Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador

El 5-Hidorximetilfurfural o 5-HMF, es un compuesto que ha adquirido un gran valor para la industria sostenible en general, teniendo un gran impacto en la industria energética y farmacéutica, con una gran cantidad de aplicaciones. El siguiente trabajo evalúa la obtención del 5-HMF a partir de glucosa...

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Autores:: Tinoco Quitian, Sebastian Felipe
Guerrero Fajardo, Carlos
Suarez , Kevin Rene

Tipo de recurso:: https://purl.org/coar/resource_type/c_7a1f

Fecha de publicación:: 2024

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: spa

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dc.title.none.fl_str_mv	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
dc.title.translated.none.fl_str_mv	Obtaining 5-Hydroxymethylfurfural (5-HMF), a compound used as an excipient in liquid or semi-solid formulations, using acetic acid as a catalyst
title	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
spellingShingle	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador 5-hidroximetilfurfural (5-hmf) Ácido acético Glucosa Temperatura Tiempo Variables de reacción 615.19 5-hydroxymethylfurfural (5-hmf) Acetic acid Glucose Temperature Time Reaction variables
title_short	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
title_full	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
title_fullStr	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
title_full_unstemmed	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
title_sort	Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador
dc.creator.fl_str_mv	Tinoco Quitian, Sebastian Felipe Guerrero Fajardo, Carlos Suarez , Kevin Rene
dc.contributor.advisor.none.fl_str_mv	Cortes Ortiz, William Giovanni
dc.contributor.author.none.fl_str_mv	Tinoco Quitian, Sebastian Felipe Guerrero Fajardo, Carlos Suarez , Kevin Rene
dc.subject.none.fl_str_mv	5-hidroximetilfurfural (5-hmf) Ácido acético Glucosa Temperatura Tiempo Variables de reacción
topic	5-hidroximetilfurfural (5-hmf) Ácido acético Glucosa Temperatura Tiempo Variables de reacción 615.19 5-hydroxymethylfurfural (5-hmf) Acetic acid Glucose Temperature Time Reaction variables
dc.subject.ddc.none.fl_str_mv	615.19
dc.subject.keywords.none.fl_str_mv	5-hydroxymethylfurfural (5-hmf) Acetic acid Glucose Temperature Time Reaction variables
description	El 5-Hidorximetilfurfural o 5-HMF, es un compuesto que ha adquirido un gran valor para la industria sostenible en general, teniendo un gran impacto en la industria energética y farmacéutica, con una gran cantidad de aplicaciones. El siguiente trabajo evalúa la obtención del 5-HMF a partir de glucosa usando el ácido acético (10,0% v/v) como catalizador, evaluando las mejores condiciones encontradas en la búsqueda bibliográfica para los catalizadores ácidos, generando un sistema factorial 22 donde se evalúa el impacto de dos variables de reacción como son: la Temperatura (170 – 200°C) y el tiempo de reacción (60 – 120 min) sobre el Rendimiento. Se obtienen mediante el uso de un reactor tipo Batch y los resultados se cuantifican por HPLC y el uso de un patrón interno (Alcohol furfurílico). Los resultados generan valores de rendimiento de reacción, de 6,9%; 30,5%; 11,7% y 18,9%, siendo el mejor rendimiento el Ensayo 2 (200°C; 60 min). Confirmando que se obtiene 5-HMF y evidenciando la influencia de las variables de reacción sobre el ensayo, alterando la cantidad generada de 5-HMF y de otras sustancias relacionadas con la reacción, también se genera un análisis estadístico que confirma que las variables tienen gran influencia en el rendimiento de reacción
