Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review

Objective: To assess clinical studies that compare synthetic or enriched natural materials to autologous osseous grafts among individuals with cleft lip and palate to determine which would be the substitute to autologous bone graft for alveolar cleft repair in humans. Materials and methods: Randomiz...

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Autores:
Colorado Osorio, Catalina
Vargas Escobar, Lina María
González Carrera, María Clara
Gamboa, Luis Fernamdo
Chambrone, Leandro
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/4109
Acceso en línea:
http://hdl.handle.net/20.500.12495/4109
https://doi.org/10.1016/j.heliyon.2020.e04646
Palabra clave:
Alveolar bone grafting
Alveolar cleft
Biomedical engineering
Biotechnology
Cleft lip
Cleft lip repair
Dental surgery
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.title.spa.fl_str_mv Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
dc.title.translated.spa.fl_str_mv Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
title Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
spellingShingle Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
Alveolar bone grafting
Alveolar cleft
Biomedical engineering
Biotechnology
Cleft lip
Cleft lip repair
Dental surgery
title_short Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
title_full Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
title_fullStr Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
title_full_unstemmed Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
title_sort Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic review
dc.creator.fl_str_mv Colorado Osorio, Catalina
Vargas Escobar, Lina María
González Carrera, María Clara
Gamboa, Luis Fernamdo
Chambrone, Leandro
dc.contributor.author.none.fl_str_mv Colorado Osorio, Catalina
Vargas Escobar, Lina María
González Carrera, María Clara
Gamboa, Luis Fernamdo
Chambrone, Leandro
dc.contributor.orcid.none.fl_str_mv González Carrera, María Clara [0000-0003-4572-1453]
Vargas Escobar, Lina María [0000-0003-0052-5467]
Chambrone, Leandro [0000-0002-2838-1015]
Colorado Osorio, Catalina [0000-0001-9275-7390]
Colorado Osorio, Catalina [0000-0001-9275-7390]
dc.subject.keywords.spa.fl_str_mv Alveolar bone grafting
Alveolar cleft
Biomedical engineering
Biotechnology
Cleft lip
Cleft lip repair
Dental surgery
topic Alveolar bone grafting
Alveolar cleft
Biomedical engineering
Biotechnology
Cleft lip
Cleft lip repair
Dental surgery
description Objective: To assess clinical studies that compare synthetic or enriched natural materials to autologous osseous grafts among individuals with cleft lip and palate to determine which would be the substitute to autologous bone graft for alveolar cleft repair in humans. Materials and methods: Randomized and controlled clinical trials on alveolar clefts treated with synthetic bone substitutes and autogenous bone grafts combined with osteoinductive factors compared with autogenous bone grafts alone (with ≥4-month follow-up and reporting clinical/radiographic data) were considered eligible. MEDLINE, EMBASE, and Central databases were searched for articles published until February 2020. Results: Of 73 eligible articles, 15 were included. Some inductive factors along with iliac crest bone decreased bone reabsorption, preserved the generated bone height/width, and reduced the required autologous bone graft volume. Bone morphogenetic protein (BMP2) as an autologous bone graft substitute, demonstrated satisfactory alveolar defect healing, by avoiding autograft use. Many materials did not yield better outcomes than did autologous grafts; however, hydroxyapatite and collagen complex, hydroxyapatite agarose composite gel, acellular dermal matrix film, fibrin glue, platelet-rich plasma, and deproteinized bovine bone showed similar bone healing outcomes, being an alternative alveolar defect treatment. Conclusions: BMP2, as an osteoinductive factor along with a synthetic matrix, yields satisfactory bone healing and avoids the need for autologous bone grafts. However, high-quality RCTs are necessary to determine the most effective and safe concentration and protocol of BMP2 utilization as a substitute for the autologous iliac crest bone grafting.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-09-16T21:47:08Z
dc.date.available.none.fl_str_mv 2020-09-16T21:47:08Z
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.heliyon.2020.e04646
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url http://hdl.handle.net/20.500.12495/4109
