud de conectividad funcional ha sido calculada a partir de un registro de resonancia magnética funcional en estado de reposo. Los resultados han permitido entender la hipofonía como un desorden de integración sensoriomotora. De manera complementaria, se han observado alteraciones adicionales de la voz relacionadas con la aspereza, el escape y la tensión. Con base en tales hallazgos se propone incluir elementos sensoriales auditivos y propioceptivos como parte de la evaluación y el tratamiento de las alteraciones de la voz y el habla secundarias a la enfermedad de Parkinson.This study aimed to determine whether there are changes in the perception of speech volume and in functional connectivity in the neural networks (the motor circuit of the basal ganglia and the speech motor control network through feedback) associated with hypophonia in patients with Parkinson’s Disease. For this purpose, a comparative analysis has been carried out on the variables of voice intensity, perception of speech volume and functional connectivity between 13 patients and 15 healthy controls. In a complementary manner, a possible relationship between voice intensity and the clinical variables of level of severity, time of evolution, medication and affected side in the patients evaluated has been analyzed. The intensity of the voice has been assessed through the Consensus Auditory-Perceptual Evaluation of Voice; the level of perception of speech volume has been obtained through a protocol consisting of three tasks: magnitude of estimation, imitation and magnitude of production; the magnitude of functional connectivity has been calculated from a resting state fMRI recording. The results have allowed us to understand hypophonia as a sensorimotor integration disorder. Additional voice disturbances related to harshness, leakiness, and tension have been observed. Based on such findings, it is proposed to include auditory and proprioceptive sensory elements as part of the evaluation and treatment of voice and speech alterations secondary to Parkinson’s disease.Universidad de La Sabana.Doctorado163 páginasapplication/pdfspaUniversidad de los AndesDoctorado en PsicologíaFacultad de Ciencias SocialesDepartamento de PsicologíaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicosFeedback mechanisms sensitive to voice intensity in Parkinson’s disease. Neurophysiological correlatesTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttps://purl.org/redcol/resource_type/TDEnfermedad de ParkinsonHipofoníaDesórdenes de la vozFMRIDisartriaPsicologíaAbur, D., Lupiani, A. A., Hickox, A. E., Shinn-Cunningham, B. G., & Stepp, C. E. (2018). Loudness perception of pure tones in Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 61(6), 1487–1496. https://doi.org/10.1044/2018_JSLHR-H-17-0382Abur, D., Subaciute, A., Daliri, A., Lester-Smith, R. A., Lupiani, A. A., Cilento, D., Enos, N. M., Weerathunge, H. R., Tardif, M. C., & Stepp, C. E. (2021). Feedback and feedforward auditory-motor processes for voice and articulation in parkinson’s disease. Journal of Speech, Language, and Hearing Research, 64(12), 4682-4694. https://doi.org/10.1044/2021_JSLHR-21-00153Acosta, S. A., Tajiri, N., de la Pena, I., Bastawrous, M., Sanberg, P. R., Kaneko, Y., & Borlongan, C. V. (2015). Alpha-Synuclein as a pathological link between chronic traumatic brain injury and parkinson’s disease. Journal of Cellular Physiology, 230(5), 1024-1032. https://doi.org/10.1002/jcp.24830Agüero, P., Tulli, J., Moscardi, G., González, E., & Uriz, A. (28 a 30 de septiembre de 2011). Estimating RASATI scores using acoustical parameters. Journal of Physics: Conference Series (JPCS), 332(012050), Mar del Plata, Argentina.Akünal Türel, C., & Arıcan, M. (2023). Deep brain stimulation in idiopathic Parkinson’s disease. Northwestern Medical Journal, 3(1) 56-61. https://doi.org/10.54307/nwmj.2023.96967Andersson, J. L. R., Hutton, C., Ashburner, J., Turner, R., & Friston, K. (2001). Modeling geometric deformations in EPI time series. NeuroImage, 13(5), 903-919. https://doi.org/10.1006/nimg.2001.0746Armstrong, M. J., & Okun, M. S. (2020). Diagnosis and Treatment of Parkinson Disease: A Review. JAMA - Journal of the American Medical Association, 323(6), 548–560. https://doi.org/10.1001/jama.2019.22360Arnold, C., Gehrig, J., Gispert, S., Seifried, C., & Kell, C. A. (2014). Pathomechanisms and compensatory efforts related to Parkinsonian speech. NeuroImage: Clinical, 4, 82–97. https://doi.org/10.1016/j.nicl.2013.10.016Ashburner, J., & Friston, K. J. (2005). Unified segmentation. NeuroImage, 26(3), 839-851. https://doi.org/10.1016/j.neuroimage.2005.02.018Aslan, S. N., & Karahalil, B. (2019). Oxidative stress and Parkinson disease. Ankara Universitesi Eczacilik Fakultesi Dergisi, 43(1), 94-116. https://doi.org/10.33483/jfpau.519964Baumann, A., Nebel, A., Granert, O., Giehl, K., Wolff, S., Schmidt, W., Baasch, C., Schmidt, G., Witt, K., Deuschl, G., Hartwigsen, G., Zeuner, K. E., & van Eimeren, T. (2018). Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease. Neurorehabilitation and Neural Repair, 32(12), 1055–1066. https://doi.org/10.1177/1545968318812726Bayram, E., Aslanbaba, E., & Akbostanci, M. C. (2019). Levodopa effect on spontaneous speech in Parkinson’s disease. Journal of Neurolinguistics, 51, 194–198. https://doi.org/10.1016/j.jneuroling.2019.03.001Behroozmand, R., Phillip, L., Johari, K., Bonilha, L., Rorden, C., Hickok, G., & Fridriksson, J. (2018). Sensorimotor impairment of speech auditory feedback processing in aphasia. NeuroImage, 165, 102–111. https://doi.org/10.1016/j.neuroimage.2017.10.014Behroozmand, R., Shebek, R., Hansen, D. R., Oya, H., Robin, D. A., Howard, M. A., & Greenlee, J. D. W. (2015). Sensory-motor networks involved in speech production and motor control: An fMRI study. NeuroImage, 109, 418–428. https://doi.org/10.1016/j.neuroimage.2015.01.040Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007). A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. NeuroImage, 