Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)
Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologica...
- Autores:
-
Martín, Claudio
Enrico, Diego
Mas, Luis
Patane, Ana Karina
Arrieta, Oscar
Soria, Tannia
Cardona, Andrés F.
Alejandro, Ruiz Patiño
Ruiz, Rossana
Rioja, Patricia
Lozano, Sophia
Zatarain Barrón, Zyanya Lucia
Barrón, Feliciano
Puparelli, Carmen
Tsou, Florencia
Corassa, Marcelo P.
Freitas, Helano C.
Cordeiro de Lima, Vladmir Cláudio
Rojas, Leonardo
Ordóñez Reyes, Camila
Corrales, Luis Alejandro
Sotelo, Carolina
Rodríguez, July
Ricaurte, Luisa
Avila, Jenny
Archila, Pilar
Rosell, Rafael
Cuello, Mauricio
Remon, Jordi
CLICaP
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/6715
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/6715
https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335
- Palabra clave:
- America latina
Oncologia medica
Timoma
Cohort studies
Latin America
Medical oncology
Thymoma
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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|
dc.title.spa.fl_str_mv |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
dc.title.translated.spa.fl_str_mv |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
title |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
spellingShingle |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) America latina Oncologia medica Timoma Cohort studies Latin America Medical oncology Thymoma |
title_short |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
title_full |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
title_fullStr |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
title_full_unstemmed |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
title_sort |
Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus) |
dc.creator.fl_str_mv |
Martín, Claudio Enrico, Diego Mas, Luis Patane, Ana Karina Arrieta, Oscar Soria, Tannia Cardona, Andrés F. Alejandro, Ruiz Patiño Ruiz, Rossana Rioja, Patricia Lozano, Sophia Zatarain Barrón, Zyanya Lucia Barrón, Feliciano Puparelli, Carmen Tsou, Florencia Corassa, Marcelo P. Freitas, Helano C. Cordeiro de Lima, Vladmir Cláudio Rojas, Leonardo Ordóñez Reyes, Camila Corrales, Luis Alejandro Sotelo, Carolina Rodríguez, July Ricaurte, Luisa Avila, Jenny Archila, Pilar Rosell, Rafael Cuello, Mauricio Remon, Jordi CLICaP |
dc.contributor.author.none.fl_str_mv |
Martín, Claudio Enrico, Diego Mas, Luis Patane, Ana Karina Arrieta, Oscar Soria, Tannia Cardona, Andrés F. Alejandro, Ruiz Patiño Ruiz, Rossana Rioja, Patricia Lozano, Sophia Zatarain Barrón, Zyanya Lucia Barrón, Feliciano Puparelli, Carmen Tsou, Florencia Corassa, Marcelo P. Freitas, Helano C. Cordeiro de Lima, Vladmir Cláudio Rojas, Leonardo Ordóñez Reyes, Camila Corrales, Luis Alejandro Sotelo, Carolina Rodríguez, July Ricaurte, Luisa Avila, Jenny Archila, Pilar Rosell, Rafael Cuello, Mauricio Remon, Jordi CLICaP |
dc.contributor.orcid.none.fl_str_mv |
Martín, Claudio [0000-0003-4135-7332] Mas, Luis [0000-0002-2323-9271] Cardona, Andrés F. [0000-0003-3525-4126] Alejandro, Ruiz Patiño [0000-0003-1274-9273] Rioja, Patricia [0000-0003-3141-7418] |
dc.subject.spa.fl_str_mv |
America latina Oncologia medica Timoma |
topic |
America latina Oncologia medica Timoma Cohort studies Latin America Medical oncology Thymoma |
dc.subject.keywords.spa.fl_str_mv |
Cohort studies Latin America Medical oncology Thymoma |
description |
Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologically proven thymomas diagnosed between 1997 and 2018. Demographics, linicopathological characteristics and therapeutic outcomes were collected locallyand analyzed in a centralized manner.Results: A total of 135 patients were included. Median age at diagnos is was 53 yearsold (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG perfor-mance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic diseaseat diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgerywas performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival(OS) at five-years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB,respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase(LDH) (≤373 IU/L) at baseline and myasthenia gravis concur rence showed signifi-cantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, highLDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baselineand not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) weresignificantly associated with increased risk of death.Conclusions: Our data provides the largest insight into the clinical characteristics andoutcomes of patients with thymomas in Latin America. Survival in patients withthymomas continues to be very favorable, especially when subjected to adequatelocal control. |
