Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica

La valoración del estado nutricional en pacientes con condiciones crónicas como el cáncer ha tomado vital importancia tanto en el manejo como en el desenlace de la patología, ya que conocer el estado nutricional y la composición corporal total de base puede permitir hacer intervenciones previas y op...

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Autores:
Gallo Tapias, Manuela
Aguirre Matallana, Diego Andrés
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2024
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
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oai:repositorio.unbosque.edu.co:20.500.12495/12766
Acceso en línea:
https://hdl.handle.net/20.500.12495/12766
Palabra clave:
Sarcopenia
Neoplasias peritoneales
Procedimientos quirúrgicos de citorreducción
Quimioterapia intraperitoneal hipertérmica
Sarcopenia
Peritoneal Neoplasms
Cytoreduction Surgical Procedures
hyperthermic Intraperitoneal Chemotherapy
WN 100
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openAccess
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Atribución-NoComercial-CompartirIgual 4.0 Internacional
id UNBOSQUE2_fe4d1d5096e7e406ee4339ddbdfa8eb6
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repository_id_str
dc.title.none.fl_str_mv Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
dc.title.translated.none.fl_str_mv Sarcopenia and Postoperative Outcomes in Patients with Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery Plus Hyperthermic Chemotherapy
title Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
spellingShingle Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
Sarcopenia
Neoplasias peritoneales
Procedimientos quirúrgicos de citorreducción
Quimioterapia intraperitoneal hipertérmica
Sarcopenia
Peritoneal Neoplasms
Cytoreduction Surgical Procedures
hyperthermic Intraperitoneal Chemotherapy
WN 100
title_short Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
title_full Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
title_fullStr Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
title_full_unstemmed Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
title_sort Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica
dc.creator.fl_str_mv Gallo Tapias, Manuela
Aguirre Matallana, Diego Andrés
dc.contributor.advisor.none.fl_str_mv Lineros Montañez, Alberto
dc.contributor.author.none.fl_str_mv Gallo Tapias, Manuela
Aguirre Matallana, Diego Andrés
dc.contributor.orcid.none.fl_str_mv Gallo Tapias, Manuela [0000-0002-5092-5971]
Aguirre Matallana, Diego Andrés [0000-0002-7352-8362]
dc.subject.none.fl_str_mv Sarcopenia
Neoplasias peritoneales
Procedimientos quirúrgicos de citorreducción
Quimioterapia intraperitoneal hipertérmica
topic Sarcopenia
Neoplasias peritoneales
Procedimientos quirúrgicos de citorreducción
Quimioterapia intraperitoneal hipertérmica
Sarcopenia
Peritoneal Neoplasms
Cytoreduction Surgical Procedures
hyperthermic Intraperitoneal Chemotherapy
WN 100
dc.subject.keywords.none.fl_str_mv Sarcopenia
Peritoneal Neoplasms
Cytoreduction Surgical Procedures
hyperthermic Intraperitoneal Chemotherapy
dc.subject.nlm.none.fl_str_mv WN 100
description La valoración del estado nutricional en pacientes con condiciones crónicas como el cáncer ha tomado vital importancia tanto en el manejo como en el desenlace de la patología, ya que conocer el estado nutricional y la composición corporal total de base puede permitir hacer intervenciones previas y oportunas que conlleven mejores desenlaces clínicos. Poder intervenir para disminuir complicaciones asociadas a los tratamientos, y tal vez, impactar en complicaciones inherentes de la enfermedad como lo son el desacondicionamiento y síndromes clínicos como la sarcopenia, permite disminuir complicaciones y mejorar la calidad de vida de los pacientes. Nuevos métodos de análisis del estado nutricional de los pacientes han permitido detectar la pérdida de masa muscular a través de métodos no invasivos y la sarcopenia se ha relacionado con peores desenlaces clínicos en otros escenarios clínicos. Determinar la relación entre la sarcopenia y los desenlaces postoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica (CCR + HIPEC) en la Fundación Santa Fe de Bogotá entre el año 2010 y el año 2022.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-30T15:46:38Z
dc.date.available.none.fl_str_mv 2024-07-30T15:46:38Z
dc.date.issued.none.fl_str_mv 2024-07
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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format https://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/12766
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv instname:Universidad El Bosque
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dc.language.iso.fl_str_mv spa
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dc.relation.references.none.fl_str_mv 1. Pletcher E, Gleeson E, Labow D. Peritoneal cancers and hyperthermic intraperitoneal chemotherapy. The Surgical clinics of North America. 2020;100(3):589-613. https://dx.doi.org/10.1016/j.suc.2020.02.009. doi: 10.1016/j.suc.2020.02.009.