37(1), 90-101. https://doi.org/10.1016/j.neuroimage.2007.04.042Bellomo, G., Paciotti, S., Gatticchi, L., & Parnetti, L. (2020). The vicious cycle between α-synuclein aggregation and autophagic-lysosomal dysfunction. In Movement Disorders, 35(1), 34-44. https://doi.org/10.1002/mds.27895Bhidayasiri, R., Chaudhuri, K. R., LeWitt, P., Martin, A., Boonpang, K., & Van Laar, T. (2015). Effective delivery of apomorphine in the management of parkinson disease: Practical considerations for clinicians and parkinson nurses. Clinical Neuropharmacology, 38(3), 89-103. https://doi.org/10.1097/WNF.0000000000000082Biundo R, Weis L, Bostantjopoulou S, Stefanova E, Falup-Pecurariu C, Kramberger MG, Geurtsen GJ, Antonini A, Weintraub D, Aarsland D. MMSE and MoCA in Parkinsons disease and dementia with Lewy bodies: a multicenter 1-year follow-up study (2016). Journal of Neural Transmission (Vienna), 123(4), 431-438. doi: 10.1007/s00702-016-1517-6.Boersma, P. (2002). Praat, a system for doing phonetics by computer. Glot International, 5(9/10), 341-347.Broadfoot, C. K., Abur, D., Hoffmeister, J. D., Stepp, C. E., & Ciucci, M. R. (2019). Research-Based Updates in Swallowing and Communication Dysfunction in Parkinson Disease: Implications for Evaluation and Management. Perspectives of the ASHA Special Interest Groups, 4(5), 825–841. https://doi.org/10.1044/2019_pers-sig3-2019-0001Bronstein, J. M., Tagliati, M., Alterman, R. L., Lozano, A. M., Volkmann, J., Stefani, A., Horak, F. B., Okun, M. S., Foote, K. D., Krack, P., Pahwa, R., Henderson, J. M., Hariz, M. I., Bakay, R. A., Rezai, A., Marks, W. J., Moro, E., Vitek, J. L., Weaver, F. M., … DeLong, M. R. (2011). Deep brain stimulation for Parkinson disease an expert consensus and review of key issues. Archives of Neurology,68(2), 165. https://doi.org/10.1001/archneurol.2010.260Brown, S., Laird, A. R., Pfordresher, P. Q., Thelen, S. M., Turkeltaub, P., & Liotti, M. (2009). The somatotopy of speech: Phonation and articulation in the human motor cortex. Brain and Cognition, 70(1), 31–41. https://doi.org/10.1016/j.bandc.2008.12.006Calhoun, V. D., Wager, T. D., Krishnan, A., Rosch, K. S., Seymour, K. E., Nebel, M. B., Mostofsky, S. H., Nyalakanai, P., & Kiehl, K. (2017). The impact of T1 versus EPI spatial normalization templates for fMRI data analyses. Human Brain Mapping, 38(11), 5331-5342. https://doi.org/10.1002/hbm.23737Carlson, N. R. (2017). Physiology of behavior. Pearson Education.Chai, X. J., Castañán, A. N., Öngür, D., & Whitfield-Gabrieli, S. (2012). Anticorrelations in resting state networks without global signal regression. NeuroImage, 59(2), 1420-1428. https://doi.org/10.1016/j.neuroimage.2011.08.048Chaudhuri, K. R., Odin, P., Ferreira, J. J., Antonini, A., Rascol, O., Kurtis, M. M., Storch, A., Bannister, K., Soares-da-Silva, P., Costa, R., Magalhães, D., & Rocha, J. F. (2022). Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial. BMC Neurology, 22(1), 88. https://doi.org/10.1186/s12883-022-02602-8Chen, H., O’Reilly, E., McCullough, M. L., Rodriguez, C., Schwarzschild, M. A., Calle, E. E., Thun, M. J., & Ascherio, A. (2007). Consumption of dairy products and risk of parkinson’s disease. American Journal of Epidemiology, 165(9), 998-1006. https://doi.org/10.1093/aje/kwk089Chen, J., Guan, Z., Wang, L., Song, G., Ma, B., & Wang, Y. (2014). Meta-analysis: Overweight, obesity, and Parkinson’s disease. International Journal of Endocrinology,2014, 203930. https://doi.org/10.1155/2014/203930Chen, J., Zhang, C., Wu, Y., & Zhang, D. (2019). Association between Hypertension and the Risk of Parkinson’s Disease: A Meta-Analysis of Analytical Studies. Neuroepidemiology, 52(3-4), 181-192. https://doi.org/10.1159/000496977Clark, J. P., Adams, S. G., Dykstra, A. D., Moodie, S., & Jog, M. (2014). Loudness perception and speech intensity control in Parkinson’s disease. Journal of Communication Disorders, 51, 1–12. https://doi.org/10.1016/j.jcomdis.2014.08.001Clarke CE, Patel S, Ives N, et al. (2016). Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB). Southampton (UK): NIHR Journals Library. (Health Technology Assessment, No. 20.63.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK379760/ doi: 10.3310/hta20630.Cófreces, P., Ofman, S. D., Estay, J. A., & Hermida, P. D. (2022). Enfermedad de Parkinson: una actualización bibliográfica de los aspectos psicosociales. Revista de La Facultad de Ciencias Médicas de Córdoba, 79(2), 181-187. https://doi.org/10.31053/1853.0605.v79.n2.33610Conte, A., Khan, N., Defazio, G., Rothwell, J. C., & Berardelli, A. (2013). Pathophysiology of somatosensory abnormalities in Parkinson disease. Nature Reviews Neurology, 9(12), 687–697. https://doi.org/10.1038/nrneurol.2013.224Dalrymple-Alford JC, MacAskill MR, Nakas CT, Livingston L, Graham C, Crucian GP, Melzer TR, Kirwan J, Keenan R, Wells S, Porter RJ, Watts R, Anderson TJ. (2010). The MoCA: well-suited screen for cognitive impairment in Parkinson disease. Neurology, 9, 75(19),1717-25. doi: 10.1212/WNL.0b013e3181fc29c9.Darainy, M., Vahdat, S., & Ostry, D. J. (2019). Neural Basis of Sensorimotor Plasticity in Speech Motor Adaptation. Cerebral Cortex, 29(7), 2876-2889. https://doi.org/10.1093/cercor/bhy153Dashtipour, K., Tafreshi, A., Lee, J., & Crawley, B. (2018). Speech disorders in Parkinson’s disease: pathophysiology, medical management and surgical approaches. Neurodegenerative disease management 8(5), 337–348. https://doi.org/10.2217/nmt-2018-0021Dauer, W., Przedborski, S., Schulz, J. B., & Falkenburger, B. H. (2003). Parkinson’s disease: mechanisms and models\rNeuronal pathology in Parkinson’s disease. Neuron, 39(6), 889–909.De Keyser, K., Santens, P., Bockstael, A., Botteldooren, D., Talsma, D., De Vos, S., Van Cauwenberghe, M., Verheugen, F., Corthals, P., & De Letter, M. (2016). The relationship between speech production and speech perception deficits in Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 59(5), 915–931. https://doi.org/10.1044/2016_JSLHR-S-15-0197De Lau, L. M. L., Giesbergen, P. C. L. M., De Rijk, M. C., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2004). Incidence of parkinsonism and Parkinson disease in a general population: The Rotterdam Study. Neurology, 63(7), 1240-1244. https://doi.org/10.1212/01.WNL.0000140706.52798.BEDelic, V., Beck, K. D., Pang, K. C. H., & Citron, B. A. (2020). Biological links between traumatic brain injury and Parkinson’s disease. Acta Neuropathologica Communications, 8(1), 45. https://doi.org/10.1186/s40478-020-00924-7Despotović I, Goossens B, Philips W. (2015). MRI segmentation of the human brain: challenges, methods, and applications. Computational and Mathematical Methods in Medicine, 450341. doi: 10.1155/2015/450341.Dromey, C., & Adams, S. (2000). Loudness perception and hypophonia in Parkinson disease. Journal of Medical Speech-Language Pathology, 8(4), 255–259.Dykstra, A. D., Adams, S. G., & Jog, M. (2012). Examining the conversational speech intelligibility of individuals with hypophonia associated with Parkinson’s disease. Journal of Medical Speech-Language Pathology, 20(4), 53.Elangovan, N., Tuite, P. J., & Konczak, J. (2018). Somatosensory Training Improves Proprioception and Untrained Motor Function in Parkinson’s Disease. Frontiers in Neurology, 9, 1053. https://doi.org/10.3389/fneur.2018.01053Elfmarková, N., Gajdoš, M., Mračková, M., Mekyska, J., Mikl, M., & Rektorová, I. (2016). Impact of Parkinson’s disease and levodopa on resting state functional connectivity related to speech prosody control. Parkinsonism and Related Disorders, 22(Suppl 1), S52-5. https://doi.org/10.1016/j.parkreldis.2015.09.006Erekat, N. S. (2022). Autophagy and Its Association with Genetic Mutations in Parkinson Disease. Medical Science Monitor, 28, e938519. https://doi.org/10.12659/MSM.938519Espay, A. J., Pagan, F. L., Walter, B. L., Morgan, J. C., Elmer, L. W., Waters, C. H., Agarwal, P., Dhall, R., Ondo, W. G., Klos, K. J., & Silver, D. E. (2017). Optimizing extended-release carbidopa/levodopa in Parkinson disease. Neurology: Clinical Practice, 7(1), 86-93. https://doi.org/10.1212/CPJ.0000000000000316Espay, A. J., Stocchi, F., Pahwa, R., Albanese, A., Ellenbogen, A., Ferreira, J. J., Giladi, N., Gurevich, T., Hassin-Baer, S., Hernandez-Vara, J., Isaacson, S. H., Kieburtz, K., LeWitt, P. A., Lopez-Manzanares, L., Olanow, C. W., Poewe, W., Sarva, H., Yardeni, T., Adar, L., … Zhukova, I. (2024). Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson’s disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial. The Lancet Neurology, 23(5), 465-476. https://doi.org/10.1016/S1474-4422(24)00052-8Fabbri, M., Guimarães, I., Cardoso, R., Coelho, M., Guedes, L. C., Rosa, M. M., Godinho, C., Abreu, D., Gonçalves, N., Antonini, A., & Ferreira, J. J. (2017). Speech and voice response to a levodopa challenge in late-stage Parkinson’s disease. Frontiers in Neurology, 8, 432. https://doi.org/10.3389/fneur.2017.00432Fahn, S., & Elton, R. L. (1987). UPDRS DEVELOPMENT COMMITTEE. Unified Parkinson’s Disease Rating Scale. Recent developments in Parkinson’s disease, 2, 153–163, 293–304.Fernández-Santiago, R., & Sharma, M. (2022). What have we learned from genome-wide association studies (GWAS) in Parkinson’s disease? Ageing Research Reviews,79, 101648. https://doi.org/10.1016/j.arr.2022.101648Ferreira, J. J., Katzenschlager, R., Bloem, B. R., Bonuccelli, U., Burn, D., Deuschl, G., Dietrichs, E., Fabbrini, G., Friedman, A., Kanovsky, P., Kostic, V., Nieuwboer, A., Odin, P., Poewe, W., Rascol, O., Sampaio, C., Schüpbach, M., Tolosa, E., Trenkwalder, C., … Oertel, W. H. (2013). Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson’s disease. European Journal of Neurology, 20(1), 5-15. https://doi.org/10.1111/j.1468-1331.2012.03866.xFox, C. M., Morrison, C. E., Ramig, L. O., & Sapir, S. (2002). Current perspectives on the Lee Silverman voice treatment (LSVT) for individuals with idiopathic Parkinson disease. American Journal of Speech-Language Pathology, 11(2), 111-123. https://doi.org/10.1044/1058-0360(2002/012)Friston, K. J., Ashburner, J., Frith, C. D., Poline, J. ‐B, Heather, J. D., & Frackowiak, R. S. J. (1995). Spatial registration and normalization of images. Human Brain Mapping, 3(3) 165-189. https://doi.org/10.1002/hbm.460030303Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3) 346-355. https://doi.org/10.1002/mrm.1910350312Gan-Or, Z., Dion, P. A., & Rouleau, G. A. (2015). Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease. Autophagy,11(9) 1443-1457. https://doi.org/10.1080/15548627.2015.1067364Goetz, C. G., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stebbins, G. T., Stern, M. B., Tilley, B. C., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., … LaPelle, N. (2007). Movement disorder society-sponsored revision of the unified Parkinson’s disease rating scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 22(1), 41–47. https://doi.org/10.1002/mds.21198Goetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., … Zweig, R. M. (2008). Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129–2170. https://doi.org/10.1002/mds.22340Gong, S., Xu, M., Tao, Y., Jin, H., Liu, Y., Sun, X., Wang, S., Yang, X., Wang, Y., Yuan, L., & Song, W. (2020). Comparison of Subthalamic Nucleus and Globus Pallidus Internus Deep Brain Stimulation Surgery on Parkinson Disease–Related Pain. World Neurosurgery, 135, e94-e99. https://doi.org/10.1016/j.wneu.2019.11.026Haas, B. M., Trew, M., & Castle, P. C. (2004). Effects of respiratory muscle weakness on daily living function, quality of life, activity levels, and exercise capacity in mild to moderate Parkinson’s disease. American Journal of Physical Medicine and Rehabilitation, 83(8), 601-607. https://doi.org/10.1097/01.PHM.0000133436.61009.02Hallquist, M. N., Hwang, K., & Luna, B. (2013). The nuisance of nuisance regression: Spectral misspecification in a common approach to resting-state fMRI preprocessing reintroduces noise and obscures functional connectivity. NeuroImage, 82, 208-225. https://doi.org/10.1016/j.neuroimage.2013.05.116Hariz, M., Lees, A. J., Blomstedt, Y., & Blomstedt, P. (2022). Serendipity and Observations in Functional Neurosurgery: From James Parkinson’s Stroke to Hamani’s & Lozano’s Flashbacks. Stereotactic and Functional Neurosurgery,100(4), 201-209. https://doi.org/10.1159/000525794Hayes, M. T. (2019). Parkinson’s Disease and Parkinsonism. American Journal of Medicine, 132(7), 802–807. https://doi.org/10.1016/j.amjmed.2019.03.001Henchcliffe, C., & Beal, F. M. (2008). Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nature Clinical Practice Neurology,4(11), 600-609. https://doi.org/10.1038/ncpneuro0924Hickok, G. (2014). The architecture of speech production and the role of the phoneme in speech processing. Language, Cognition and Neuroscience, 29(1), 2–20. https://doi.org/10.1080/01690965.2013.834370Hirano, M. (1981). Psycho-acoustic evaluation of voice: GRBAS scale for evaluating the hoarse voice. Clinical examination of voice.Hlavnika, J., Cmejla, R., Tykalová, T., Šonka, K., Ruzicka, E., & Rusz, J. (2017). Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder. Scientific Reports, 7(1), 12. https://doi.org/10.1038/s41598-017-00047-5Ho, A. K., Bradshaw, J. L., & Iansek, R. (2000). Volume perception in Parkinsonian speech. Movement Disorders, 15(6), 1125–1131. https://doi.org/10.1002/1531-8257(200011)15:6<1125::AID-MDS1010>3.0.CO;2-RHo, A. K., Bradshaw, J. L., & Iansek, R. (2008). For better or worse: The effect of Levodopa on speech in Parkinson’s disease. Movement Disorders, 23(4), 574–580. https://doi.org/10.1002/mds.21899Ho, A. K., Bradshaw, J. L., Iansek, R., & Alfredson, R. (1999). Speech volume regulation in Parkinson’s disease: Effects of implicit cues and explicit instructions. Neuropsychologia, 37(13), 1453-1460. https://doi.org/10.1016/S0028-3932(99)00067-6Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: Onset, progression, and mortality. Neurology, 17(5), 427-442. https://doi.org/10.1212/wnl.17.5.427Hong, C. T., Chan, L., & Bai, C. H. (2020). The effect of caffeine on the risk and progression of Parkinson’s disease: A meta-analysis. Nutrients, 12(6), 1860. https://doi.org/10.3390/nu12061860Houde, J. F., & Nagarajan, S. S. (2011). Speech production as state feedback control. Frontiers in Human Neuroscience, 5(82), 1-14. https://doi.org/10.3389/fnhum.2011.00082Huang, X., Chen, X., Yan, N., Jones, J. A., Wang, E. Q., Chen, L., Guo, Z., Li, W., Liu, P., & Liu, H. (2016). The impact of Parkinson’s disease on the cortical mechanisms that support auditory–motor integration for voice control. Human Brain Mapping, 37(12), 4248–4261. https://doi.org/10.1002/hbm.23306Hubsher, G., Haider, M., & Okun, M. S. (2012). Amantadine: The journey from fighting flu to treating Parkinson disease. Neurology, 78(14), 1096-1099. https://doi.org/10.1212/WNL.0b013e31824e8f0dIm, H., Adams, S., Abeysekera, A., Pieterman, M., Gilmore, G., & Jog, M. (2019). Effect of Levodopa on Speech Dysfluency in Parkinson’s Disease. Movement Disorders Clinical Practice, 6(2), 150–154. https://doi.org/10.1002/mdc3.12714Jenkinson, C., Fitzpatrick, R., Peto, V., Greenhall, R., & Hyman, N. (1997). The Parkinson’s disease questionnaire (PDQ-39): Development and validation of a Parkinson’s disease summary index score. Age and Ageing, 26(5), 353-357. https://doi.org/10.1093/ageing/26.5.353Karine, R., Luc, N. J., & Nadine, V. (2010). The effect of levodopa on speech in Parkinson’s disease: Musical’ scale study. Proceedings of the International Conference on Speech Prosody, 1-4. https://doi.org/10.21437/speechprosody.2010-244Kaut, O., Schmitt, I., Stahl, F., Fröhlich, H., Hoffmann, P., Gonzalez, F. J., & Wüllner, U. (2022). Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex. Life, 12(4), 502. https://doi.org/10.3390/life12040502Kempster, G. B., Gerratt, B. R., Abbott, K. V., Barkmeier-Kraemer, J., & Hillman, R. E. (2009). Consensus auditory-perceptual evaluation of voice: Development of a standardized clinical protocol. American Journal of Speech-Language Pathology, 18(2), 124–132. https://doi.org/10.1044/1058-0360(2008/08-0017)Keus, S. H. J., Munneke, M., Nijkrake, M. J., Kwakkel, G., & Bloem, B. R. (2009). Physical therapy in Parkinson’s disease: Evolution and future challenges. Movement Disorders, 24(1), 1-14. https://doi.org/10.1002/mds.22141Kim, J. J., Vitale, D., Veliz-Otani, D., Lian, M., Heilbron, K., Team, the 23andMe R., Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E.-K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Blauwendraat, C., Nalls, M. A., Foo, J. N., & Mata, I. (2024). Multi-ancestry genome-wide meta-analysis in Parkinson’s disease. Nature Genetics, 56(1), 27-36.Kim, K. S., Gaines, J. L., Parrell, B., Ramanarayanan, V., Nagarajan, S. S., & Houde, J. F. (2023). Mechanisms of sensorimotor adaptation in a hierarchical state feedback control model of speech. PLoS Computational Biology, 19(7), e1011244. https://doi.org/10.1371/journal.pcbi.1011244Knight, E. J., Testini, P., Min, H. K., Gibson, W. S., Gorny, K. R., Favazza, C. P., Felmlee, J. P., Kim, I., Welker, K. M., Clayton, D. A., Klassen, B. T., Chang, S. Y., & Lee, K. H. (2015). Motor and nonmotor circuitry activation induced by subthalamic nucleus deep brain stimulation in patients with Parkinson disease: Intraoperative functional magnetic resonance imaging for deep brain stimulation. Mayo Clinic Proceedings, 90(6), 773-785. https://doi.org/10.1016/j.mayocp.2015.03.022Kobayashi, S., Maki, T., & Kunimoto, M. (2011). Clinical symptoms of bilateral anterior cerebral artery territory infarction. Journal of Clinical Neuroscience, 18(2), 218-222. https://doi.org/10.1016/j.jocn.2010.05.013Kolb, B., & Whishaw, I. (2014). An Introduction to Brain and Behavior (4th ed.). Worth