Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance

La revisión de alcance fue realizada teniendo en cuenta los lineamientos para revisiones de alcance proporcionados por la extensión PRISMA (PRISMA-ScR).

Autores:: Medina Trujillo, Geraldinne

Tipo de recurso:: Trabajo de grado de pregrado

Fecha de publicación:: 2022

Institución:: Universidad de los Andes

Repositorio:: Séneca: repositorio Uniandes

Idioma:: spa

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network_acronym_str	UNIANDES2
network_name_str	Séneca: repositorio Uniandes
repository_id_str
dc.title.none.fl_str_mv	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
title	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
spellingShingle	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance Morinda citrifolia noni efecto inmunomodulador salud humana revisión de alcance Microbiología
title_short	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
title_full	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
title_fullStr	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
title_full_unstemmed	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
title_sort	Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance
dc.creator.fl_str_mv	Medina Trujillo, Geraldinne
dc.contributor.advisor.none.fl_str_mv	Valderrama Aguirre, Augusto Elías
dc.contributor.author.none.fl_str_mv	Medina Trujillo, Geraldinne
dc.contributor.jury.none.fl_str_mv	Realpe Rebolledo, Emilio Antonio
dc.subject.keyword.none.fl_str_mv	Morinda citrifolia noni efecto inmunomodulador salud humana revisión de alcance
topic	Morinda citrifolia noni efecto inmunomodulador salud humana revisión de alcance Microbiología
dc.subject.themes.es_CO.fl_str_mv	Microbiología
description	La revisión de alcance fue realizada teniendo en cuenta los lineamientos para revisiones de alcance proporcionados por la extensión PRISMA (PRISMA-ScR).
publishDate	2022
dc.date.accessioned.none.fl_str_mv	2022-07-29T20:31:12Z
dc.date.available.none.fl_str_mv	2022-07-29T20:31:12Z
dc.date.issued.none.fl_str_mv	2022-07-28
dc.type.none.fl_str_mv	Trabajo de grado - Pregrado
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.content.es_CO.fl_str_mv	Text
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/TP
format	http://purl.org/coar/resource_type/c_7a1f
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/1992/59403
dc.identifier.instname.none.fl_str_mv	instname:Universidad de los Andes
dc.identifier.reponame.none.fl_str_mv	reponame:Repositorio Institucional Séneca
dc.identifier.repourl.none.fl_str_mv	repourl:https://repositorio.uniandes.edu.co/
url	http://hdl.handle.net/1992/59403
identifier_str_mv	instname:Universidad de los Andes reponame:Repositorio Institucional Séneca repourl:https://repositorio.uniandes.edu.co/
dc.language.iso.es_CO.fl_str_mv	spa
language	spa
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Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni). Angiogenesis, 6(2), 143-149. ttps://doi.org/10.1023/B:AGEN.0000011800.04507.4b Aziz, M. Y., Abu, N., Yeap, S. K., Ho, W. Y., Omar, A. R., Ismail, N. H., Ahmad, S., Pirozyan, M. R., Akhtar, N. M., & Alitheen, N. B. (2016). Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro. Molecules (Basel, Switzerland), 21(9), 1228. https://doi.org/10.3390/molecules21091228 Nualsanit, T., Rojanapanthu, P., Gritsanapan, W., Lee, S. H., Lawson, D., & Baek, S. J. (2012). Damnacanthal, a noni component, exhibits antitumorigenic activity in human colorectal cancer cells. The Journal of nutritional biochemistry, 23(8), 915-923. ttps://doi.org/10.1016/j.jnutbio.2011.04.017 Shaghayegh, G., Alabsi, A. M., Ali-Saeed, R., Ali, A. M., Vincent-Chong, V. K., Ismail, N. H., Choon, Y. F., & Zain, R. B. (2017). Effects of Damnacanthal and Nordamnacanthal on Proliferation, Apoptosis, and Migration of Oral Squamous Cell Carcinoma Cells. Asian Pacific journal of cancer prevention: APJCP, 18(12), 3333-3341. https://doi.org/10.22034/APJCP.2017.18.12.3333 Aziz, M. Y., Omar, A. R., Subramani, T., Yeap, S. K., Ho, W. Y., Ismail, N. H., Ahmad, S., & Alitheen, N. B. (2014). Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells. Oncology letters, 7(5), 1479-1484. https://doi.org/10.3892/ol.2014.1898 Kamiya, K., Hamabe, W., Tokuyama, S., Hirano, K., Satake, T., Kumamoto-Yonezawa, Y., Yoshida, H., Mizushina, Y. (2010). Inhibitory effect of anthraquinones isolated from the Noni (Morinda citrifolia) root on animal A-, B- and Y-families of DNA polymerases and human cancer cell proliferation. Food Chemistry, 118(3), 725-730. https://doi.org/10.1016/j.foodchem.2009.05.053 Thani, W., Vallisuta, O., Siripong, P., & Ruangwises, N. (2010). Anti-proliferative and antioxidative activities of Thai noni/Yor (Morinda citrifolia Linn.) leaf extract. The Southeast Asian journal of tropical medicine and public health, 41(2), 482-489. Huang, H. L., Liu, C. T., Chou, M. C., Ko, C. H., & Wang, C. K. (2015). Noni (Morinda citrifolia L.) Fruit Extracts Improve Colon Microflora and Exert Anti-Inflammatory Activities in Caco-2 Cells. Journal of medicinal food, 18(6), 663-676. https://doi.org/10.1089/jmf.2014.3213 Inada, A. C., Figueiredo, P. S., Santos-Eichler, R., Freitas, K. C., Hiane, P. A., Castro, A. P., & Guimarães, R. (2017). Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction. Nutrients, 9(6), 540. https://doi.org/10.3390/nu9060540 Fletcher, H. M., Dawkins, J., Rattray, C., Wharfe, G., Reid, M., & Gordon-Strachan, G. (2013). Morinda citrifolia (Noni) as an Anti-Inflammatory Treatment in Women with Primary Dysmenorrhoea: A Randomised Double-Blind Placebo-Controlled Trial. Obstetrics and gynecology international, 2013, 195454. https://doi.org/10.1155/2013/195454 West, B. J., Deng, S., Palu, A. K., & Jensen, C. J. (2009). Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema. Journal of natural medicines, 63(3), 351-354. https://doi.org/10.1007/s11418-009-0327-7 Masuda, M., Murata, K., Naruto, S., Uwaya, A., Isami, F., & Matsuda, H. (2012). Matrix metalloproteinase-1 inhibitory activities of Morinda citrifolia seed extract and its constituents in UVA-irradiated human dermal fibroblasts. Biological & pharmaceutical bulletin, 35(2), 210-215. https://doi.org/10.1248/bpb.35.210 Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umezawa, K., Ito, H., & Suzuki, N. (1999). Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS letters, 444(2-3), 173-176. https://doi.org/10.1016/s0014-5793(99)00057-5 Oh, J. S., Seong, G. S., Kim, Y. D., & Choung, S. Y. (2021). Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells. Molecules (Base, Switzerland), 26(11), 3298. https://doi.org/10.3390/molecules26113298 Huang, H. L., Ko, C. H., Yan, Y. Y., & Wang, C. K. (2014). Antiadhesion and anti-inflammation effects of noni (Morinda citrifolia) fruit extracts on AGS cells during Helicobacter pylori infection. Journal of agricultural and food chemistry, 62(11), 2374-2383. https://doi.org/10.1021/jf405199w Lee, D. S., Keo, S., Cheng, S. K., Oh, H., & Kim, Y. C. (2017). Protective effects of Cambodian medicinal plants on tertbutyl hydroperoxide induced hepatotoxicity via Nrf2 mediated heme oxygenase1. Molecular medicine reports, 15(1), 451-459. https://doi.org/10.3892/mmr.2016.6011 