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-05-18T02:41:28Z
dc.date.available.none.fl_str_mv	2024-05-18T02:41:28Z
dc.date.issued.none.fl_str_mv	2024-04
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.local.none.fl_str_mv	Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.coar.none.fl_str_mv	https://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
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format	https://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12495/12148
dc.identifier.instname.spa.fl_str_mv	Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv	repourl:https://repositorio.unbosque.edu.co
url	https://hdl.handle.net/20.500.12495/12148
identifier_str_mv	Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co
dc.language.iso.fl_str_mv	spa
language	spa
dc.relation.references.none.fl_str_mv	Z. Zhou, M. Zhu, G. Zhang, X. Hu, and J. Pan, ‘Novel insights into the interaction mechanism of 5-hydroxymethyl-2-furaldehyde with β-casein and its effects on the structure and function of β-casein’, LWT, vol. 152, Dec. 2021, doi: 10.1016/j.lwt.2021.112360 M. Bachar et al., ‘Development and characterization of a novel drug nanocarrier for oral delivery, based on self-assembled β-casein micelles’, Journal of Controlled Release, vol. 160, no. 2, pp. 164–171, Jun. 2012, doi: 10.1016/J.JCONREL.2012.01.004 A. A. Rosatella, S. P. Simeonov, R. F. M. Frade, and C. A. M. Afonso, ‘5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications’, Green Chemistry, vol. 13, no. 4, pp. 754–793, Apr. 2011, doi: 10.1039/c0gc00401d. T. N. Gevrek and A. Sanyal, ‘Furan-containing polymeric Materials: Harnessing the Diels-Alder chemistry for biomedical applications’, European Polymer Journal, vol. 153. 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Science in China Press, pp. 870–886, Jul. 01, 2017. doi: 10.1007/s11426-016-9035-1 C. Lu, Y. Zhou, L. Li, H. Chen, and L. Yan, ‘Conversion of glucose into 5-hydroxymethylfurfural catalyzed by Cr-and Fe-containing mixed-metal metal–organic frameworks’, Fuel, vol. 333, 2023, doi: 10.1016/j.fuel.2022.126415 S. Wang, T. L. Eberhardt, D. Guo, J. Feng, and H. Pan, ‘Efficient conversion of glucose into 5-HMF catalyzed by lignin-derived mesoporous carbon solid acid in a biphasic system’, Renew Energy, vol. 190, pp. 1–10, May 2022, doi: 10.1016/J.RENENE.2022.03.021 V. Kumar Vaidyanathan, K. Saikia, P. Senthil Kumar, A. Karanam Rathankumar, G. Rangasamy, and G. Da-ttatraya Saratale, ‘Advances in enzymatic conversion of biomass derived furfural and 5-hydroxymethylfurfural to value-added chemicals and solvents’, Bioresour Technol, vol. 378, p. 128975, Jun. 2023, doi: 10.1016/J.BIORTECH.2023.128975 B. L. S. Santiago and R. Guirardello, ‘5-hydroxymethylfurfural production in a lignocellulosic biorefinery: Techno-economic analysis’, Chem Eng Trans, vol. 80, pp. 139–144, 2020, doi: 10.3303/CET2080024 L. Yang, G. Tsilomelekis, S. Caratzoulas, and D. G. Vlachos, ‘Mechanism of Brønsted Acid-Catalyzed Glucose Dehydration’, ChemSusChem, vol. 8, no. 8, pp. 1334–1341, Apr. 2015, doi: 10.1002/CSSC.201403264 G. Portillo Perez, A. Mukherjee, and M. J. Dumont, ‘Insights into HMF catalysis’, Journal of Industrial and En-gineering Chemistry, vol. 70. Korean Society of Industrial