Publishers.Konczak, J., Corcos, D. M., Horak, F., Poizner, H., Shapiro, M., Tuite, P., Volkmann, J., & Maschke, M. (2009). Proprioception and Motor Control in Parkinson’s Disease. Journal of Motor Behavior, 41(6), 543–552. https://doi.org/10.3200/35-09-002Kreiman, J., & Gerratt, B. R. (2000). Sources of listener disagreement in voice quality assessment. The Journal of the Acoustical Society of America, 108(4), 1867-1876. https://doi.org/10.1121/1.1289362Lechien, J. R., Delsaut, B., Abderrakib, A., Huet, K., Delvaux, V., Piccaluga, M., Khalife, M., Harmegnies, B., Saussez, S., & Blecic, S. (2020). Orofacial Strength and Voice Quality as Outcome of Levodopa Challenge Test in Parkinson Disease. Laryngoscope, 130(12), E896-E903. https://doi.org/10.1002/lary.28645Lees, A. J., Hardy, J., & Revesz, T. (2009). Parkinson’s disease. The Lancet, 373(9680), 2055–2066. https://doi.org/10.1016/S0140-6736(09)60492-XLi, S. H., Chen, H. B., Wang, Z. F., Tang, R. H., Zhang, X. Y., Yang, J. S., Zhao, W. Q., Sun, X. R., & Ma, J. (2013). Efficacy and safety of ropinirole in the treatment of Parkinson disease: a multi-center, randomized, double-blind and bromocriptine-controlled trial. National Medical Journal of China, 93(25), 1952-1957. https://doi.org/10.3760/cma.j.issn.0376-2491.2013.25.005Lieberman, A. N., & Goldstein, M. (1985). Bromocriptine in Parkinson disease. Pharmacological Reviews, 37(2), 217-227. https://doi.org/10.1212/wnl.29.3.363Lin, M. T., Cantuti-Castelvetri, I., Zheng, K., Jackson, K. E., Tan, Y. B., Arzberger, T., Lees, A. J., Betensky, R. A., Beal, M. F., & Simon, D. K. (2012). Somatic mitochondrial DNA mutations in early Parkinson and incidental lewy body disease. Annals of Neurology, 71(6), 850-854. https://doi.org/10.1002/ana.23568Lombard, E. (1911). Le signe de l’élévation de la voix (translated from French). Annales Des Maladies de l’oreille et Du Larynx, 37(2), 101-119.Lukos, J. R., Snider, J., Hernandez, M. E., Tunik, E., Hillyard, S., & Poizner, H. (2013). Parkinson’s disease patients show impaired corrective grasp control and eye-hand coupling when reaching to grasp virtual objects. Neuroscience, 254, 205-221. https://doi.org/10.1016/j.neuroscience.2013.09.026Manes, J. L., Kurani, A. S., Herschel, E., Roberts, A. C., Tjaden, K., Parrish, T., & Corcos, D. M. (2023). Premotor cortex is hypoactive during sustained vowel production in individuals with Parkinson’s disease and hypophonia. Frontiers in Human Neuroscience, 17, 1250114. https://doi.org/10.3389/fnhum.2023.1250114Manes, J. L., Parkinson, A. L., Larson, C. R., Greenlee, J. D., Eickhoff, S. B., Corcos, D. M., & Robin, D. A. (2014). Connectivity of the subthalamic nucleus and globus pallidus pars interna to regions within the speech network: A meta-analytic connectivity study. Human Brain Mapping, 35(7), 3499–3516. https://doi.org/10.1002/hbm.22417Manes, J. L., Tjaden, K., Parrish, T., Simuni, T., Roberts, A., Greenlee, J. D., Corcos, D. M., & Kurani, A. S. (2018). Altered resting-state functional connectivity of the putamen and internal globus pallidus is related to speech impairment in Parkinson’s disease. Brain and Behavior, 8(9), e01073. https://doi.org/10.1002/brb3.1073Margolesky, J., & Singer, C. (2018). Extended-release oral capsule of carbidopa-levodopa in parkinson disease. Therapeutic Advances in Neurological Disorders, 11, 1756285617737728. https://doi.org/10.1177/1756285617737728Marín-M, D. S., Carmona-V, H., Ibarra-Q, M., & Gámez-C, M. (2022). Enfermedad de Parkinson: fisiopatología, diagnóstico y tratamiento. Revista de la Universidad Industrial de Santander Salud, 50(1), 79-92.Marín-Medina, D. S., Quintero-Moreno, J. F., Valencia-Vásquez, A., Duque-Salazar, C., Gil-Restrepo, A. F., Castaño-Montoya, J. P., García-Rodríguez, D., & Carmona-Villada, H. (2018). Deep brain stimulation in parkinson disease. Iatreia, 31(3), 262–273. https://doi.org/10.17533/udea.iatreia.v31n3a04Martínez-Fernández, R., Gasca-Salas, C., Sánchez-Ferro, Á., & Obeso, J. Á. (2016). Actualización en la enfermedad de Parkinson. Revista Médica Clínica Las Condes, 27(3), 363–379.Martínez-Fernández, R., Máñez-Miró, J. U., Rodríguez-Rojas, R., del Álamo, M., Shah, B. B., Hernández-Fernández, F., Pineda-Pardo, J. A., Monje, M. H. G., Fernández-Rodríguez, B., Sperling, S. A., Mata-Marín, D., Guida, P., Alonso-Frech, F., Obeso, I., Gasca-Salas, C., Vela-Desojo, L., Elias, W. J., & Obeso, J. A. (2020). Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease. New England Journal of Medicine, 383(26), 2501-2513. https://doi.org/10.1056/nejmoa2016311Mata-Marín, D., Pineda-Pardo, J. A., Molina, J. A., Vela, L., Alonso-Frech, F., & Obeso, I. (2021). Aberrant Salient and Corticolimbic Connectivity in Hypersexual Parkinson’s Disease. Brain Connectivity, 11(8), 639-650. https://doi.org/10.1089/brain.2020.0868McDonnell, M. N., Rischbieth, B., Schammer, T. T., Seaforth, C., Shaw, A. J., & Phillips, A. C. (2018). Lee Silverman Voice Treatment (LSVT)-BIG to improve motor function in people with Parkinson’s disease: a systematic review and meta-analysis. Clinical Rehabilitation, 32(5), 607-618. https://doi.org/10.1177/0269215517734385Meléndez Flores, J. D., Castillo Torres, S. A., Cerda Contreras, C., Chávez Luévanos, B. E., & Estrada Bellmann, I. (2021). Características clínicas del síndrome metabólico en pacientes con enfermedad de Parkinson. Revista de Neurología, 72(1), 9-15. https://doi.org/10.33588/rn.7201.2020323Miller, N., Noble, E., Jones, D., & Burn, D. (2006). Life with communication changes in Parkinson’s disease. Age and Ageing, 35(3), 235–239. https://doi.org/10.1093/ageing/afj053Morato-Galán, M. (2014). Análisis perceptual de la disfonía: adaptación y validación del método CAPE-V al español. Universidad de Oviedo.Moreau, C., & Pinto, S. (2019). Misconceptions about speech impairment in Parkinson’s disease. Movement Disorders, 34(10), 1471–1475. https://doi.org/10.1002/mds.27791Nagaratnam, N., Nagaratnam, K., Ng, K., & Diu, P. (2004). Akinetic