Cornejo, F., Asmat, A., & Ruez, R. (2014). Post Exodontia Analgesic Effect of Morinda citrifolia (Noni): A Randomized Clinical Trial in Parallel Groups. International Journal of Odontostomatology, 8(3), 433-438. Chen, J., Shi, X., Chen, Y., Liang, H., Cheng, C., & He, Q. (2018). Neuroprotective effects of chloroform and aqueous fractions of noni juice against t-Butyl hydroperoxide-induced oxidative damage in SH-SY5Y cells. Food & nutrition research, 62, 10.29219/fnr.v62.1605. https://doi.org/10.29219/fnr.v62.1605 Nima, S., Kasiwong, S., Ridtitid, W., Thaenmanee, N., & Mahattanadul, S. (2012). Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. Journal of ethnopharmacology, 142(2), 354-361. https://doi.org/10.1016/j.jep.2012.04.044 Algenstaedt, P., Stumpenhagen, A., & Westendorf, J. (2018). The Effect of Morinda citrifolia L. Fruit Juice on the Blood Sugar Level and Other Serum Parameters in Patients with Diabetes Type 2. Evidence-based complementary and alternative medicine: eCAM, 2018, 3565427. https://doi.org/10.1155/2018/3565427 Sabitha, P., Adhikari Prabha, M. R., Shetty Rukmini, M. S., Anupama, H., & Asha, K. (2009). The beneficial effects of Noni fruit juice in diabetic patients. Journal of Clinical and Diagnostic Research, 3(6), 1822-1826. Kusirisin, W., Srichairatanakool, S., Lerttrakarnnon, P., Lailerd, N., Suttajit, M., Jaikang, C., & Chaiyasut, C. (2009). Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Medicinal chemistry (Shariqah (United Arab Emirates)), 5(2), 139-147. https://doi.org/10.2174/157340609787582918 West, B.J., Martínez, R., Cano, M., White, A., Palu, A.K., Jensen, C.J., & Deng, S. (2013). Noni Fruit Juice May Increase Oxygen Uptake in Athletes During Exercise. Current Research Journal of Biological Sciences, 5(4), 177-181. Anugweje, K.C., & Io, O. (2012). Effect of Noni Supplementation on the Serum Creatine Kinase (CK) Levels of Athletes. World Journal of Sport Sciences, 7 (1), 41-47. Palu, A.K., Seifulla, R. D., & West, B.J. (2008). Morinda citrifolia L.(noni) improves athlete endurance: Its mechanisms of action. Journal of Medicinal Plants Research. 2(7), 154-158. Palu, A. K., West, B. J., & Jensen, J. (2011). Noni-based nutritional supplementation and exercise interventions influence body composition. North American journal of medical sciences, 3(12), 552-556. https://doi.org/10.4297/najms.2011.3552 Prapaitrakool, S., & Itharat, A. (2010). Morinda citrifolia Linn. for prevention of postoperative nausea and vomiting. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 93 Suppl 7, S204-S209.
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spelling	Attribution-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Valderrama Aguirre, Augusto Elías1dcca6a6-7238-415f-8a9d-6efd686127b6600Medina Trujillo, Geraldinnec678521c-d514-41d7-b625-279163fec0c0600Realpe Rebolledo, Emilio Antonio2022-07-29T20:31:12Z2022-07-29T20:31:12Z2022-07-28http://hdl.handle.net/1992/59403instname:Universidad de los Andesreponame:Repositorio Institucional Sénecarepourl:https://repositorio.uniandes.edu.co/La revisión de alcance fue realizada teniendo en cuenta los lineamientos para revisiones de alcance proporcionados por la extensión PRISMA (PRISMA-ScR).Morinda citrifolia o noni es una planta a la que se le atribuyen variedad de efectos positivos para la salud humana, sin embargo los estudios sobre su mecanismo de acción y efecto sobre los humanos son aun limitados. La presente revisión de alcance tuvo como fin reunir toda la evidencia formalmente publicada en la literatura científica disponible sobre el potencial inmunomodulador del noni en humanos y sintetizarla. Se encontró y procesó una cantidad total de 5.584 registros y fueron incluidos 101 estudios como elegibles, en los cuales se confirmó el potencial de la planta y sus componentes sobre el sistema inmune.MicrobiólogoPregrado79 páginasapplication/pdfspaUniversidad de los AndesMicrobiologíaFacultad de CienciasDepartamento de Ciencias BiológicasPotencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcanceTrabajo de grado - Pregradoinfo:eu-repo/semantics/bachelorThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1fTexthttp://purl.org/redcol/resource_type/TPMorinda citrifolianoniefecto inmunomoduladorsalud humanarevisión de alcanceMicrobiologíaAlmeida, É. S., de Oliveira, D., & Hotza, D. (2019). Properties and Applications of Morinda citrifolia (Noni): A Review. In Comprehensive Reviews in Food Science and Food Safety, 18(4), 883-909. https://doi.org/10.1111/1541-4337.12456Chan-Blanco, Y., Vaillant, F., Mercedes Perez, A., Reynes, M., Brillouet, J. M., & Brat, P. (2006). The noni fruit (Morinda citrifolia L.): A review of agricultural research, nutritional and therapeutic properties. Journal of Food Composition and Analysis, 19(6-7), 645-654. https://doi.org/10.1016/J.JFCA.2005.10.001Dixon, A. R., McMillen, H., & Etkin, N. L. (1999). Ferment this: The transformation of Noni, a traditional polynesian medicine (Morinda Citrifolia, Rubiaceae). Economic Botany 1999 53:1, 53(1), 51-68. https://doi.org/10.1007/BF02860792Holanda, L., Bezerra, G. B., & Ramos, C. S. (2020). Potent Antifungal Activity of Essential Oil from Morinda Citrifolia Fruits Rich in Short-chain Fatty Acids. International Journal of Fruit Science, 20(S2), S448-S454. https://doi.org/10.1080/15538362.2020.1738975Jahurul, M. H. A., Patricia, M., Shihabul, A., Norazlina, M. R., Ramlah George, M. R., Noorakmar, A. W., Lee, J. S., Jumardi, R., Jinap, S., & Zaidul, I. S. M. (2021). A review on functional and nutritional properties of noni fruit seed (Morinda citrifolia L.) and its oil. Food Bioscience, 41. https://doi.org/10.1016/J.FBIO.2021.101000Potterat, O., & Hamburger, M. (2007). Morinda citrifolia (Noni) fruit - Phytochemistry, pharmacology, safety. Planta Medica, 73(3), 191-199. https://doi.org/10.1055/S-2007-967115Lohani, M., Majrashi, M., Govindarajulu, M., Patel, M., Ramesh, S., Bhattacharya, D., Joshi, S., Fadan, M., Nadar, R., Darien, B., Maurice, D. v., Kemppainen, B., & Dhanasekaran, M. (2019). Immunomodulatory actions of a Polynesian herb Noni (Morinda citrifolia) and its clinical applications. Complementary Therapies in Medicine, 47, 102206. https://doi.org/10.1016/J.CTIM.2019.102206Torres, M. A. O., de Fátima Braga Magalhães, I., Mondêgo-Oliveira, R., de Sá, J. C., Rocha, A. L., & Abreu-Silva, A. L. (2017). One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia. Phytotherapy Research, 31(7), 971-979. https://doi.org/10.1002/PTR.5817Nerurkar, P. v., Hwang, P. W., & Saksa, E. (2015). Anti-Diabetic Potential of Noni: The Yin and the Yang. Molecules 2015, Vol. 20, Pages 17684-17719, 20(10), 17684-17719. https://doi.org/10.3390/MOLECULES201017684West, B. J., Deng, S., Isami, F., Uwaya, A., & Jensen, C. J. (2018). The Potential Health Benefits of Noni Juice: A Review of Human Intervention Studies. Foods, 7(4), 58. https://doi.org/10.3390/FOODS7040058Gupta, R. K., & Patel, A. K. (2013). Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects. Asian Pacific Journal of Cancer Prevention, 14(8), 4495-4499. https://doi.org/10.7314/APJCP.2013.14.8.4495Cooper, S., Cant, R., Kelly, M., Levett-Jones, T., McKenna, L., Seaton, P., & Bogossian, F. (2021). An Evidence-Based Checklist for Improving Scoping Review Quality. Clinical Nursing Research, 30(3), 230240. https://doi.org/10.1177/1054773819846024The EQUATOR Network. (2021, November 19). PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. https://www.equator-network.org/reporting-guidelines/prisma-scr/Tricco, A. C., Lillie, E., Zarin, W., O'Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., Straus, S. E. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. In Annals of Internal Medicine (Vol. 169, Issue 7). https://doi.org/10.7326/M18-0850Cooke, A., Smith, D., & Booth, A. (2012). Beyond PICO: the SPIDER tool for qualitative evidence synthesis. Qualitative Health Research, 22(10), 1435-1443. https://doi.org/10.1177/1049732312452938Davies, K. S. (2011). Formulating the evidence based practice question: A review of the frameworks. Evidence Based Library and Information Practice, 6(2), 75-80. https://doi.org/10.18438/B8WS5NWinona State University. (2021, November 22). Evidence Based Practice Toolkit. https://libguides.winona.edu/ebptoolkit/Levels-EvidenceKodolitsch, Y. von, Bernhardt, A. M., Robinson, P. N., Kölbel, T., Reichenspurner, H., Debus, S., & Detter, C. (2015). Analysis of Strengths, Weaknesses, Opportunities, and Threats as a Tool for Translating Evidence into Individualized Medical Strategies (I-SWOT). AORTA Journal, 3(3), 98. https://doi.org/10.12945/J.AORTA.2015.14.064Chaitanya, B. V., Somisetty, K. V., Diwan, A., Pasha, S., Shetty, N., Reddy, Y., & Nadigar, S. (2016). Comparison of Antibacterial Efficacy of Turmeric Extract, Morinda Citrifolia and 3% Sodium Hypochlorite on Enterococcus faecalis: An In-vitro Study. Journal of clinical and diagnostic research: JCDR, 10(10), ZC55-ZC57. https://doi.org/10.7860/JCDR/2016/19718.8650Podar, R., Kulkarni, G. P., Dadu, S. S., Singh, S., & Singh, S. H. (2015). In vivo antimicrobial efficacy of 6% Morinda citrifolia, Azadirachta indica, and 3% sodium hypochlorite as root canal irrigants. European journal of dentistry, 9(4), 529-534. https://doi.org/10.4103/1305-7456.172615Choudhary, E., Indushekar, K. R., Saraf, B. G., Sheoran, N., Sardana, D., & Shekhar, A. (2018). Exploring the role of Morinda citrifolia and Triphala juice in root canal irrigation: An ex vivo study. Journal of conservative dentistry: JCD, 21(4), 443-449. https://doi.org/10.4103/JCD.JCD_58_18Divia, A. R., Nair, M. G., Varughese, J. M., & Kurien, S. (2018). A comparative evaluation of Morinda citrifolia, green tea polyphenols, and Triphala with 5% sodium hypochlorite as an endodontic irrigant against Enterococcus faecalis: An in vitro study. Dental research journal, 15(2), 117-122.Chandwani, M., Mittal, R., Chandak, S., & Pimpale, J. (2017). Effectiveness of Morinda citrifolia juice as an intracanal irrigant in deciduous molars: An in vivo study. Dental research journal, 14(4), 246-251. https://doi.org/10.4103/1735-3327.211630Murray, P. E., Farber, R. M., Namerow, K. N., Kuttler, S., & Garcia-Godoy, F. (2008). Evaluation of Morinda citrifolia as an endodontic irrigant. Journal of endodontics, 34(1), 66-70. https://doi.org/10.1016/j.joen.2007.09.016Tyagi, S. P., Sinha, D. J., Garg, P., Singh, U. P., Mishra, C. C., & Nagpal, R. (2013). Comparison of antimicrobial efficacy of propolis, Morinda citrifolia, Azadirachta indica (Neem) and 5% sodium hypochlorite on Candida albicans biofilm formed on tooth substrate: An in-vitro study. Journal of conservative dentistry: JCD, 16(6), 532-535. https://doi.org/10.4103/0972-0707.120973Bhardwaj, A., Ballal, S., & Velmurugan, N. (2012). Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study. Journal of conservative dentistry: JCD, 15(3), 293-297. https://doi.org/10.4103/0972-0707.97964Kandaswamy, D., Venkateshbabu, N., Gogulnath, D., & Kindo, A. J. (2010). Dentinal tubule disinfection with 2% chlorhexidine gel, propolis, morinda citrifolia juice, 2% povidone iodine, and calcium hydroxide. International endodontic journal, 43(5), 419¿423. https://doi.org/10.1111/j.1365-2591.2010.01696.xRosaline, H., Kandaswamy, D., Gogulnath, D., & Rubin, M. (2013). Influence of various herbal irrigants as a final rinse on the adherence of Enterococcus faecalis by fluorescence confocal laser scanning microscope. 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P., Mele, R., Leto, A., Fuschi, A., Al Salhi, Y., Velotti, G., Al Rawashdah, S., Coppola, G., Maurizi, A., Maruccia, S., & Pastore, A. L. (2017). Prospective study to compare antibiosis versus the association of N-acetylcysteine, D-mannose and Morinda citrifolia fruit extract in preventing urinary tract infections in patients submitted to urodynamic investigation. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 89(1), 45-50. https://doi.org/10.4081/aiua.2017.1.45Selvam, P., Murugesh, N., Witvrouw, M., Keyaerts, E., & Neyts, J. (2009). Studies of Antiviral Activity and Cytotoxicity of Wrightia tinctoria and Morinda citrifolia. Indian journal of pharmaceutical sciences, 71(6), 670-672. https://doi.org/10.4103/0250-474X.59550Ratnoglik, S. L., Aoki, C., Sudarmono, P., Komoto, M., Deng, L., Shoji, I., Fuchino, H., Kawahara, N., & Hotta, H. (2014). 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The Effects of Morinda citrifolia (Noni) on the Cellular Viability and Osteogenesis of Stem Cell Spheroids. Medicina (Kaunas, Lithuania), 56(8), 389. https://doi.org/10.3390/medicina56080389Gu, H., Boonanantanasarn, K., Kang, M., Kim, I., Woo, K. M., Ryoo, H. M., & Baek, J. H. (2018). Morinda citrifolia Leaf Extract Enhances Osteogenic Differentiation Through Activation of Wnt/-Catenin Signaling. Journal of medicinal food, 21(1), 57-69. https://doi.org/10.1089/jmf.2017.3933Boonanantanasarn, K., Janebodin, K., Suppakpatana, P., Arayapisit, T., Rodsutthi, J. A., Chunhabundit, P., Boonanuntanasarn, S., & Sripairojthikoon, W. (2014). Morinda citrifolia leaves enhance osteogenic differentiation and mineralization of human periodontal ligament cells. Dental materials journal, 33(2), 157- 165. https://doi.org/10.4012/dmj.2012-053-rSong, Y. M., Lee, H. J., Min, S. K., Park, Y. H., Oh, J. K., Kim, J. Y., & Park, J. B. (2022). 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Journal of Medicinal Plants Research. 2(7), 154-158.Palu, A. K., West, B. J., & Jensen, J. (2011). Noni-based nutritional supplementation and exercise interventions influence body composition. North American journal of medical sciences, 3(12), 552-556. https://doi.org/10.4297/najms.2011.3552Prapaitrakool, S., & Itharat, A. (2010). Morinda citrifolia Linn. for prevention of postoperative nausea and vomiting. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 93 Suppl 7, S204-S209.201615610PublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8799https://repositorio.uniandes.edu.co/bitstreams/d41e5d38-5399-4958-ad1c-bb4a4e61371f/downloadf7d494f61e544413a13e6ba1da2089cdMD52ORIGINALPotencial inmunomodulador de la planta Morinda citrifolia (noni). Revisión de alcance.pdfPotencial inmunomodulador de la planta Morinda citrifolia (noni). 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Potencial inmunomodulador de la planta Morinda citrifolia (noni): revisión de alcance

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