Engineering Chemistry, pp. 1–34, Feb. 25, 2019. doi: 10.1016/j.jiec.2018.10.002 D. C. Harris, ‘Análisis químico cuantitativo (3a. ed.)’, p. 942, 2016, doi: 10.0/CSS/ALL.MIN.D74D1A5D029B.CSS L. G. Wade Jr., Organic Chemistry, Sixth edtion. Pearson education, 2006 Francis A. Carey, ORGANIC CHEMISTRY, 4th ed. The McGraw-Hill, 2000 P. Sykes, D. Mauleón Casellas, and P. Translation of: Sykes, ‘Mecanismos de reacción en química orgánica’, Editorial Reverté, 2020, doi: 10.0/CSS/ALL.MIN.D74D1A5D029B.CSS X. Qian, ‘Mechanisms and energetics for brønsted acid-catalyzed glucose condensation, dehydration and isomerization reactions’, Top Catal, vol. 55, no. 3–4, pp. 218–226, May 2012, doi: 10.1007/S11244-012-9790-6/METRICS G. Yang, E. A. Pidko, and E. J. M. Hensen, ‘Mechanism of Bronsted acid-catalyzed conversion of carbohydra-tes’, J Catal, vol. 295, pp. 122–132, Nov. 2012, doi: 10.1016/J.JCAT.2012.08.002 N. Jiang, W. Qi, Z. Wu, R. Su, and Z. He, ‘“One-pot” conversions of carbohydrates to 5-hydroxymethylfurfural using Sn-ceramic powder and hydrochloric acid’, Catal Today, vol. 302, pp. 94–99, Mar. 2018, doi: 10.1016/j.cattod.2017.05.081 H. Li, Z. Xia, P. Yan, and Z. C. Zhang, ‘Production of crude 5-hydroxymethylfurfural from glucose by dual catalysts with functional promoters in low-boiling hybrid solvent’, Catal Today, vol. 402, pp. 10–16, Sep. 2022, doi: 10.1016/J.CATTOD.2022.01.017 H. L. Solano, Estadística Inferencial. Area metropolitana de Barranquilla, Colombia: Universidad del Norte, 2017. [Online]. Available: https://login.ezproxy.unbosque.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=e086sww&AN=1800044&lang=es&site=eds-live&scope=site Q. Qing et al., ‘One-pot synthesis of 5-Hydroxymethylfurfural from glucose and corn stover in an aqueous choline chloride/ acetone ternary solvent’, Ind Crops Prod, vol. 188, 2022, doi: 10.1016/j.indcrop.2022.115681 B. Das and K. Mohanty, ‘Sulfonic acid-functionalized carbon coated red mud as an efficient catalyst for the direct production of 5-HMF from d-glucose under microwave irradiation’, Appl Catal A Gen, vol. 622, p. 118237, 2021, doi: https://doi.org/10.1016/j.apcata.2021.118237 S. Fernández, ‘Diseño de experimentos: Diseño factorial’, 2020 A. A. Marianou, C. M. Michailof, A. Pineda, E. F. Iliopoulou, K. S. Triantafyllidis, and A. A. Lappas, ‘Effect of Lewis and Brønsted acidity on glucose conversion to 5-HMF and lactic acid in aqueous and organic media’, Appl Catal A Gen, vol. 555, pp. 75–87, Apr. 2018, doi: 10.1016/J.APCATA.2018.01.029 Y. J. Pagán-Torres, T. Wang, J. M. R. Gallo, B. H. Shanks, and J. A. Dumesic, ‘Production of 5-hydroxymethylfurfural from glucose using a combination of lewis and brønsted acid catalysts in water in a biphasic reactor with an alkylphenol solvent’, ACS Catal, vol. 2, no. 6, pp. 930–934, Jun. 2012, doi: 10.1021/cs300192z J. Zhao et al., ‘Design and synthesis of Brønsted-Lewis acidic tetraimidazolyl ionic liquids for efficient cataly-tic conversion of glucose to 5-hydroxymethylfurfural in water/1-octanol’, Appl Catal A Gen, vol. 649, Jan. 2023, doi: 10.1016/J.APCATA.2022.118981 A. J. Kunov-Kruse, A. Riisager, S. Saravanamurugan, R. W. Berg, S. B. Kristensen, and R. Fehrmann, ‘Revisi-ting the Brønsted acid catalysed hydrolysis kinetics of polymeric carbohydrates in ionic liquids by in situ ATR-FTIR spectroscopy’, Green Chem., vol. 15, no. 10, pp. 2843–2848, 2013, doi: 10.1039/C3GC41174E P. Atkins, Fisicoquímica. 