Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.

Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlightin...

Full description

Autores:
Beltrán Hernández, M.F
Rodríguez Romero, M.L
Moncada Cárdenas, B.
Pombo Ospina, L.M.
Pedraza Arévalo, L.C
Andrade Barreiro, William Alejandro
Rodríguez Aguirre, Oscar Eduardo
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/2086
Acceso en línea:
http://hdl.handle.net/20.500.12495/2086
Palabra clave:
Líquenes
Formas de los organismos
Mecanismos moleculares de acción farmacológica
Lichen
Secondary metabolites
Teloschistes exilis
Vain
Antioxidant
Antifungal
Rights
License
Acceso cerrado
id UNBOSQUE2_ce6221495124b66b3a382601c905f670
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/2086
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
dc.title.translated.none.fl_str_mv Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
title Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
spellingShingle Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
Líquenes
Formas de los organismos
Mecanismos moleculares de acción farmacológica
Lichen
Secondary metabolites
Teloschistes exilis
Vain
Antioxidant
Antifungal
title_short Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
title_full Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
title_fullStr Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
title_full_unstemmed Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
title_sort Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
dc.creator.fl_str_mv Beltrán Hernández, M.F
Rodríguez Romero, M.L
Moncada Cárdenas, B.
Pombo Ospina, L.M.
Pedraza Arévalo, L.C
Andrade Barreiro, William Alejandro
Rodríguez Aguirre, Oscar Eduardo
dc.contributor.author.none.fl_str_mv Beltrán Hernández, M.F
Rodríguez Romero, M.L
Moncada Cárdenas, B.
Pombo Ospina, L.M.
Pedraza Arévalo, L.C
Andrade Barreiro, William Alejandro
Rodríguez Aguirre, Oscar Eduardo
dc.contributor.orcid.none.fl_str_mv Rodríguez Aguirre, Oscar Eduardo [0000-0002-5934-0451]
dc.subject.decs.spa.fl_str_mv Líquenes
Formas de los organismos
Mecanismos moleculares de acción farmacológica
topic Líquenes
Formas de los organismos
Mecanismos moleculares de acción farmacológica
Lichen
Secondary metabolites
Teloschistes exilis
Vain
Antioxidant
Antifungal
dc.subject.keywords.spa.fl_str_mv Lichen
Secondary metabolites
Teloschistes exilis
Vain
Antioxidant
Antifungal
description Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For that reason, this study evaluated the antioxidant capacity with 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS*+ assay) and the antifungal activity of the total ethanolic extract (EtOH) and different polarity fractions from Teloschistes exilis (Michx.) Vain against Penicillium digitatum and Aspergillus niger using disk diffusion technique. According to antioxidant activity, the best-obtained value was for the EtOH with 37.58 mg/L MeOH, with ascorbic acid. In terms of antifungal activity, for equivalent sensitivity, against Penicillium digitatum, for each mg of ketoconazole, 213.4 mg of Petroleum ether fraction were required, while for each mg of fluconazole, 228.3 mg of Petroleum ether fraction were required. Regarding to antifungal activity against Aspergillus niger, for each mg of ketoconazole, 465.6 mg of Petroleum ether fraction are required, while for each mg of fluconazole, 174.6 mg of Petroleum ether fraction are needed. The highest polarity solvents have a better relative antioxidant activity in relation with standard solutions, whereas susceptibility tests applied for Aspergillus niger and Penicillium digitatum showed the best antifungal activity for the low polarity fraction of Petroleum ether for both controls. Considering that are fractions, the antioxidant and antifungal potential of Teloschistes exilis (Michx.) Vain should be elucidated in posterior studies.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2020-03-24T14:49:31Z
dc.date.available.none.fl_str_mv 2020-03-24T14:49:31Z
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1827-8620
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/2086
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1827-8620
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/2086
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv PharmacologyOnLine, 1827-8620, Vol. 3, 2019, p.28-35
dc.relation.uri.none.fl_str_mv https://pharmacologyonline.silae.it/files/archives/2019/vol3/PhOL_2019_3_A003_Beltran.pdf
