Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study

Objectives To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA,reactive arthritis or juvenile SpA (Juv-SpA)) fitted the patient best. Peripheral manifestations (ie, peripheral joint disease, enthesitis, dactylitis and root joint disease), their localisation and treatments were evaluated. Results A total of 4465 patients were included (61% men, mean age 44.5 years) from four geographic areas: Latin merica (n=538), Europe plus North America (n=1677), Asia (n=975) and the Middle East plus North Africa (n=1275). Of those, 78% had ever suffered from at least one peripheral musculoskeletal manifestation; 57% had peripheral joint disease, 44% had enthesitis and 15% had dactylitis. Latin American had far more often peripheral joint disease (80%) than patients from other areas. Patients with PsA had predominantly upper limb and small joint involvement (52%). Hip and shoulder involvement was found in 34% of patients. The prevalence of enthesitis ranged between 41% in patients with axSpA and 65% in patients with Juv-SpA. Dactylitis was most frequent among patients with PsA (37%). Conclusion These results suggest that all peripheral features can be found in all subtypes of SpA, and that differences are quantitative rather than qualitative. In a high proportion of patients, axial and peripheral manifestations coincided. These findings reconfirm SpA clinical subtypes are descendants of the same underlying disease, called SpA.

• Autores: López Medina, Clementina; Molto, Anna; Sieper, Joachim; Duruöz, Tuncay; Kiltz, Uta; Elzorkany, Bassel; Hajjaj Hassouni, Najia; Burgos Vargas, Ruben; Maldonado Cocco, José; Ziade, Nelly; Gavali, Meghna; Navarro Compan, Victoria; Luo, Shue Fen; Monti, Sara; Tae Jong, Kim; Kishimoto, Mitsumasa; Pimentel Santos, F M; Gu, Jieruo; Schiotis, Ruxandra; van Gaalen, Floris A; Geher, Pál; Magrey, Marina; Ibáñez Vodnizza, Sebastián E; Bautista Molano, Wilson; Maksymowych, Walter; Machado, Pedro M; Landewé, Robert; van der Heijde, Desirée; Dougados, Maxime
• Tipo de recurso: Article of journal
• Fecha de publicación: 2021
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/5890
• Acceso en línea: http://hdl.handle.net/20.500.12495/5890; https://doi.org/10.1136/RMDOPEN-2020-001450
• Palabra clave: Ankylosing; Arthritis; Juvenile; Psoriatic; Spondylitis
• Rights: openAccess
• License: Atribución-NoComercial 4.0 Internacional