Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos
Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con...
- Autores:
-
Cárdenas Palacio, Carlos Andrés
- Tipo de recurso:
- Doctoral thesis
- Fecha de publicación:
- 2024
- Institución:
- Universidad de los Andes
- Repositorio:
- Séneca: repositorio Uniandes
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.uniandes.edu.co:1992/74621
- Acceso en línea:
- https://hdl.handle.net/1992/74621
- Palabra clave:
- Enfermedad de Parkinson
Hipofonía
Desórdenes de la voz
FMRI
Disartria
Psicología
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| dc.title.alternative.none.fl_str_mv |
Feedback mechanisms sensitive to voice intensity in Parkinson’s disease. Neurophysiological correlates |
| title |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| spellingShingle |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria Psicología |
| title_short |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_full |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_fullStr |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_full_unstemmed |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| title_sort |
Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicos |
| dc.creator.fl_str_mv |
Cárdenas Palacio, Carlos Andrés |
| dc.contributor.advisor.none.fl_str_mv |
Cárdenas Parra, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Cárdenas Palacio, Carlos Andrés |
| dc.contributor.jury.none.fl_str_mv |
López Velásquez, Norman Darío Strange, Bryan Andrew Báez Buitrago, Sandra Jimena Monsalve Duarte, Guillermo Alfonso |
| dc.contributor.researchgroup.none.fl_str_mv |
Facultad de Ciencias Sociales::Neurociencia y Comportamiento |
| dc.subject.keyword.none.fl_str_mv |
Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria |
| topic |
Enfermedad de Parkinson Hipofonía Desórdenes de la voz FMRI Disartria Psicología |
| dc.subject.themes.none.fl_str_mv |
Psicología |
| description |
Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con Enfermedad de Parkinson. Para tal fin, se ha realizado un análisis comparativo en las variables de intensidad de la voz, percepción del volumen del habla y conectividad funcional, en las redes neurales mencionadas, entre 13 pacientes con enfermedad de Parkinson y 15 controles sanos. De manera complementaria, se ha analizado una posible relación de la intensidad de la voz con las variables clínicas de nivel de severidad, tiempo de evolución, medicación y lado afectado en los pacientes evaluados. La intensidad de la voz ha sido valorada a través de la Consensus Auditory-Perceptual Evaluation of Voice; el nivel de percepción del volumen del habla se ha obtenido mediante un protocolo consistente en tres tareas: magnitud de la estimación, imitación y magnitud de la producción; la magnitud de conectividad funcional ha sido calculada a partir de un registro de resonancia magnética funcional en estado de reposo. Los resultados han permitido entender la hipofonía como un desorden de integración sensoriomotora. De manera complementaria, se han observado alteraciones adicionales de la voz relacionadas con la aspereza, el escape y la tensión. Con base en tales hallazgos se propone incluir elementos sensoriales auditivos y propioceptivos como parte de la evaluación y el tratamiento de las alteraciones de la voz y el habla secundarias a la enfermedad de Parkinson. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-22T13:06:21Z |
| dc.date.available.none.fl_str_mv |
2024-07-22T13:06:21Z |
| dc.date.issued.none.fl_str_mv |
2024-06-21 |
| dc.type.none.fl_str_mv |
Trabajo de grado - Doctorado |
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info:eu-repo/semantics/doctoralThesis |
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info:eu-repo/semantics/acceptedVersion |
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http://purl.org/coar/resource_type/c_db06 |
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Text |
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https://purl.org/redcol/resource_type/TD |
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instname:Universidad de los Andes |
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Cárdenas Parra, Luis Fernandovirtual::19096-1Cárdenas Palacio, Carlos AndrésLópez Velásquez, Norman DaríoStrange, Bryan AndrewBáez Buitrago, Sandra Jimenavirtual::19098-1Monsalve Duarte, Guillermo Alfonsovirtual::19099-1Facultad de Ciencias Sociales::Neurociencia y Comportamiento2024-07-22T13:06:21Z2024-07-22T13:06:21Z2024-06-21https://hdl.handle.net/1992/74621instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/Este estudio ha pretendido determinar si se presentan cambios en la percepción del volumen del habla y en la conectividad funcional en las redes neuronales (el circuito motor de los ganglios basales y la red de control motor del habla por retroalimentación) asociados a la hipofonía de pacientes con Enfermedad de Parkinson. Para tal fin, se ha realizado un análisis comparativo en las variables de intensidad de la voz, percepción del volumen del habla y conectividad funcional, en las redes neurales mencionadas, entre 13 pacientes con enfermedad de Parkinson y 15 controles sanos. De manera complementaria, se ha analizado una posible relación de la intensidad de la voz con las variables clínicas de nivel de severidad, tiempo de evolución, medicación y lado afectado en los pacientes evaluados. La intensidad de la voz ha sido valorada a través de la Consensus Auditory-Perceptual Evaluation of Voice; el nivel de percepción del volumen del habla se ha obtenido mediante un protocolo consistente en tres tareas: magnitud de la estimación, imitación y magnitud de la producción; la