2. Coccolini F, Gheza F, Lotti M, et al. Peritoneal carcinomatosis. World journal of gastroenterology : WJG. 2013;19(41):6979-6994. https://www.ncbi.nlm.nih.gov/pubmed/24222942. doi: 10.3748/wjg.v19.i41.6979.
3. Brücher BL, Piso P, Verwaal V, Esquivel J, Derraco M, Yonemura Y, Gonzalez-Moreno S, Pelz J, Königsrainer A, Ströhlein M, Levine EA, Morris D, Bartlett D, Glehen O, Garofalo A, Nissan A. Peritoneal carcinomatosis: cytoreductive surgery and HIPEC--overview and basics. Cancer Invest. 2012 Mar;30(3):209-24. doi: 10.3109/07357907.2012.654871. PMID: 22360361.
4. Martin L, Birdsell lL Macdonald N, et al. Cancer cachexia in the age of obesity: Skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. Journal of clinical oncology. 2013;31(12):1539-1547
5. Bossi P, Delrio P, Mascheroni A, Zanetti M. The spectrum of malnutrition/cachexia/sarcopenia in oncology according to different cancer types and settings: A narrative review. Nutrients. 2021;13(6):1980. https://search.proquest.com/docview/2544926440. doi: 10.3390/nu13061980.
6. Galan A, Rousset P, Mercier F, et al. Overall survival of pseudomyxoma peritonei and peritoneal mesothelioma patients after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy can be predicted by computed tomography quantified sarcopenia. European journal of surgical oncology. 2018;44(11):1818-1823. https://dx.doi.org/10.1016/j.ejso.2018.07.060. doi: 10.1016/j.ejso.2018.07.060.
7. Rier H, Jager A, Sleijfer S, Maier A, Levin M. The prevalence and prognostic value of low muscle mass in cancer patients: A review of the literature. The oncologist (Dayton, Ohio). 2016;21(11):1396-1409. https://www.narcis.nl/publication/RecordID/oai:repub.eur.nl:96560. doi: 10.1634/theoncologist.2016-0066
8. Xia L, Zhao R, Wan Q, et al. Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies. Cancer Med. 2020;9(21):7964. doi: 10.1002/cam4.3428.
9. Fuggle, N., Shaw, S., Dennison, E., Cooper, C., 2017. Sarcopenia. Best Practice & Research Clinical Rheumatology 31, 218–242.. doi:10.1016/j.berh.2017.11.007
10. Arias F, Otero JM, Londoño E, et al. Morbilidad y mortalidad en una serie de pacientes con neoplasias del peritoneo, tratados con citorreducción peritoneal más quimioterapia hipertérmica intraperitoneal en el hospital universitario de la fundación santa fe de bogotá ( ONCOLGroup - estudio ATIA). Revista de Gastroenterología de México. 2011;77(2):66-75. https://www.clinicalkey.es/playcontent/1-s2.0-S0375090612000031. doi: 10.1016/j.rgmx.2012.03.001.
11. Miller J, Wynn WH. A malignant tumour arising from the endothelium of the peritoneum, and producing a mucoid ascitic fluid. Journal of pathology and bacteriology. 1908;12(2):267-278. https://api.istex.fr/ark:/67375/WNG-G7BSZ70D-K/fulltext.pdf. doi: 10.1002/path.1700120212.