1999 H. Zhang et al., ‘Continuous synthesis of 5-hydroxymethylfurfural using deep eutectic solvents and its kine-tic study in microreactors’, Chemical Engineering Journal, vol. 391, Jul. 2020, doi: 10.1016/J.CEJ.2019.123580 T. 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He, ‘Integrating enzymatic and acid catalysis to convert glucose into 5-hydroxymethylfurfural’, Chemical Communications, vol. 46, no. 7, pp. 1115–1117, 2010, doi: 10.1039/B921306F Ignacio Jiménez-Morales, Mercedes Moreno-Recio, José Santamaría-González, and Pedro Maireles-Torres, ‘Production of 5-hydroxymethylfurfural from glucose using aluminium doped MCM-41 silica as acid ca-talyst’, Appl Catal B, vol. 164, pp. 70–76, 2015, doi: 10.1016/j.apcatb.2014.09.002 I. Jiménez-Morales, A. Teckchandani-Ortiz, J. Santamaría-González, P. Maireles-Torres, and A. Jimé-nez-López, ‘Selective dehydration of glucose to 5-hydroxymethylfurfural on acidic mesoporous tantalum phosphate’, Appl Catal B, vol. 144, no. 1, pp. 22–28, Jan. 2014, doi: 10.1016/J.APCATB.2013.07.002 L. Li, J. Ding, J. G. Jiang, Z. Zhu, and P. 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Guirardello, ‘5-Hydroxymethylfurfural Production in a Lignocellulosic Biorefinery: Techno-economic Analysis’, Chem Eng Trans, vol. 80, p. 2020, 2020, doi: 10.3303/CET2080024 T. Ståhlberg, W. Fu, J. M. Woodley, and A. Riisager, ‘Synthesis of 5-(hydroxymethyl)furfural in ionic liquids: Paving the way to renewable chemicals’, ChemSusChem, vol. 4, no. 4. Wiley-VCH Verlag, pp. 451–458, Apr. 18, 2011. doi: 10.1002/cssc.201000374 N. I. Villanueva Martínez, ‘Obtención de 5-hidroxmetilfurfural a partir de glucosa proveniente de licores de corteza de pino y eucaliptu, utilizando catalizadores sólidos en medio acuoso’, 2017 X. Yang et al., ‘A new method for conversion of fructose and glucose to 5-hydroxymethylfurfural by magnetic mesoporous of SBA-16 was modified to sulfonic acid as Lewis’s acid catalysts’, Renew Energy, vol. 209, pp. 145–156, Jun. 2023, doi: 10.1016/J.RENENE.2023.03.102 W. Zhang et al., ‘Sn doping on partially dealuminated Beta zeolite by solid state ion exchange for 5-hydroxymethylfurfural (5-HMF) production from glucose’, Journal of Chemical Technology and Biotechnology, vol. 98, no. 3, pp. 773–781, 2023, doi: 10.1002/jctb.7282
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spelling	Cortes Ortiz, William GiovanniTinoco Quitian, Sebastian FelipeGuerrero Fajardo, CarlosSuarez , Kevin Rene2024-05-18T02:41:28Z2024-05-18T02:41:28Z2024-04https://hdl.handle.net/20.500.12495/12148Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl 5-Hidorximetilfurfural o 5-HMF, es un compuesto que ha adquirido un gran valor para la industria sostenible en general, teniendo un gran impacto en la industria energética y farmacéutica, con una gran cantidad de aplicaciones. El siguiente trabajo evalúa la obtención del 5-HMF a partir de glucosa usando el ácido acético (10,0% v/v) como catalizador, evaluando las mejores condiciones encontradas en la búsqueda bibliográfica para los catalizadores ácidos, generando un sistema factorial 22 donde se evalúa el impacto de dos variables de reacción como son: la Temperatura (170 – 200°C) y el tiempo de reacción (60 – 120 min) sobre el Rendimiento. Se obtienen mediante el uso de un reactor tipo Batch y los resultados se cuantifican por HPLC y el uso de un patrón interno (Alcohol furfurílico). Los resultados generan valores de rendimiento de reacción, de 6,9%; 30,5%; 11,7% y 18,9%, siendo el mejor rendimiento el Ensayo 2 (200°C; 60 min). Confirmando que se obtiene 5-HMF y evidenciando la influencia de las variables de reacción sobre el ensayo, alterando la cantidad generada de 5-HMF y de otras sustancias relacionadas con la reacción, también se genera un análisis estadístico que confirma que las variables tienen gran influencia en el rendimiento de reacciónPregradoQuímico Farmacéutico5-Hydorxymethylfurfural or 5-HMF, is a compound that has acquired great value for the sustainable industry in general, having a great impact on the energy and pharmaceutical industries, with a large number of applications. The following work evaluates the obtaining of 5-HMF from glucose using acetic acid (10.0% v/v) as a catalyst, evaluating the best conditions found in the biobibliographic search for acid catalysts, generating a 22 factorial system where The impact of two reaction variables such as: Temperature (170 – 200°C) and reaction time (60 – 120 min) on the Yield is evaluated. They are obtained by using a Batch type reactor and the results are quantified by HPLC and the use of an internal standard (furfuryl alcohol). The results generate reaction yield values of 6.9%; 30.5%; 11.7% and 18.9%, with the best performance being Test 2 (200°C; 60 min). Confirming that 5-HMF is obtained and evidencing the influence of the reaction variables on the test, altering the generated amount of 5-HMF and other substances related to the reaction, a statistical analysis is also generated that confirms that the variables have great influence on the reaction yieldapplication/pdfAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf25-hidroximetilfurfural (5-hmf)Ácido acéticoGlucosaTemperaturaTiempoVariables de reacción615.195-hydroxymethylfurfural (5-hmf)Acetic acidGlucoseTemperatureTimeReaction variablesObtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizadorObtaining 5-Hydroxymethylfurfural (5-HMF), a compound used as an excipient in liquid or semi-solid formulations, using acetic acid as a catalystQuímica FarmacéuticaUniversidad El BosqueFacultad de CienciasTesis/Trabajo de grado - Monografía - Pregradohttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aaZ. 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Zhang et al., ‘Sn doping on partially dealuminated Beta zeolite by solid state ion exchange for 5-hydroxymethylfurfural (5-HMF) production from glucose’, Journal of Chemical Technology and Biotechnology, vol. 98, no. 3, pp. 773–781, 2023, doi: 10.1002/jctb.7282spaORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf1667617https://repositorio.unbosque.edu.co/bitstreams/fd53e5fe-bb2e-4960-b3a9-5d6ecf0d55fc/download385a823008d4ac60bfdb545d09af57e0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81019https://repositorio.unbosque.edu.co/bitstreams/e1e5dfe1-ce35-4b11-b2d4-fbe579b0607e/download313ea3fe4cd627df823c57a0f12776e5MD55LICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/a689d593-c47b-4d01-885c-5129e62b3229/download17cc15b951e7cc6b3728a574117320f9MD56Anexo 1 Acta de aprobacion.pdfapplication/pdf9827032https://repositorio.unbosque.edu.co/bitstreams/971e1250-985d-4724-93cd-77b0646f437d/downloadeeb343f378e90a038852cd00e073d216MD513Carta de autorizacion.pdfapplication/pdf206406https://repositorio.unbosque.edu.co/bitstreams/5bc43018-16c7-40de-b98c-ca7d9d3d18b5/download9e36c057d19550625990d6888468b08aMD514TEXTTrabajo de grado.pdf.txtTrabajo de grado.pdf.txtExtracted texttext/plain82082https://repositorio.unbosque.edu.co/bitstreams/26dc6c6a-b030-43e2-bd34-8ab98c5dead8/downloadcaa87b07219ca9c4cea70b86e03a3838MD57THUMBNAILTrabajo de grado.pdf.jpgTrabajo de grado.pdf.jpgGenerated Thumbnailimage/jpeg5381https://repositorio.unbosque.edu.co/bitstreams/04d0d685-474a-4eb2-9a9f-d85fad760006/download5334af41ae5d3f8c455bd4e8e1da69aaMD5820.500.12495/12148oai:repositorio.unbosque.edu.co:20.500.12495/121482024-07-04 10:30:44.178http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.comTGljZW5jaWEgZGUgRGlzdHJpYnVjacOzbiBObyBFeGNsdXNpdmEKClBhcmEgcXVlIGVsIFJlcG9zaXRvcmlvIGRlIGxhIFVuaXZlcnNpZGFkIEVsIEJvc3F1ZSBhIHB1ZWRhIHJlcHJvZHVjaXIgeSBjb211bmljYXIgcMO6YmxpY2FtZW50ZSBzdSBkb2N1bWVudG8gZXMgbmVjZXNhcmlvIGxhIGFjZXB0YWNpw7NuIGRlIGxvcyBzaWd1aWVudGVzIHTDqXJtaW5vcy4gUG9yIGZhdm9yLCBsZWEgbGFzIHNpZ3VpZW50ZXMgY29uZGljaW9uZXMgZGUgbGljZW5jaWE6CgoxLiBBY2VwdGFuZG8gZXN0YSBsaWNlbmNpYSwgdXN0ZWQgKGVsIGF1dG9yL2VzIG8gZWwgcHJvcGlldGFyaW8vcyBkZSBsb3MgZGVyZWNob3MgZGUgYXV0b3IpIGdhcmFudGl6YSBhIGxhIFVuaXZlcnNpZGFkIEVsIEJvc3F1ZSBlbCBkZXJlY2hvIG5vIGV4Y2x1c2l2byBkZSBhcmNoaXZhciwgcmVwcm9kdWNpciwgY29udmVydGlyIChjb21vIHNlIGRlZmluZSBtw6FzIGFiYWpvKSwgY29tdW5pY2FyIHkvbyBkaXN0cmlidWlyIHN1IGRvY3VtZW50byBtdW5kaWFsbWVudGUgZW4gZm9ybWF0byBlbGVjdHLDs25pY28uCgoyLiBUYW1iacOpbiBlc3TDoSBkZSBhY3VlcmRvIGNvbiBxdWUgbGEgVW5pdmVyc2lkYWQgRWwgQm9zcXVlIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBkZSBlc3RlIGRvY3VtZW50byB5LCBzaW4gYWx0ZXJhciBzdSBjb250ZW5pZG8sIGNvbnZlcnRpcmxvIGEgY3VhbHF1aWVyIGZvcm1hdG8gZGUgZmljaGVybywgbWVkaW8gbyBzb3BvcnRlLCBwYXJhIHByb3DDs3NpdG9zIGRlIHNlZ3VyaWRhZCwgcHJlc2VydmFjacOzbiB5IGFjY2Vzby4KCjMuIERlY2xhcmEgcXVlIGVsIGRvY3VtZW50byBlcyB1biB0cmFiYWpvIG9yaWdpbmFsIHN1eW8geS9vIHF1ZSB0aWVuZSBlbCBkZXJlY2hvIHBhcmEgb3RvcmdhciBsb3MgZGVyZWNob3MgY29udGVuaWRvcyBlbiBlc3RhIGxpY2VuY2lhLiBUYW1iacOpbiBkZWNsYXJhIHF1ZSBzdSBkb2N1bWVudG8gbm8gaW5mcmluZ2UsIGVuIHRhbnRvIGVuIGN1YW50byBsZSBzZWEgcG9zaWJsZSBzYWJlciwgbG9zIGRlcmVjaG9zIGRlIGF1dG9yIGRlIG5pbmd1bmEgb3RyYSBwZXJzb25hIG8gZW50aWRhZC4KCjQuIFNpIGVsIGRvY3VtZW50byBjb250aWVuZSBtYXRlcmlhbGVzIGRlIGxvcyBjdWFsZXMgbm8gdGllbmUgbG9zIGRlcmVjaG9zIGRlIGF1dG9yLCBkZWNsYXJhIHF1ZSBoYSBvYnRlbmlkbyBlbCBwZXJtaXNvIHNpbiByZXN0cmljY2nDs24gZGVsIHByb3BpZXRhcmlvIGRlIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBwYXJhIG90b3JnYXIgYSBsYSBVbml2ZXJzaWRhZCBFbCBCb3NxdWUgbG9zIGRlcmVjaG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW5jaWEsIHkgcXVlIGVzZSBtYXRlcmlhbCBjdXlvcyBkZXJlY2hvcyBzb24gZGUgdGVyY2Vyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8geSByZWNvbm9jaWRvIGVuIGVsIHRleHRvIG8gY29udGVuaWRvIGRlbCBkb2N1bWVudG8gZW50cmVnYWRvLgoKNS4gU2kgZWwgZG9jdW1lbnRvIHNlIGJhc2EgZW4gdW5hIG9icmEgcXVlIGhhIHNpZG8gcGF0cm9jaW5hZGEgbyBhcG95YWRhIHBvciB1bmEgYWdlbmNpYSB1IG9yZ2FuaXphY2nDs24gZGlmZXJlbnRlIGRlIGxhIFVuaXZlcnNpZGFkIEVsIEJvc3F1ZSwgc2UgcHJlc3Vwb25lIHF1ZSBzZSBoYSBjdW1wbGlkbyBjb24gY3VhbHF1aWVyIGRlcmVjaG8gZGUgcmV2aXNpw7NuIHUgb3RyYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIGVzdGUgY29udHJhdG8gbyBhY3VlcmRvLgoKNi4gVW5pdmVyc2lkYWQgRWwgQm9zcXVlIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBzdS9zIG5vbWJyZS9zIGNvbW8gZWwvbG9zIGF1dG9yL2VzIG8gcHJvcGlldGFyaW8vcyBkZSBsb3MgZGVyZWNob3MgZGVsIGRvY3VtZW50bywgeSBubyBoYXLDoSBuaW5ndW5hIGFsdGVyYWNpw7NuIGRlIHN1IGRvY3VtZW50byBkaWZlcmVudGUgYSBsYXMgcGVybWl0aWRhcyBlbiBlc3RhIGxpY2VuY2lhLgo=

Obtención de 5-Hidroximetilfurfural (5-HMF), compuesto usado como excipiente en formulaciones líquidas o semisólidas, usando ácido acético como catalizador

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