https://doi.org/10.1016/j.heliyon.2020.e04646
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Heliyon, 2405-8440, Vol. 6, Nro. 9, 2020
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eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv Heliyon
institution Universidad El Bosque
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spelling Colorado Osorio, CatalinaVargas Escobar, Lina MaríaGonzález Carrera, María ClaraGamboa, Luis FernamdoChambrone, LeandroGonzález Carrera, María Clara [0000-0003-4572-1453]Vargas Escobar, Lina María [0000-0003-0052-5467]Chambrone, Leandro [0000-0002-2838-1015]Colorado Osorio, Catalina [0000-0001-9275-7390]Colorado Osorio, Catalina [0000-0001-9275-7390]2020-09-16T21:47:08Z2020-09-16T21:47:08Z2405-8440http://hdl.handle.net/20.500.12495/4109https://doi.org/10.1016/j.heliyon.2020.e04646instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengElsevierHeliyonHeliyon, 2405-8440, Vol. 6, Nro. 9, 2020https://www.cell.com/heliyon/fulltext/S2405-8440(20)31490-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844020314900%3Fshowall%3DtrueAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2020-08-03Evaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic reviewEvaluation of density, volume, height and rate of bone resorption of substitutes of autologous bone grafts for the repair of alveolar clefts in humans: a systematic reviewArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Alveolar bone graftingAlveolar cleftBiomedical engineeringBiotechnologyCleft lipCleft lip repairDental surgeryObjective: To assess clinical studies that compare synthetic or enriched natural materials to autologous osseous grafts among individuals with cleft lip and palate to determine which would be the substitute to autologous bone graft for alveolar cleft repair in humans. Materials and methods: Randomized and controlled clinical trials on alveolar clefts treated with synthetic bone substitutes and autogenous bone grafts combined with osteoinductive factors compared with autogenous bone grafts alone (with ≥4-month follow-up and reporting clinical/radiographic data) were considered eligible. MEDLINE, EMBASE, and Central databases were searched for articles published until February 2020. Results: Of 73 eligible articles, 15 were included. Some inductive factors along with iliac crest bone decreased bone reabsorption, preserved the generated bone height/width, and reduced the required autologous bone graft volume. Bone morphogenetic protein (BMP2) as an autologous bone graft substitute, demonstrated satisfactory alveolar defect healing, by avoiding autograft use. Many materials did not yield better outcomes than did autologous grafts; however, hydroxyapatite and collagen complex, hydroxyapatite agarose composite gel, acellular dermal matrix film, fibrin glue, platelet-rich plasma, and deproteinized bovine bone showed similar bone healing outcomes, being an alternative alveolar defect treatment. Conclusions: BMP2, as an osteoinductive factor along with a synthetic matrix, yields satisfactory bone healing and avoids the need for autologous bone grafts. However, high-quality RCTs are necessary to determine the most effective and safe concentration and protocol of BMP2 utilization as a substitute for the autologous iliac crest bone grafting.CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.unbosque.edu.co/bitstreams/a0515947-e2a2-409b-990e-879f3b30db29/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/cd252133-26e9-47a0-b009-0c1d9b41436a/download8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALCatalina Colorado Osorioa, Lina María Escobar_2020.pdfCatalina Colorado Osorioa, Lina María Escobar_2020.pdfapplication/pdf443169https://repositorio.unbosque.edu.co/bitstreams/b6c8f33d-815f-4111-a6c6-fe7c42283235/download7b9a47c70710ba86bdfa165d1c0843a2MD51THUMBNAILCatalina Colorado Osorioa, Lina María Escobar_2020.pdf.jpgCatalina Colorado Osorioa, Lina María Escobar_2020.pdf.jpgIM Thumbnailimage/jpeg11439https://repositorio.unbosque.edu.co/bitstreams/9eaa0e7f-cf39-49a9-afe9-a94c74d74f69/download1ad948ada6b3c07e955aedbae6f6b149MD54TEXTCatalina Colorado Osorioa, Lina María Escobar_2020.pdf.txtCatalina Colorado Osorioa, Lina María Escobar_2020.pdf.txtExtracted texttext/plain60541https://repositorio.unbosque.edu.co/bitstreams/8b56ce5a-874f-4a1f-b3f6-1fee9b7030b8/download9a16d2f22d6901e19d4468e6add58743MD5520.500.12495/4109oai:repositorio.unbosque.edu.co:20.500.12495/41092024-02-07 06:35:58.472http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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