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso cerrado
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf34
dc.rights.creativecommons.none.fl_str_mv 2019
rights_invalid_str_mv Acceso cerrado
http://purl.org/coar/access_right/c_abf34
2019
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Silae
dc.publisher.journal.spa.fl_str_mv PharmacologyOnLine
institution Universidad El Bosque
bitstream.url.fl_str_mv https://repositorio.unbosque.edu.co/bitstreams/e4f13099-c60b-4f3c-942a-fd66536dbe99/download
https://repositorio.unbosque.edu.co/bitstreams/dd4b1f21-2744-4925-ae50-c49691bb9ce8/download
https://repositorio.unbosque.edu.co/bitstreams/7e0d6ae0-ea1e-4b55-bfee-11f8f8b760f8/download
https://repositorio.unbosque.edu.co/bitstreams/6c8c2025-fdc1-457a-b433-fb99b27af344/download
bitstream.checksum.fl_str_mv d1697783d642d0b7db795ea014a40447
8a4605be74aa9ea9d79846c1fba20a33
7210a811635d1799e7c05fee5d259be7
b9711d1ec8f6f3c9a1dbd46aa6fded92
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad El Bosque
repository.mail.fl_str_mv bibliotecas@biteca.com
_version_ 1814100796256550912
spelling Beltrán Hernández, M.FRodríguez Romero, M.LMoncada Cárdenas, B.Pombo Ospina, L.M.Pedraza Arévalo, L.CAndrade Barreiro, William AlejandroRodríguez Aguirre, Oscar EduardoRodríguez Aguirre, Oscar Eduardo [0000-0002-5934-0451]2020-03-24T14:49:31Z2020-03-24T14:49:31Z20191827-8620http://hdl.handle.net/20.500.12495/2086instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengSilaePharmacologyOnLinePharmacologyOnLine, 1827-8620, Vol. 3, 2019, p.28-35https://pharmacologyonline.silae.it/files/archives/2019/vol3/PhOL_2019_3_A003_Beltran.pdfEvaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.articleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LíquenesFormas de los organismosMecanismos moleculares de acción farmacológicaLichenSecondary metabolitesTeloschistes exilisVainAntioxidantAntifungalTeloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For that reason, this study evaluated the antioxidant capacity with 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS*+ assay) and the antifungal activity of the total ethanolic extract (EtOH) and different polarity fractions from Teloschistes exilis (Michx.) Vain against Penicillium digitatum and Aspergillus niger using disk diffusion technique. According to antioxidant activity, the best-obtained value was for the EtOH with 37.58 mg/L MeOH, with ascorbic acid. In terms of antifungal activity, for equivalent sensitivity, against Penicillium digitatum, for each mg of ketoconazole, 213.4 mg of Petroleum ether fraction were required, while for each mg of fluconazole, 228.3 mg of Petroleum ether fraction were required. Regarding to antifungal activity against Aspergillus niger, for each mg of ketoconazole, 465.6 mg of Petroleum ether fraction are required, while for each mg of fluconazole, 174.6 mg of Petroleum ether fraction are needed. The highest polarity solvents have a better relative antioxidant activity in relation with standard solutions, whereas susceptibility tests applied for Aspergillus niger and Penicillium digitatum showed the best antifungal activity for the low polarity fraction of Petroleum ether for both controls. Considering that are fractions, the antioxidant and antifungal potential of Teloschistes exilis (Michx.) Vain should be elucidated in posterior studies.Acceso cerradohttp://purl.org/coar/access_right/c_abf342019http://purl.org/coar/access_right/c_abf2ORIGINALBeltrán Hernández, M.F..pdfBeltrán Hernández, M.F..pdfapplication/pdf529079https://repositorio.unbosque.edu.co/bitstreams/e4f13099-c60b-4f3c-942a-fd66536dbe99/downloadd1697783d642d0b7db795ea014a40447MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/dd4b1f21-2744-4925-ae50-c49691bb9ce8/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILBeltrán Hernández, M.F..pdf.jpgBeltrán Hernández, M.F..pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/7e0d6ae0-ea1e-4b55-bfee-11f8f8b760f8/download7210a811635d1799e7c05fee5d259be7MD53TEXTBeltrán Hernández, M.F..pdf.txtBeltrán Hernández, M.F..pdf.txtExtracted texttext/plain24595https://repositorio.unbosque.edu.co/bitstreams/6c8c2025-fdc1-457a-b433-fb99b27af344/downloadb9711d1ec8f6f3c9a1dbd46aa6fded92MD5420.500.12495/2086oai:repositorio.unbosque.edu.co:20.500.12495/20862024-02-07 06:53:30.516restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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