12. Cortés-Guiral, D., Hübner, M., Alyami, M., Bhatt, A., Ceelen, W., Glehen, O., Lordick, F., Ramsay, R., Sgarbura, O., Van Der Speeten, K., Turaga, K.K., Chand, M., 2021. Primary and metastatic peritoneal surface malignancies. Nature Reviews Disease Primers 7.. doi:10.1038/s41572-021-00326-6
13. Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A. Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. British journal of surgery. 2012;99(5):699-705. https://api.istex.fr/ark:/67375/WNG-LZCHLLJH-T/fulltext.pdf. doi: 10.1002/bjs.8679.
14. Dedrick RL. Theoretical and experimental bases of intraperitoneal chemotherapy. Semin Oncol. 1985 Sep;12(3 Suppl 4):1-6. PMID: 4048968.
15. Sugarbaker PH. Peritonectomy procedures. In: Cancer treatment and research. Vol 82. Boston, MA: Springer US; 1996:235-253. http://link.springer.com/10.1007/978-1-4613-1247-5_15. 10.1007/978-1-4613-1247-5_15.
16. Bhatt, A., De Hingh, I., Van Der Speeten, K., Hubner, M., Deraco, M., Bakrin, N., Villeneuve, L., Kusamura, S., Glehen, O., 2021. HIPEC Methodology and Regimens: The Need for an Expert Consensus. Annals of Surgical Oncology 28, 9098–9113. doi:10.1245/s10434-021-10193-w
17. Agalar C, Sokmen S, Arslan C, et al. The impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A 10-year longitudinal analysis of a single-center experience. Techniques in coloproctology. 2020;24(4):301-308. https://www.ncbi.nlm.nih.gov/pubmed/32080800. doi: 10.1007/s10151-020-02159-z.
18. Elzarkaa, A.A., Shaalan, W., Elemam, D., Mansour, H., Melis, M., Malik, E., Soliman, A.A., 2018. Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: a prospective study. Journal of Gynecologic Oncology 29.. doi:10.3802/jgo.2018.29.e47.
19. Cruz-Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T., Landi, F., Martin, F.C., Michel, J.-P., Rolland, Y., Schneider, S.M., Topinkova, E., Vandewoude, M., Zamboni, M., 2010. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing 39, 412–423.. doi:10.1093/ageing/afq034
20. Murray, T.É., Williams, D., Lee, M.J., 2017. Osteoporosis, obesity, and sarcopenia on abdominal CT: a review of epidemiology, diagnostic criteria, and management strategies for the reporting radiologist. Abdominal Radiology 42, 2376–2386.. doi:10.1007/s00261-017-1124-5
21. Marty E, Liu Y, Samuel A, Or O, Lane J. A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease. Bone. 2017;105:276-86.
22. Sergi G, Trevisan C, Veronese N, Lucato P, Manzato E. Imaging of sarcopenia. Eur J Radiol. 2016;85(8):1519-24.
23. Albano, D., Messina, C., Vitale, J., Sconfienza, L.M., 2020. Imaging of sarcopenia: old evidence and new insights. European Radiology 30, 2199–2208.. doi:10.1007/s00330-019-06573-2
24. Boutin RD, Yao L, Canter RJ, Lenchik L. Sarcopenia: Current Concepts and Imaging Implications. AJR Am J Roentgenol. 2015;205(3):W255-66.
25. Daly LE, Prado CM, Ryan AM. A window beneath the skin: how computed tomography assessment of body composition can assist in the identification of hidden wasting conditions in oncology that profoundly impact outcomes. Proc Nutr Soc. 2018 May;77(2):135-151. doi: 10.1017/S0029665118000046. PMID: 29745361.
26. Prado, C.M.; Lieffers, J.R.; McCargar, L.J.; Reiman, T.; Sawyer, M.B.; Martin, L.; Baracos, V.E. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study. Lancet Oncol. 2008, 9, 629–635
27. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011 May;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7. Epub 2011 Feb 4. PMID: 21296615.
28. Yang YX, Chong MS, Lim WS, Tay L, Yew S, Yeo A, et al. Validity of estimating muscle and fat volume from a single MRI section in older adults with sarcopenia and sarcopenic obesity. Clin Radiol. 2017;72(5):427 e9- e14.
