Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.
Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlightin...
- Autores:
-
Beltrán Hernández, M.F
Rodríguez Romero, M.L
Moncada Cárdenas, B.
Pombo Ospina, L.M.
Pedraza Arévalo, L.C
Andrade Barreiro, William Alejandro
Rodríguez Aguirre, Oscar Eduardo
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/2086
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/2086
- Palabra clave:
- Líquenes
Formas de los organismos
Mecanismos moleculares de acción farmacológica
Lichen
Secondary metabolites
Teloschistes exilis
Vain
Antioxidant
Antifungal
- Rights
- License
- Acceso cerrado
id |
UNBOSQUE2_ce6221495124b66b3a382601c905f670 |
---|---|
oai_identifier_str |
oai:repositorio.unbosque.edu.co:20.500.12495/2086 |
network_acronym_str |
UNBOSQUE2 |
network_name_str |
Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
dc.title.translated.none.fl_str_mv |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
title |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
spellingShingle |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. Líquenes Formas de los organismos Mecanismos moleculares de acción farmacológica Lichen Secondary metabolites Teloschistes exilis Vain Antioxidant Antifungal |
title_short |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
title_full |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
title_fullStr |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
title_full_unstemmed |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
title_sort |
Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain. |
dc.creator.fl_str_mv |
Beltrán Hernández, M.F Rodríguez Romero, M.L Moncada Cárdenas, B. Pombo Ospina, L.M. Pedraza Arévalo, L.C Andrade Barreiro, William Alejandro Rodríguez Aguirre, Oscar Eduardo |
dc.contributor.author.none.fl_str_mv |
Beltrán Hernández, M.F Rodríguez Romero, M.L Moncada Cárdenas, B. Pombo Ospina, L.M. Pedraza Arévalo, L.C Andrade Barreiro, William Alejandro Rodríguez Aguirre, Oscar Eduardo |
dc.contributor.orcid.none.fl_str_mv |
Rodríguez Aguirre, Oscar Eduardo [0000-0002-5934-0451] |
dc.subject.decs.spa.fl_str_mv |
Líquenes Formas de los organismos Mecanismos moleculares de acción farmacológica |
topic |
Líquenes Formas de los organismos Mecanismos moleculares de acción farmacológica Lichen Secondary metabolites Teloschistes exilis Vain Antioxidant Antifungal |
dc.subject.keywords.spa.fl_str_mv |
Lichen Secondary metabolites Teloschistes exilis Vain Antioxidant Antifungal |
description |
Teloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For that reason, this study evaluated the antioxidant capacity with 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS*+ assay) and the antifungal activity of the total ethanolic extract (EtOH) and different polarity fractions from Teloschistes exilis (Michx.) Vain against Penicillium digitatum and Aspergillus niger using disk diffusion technique. According to antioxidant activity, the best-obtained value was for the EtOH with 37.58 mg/L MeOH, with ascorbic acid. In terms of antifungal activity, for equivalent sensitivity, against Penicillium digitatum, for each mg of ketoconazole, 213.4 mg of Petroleum ether fraction were required, while for each mg of fluconazole, 228.3 mg of Petroleum ether fraction were required. Regarding to antifungal activity against Aspergillus niger, for each mg of ketoconazole, 465.6 mg of Petroleum ether fraction are required, while for each mg of fluconazole, 174.6 mg of Petroleum ether fraction are needed. The highest polarity solvents have a better relative antioxidant activity in relation with standard solutions, whereas susceptibility tests applied for Aspergillus niger and Penicillium digitatum showed the best antifungal activity for the low polarity fraction of Petroleum ether for both controls. Considering that are fractions, the antioxidant and antifungal potential of Teloschistes exilis (Michx.) Vain should be elucidated in posterior studies. |
publishDate |
2019 |
dc.date.issued.none.fl_str_mv |
2019 |
dc.date.accessioned.none.fl_str_mv |
2020-03-24T14:49:31Z |
dc.date.available.none.fl_str_mv |
2020-03-24T14:49:31Z |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
1827-8620 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/2086 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1827-8620 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/2086 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
PharmacologyOnLine, 1827-8620, Vol. 3, 2019, p.28-35 |
dc.relation.uri.none.fl_str_mv |
https://pharmacologyonline.silae.it/files/archives/2019/vol3/PhOL_2019_3_A003_Beltran.pdf |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Acceso cerrado |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf34 |
