Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)

El proceso de cicatrización se puede ver afectado por diferentes enfermedades como lo es la diabetes, debido a la influencia que tiene la hiperglicemia y la exacerbación del estrés oxidativo. En este trabajo se presenta el desarrollo y caracterización de un parche de hidrogel como sistema de adminis...

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Autores:
Sierra Guaqueta, Mariana
Gomez Villamil, Angie Valentina
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2025
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/14347
Acceso en línea:
https://hdl.handle.net/20.500.12495/14347
Palabra clave:
Vitamina C
Cafeína
Hidrogel
Antioxidantes
Alginato de sodio
Alcohol polivinílico
615.19
Vitamin C
Caffeine
Hydrogel
Antioxidants
Sodium alginate
Polyvinyl alcohol
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License
Attribution-NonCommercial-NoDerivatives 4.0 International
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/14347
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
dc.title.translated.none.fl_str_mv Contribution to the formulation of a hydrogel patch containing caffeine and ascorbic acid (vitamin C)
title Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
spellingShingle Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
Vitamina C
Cafeína
Hidrogel
Antioxidantes
Alginato de sodio
Alcohol polivinílico
615.19
Vitamin C
Caffeine
Hydrogel
Antioxidants
Sodium alginate
Polyvinyl alcohol
title_short Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
title_full Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
title_fullStr Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
title_full_unstemmed Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
title_sort Aporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)
dc.creator.fl_str_mv Sierra Guaqueta, Mariana
Gomez Villamil, Angie Valentina
dc.contributor.advisor.none.fl_str_mv Velandia Paris, Maria Angelica
Jiménez Cruz, Ronald Andrés
dc.contributor.author.none.fl_str_mv Sierra Guaqueta, Mariana
Gomez Villamil, Angie Valentina
dc.subject.none.fl_str_mv Vitamina C
Cafeína
Hidrogel
Antioxidantes
Alginato de sodio
Alcohol polivinílico
topic Vitamina C
Cafeína
Hidrogel
Antioxidantes
Alginato de sodio
Alcohol polivinílico
615.19
Vitamin C
Caffeine
Hydrogel
Antioxidants
Sodium alginate
Polyvinyl alcohol
dc.subject.ddc.none.fl_str_mv 615.19
dc.subject.keywords.none.fl_str_mv Vitamin C
Caffeine
Hydrogel
Antioxidants
Sodium alginate
Polyvinyl alcohol
description El proceso de cicatrización se puede ver afectado por diferentes enfermedades como lo es la diabetes, debido a la influencia que tiene la hiperglicemia y la exacerbación del estrés oxidativo. En este trabajo se presenta el desarrollo y caracterización de un parche de hidrogel como sistema de administración tópica de cafeína y ácido ascórbico, dos antioxidantes con potencial terapéutico. Se llevó a cabo un estudio de pre-formulación para evaluar la compatibilidad entre los excipientes y se diseñaron tres diferentes formulaciones de hidrogeles variando las concentraciones (1.5%m/v, 3.0%m/v y 5.0%m/v) de los polímeros seleccionados, los cuales fueron alginato de sodio y alcohol polivinílico. Posteriormente, los parches fueron caracterizados mediante pruebas mecánicas basadas en el módulo de Young por compresión, reológicas mediante el módulo de almacenamiento y perdida además de liberación in vitro de principios activos por medio de modelos cinéticos como el modelo de Korsmeyer-Peppas, el modelo de difusión de Higuchi y el modelo de Hixxon-Crowell. Los resultados muestran que la formulación propuesta posee propiedades mecánicas adecuadas y permite una liberación controlada de los antioxidantes, lo que podría contribuir a mejorar el proceso de cicatrización en pacientes diabéticos.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-05-15T14:53:21Z
dc.date.available.none.fl_str_mv 2025-05-15T14:53:21Z
dc.date.issued.none.fl_str_mv 2025-05
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.none.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
dc.type.coar.none.fl_str_mv https://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
dc.type.coarversion.none.fl_str_mv https://purl.org/coar/version/c_ab4af688f83e57aa
format https://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/14347
dc.identifier.instname.spa.fl_str_mv Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
url https://hdl.handle.net/20.500.12495/14347
identifier_str_mv Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
dc.language.iso.fl_str_mv spa
language spa
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spelling Velandia Paris, Maria AngelicaJiménez Cruz, Ronald AndrésSierra Guaqueta, MarianaGomez Villamil, Angie Valentina2025-05-15T14:53:21Z2025-05-15T14:53:21Z2025-05https://hdl.handle.net/20.500.12495/14347Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl proceso de cicatrización se puede ver afectado por diferentes enfermedades como lo es la diabetes, debido a la influencia que tiene la hiperglicemia y la exacerbación del estrés oxidativo. En este trabajo se presenta el desarrollo y caracterización de un parche de hidrogel como sistema de administración tópica de cafeína y ácido ascórbico, dos antioxidantes con potencial terapéutico. Se llevó a cabo un estudio de pre-formulación para evaluar la compatibilidad entre los excipientes y se diseñaron tres diferentes formulaciones de hidrogeles variando las concentraciones (1.5%m/v, 3.0%m/v y 5.0%m/v) de los polímeros seleccionados, los cuales fueron alginato de sodio y alcohol polivinílico. Posteriormente, los parches fueron caracterizados mediante pruebas mecánicas basadas en el módulo de Young por compresión, reológicas mediante el módulo de almacenamiento y perdida además de liberación in vitro de principios activos por medio de modelos cinéticos como el modelo de Korsmeyer-Peppas, el modelo de difusión de Higuchi y el modelo de Hixxon-Crowell. Los resultados muestran que la formulación propuesta posee propiedades mecánicas adecuadas y permite una liberación controlada de los antioxidantes, lo que podría contribuir a mejorar el proceso de cicatrización en pacientes diabéticos.PregradoQuímico FarmacéuticoThe healing process can be affected by different diseases such as diabetes, due to the influence of hyperglycemia and the exacerbation of oxidative stress. This work presents the development and characterization of a hydrogel patch as a topical delivery system for caffeine and ascorbic acid, two antioxidants with therapeutic potential. A pre-formulation study was conducted to evaluate the compatibility between the excipients, and three different hydrogel formulations were designed, varying the concentrations (1.5% w/v, 3.0% w/v, and 5.0% w/v) of the selected polymers, which were sodium alginate and polyvinyl alcohol. Subsequently, the patches were characterized through mechanical tests based on Young's modulus by compression, rheological tests using the loading and unloading modulus, and in vitro release of active ingredients using kinetic models such as the Korsmeyer-Peppas model, the Higuchi diffusion model, and the Hixxon-Crowell model. The results show that the proposed formulation has adequate mechanical properties and allows for controlled release of antioxidants, which could contribute to improving the healing process in diabetic patients.application/pdfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2Vitamina CCafeínaHidrogelAntioxidantesAlginato de sodioAlcohol polivinílico615.19Vitamin CCaffeineHydrogelAntioxidantsSodium alginatePolyvinyl alcoholAporte a la formulación de un parche de hidrogel que contiene cafeína y ácido ascórbico (vitamina C)Contribution to the formulation of a hydrogel patch containing caffeine and ascorbic acid (vitamin C)Química FarmacéuticaUniversidad El BosqueFacultad de CienciasTesis/Trabajo de grado - Monografía - Pregradohttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. 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