29. Freudenberger DC, Vudatha V, Riner AN, Herremans KM, Fernandez LJ, Trevino JG. A Review of the Clinical Implications of Cachexia, Sarcopenia, and BMI in Patients with Peritoneal Carcinomatosis Receiving Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Cancers (Basel). 2022 Jun 9;14(12):2853. doi: 10.3390/cancers14122853. PMID: 35740519; PMCID: PMC9221457.
30. Pickhardt PJ, Graffy PM, Perez AA, Lubner MG, Elton DC, Summers RM. Opportunistic Screening at Abdominal CT: Use of Automated Body Composition Biomarkers for Added Cardiometabolic Value. Radiographics. 2021 Mar-Apr;41(2):524-542. doi: 10.1148/rg.2021200056. PMID: 33646902; PMCID: PMC7924410.
31. Chemama S, Bayar MA, Lanoy E, et al. Sarcopenia is associated with chemotherapy toxicity in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal cancer. Ann Surg Oncol. 2016;23(12):3891. doi: 10.1245/s10434-016-5360-7.
32. Juris A, Taylor-Gehman A, Spencer B, Schaefer E, Pameijer C. The Impact of Sarcopenia in Patients with Peritoneal Surface Disease. Pathol Oncol Res. 2021 Aug 30;27:638857. doi: 10.3389/pore.2021.638857. PMID: 34526857; PMCID: PMC8435582.
33. van Vugt JL, Braam HJ, van Oudheusden TR, Vestering A, Bollen TL, Wiezer MJ, de Hingh IH, van Ramshorst B, Boerma D. Skeletal Muscle Depletion is Associated with Severe Postoperative Complications in Patients Undergoing Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Colorectal Cancer. Ann Surg Oncol. 2015 Oct;22(11):3625-31. doi: 10.1245/s10434-015-4429-z. Epub 2015 Feb 12. Erratum in: Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1610. PMID: 25672564.
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35. Banaste N, Rousset P, Mercier F, Rieussec C, Valette PJ, Glehen O, Passot G. Preoperative nutritional risk assessment in patients undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for colorectal carcinomatosis. Int J Hyperthermia. 2018 Aug;34(5):589-594. doi: 10.1080/02656736.2017.1371342. Epub 2017 Sep 3. PMID: 28828897.
36. Dietz MV, van Kooten JP, van Vugt JLA, Brandt-Kerkhof ARM, Verhoef C, Madsen EVE. The Impact of Low Skeletal Muscle Mass on Short- and Long-Term Outcomes After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2022 Sep;29(9):5830-5841. doi: 10.1245/s10434-022-11941-2. Epub 2022 Jun 1. PMID: 35650370; PMCID: PMC9356922.
37. Al Khaldi M, Fellouah M, Drolet P, Côté J, Trilling B, Brind'Amour A, Dugas A, Tremblay JF, Fortin S, De Guerké L, Auclair MH, Dubé P, Soucisse M, Sideris L. The Impact of Computed Tomography Measurements of Sarcopenia on Postoperative and Oncologic Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Curr Oncol. 2022 Nov 29;29(12):9314-9324. doi: 10.3390/curroncol29120730. PMID: 36547144; PMCID: PMC9777197.
38. Di Giorgio A, Rotolo S, Cintoni M, Rinninella E, Pulcini G, Schena CA, Ferracci F, Grassi F, Raoul P, Moroni R, Pacelli F, Gasbarrini A, Mele MC. The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorectal cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 2022 Mar;48(3):649-656. doi: 10.1016/j.ejso.2021.10.008.
39. Gearing PF, Hawke JA, Mohan H, Heriot AG, Khan A, Beaumont A, Laing E, Waters PS. Perioperative nutritional assessment and interventions in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): A systematic review. Eur J Surg Oncol. 2023 May;49(5):902-917. doi: 10.1016/j.ejso.2023.02.015.
40. Amini B, Boyle SP, Boutin RD, Lenchik L. Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review. J Gerontol A Biol Sci Med Sci. 2019 Sep 15;74(10):1671-1678. doi: 10.1093/gerona/glz034. PMID: 30726878; PMCID: PMC7357454.
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spelling Lineros Montañez, AlbertoGallo Tapias, ManuelaAguirre Matallana, Diego AndrésGallo Tapias, Manuela [0000-0002-5092-5971]Aguirre Matallana, Diego Andrés [0000-0002-7352-8362]2024-07-30T15:46:38Z2024-07-30T15:46:38Z2024-07https://hdl.handle.net/20.500.12495/12766instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLa valoración del estado nutricional en pacientes con condiciones crónicas como el cáncer ha tomado vital importancia tanto en el manejo como en el desenlace de la patología, ya que conocer el estado nutricional y la composición corporal total de base puede permitir hacer intervenciones previas y oportunas que conlleven mejores desenlaces clínicos. Poder intervenir para disminuir complicaciones asociadas a los tratamientos, y tal vez, impactar en complicaciones inherentes de la enfermedad como lo son el desacondicionamiento y síndromes clínicos como la sarcopenia, permite disminuir complicaciones y mejorar la calidad de vida de los pacientes. Nuevos métodos de análisis del estado nutricional de los pacientes han permitido detectar la pérdida de masa muscular a través de métodos no invasivos y la sarcopenia se ha relacionado con peores desenlaces clínicos en otros escenarios clínicos. Determinar la relación entre la sarcopenia y los desenlaces postoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmica (CCR + HIPEC) en la Fundación Santa Fe de Bogotá entre el año 2010 y el año 2022.Fundación Santa Fe de BogotáEspecialista en Radiología e Imágenes DiagnósticasEspecializaciónThe assessment of nutritional status in patients with chronic conditions such as cancer has become vitally important in both the management and outcome of the disease. Knowing the baseline nutritional status and total body composition can allow for early and timely interventions that lead to better clinical outcomes. Intervening to reduce treatment-associated complications and possibly impact disease-inherent complications such as deconditioning and clinical syndromes like sarcopenia can reduce complications and improve patient's quality of life. New methods of analyzing patients' nutritional status have enabled the detection of muscle mass loss through non-invasive procedures, and sarcopenia has been associated with worse clinical outcomes in other clinical scenarios. To determine the relationship between sarcopenia and postoperative outcomes in patients with peritoneal carcinomatosis undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) at Fundación Santa Fe de Bogotá between 2010 and 2022.application/pdfAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2SarcopeniaNeoplasias peritonealesProcedimientos quirúrgicos de citorreducciónQuimioterapia intraperitoneal hipertérmicaSarcopeniaPeritoneal NeoplasmsCytoreduction Surgical Procedureshyperthermic Intraperitoneal ChemotherapyWN 100Sarcopenia y desenlaces posoperatorios en pacientes con carcinomatosis peritoneal llevados a cirugía de citorreducción más quimioterapia hipertérmicaSarcopenia and Postoperative Outcomes in Patients with Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery Plus Hyperthermic ChemotherapyEspecialización en Radiología e Imágenes DiagnósticasUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. Pletcher E, Gleeson E, Labow D. Peritoneal cancers and hyperthermic intraperitoneal chemotherapy. The Surgical clinics of North America. 2020;100(3):589-613. https://dx.doi.org/10.1016/j.suc.2020.02.009. doi: 10.1016/j.suc.2020.02.009.2. Coccolini F, Gheza F, Lotti M, et al. Peritoneal carcinomatosis. World journal of gastroenterology : WJG. 2013;19(41):6979-6994. https://www.ncbi.nlm.nih.gov/pubmed/24222942. doi: 10.3748/wjg.v19.i41.6979.3. Brücher BL, Piso P, Verwaal V, Esquivel J, Derraco M, Yonemura Y, Gonzalez-Moreno S, Pelz J, Königsrainer A, Ströhlein M, Levine EA, Morris D, Bartlett D, Glehen O, Garofalo A, Nissan A. Peritoneal carcinomatosis: cytoreductive surgery and HIPEC--overview and basics. Cancer Invest. 2012 Mar;30(3):209-24. doi: 10.3109/07357907.2012.654871. PMID: 22360361.4. Martin L, Birdsell lL Macdonald N, et al. Cancer cachexia in the age of obesity: Skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. 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