Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)

Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologica...

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Autores:
Martín, Claudio
Enrico, Diego
Mas, Luis
Patane, Ana Karina
Arrieta, Oscar
Soria, Tannia
Cardona, Andrés F.
Alejandro, Ruiz Patiño
Ruiz, Rossana
Rioja, Patricia
Lozano, Sophia
Zatarain Barrón, Zyanya Lucia
Barrón, Feliciano
Puparelli, Carmen
Tsou, Florencia
Corassa, Marcelo P.
Freitas, Helano C.
Cordeiro de Lima, Vladmir Cláudio
Rojas, Leonardo
Ordóñez Reyes, Camila
Corrales, Luis Alejandro
Sotelo, Carolina
Rodríguez, July
Ricaurte, Luisa
Avila, Jenny
Archila, Pilar
Rosell, Rafael
Cuello, Mauricio
Remon, Jordi
CLICaP
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/6715
Acceso en línea:
http://hdl.handle.net/20.500.12495/6715
https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335
Palabra clave:
America latina
Oncologia medica
Timoma
Cohort studies
Latin America
Medical oncology
Thymoma
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/6715
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
dc.title.translated.spa.fl_str_mv Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
title Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
spellingShingle Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
America latina
Oncologia medica
Timoma
Cohort studies
Latin America
Medical oncology
Thymoma
title_short Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
title_full Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
title_fullStr Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
title_full_unstemmed Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
title_sort Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
dc.creator.fl_str_mv Martín, Claudio
Enrico, Diego
Mas, Luis
Patane, Ana Karina
Arrieta, Oscar
Soria, Tannia
Cardona, Andrés F.
Alejandro, Ruiz Patiño
Ruiz, Rossana
Rioja, Patricia
Lozano, Sophia
Zatarain Barrón, Zyanya Lucia
Barrón, Feliciano
Puparelli, Carmen
Tsou, Florencia
Corassa, Marcelo P.
Freitas, Helano C.
Cordeiro de Lima, Vladmir Cláudio
Rojas, Leonardo
Ordóñez Reyes, Camila
Corrales, Luis Alejandro
Sotelo, Carolina
Rodríguez, July
Ricaurte, Luisa
Avila, Jenny
Archila, Pilar
Rosell, Rafael
Cuello, Mauricio
Remon, Jordi
CLICaP
dc.contributor.author.none.fl_str_mv Martín, Claudio
Enrico, Diego
Mas, Luis
Patane, Ana Karina
Arrieta, Oscar
Soria, Tannia
Cardona, Andrés F.
Alejandro, Ruiz Patiño
Ruiz, Rossana
Rioja, Patricia
Lozano, Sophia
Zatarain Barrón, Zyanya Lucia
Barrón, Feliciano
Puparelli, Carmen
Tsou, Florencia
Corassa, Marcelo P.
Freitas, Helano C.
Cordeiro de Lima, Vladmir Cláudio
Rojas, Leonardo
Ordóñez Reyes, Camila
Corrales, Luis Alejandro
Sotelo, Carolina
Rodríguez, July
Ricaurte, Luisa
Avila, Jenny
Archila, Pilar
Rosell, Rafael
Cuello, Mauricio
Remon, Jordi
CLICaP
dc.contributor.orcid.none.fl_str_mv Martín, Claudio [0000-0003-4135-7332]
Mas, Luis [0000-0002-2323-9271]
Cardona, Andrés F. [0000-0003-3525-4126]
Alejandro, Ruiz Patiño [0000-0003-1274-9273]
Rioja, Patricia [0000-0003-3141-7418]
dc.subject.spa.fl_str_mv America latina
Oncologia medica
Timoma
topic America latina
Oncologia medica
Timoma
Cohort studies
Latin America
Medical oncology
Thymoma
dc.subject.keywords.spa.fl_str_mv Cohort studies
Latin America
Medical oncology
Thymoma
description Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologically proven thymomas diagnosed between 1997 and 2018. Demographics, linicopathological characteristics and therapeutic outcomes were collected locallyand analyzed in a centralized manner.Results: A total of 135 patients were included. Median age at diagnos is was 53 yearsold (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG perfor-mance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic diseaseat diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgerywas performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival(OS) at five-years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB,respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase(LDH) (≤373 IU/L) at baseline and myasthenia gravis concur rence showed signifi-cantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, highLDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baselineand not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) weresignificantly associated with increased risk of death.Conclusions: Our data provides the largest insight into the clinical characteristics andoutcomes of patients with thymomas in Latin America. Survival in patients withthymomas continues to be very favorable, especially when subjected to adequatelocal control.
publishDate 2021
dc.date.issued.none.fl_str_mv 2021
dc.date.accessioned.none.fl_str_mv 2022-02-02T20:26:07Z
dc.date.available.none.fl_str_mv 2022-02-02T20:26:07Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.none.fl_str_mv Artículo de revista
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 1759-7714
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/6715
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv 1759-7714
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/6715
https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Thoracic Cancer, 1759-7714, May, 12(9),2021,1328-1335
dc.relation.uri.none.fl_str_mv https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13901
dc.rights.*.fl_str_mv Atribución-NoComercial 4.0 Internacional
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
Acceso abierto
rights_invalid_str_mv Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
Acceso abierto
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv China Lung Oncology Group
John Wiley & Sons Australia, Ltd
dc.publisher.journal.spa.fl_str_mv Thoracic Cancer
institution Universidad El Bosque
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spelling Martín, ClaudioEnrico, DiegoMas, LuisPatane, Ana KarinaArrieta, OscarSoria, TanniaCardona, Andrés F.Alejandro, Ruiz PatiñoRuiz, RossanaRioja, PatriciaLozano, SophiaZatarain Barrón, Zyanya LuciaBarrón, FelicianoPuparelli, CarmenTsou, FlorenciaCorassa, Marcelo P.Freitas, Helano C.Cordeiro de Lima, Vladmir CláudioRojas, LeonardoOrdóñez Reyes, CamilaCorrales, Luis AlejandroSotelo, CarolinaRodríguez, JulyRicaurte, LuisaAvila, JennyArchila, PilarRosell, RafaelCuello, MauricioRemon, JordiCLICaPMartín, Claudio [0000-0003-4135-7332]Mas, Luis [0000-0002-2323-9271]Cardona, Andrés F. [0000-0003-3525-4126]Alejandro, Ruiz Patiño [0000-0003-1274-9273]Rioja, Patricia [0000-0003-3141-7418]2022-02-02T20:26:07Z2022-02-02T20:26:07Z20211759-7714http://hdl.handle.net/20.500.12495/6715https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengChina Lung Oncology GroupJohn Wiley & Sons Australia, LtdThoracic CancerThoracic Cancer, 1759-7714, May, 12(9),2021,1328-1335https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13901Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abiertoAmerica latinaOncologia medicaTimomaCohort studiesLatin AmericaMedical oncologyThymomaCharacteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologically proven thymomas diagnosed between 1997 and 2018. Demographics, linicopathological characteristics and therapeutic outcomes were collected locallyand analyzed in a centralized manner.Results: A total of 135 patients were included. Median age at diagnos is was 53 yearsold (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG perfor-mance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic diseaseat diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgerywas performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival(OS) at five-years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB,respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase(LDH) (≤373 IU/L) at baseline and myasthenia gravis concur rence showed signifi-cantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, highLDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baselineand not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) weresignificantly associated with increased risk of death.Conclusions: Our data provides the largest insight into the clinical characteristics andoutcomes of patients with thymomas in Latin America. 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