mutism following stroke. Journal of Clinical Neuroscience, 11(1), 25-30. https://doi.org/10.1016/j.jocn.2003.04.002Nagle, K. F. (2022). Clinical Use of the CAPE-V Scales: Agreement, Reliability and Notes on Voice Quality. Journal of Voice, S08921997(22), 00366-6. https://doi.org/10.1016/j.jvoice.2022.11.014Nakamura, M., Hamamoto, M., Uchida, S., Nagayama, H., Amemiya, S., Okubo, S., & Tanaka, K. (2003). A case of micrographia after subcortical infarction: Possible involvement of frontal lobe function. European Journal of Neurology, 10(5), 593-596. https://doi.org/10.1046/j.1468-1331.2003.00641.xNarea-Veas, M. S., Farías, P. G., & Vázquez Fernández, P. (2023). Consensus Auditory Perceptual Evaluation of Voice (CAPE-V): Systematic Review of Methods Used for Adaptation and Validation. Revista de Investigacion e Innovacion en Ciencias de la Salud, 5(2), 178-204. https://doi.org/10.46634/riics.206Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.xNew, A. B., Robin, D. A., Parkinson, A. L., Eickhoff, C. R., Reetz, K., Hoffstaedter, F., Mathys, C., Sudmeyer, M., Grefkes, C., Larson, C. R., Ramig, L. O., Fox, P. T., & Eickhoff, S. B. (2015). The intrinsic resting state voice network in Parkinson’s disease. Human Brain Mapping, 36(5), 1951–1962. https://doi.org/10.1002/hbm.22748Nieto-Castanon, A. (2020). Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN. Hilbert-Press. https://doi.org/10.56441/hilbertpress.2207.6598Niziolek, C. A., & Guenther, F. H. (2013). Vowel category boundaries enhance cortical and behavioral responses to speech feedback alterations. Journal of Neuroscience, 33(29), 12090–12098. https://doi.org/10.1523/JNEUROSCI.1008-13.2013Núñez-Batalla, F., Morato-Galán, M., García-López, I., & Ávila-Menéndez, A. (2015). Adaptación fonética y validación del método de valoración perceptual de la voz CAPE-V al español. Acta Otorrinolaringologica Espanola, 66(5), 249–257. https://doi.org/10.1016/j.otorri.2014.07.007Obeso, J. A., Marin, C., Rodriguez-Oroz, C., Blesa, J., Benitez-Temiño, B., Mena-Segovia, J., Rodríguez, M., & Olanow, C. W. (2008). The basal ganglia in Parkinson’s disease: Current concepts and unexplained observations. Annals of Neurology, 64(2), S30-46. https://doi.org/10.1002/ana.21481Obeso, J. A., Rodríguez-Oroz, M. C., Benitez-Temino, B., Blesa, F. J., Guridi, J., Marin, C., & Rodriguez, M. (2008). Functional organization of the basal ganglia: Therapeutic implications for Parkinson’s disease. Movement Disorders, 23(Suppl. 3), S548-559. https://doi.org/10.1002/mds.22062Ohtomo, R., Iwata, A., & Tsuji, S. (2014). Unilateral opercular infarction presenting with foix-chavany-marie syndrome. Journal of Stroke and Cerebrovascular Diseases, 23(1), 179-181. https://doi.org/10.1016/j.jstrokecerebrovasdis.2012.08.015Paccosi, E., & Proietti-De-Santis, L. (2023). Parkinson’s Disease: From Genetics and Epigenetics to Treatment, a miRNA-Based Strategy. International Journal of Molecular Sciences,24(11), 9547. https://doi.org/10.3390/ijms24119547Panza, F., Lozupone, M., Sardone, R., Battista, P., Piccininni, M., Dibello, V., La Montagna, M., Stallone, R., Venezia, P., Liguori, A., Giannelli, G., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Quaranta, N., & Logroscino, G. (2019). Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life. Therapeutic Advances in Chronic Disease, 10, 1–17. https://doi.org/10.1177/2040622318811000Pedraza, O. L., Salazar, A. M., Sierra, F. A., Soler, D., Castro, J., Castillo, P. C., Hernandez, M. A., & Piñeros, C. (2017). Confiabilidad, validez de criterio y discriminante del Montreal Cognitive Assessment (MoCA) test, en un grupo de Adultos de Bogotá. Acta Médica Colombiana, 41(4), 221–228. https://doi.org/10.36104/amc.2016.693Phokaewvarangkul, O., Boonpang, K., & Bhidayasiri, R. (2019). Subthalamic deep brain stimulation aggravates speech problems in Parkinson’s disease: Objective and subjective analysis of the influence of stimulation frequency and electrode contact location. Parkinsonism and Related Disorders, 66(April), 110–116. https://doi.org/10.1016/j.parkreldis.2019.07.020Pihlstrøm, L., Shireby, G., Geut, H., Henriksen, S. P., Rozemuller, A. J. M., Tunold, J. A., Hannon, E., Francis, P., Thomas, A. J., Love, S., Mill, J., van de Berg, W. D. J., & Toft, M. (2022). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Nature Communications, 13(1), 4932. https://doi.org/10.1038/s41467-022-32619-zPinel, J. P. J., & Barnes, S. (2021). Biopsychology (10th Edition). Pearson Education.Pinho, S. R., & Pontes, P. (2002). Escala de evaluación perceptiva de la fuente glótica: RASAT. Vox Brasilis, 8(3), 1-4.Pinto, S., Ozsancak, C., Tripoliti, E., Thobois, S., Limousin-Dowsey, P., & Auzou, P. (2004). Treatments for dysarthria in Parkinson’s disease. Lancet Neurology, 3(9), 547–556. https://doi.org/10.1016/S1474-4422(04)00854-3Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A. E., & Lang, A. E. (2017). Parkinson disease. Nature Reviews Disease Primers, 3, 17013.Portet, F., Ousset, P. J., Visser, P. J., Frisoni, G. B., Nobili, F., Scheltens, P., Vellas, B., & Touchon, J. (2006). Mild cognitive impairment (MCI) in medical practice: A critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. Journal of Neurology, Neurosurgery and Psychiatry, 77(6), 714-718. https://doi.org/10.1136/jnnp.2005.085332Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G. (2015). MDS clinical diagnostic criteria for Parkinsons disease. Movement Disorders, 30(12), 1591-601. doi: 10.1002/mds.26424. PMID: 26474316.Power, J. D., Mitra, A., Laumann, T. O., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2014). Methods to detect, characterize, and remove motion artifact in resting state fMRI. NeuroImage, 84, 320–341. https://doi.org/10.1016/j.neuroimage.2013.08.048Railo, H., Nokelainen, N., Savolainen, S., & Kaasinen, V. (2020). Deficits in monitoring self-produced speech in Parkinson’s disease. Clinical Neurophysiology, 131(9), 2140–2147. https://doi.org/10.1016/j.clinph.2020.05.038Ramig, L., Fox, C., & Sapir, S. (2008). Speech treatment for Parkinson’s disease. Expert Review of Neurotherapeutics, 8(2), 299–311. https://doi.org/10.1586/14737175.8.2.297Ray Dorsey, E., Elbaz, A., Nichols, E., Abd-Allah, F., Abdelalim, A., Adsuar, J. C., Ansha, M. G., Brayne, C., Choi, J. Y. J., Collado-Mateo, D., Dahodwala, N., Do, H. P., Edessa, D., Endres, M., Fereshtehnejad, S. M., Foreman, K. J., Gankpe, F. G., Gupta, R., Hankey, G. J., … Murray, C. J. L. (2018). Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939-953. https://doi.org/10.1016/S1474-4422(18)30295-3Ray, M., Dening, T., & Crosbie, B. (2019). Dementia and hearing loss: A narrative review. Maturitas, 128, 64–69. https://doi.org/10.1016/j.maturitas.2019.08.001Rektorova, I., Barrett, J., Mikl, M., Rektor, I., & Paus, T. (2007). Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson’s disease. Movement Disorders, 22(14), 2043–2051. https://doi.org/10.1002/mds.21548Rektorova, I., Mikl, M., Barrett, J., Marecek, R., Rektor, I., & Paus, T. (2012). Functional neuroanatomy of vocalization in patients with Parkinson’s disease. Journal of the Neurological Sciences, 313(1–2), 7–12. https://doi.org/10.1016/j.jns.2011.10.020Rhonda, J. H., Oates, J. M., Debbie, J. P., & Andrew, J. H. (2000). Voice characteristics in the progression of Parkinson’s disease. International Journal of Language and Communication Disorders, 35(3), 407-418. https://doi.org/10.1080/136828200410654Ricci-Maccarini, A., Schindler, A., Mozzanica, F., Fantini, M., Murry, T., & Dejonckere, P. (2022, en prensa). Validity, Reliability and Reproducibility of the “Extended GRBAS Scale,” A Comprehensive Perceptual Evaluation of Dysphonia. Journal of Voice. https://doi.org/10.1016/j.jvoice.2022.09.008Riederer, P., & Müller, T. (2018). Monoamine oxidase-B inhibitors in the treatment of Parkinson’s disease: clinical–pharmacological aspects. Journal of Neural Transmission, 125(11), 1751-1757. https://doi.org/10.1007/s00702-018-1876-2Rizek, P., Kumar, N., & Jog, M. S. (2016). An update on the diagnosis and treatment of Parkinson disease. CMAJ, 188(16), 1157-1165. https://doi.org/10.1503/cmaj.151179Rodríguez-López, C., Ayuso García, B., & Moreno García, S. (2018). Hypophonia as a sign of thalamus lesion: a case report. International Journal of Neuroscience, 128(1), 100–101. https://doi.org/10.1080/00207454.2017.1358716Rodriguez-Sabate, C., Morales, I., Lorenzo, J. N., & Rodriguez, M. (2019). The organization of the basal ganglia functional connectivity network is non-linear in Parkinson’s disease. NeuroImage: Clinical, 22, 101708. https://doi.org/10.1016/j.nicl.2019.101708Rosqvist, K., Horne, M., Hagell, P., Iwarsson, S., Nilsson, M. H., & Odin, P. (2018). Levodopa effect and motor function in late stage Parkinson’s disease. Journal of Parkinson’s Disease, 8(1), 59–70. https://doi.org/10.3233/JPD-171181Rughani, A., Schwalb, J. M., Sidiropoulos, C., Pilitsis, J., Ramirez-Zamora, A., Sweet, J. A., Mittal, S., Espay, A. J., Martinez, J. G., Abosch, A., Eskandar, E., Gross, R., Alterman, R., & Hamani, C. (2018). Congress of neurological surgeons systematic review and evidence-based guideline on subthalamic nucleus and globus pallidus internus deep brain stimulation for the treatment of patients with Parkinson’s disease: Executive summary. Neurosurgery, 82(6), 753-756. https://doi.org/10.1093/neuros/nyy037Sadagopan, N., & Huber, J. E. (2007). Effects of loudness cues on respiration in individuals with Parkinson’s disease. Movement Disorders, 22(5), 651-659. https://doi.org/10.1002/mds.21375Sapir, S., Ramig, L. O., & Fox, C. M. (2011). Intensive voice treatment in Parkinson’s disease: Lee Silverman Voice Treatment. Expert Review of Neurotherapeutics, 11(6), 815-830. https://doi.org/10.1586/ern.11.43Scarpa, A., Cassandro, C., Vitale, C., Ralli, M., Policastro, A., Barone, P., Cassandro, E., & Pellecchia, M. T. (2020). A comparison of auditory and vestibular dysfunction in Parkinson’s disease and Multiple System Atrophy. Parkinsonism and Related Disorders, 71, 51–57. https://doi.org/10.1016/j.parkreldis.2020.01.018Schneider, J. S., Diamond, S. G., & Markham, C. H. (1986). Deficits in orofacial sensorimotor function in Parkinson’s disease. Annals of Neurology, 19(3), 275-282. https://doi.org/10.1002/ana.410190309Scott, R., Gregory, R., Hines, N., Carroll, C., Hyman, N., Papanasstasiou, V., Leather, C., Rowe, J., Silburn, P., & Aziz, T. (1998). Neuropsychological, neurological and functional outcome following pallidotomy for Parkinson’s disease. A consecutive series of eight simultaneous bilateral and twelve unilateral procedures. Brain, 121(4), 659-675. https://doi.org/10.1093/brain/121.4.659Senthinathan, A., Adams, S., Page, A. D., & Jog, M. (2021). Speech intensity response to altered intensity feedback in individuals with Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 64(6s), 2261-2275. https://doi.org/10.1044/2021_JSLHR-20-00278Simon, D. K., Tanner, C. M., & Brundin, P. (2020). Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in Geriatric Medicine, 36(1), 1–12. https://doi.org/10.1016/j.cger.2019.08.002Smith, K. M., & Caplan, D. N. (2018). Communication impairment in Parkinson’s disease: Impact of motor and cognitive symptoms on speech and language. Brain and Language, 185(July), 38–46. https://doi.org/10.1016/j.bandl.2018.08.002Smith, L. J., Lee, C. Y., Menozzi, E., & Schapira, A. H. V. (2022). Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease. Frontiers in Neurology, 13, 971252. https://doi.org/10.3389/fneur.2022.971252Solomon, N. P., & Hixon, T. J. (1993). Speech breathing in Parkinson’s disease. Journal of Speech and Hearing Research, 36(2) 294-310. https://doi.org/10.1044/jshr.3602.294Sonkaya, Z. Z., Ceylan, M., & Sonkaya, A. R. (2021). Speech characteristics of parkinson disease. Medical Science and Discovery, 8(12), 666-670. https://doi.org/10.36472/msd.v8i12.645Stathopoulos, E. T., Huber, J. E., Richardson, K., Kamphaus, J., DeCicco, D., Darling, M., Fulcher, K., & Sussman, J. E. (2014). Increased vocal intensity due to the Lombard effect in speakers with Parkinson’s disease: Simultaneous laryngeal and respiratory strategies. Journal of Communication Disorders, 48(1), 1–17. https://doi.org/10.1016/j.jcomdis.2013.12.001Stathopoulos, E. T., & Sapienza, C. M. (1997). Developmental changes in laryngeal and respiratory function with variations in sound pressure level. Journal of Speech, Language, and Hearing Research, 40(3), 595-614. https://doi.org/10.1044/jslhr.4003.595Strickland, D. (2012). Rural environment and Parkinson’s disease. En R. F. Pfeiffer, Z. K. Wszolek & M. Ebadi (Eds.) Parkinson’s Disease (2nd Edition) (pp. 63–71). CRC Press. https://doi.org/10.1201/b12948Suárez Torres, M., Cano Villagrasa, A., & Valles González, B. (2020). Diagnósticos Fonoaudiológicos y Síntomas no Motores en Pacientes con Enfermedad de Parkinson. Areté, 20(2), 63-71. https://doi.org/10.33881/1657-2513.art20207Thacker, E. L., O’Reilly, E. J., Weisskopf, M. G., Chen, H., Schwarzschild, M. A., McCullough, M. L., Calle, E. E., Thun, M. J., & Ascherio, A. (2007). Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology, 68(10), 764-768. https://doi.org/10.1212/01.wnl.0000256374.50227.4bTiwari, P. C., & Pal, R. (2017). The potential role of neuroinflammation and transcription factors in Parkinson disease. Dialogues in Clinical Neuroscience, 19(1), 71-80. https://doi.org/10.31887/dcns.2017.19.1/rpalTsalenchuk, M., Gentleman, S. M., & Marzi, S. J. (2023). Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease. NPJ Parkinson’s Disease, 9(1), 123. https://doi.org/10.1038/s41531-023-00568-zTursunov, D. (2020). L-Dopa induced dyskinesia. Parkinsonism & Related Disorders, 79, e94. https://doi.org/10.1016/j.parkreldis.2020.06.342Ulla, M., Bonny, J. M., Ouchchane, L., Rieu, I., Claise, B., & Durif, F. (2013). Is R2* a New MRI Biomarker for the Progression of Parkinson’s Disease? A Longitudinal Follow-Up. PLoS ONE, 8(3), e57904. https://doi.org/10.1371/journal.pone.0057904Ullah, I., Zhao, L., Hai, Y., Fahim, M., Alwayli, D., Wang, X., & Li, H. (2021). “Metal elements and pesticides as risk factors for Parkinson’s disease - A review.” Toxicology Reports, 8, 607-616. https://doi.org/10.1016/j.toxrep.2021.03.009Van Den Eeden, S. K., Tanner, C. M., Bernstein, A. L., Fross, R. D., Leimpeter, A., Bloch, D. A., & Nelson, L. M. (2003). Incidence of Parkinson’s disease: Variation by age, gender, and race/ethnicity. American Journal of Epidemiology, 157(11) 1015-1022. https://doi.org/10.1093/aje/kwg068Vara, A. C., Medeiros, R., & Striebel, V. L. W. (2012). Physical therapy in parkinson’s disease. Revista Neurociencias, 20(2), 266–272. https://doi.org/10.34024/rnc.2012.v20.8281Venezia, J. H., Fillmore, P., Matchin, W., Lisette Isenberg, A., Hickok, G., & Fridriksson, J. (2016). Perception drives production across sensory modalities: A network for sensorimotor integration of visual speech. NeuroImage, 126, 196–207. https://doi.org/10.1016/j.neuroimage.2015.11.038Vitale, C., Marcelli, V., Abate, T., Pianese, A., Allocca, R., Moccia, M., Spina, E., Barone, P., Santangelo, G., & Cavaliere, M. (2016). Speech discrimination is impaired in parkinsonian patients: Expanding the audiologic findings of Parkinson’s disease. Parkinsonism and Related Disorders, 22(Suppl 1), S138–S143. https://doi.org/10.1016/j.parkreldis.2015.09.040Walker, G. M., & Hickok, G. (2016). Bridging computational approaches to speech production: The semantic–lexical–auditory–motor model (SLAM). Psychonomic Bulletin and Review, 23(2), 339–352. https://doi.org/10.3758/s13423-015-0903-7Walshe, M., & Miller, N. (2011). Living with acquired dysarthria: The speaker’s perspective. Disability and Rehabilitation, 33(3), 195–203. https://doi.org/10.3109/09638288.2010.511685Yang, W., Liu, B., Huang, B., Huang, R., Wang, L., Zhang, Y., Zhang, X., & Wu, K. (2016). Altered resting-state functional connectivity of the striatum in Parkinson’s disease after levodopa administration. PLoS ONE, 11(9), e0161935. https://doi.org/10.1371/journal.pone.0161935Yin, H. H. (2017). The Basal Ganglia in Action. Neuroscientist, 23(3), 299-313. https://doi.org/10.1177/1073858416654115Yu, Q. W., Ye, T. F., & Qian, W. J. (2021). Rare coexistence of multiple manifestations secondary to thalamic hemorrhage: A case report. World Journal of Clinical Cases, 9(18), 4817-4822. https://doi.org/10.12998/wjcc.v9.i18.4817Yuan, F., Guo, X., Wei, X., Xie, F., Zheng, J., Huang, Y., Huang, Z., Chang, Z., Li, H., Guo, Y., Chen, J., Guo, J., Tang, B., Deng, B., & Wang, Q. (2020). Lee Silverman Voice Treatment for dysarthria in patients with Parkinson’s disease: a systematic review and meta-analysis. European Journal of Neurology, 27(10), 1957-1970. https://doi.org/10.1111/ene.14399Zarzur, A. P., Duprat, A. C., Shinzato, G., & Eckley, C. A. (2007). Laryngeal electromyography in adults with Parkinson’s disease and voice complaints. Laryngoscope, 117(5), 831-834. https://doi.org/10.1097/MLG.0b013e3180333145Zegleń, M., Sladowska, K., Kawalec, P., & Brzostek, T. (2022). Opicapone as an add-on to levodopa for reducing end-of-dose motor fluctuations in Parkinson’s disease: a systematic review and meta-analysis. Journal of Comparative Effectiveness Research, 11(12), 889-904. https://doi.org/10.2217/cer-2022-0031Zeighami, Y., Ulla, M., Iturria-Medina, Y., Dadar, M., Zhang, Y., Larcher, K. M. H., Fonov, V., Evans, A. C., Collins, D. L., & Dagher, A. (2015). Network structure of brain atrophy in de novo Parkinson’s disease. ELife, 4, e08440. https://doi.org/10.7554/eLife.08440Zhang, K., Paul, K. C., Jacobs, J. P., Chou, H. C. (Lori), Duarte Folle, A., Del Rosario, I., Yu, Y., Bronstein, J. M., Keener, A. M., & Ritz, B. (2022). Parkinson’s Disease and the Gut Microbiome in Rural California. 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