publishDate |
2021 |
dc.date.issued.none.fl_str_mv |
2021 |
dc.date.accessioned.none.fl_str_mv |
2022-02-02T20:26:07Z |
dc.date.available.none.fl_str_mv |
2022-02-02T20:26:07Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1759-7714 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/6715 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1759-7714 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/6715 https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Thoracic Cancer, 1759-7714, May, 12(9),2021,1328-1335 |
dc.relation.uri.none.fl_str_mv |
https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13901 |
dc.rights.*.fl_str_mv |
Atribución-NoComercial 4.0 Internacional |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
rights_invalid_str_mv |
Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
China Lung Oncology Group John Wiley & Sons Australia, Ltd |
dc.publisher.journal.spa.fl_str_mv |
Thoracic Cancer |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
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Martín, ClaudioEnrico, DiegoMas, LuisPatane, Ana KarinaArrieta, OscarSoria, TanniaCardona, Andrés F.Alejandro, Ruiz PatiñoRuiz, RossanaRioja, PatriciaLozano, SophiaZatarain Barrón, Zyanya LuciaBarrón, FelicianoPuparelli, CarmenTsou, FlorenciaCorassa, Marcelo P.Freitas, Helano C.Cordeiro de Lima, Vladmir CláudioRojas, LeonardoOrdóñez Reyes, CamilaCorrales, Luis AlejandroSotelo, CarolinaRodríguez, JulyRicaurte, LuisaAvila, JennyArchila, PilarRosell, RafaelCuello, MauricioRemon, JordiCLICaPMartín, Claudio [0000-0003-4135-7332]Mas, Luis [0000-0002-2323-9271]Cardona, Andrés F. [0000-0003-3525-4126]Alejandro, Ruiz Patiño [0000-0003-1274-9273]Rioja, Patricia [0000-0003-3141-7418]2022-02-02T20:26:07Z2022-02-02T20:26:07Z20211759-7714http://hdl.handle.net/20.500.12495/6715https://doi.org/10.1111/1759 -7714.13901MARTÍN ET AL. 1335instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengChina Lung Oncology GroupJohn Wiley & Sons Australia, LtdThoracic CancerThoracic Cancer, 1759-7714, May, 12(9),2021,1328-1335https://onlinelibrary.wiley.com/doi/10.1111/1759-7714.13901Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abiertoAmerica latinaOncologia medicaTimomaCohort studiesLatin AmericaMedical oncologyThymomaCharacteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)Characteristics and outcomes of thymomas in Latin America: results from over 10 years of experience (CLICaP-LATimus)Artículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Background: Thymomas are a group of rare neoplasms of the anterior mediastinum.The objective of this study was to describe the demographics, clinical characteristicsand treatment approaches in Latin America.Methods: This was a retrospective multicenter cohort study including patients withhistologically proven thymomas diagnosed between 1997 and 2018. Demographics, linicopathological characteristics and therapeutic outcomes were collected locallyand analyzed in a centralized manner.Results: A total of 135 patients were included. Median age at diagnos is was 53 yearsold (19–84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG perfor-mance score ranging from 0–1. A total of 47 patients (34.8%) had metastatic diseaseat diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgerywas performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival(OS) at five-years was 73.4%, 63.8% and 51%, at stages I–II, III–IVA and IVB,respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase(LDH) (≤373 IU/L) at baseline and myasthenia gravis concur rence showed signifi-cantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, highLDH levels (HR 2.8 [95% confidence interval [CI]: 1.1–7.8]; p = 0.036) at baselineand not performing a surgical resection (HR 4.1 [95% CI: 1.3–12.7]; p = 0.016) weresignificantly associated with increased risk of death.Conclusions: Our data provides the largest insight into the clinical characteristics andoutcomes of patients with thymomas in Latin America. 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