magnitud de conectividad funcional ha sido calculada a partir de un registro de resonancia magnética funcional en estado de reposo. Los resultados han permitido entender la hipofonía como un desorden de integración sensoriomotora. De manera complementaria, se han observado alteraciones adicionales de la voz relacionadas con la aspereza, el escape y la tensión. Con base en tales hallazgos se propone incluir elementos sensoriales auditivos y propioceptivos como parte de la evaluación y el tratamiento de las alteraciones de la voz y el habla secundarias a la enfermedad de Parkinson.This study aimed to determine whether there are changes in the perception of speech volume and in functional connectivity in the neural networks (the motor circuit of the basal ganglia and the speech motor control network through feedback) associated with hypophonia in patients with Parkinson’s Disease. For this purpose, a comparative analysis has been carried out on the variables of voice intensity, perception of speech volume and functional connectivity between 13 patients and 15 healthy controls. In a complementary manner, a possible relationship between voice intensity and the clinical variables of level of severity, time of evolution, medication and affected side in the patients evaluated has been analyzed. The intensity of the voice has been assessed through the Consensus Auditory-Perceptual Evaluation of Voice; the level of perception of speech volume has been obtained through a protocol consisting of three tasks: magnitude of estimation, imitation and magnitude of production; the magnitude of functional connectivity has been calculated from a resting state fMRI recording. The results have allowed us to understand hypophonia as a sensorimotor integration disorder. Additional voice disturbances related to harshness, leakiness, and tension have been observed. Based on such findings, it is proposed to include auditory and proprioceptive sensory elements as part of the evaluation and treatment of voice and speech alterations secondary to Parkinson’s disease.Universidad de La Sabana.Doctorado163 páginasapplication/pdfspaUniversidad de los AndesDoctorado en PsicologíaFacultad de Ciencias SocialesDepartamento de PsicologíaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson. Correlatos neurofisiológicosFeedback mechanisms sensitive to voice intensity in Parkinson’s disease. Neurophysiological correlatesTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttps://purl.org/redcol/resource_type/TDEnfermedad de ParkinsonHipofoníaDesórdenes de la vozFMRIDisartriaPsicologíaAbur, D., Lupiani, A. A., Hickox, A. E., Shinn-Cunningham, B. G., & Stepp, C. E. (2018). Loudness perception of pure tones in Parkinson’s disease. Journal of Speech, Language, and Hearing Research, 61(6), 1487–1496. https://doi.org/10.1044/2018_JSLHR-H-17-0382Abur, D., Subaciute, A., Daliri, A., Lester-Smith, R. A., Lupiani, A. A., Cilento, D., Enos, N. M., Weerathunge, H. R., Tardif, M. C., & Stepp, C. E. (2021). Feedback and feedforward auditory-motor processes for voice and articulation in parkinson’s disease. Journal of Speech, Language, and Hearing Research, 64(12), 4682-4694. https://doi.org/10.1044/2021_JSLHR-21-00153Acosta, S. A., Tajiri, N., de la Pena, I., Bastawrous, M., Sanberg, P. 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JAMA - Journal of the American Medical Association, 323(6), 548–560. https://doi.org/10.1001/jama.2019.22360Arnold, C., Gehrig, J., Gispert, S., Seifried, C., & Kell, C. A. (2014). Pathomechanisms and compensatory efforts related to Parkinsonian speech. NeuroImage: Clinical, 4, 82–97. https://doi.org/10.1016/j.nicl.2013.10.016Ashburner, J., & Friston, K. J. (2005). Unified segmentation. NeuroImage, 26(3), 839-851. https://doi.org/10.1016/j.neuroimage.2005.02.018Aslan, S. N., & Karahalil, B. (2019). Oxidative stress and Parkinson disease. Ankara Universitesi Eczacilik Fakultesi Dergisi, 43(1), 94-116. https://doi.org/10.33483/jfpau.519964Baumann, A., Nebel, A., Granert, O., Giehl, K., Wolff, S., Schmidt, W., Baasch, C., Schmidt, G., Witt, K., Deuschl, G., Hartwigsen, G., Zeuner, K. E., & van Eimeren, T. (2018). Neural Correlates of Hypokinetic Dysarthria and Mechanisms of Effective Voice Treatment in Parkinson Disease. 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Journal of Parkinson’s Disease, 12(8), 2441-2452. https://doi.org/10.3233/JPD-223500200327678Publicationhttps://scholar.google.com/citations?hl=es&user=YfNeJIAAAAAJvirtual::19096-1https://scholar.google.es/citations?user=WLryvYoAAAAJvirtual::19098-10000-0002-8826-6211virtual::19096-10000-0003-0875-1709virtual::19098-1https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000699195virtual::19096-163debca4-c66a-465e-a43f-72049a27497avirtual::19096-163debca4-c66a-465e-a43f-72049a27497avirtual::19096-138584391-87dc-4841-a0cf-f0b9ea1ec603virtual::19098-158f3a1b1-0acf-4e4b-9259-13c8c7c4de84virtual::19099-138584391-87dc-4841-a0cf-f0b9ea1ec603virtual::19098-158f3a1b1-0acf-4e4b-9259-13c8c7c4de84virtual::19099-1ORIGINALAutorizacion tesis - Carlos Cárdenas.pdfAutorizacion tesis - Carlos Cárdenas.pdfHIDEapplication/pdf190476https://repositorio.uniandes.edu.co/bitstreams/fa823b47-9c5a-40fe-9b4d-2e6a6f6accc2/downloadeb0c0b5cc506ad7ebf8cad04000b7ddaMD52Mecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson.pdfMecanismos de retroalimentación sensitiva en la intensidad de la voz de pacientes con enfermedad de Parkinson.pdfapplication/pdf2775622https://repositorio.uniandes.edu.co/bitstreams/bf6a74af-5757-4363-ad48-d634747a879a/download799b0fe792fdda638528237af565c0caMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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