dc.rights.creativecommons.none.fl_str_mv |
2019 |
rights_invalid_str_mv |
Acceso cerrado http://purl.org/coar/access_right/c_abf34 2019 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Silae |
dc.publisher.journal.spa.fl_str_mv |
PharmacologyOnLine |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
https://repositorio.unbosque.edu.co/bitstreams/e4f13099-c60b-4f3c-942a-fd66536dbe99/download https://repositorio.unbosque.edu.co/bitstreams/dd4b1f21-2744-4925-ae50-c49691bb9ce8/download https://repositorio.unbosque.edu.co/bitstreams/7e0d6ae0-ea1e-4b55-bfee-11f8f8b760f8/download https://repositorio.unbosque.edu.co/bitstreams/6c8c2025-fdc1-457a-b433-fb99b27af344/download |
bitstream.checksum.fl_str_mv |
d1697783d642d0b7db795ea014a40447 8a4605be74aa9ea9d79846c1fba20a33 7210a811635d1799e7c05fee5d259be7 b9711d1ec8f6f3c9a1dbd46aa6fded92 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad El Bosque |
repository.mail.fl_str_mv |
bibliotecas@biteca.com |
_version_ |
1814100796256550912 |
spelling |
Beltrán Hernández, M.FRodríguez Romero, M.LMoncada Cárdenas, B.Pombo Ospina, L.M.Pedraza Arévalo, L.CAndrade Barreiro, William AlejandroRodríguez Aguirre, Oscar EduardoRodríguez Aguirre, Oscar Eduardo [0000-0002-5934-0451]2020-03-24T14:49:31Z2020-03-24T14:49:31Z20191827-8620http://hdl.handle.net/20.500.12495/2086instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengSilaePharmacologyOnLinePharmacologyOnLine, 1827-8620, Vol. 3, 2019, p.28-35https://pharmacologyonline.silae.it/files/archives/2019/vol3/PhOL_2019_3_A003_Beltran.pdfEvaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.Evaluation of antioxidant capacity and antifungal activity of the total ethanolic extract and fractions from teloschistes exilis (Michx.) vain.articleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501LíquenesFormas de los organismosMecanismos moleculares de acción farmacológicaLichenSecondary metabolitesTeloschistes exilisVainAntioxidantAntifungalTeloschistes exilis (Michx.) Vain is an underexplored lichen. In the last decades, there has been a growing interest for the study of lichenic biodiversity, as a source of new natural products, because these produce potential secondary metabolites for pharmacological and industrial uses, highlighting their antioxidant and antifungal properties. For that reason, this study evaluated the antioxidant capacity with 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS*+ assay) and the antifungal activity of the total ethanolic extract (EtOH) and different polarity fractions from Teloschistes exilis (Michx.) Vain against Penicillium digitatum and Aspergillus niger using disk diffusion technique. According to antioxidant activity, the best-obtained value was for the EtOH with 37.58 mg/L MeOH, with ascorbic acid. In terms of antifungal activity, for equivalent sensitivity, against Penicillium digitatum, for each mg of ketoconazole, 213.4 mg of Petroleum ether fraction were required, while for each mg of fluconazole, 228.3 mg of Petroleum ether fraction were required. Regarding to antifungal activity against Aspergillus niger, for each mg of ketoconazole, 465.6 mg of Petroleum ether fraction are required, while for each mg of fluconazole, 174.6 mg of Petroleum ether fraction are needed. The highest polarity solvents have a better relative antioxidant activity in relation with standard solutions, whereas susceptibility tests applied for Aspergillus niger and Penicillium digitatum showed the best antifungal activity for the low polarity fraction of Petroleum ether for both controls. Considering that are fractions, the antioxidant and antifungal potential of Teloschistes exilis (Michx.) Vain should be elucidated in posterior studies.Acceso cerradohttp://purl.org/coar/access_right/c_abf342019http://purl.org/coar/access_right/c_abf2ORIGINALBeltrán Hernández, M.F..pdfBeltrán Hernández, M.F..pdfapplication/pdf529079https://repositorio.unbosque.edu.co/bitstreams/e4f13099-c60b-4f3c-942a-fd66536dbe99/downloadd1697783d642d0b7db795ea014a40447MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/dd4b1f21-2744-4925-ae50-c49691bb9ce8/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILBeltrán Hernández, M.F..pdf.jpgBeltrán Hernández, M.F..pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/7e0d6ae0-ea1e-4b55-bfee-11f8f8b760f8/download7210a811635d1799e7c05fee5d259be7MD53TEXTBeltrán Hernández, M.F..pdf.txtBeltrán Hernández, M.F..pdf.txtExtracted texttext/plain24595https://repositorio.unbosque.edu.co/bitstreams/6c8c2025-fdc1-457a-b433-fb99b27af344/downloadb9711d1ec8f6f3c9a1dbd46aa6fded92MD5420.500.12495/2086oai:repositorio.unbosque.edu.co:20.500.12495/20862024-02-07 06:53:30.516restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |