Development of a Model of Pediatric Lung Failure Pathophysiology

A pediatric artificial lung (PAL) is under development as a bridge to transplantation or lung remodeling for children with end-stage lung failure (ESLF). To evaluate the efficiency of a PAL, a disease model mimicking the physiologic derangements of pediatric ESLF is needed. Our previous right pulmonary artery (rPA) ligation model (rPA-LM) achieved that goal, but caused immediate mortality in nearly half of the animals. In this study, we evaluated a new technique of gradual postoperative right pulmonary artery occlusion using a Rummel tourniquet (rPA-RT) in seven (25–40 kg) sheep. This technique created a stable model of ESLF pathophysiology, characterized by high alveolar dead space (58.0% ± 3.8%), pulmonary hypertension (38.4 ± 2.2 mm Hg), tachypnea (79 ± 20 breaths per minute), and intermittent supplemental oxygen requirement. This improvement to our technique provides the necessary physiologic derangements for testing a PAL, whereas avoiding the problem of high immediate perioperative mortality.

• Autores: Trahanas, John M.; Alghanem, Fares; Ceballos-Muriel, Catalina; Hoffman, Hayley R.; Xu, Alice; Deatrick, Kristopher Barry; Cornell, Marie S.; Rojas-Pena, Alvaro; Bartlett, Robert H.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3436
• Acceso en línea: http://hdl.handle.net/20.500.12495/3436; https://doi.org/10.1097/mat.0000000000000463; https://repositorio.unbosque.edu.co
• Palabra clave: Prótesis e implantes; Mortalidad del niño; trasplante de pulmón; lung failure; Animal mode; Pulmonary hypertension
• Rights: openAccess
• License: Acceso abierto