In vivo differential susceptibility of sensory neurons to rabies virus infection
There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root gang...
- Autores:
-
Velandia-Romero, Myriam Lucía
Castellanos, Jaime
Martínez-Gutiérrez, Marlén
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2013
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/4597
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/4597
https://doi.org/10.1007/s13365-013-0179-5
https://repositorio.unbosque.edu.co
- Palabra clave:
- Rabies virus
Sensory neurons
Motors neurons
Transynaptic infection
- Rights
- openAccess
- License
- Acceso abierto
id |
UNBOSQUE2_c51577995311f95d758c210142c5b876 |
---|---|
oai_identifier_str |
oai:repositorio.unbosque.edu.co:20.500.12495/4597 |
network_acronym_str |
UNBOSQUE2 |
network_name_str |
Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
dc.title.translated.spa.fl_str_mv |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
title |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
spellingShingle |
In vivo differential susceptibility of sensory neurons to rabies virus infection Rabies virus Sensory neurons Motors neurons Transynaptic infection |
title_short |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
title_full |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
title_fullStr |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
title_full_unstemmed |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
title_sort |
In vivo differential susceptibility of sensory neurons to rabies virus infection |
dc.creator.fl_str_mv |
Velandia-Romero, Myriam Lucía Castellanos, Jaime Martínez-Gutiérrez, Marlén |
dc.contributor.author.none.fl_str_mv |
Velandia-Romero, Myriam Lucía Castellanos, Jaime Martínez-Gutiérrez, Marlén |
dc.contributor.orcid.none.fl_str_mv |
Castellanos, Jaime [0000-0003-1596-8383] Velandia-Romero, Myriam Lucía [0000-0002-3340-7304] |
dc.subject.keywords.spa.fl_str_mv |
Rabies virus Sensory neurons Motors neurons Transynaptic infection |
topic |
Rabies virus Sensory neurons Motors neurons Transynaptic infection |
description |
There is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory neurons capture and transport the virus to the spinal cord (SC) and then to the brain. It is probable that preferences for one pathway or another depend on the site of inoculation and the post-infection time. Therefore, in the present study, we evaluated different vertebral segments and post-infection times, along with the location, number, and subpopulation of sensory neurons susceptible to infection after inoculating RABV in the footpads of adult mice. It was noted that the virus inoculated in the footpad preferentially entered the CNS through the large-sized DRG sensory neurons, while infection of the motor neurons occurred later. Further, it was found that the virus was dispersed in spinal cord trans-synaptically through the interneurons, arriving at both sensory neurons and contralateral motor neurons. In conclusion, we observed that RABV inoculated in the plantar footpad is captured preferentially by large sensory neurons and is transported to the DRG, where it replicates and is spread to the SC using transynaptic jumps, infecting sensory and motor neurons at the same level before ascending to the brain. |
publishDate |
2013 |
dc.date.issued.none.fl_str_mv |
2013 |
dc.date.accessioned.none.fl_str_mv |
2020-10-28T22:00:19Z |
dc.date.available.none.fl_str_mv |
2020-10-28T22:00:19Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1355-0284 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/4597 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s13365-013-0179-5 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unbosque.edu.co |
identifier_str_mv |
1355-0284 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
url |
http://hdl.handle.net/20.500.12495/4597 https://doi.org/10.1007/s13365-013-0179-5 https://repositorio.unbosque.edu.co |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Journal of NeuroVirology, 1355-0284, Vol. 19, 2013, p. 367–375 |
dc.relation.uri.none.fl_str_mv |
https://link-springer-com.ezproxy.unbosque.edu.co/article/10.1007/s13365-013-0179-5 |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2013-08-20 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2013-08-20 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer |
dc.publisher.journal.spa.fl_str_mv |
Journal of NeuroVirology |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
https://repositorio.unbosque.edu.co/bitstreams/67b01bf1-6ca4-4582-8573-16e7971e466c/download https://repositorio.unbosque.edu.co/bitstreams/dc47c5d6-db01-4458-ba62-c05192e0e994/download https://repositorio.unbosque.edu.co/bitstreams/cd7dd82e-77fa-45ad-a32f-8bdadcf863b7/download https://repositorio.unbosque.edu.co/bitstreams/a77fbb1b-e12b-4c7f-85b5-35f1b84fae82/download |
bitstream.checksum.fl_str_mv |
8f75bfe095d06c032fae2d78abf9a32f 8a4605be74aa9ea9d79846c1fba20a33 170464823eb010ec32e40f3144187ef1 3ed3401f025b08469e442d4e46f652f5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad El Bosque |
repository.mail.fl_str_mv |
bibliotecas@biteca.com |
_version_ |
1814100773052612608 |
spelling |
Velandia-Romero, Myriam LucíaCastellanos, JaimeMartínez-Gutiérrez, MarlénCastellanos, Jaime [0000-0003-1596-8383]Velandia-Romero, Myriam Lucía [0000-0002-3340-7304]2020-10-28T22:00:19Z2020-10-28T22:00:19Z20131355-0284http://hdl.handle.net/20.500.12495/4597https://doi.org/10.1007/s13365-013-0179-5instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengSpringerJournal of NeuroVirologyJournal of NeuroVirology, 1355-0284, Vol. 19, 2013, p. 367–375https://link-springer-com.ezproxy.unbosque.edu.co/article/10.1007/s13365-013-0179-5In vivo differential susceptibility of sensory neurons to rabies virus infectionIn vivo differential susceptibility of sensory neurons to rabies virus infectionArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Rabies virusSensory neuronsMotors neuronsTransynaptic infectionThere is controversy with regard to the entry pathway of the rabies virus (RABV) into the central nervous system (CNS). Some authors have suggested that the virus inoculated at the periphery is captured and transported to CNS only by motor neurons; however, it has been reported that dorsal root ganglia (DRG) sensory neurons capture and transport the virus to the spinal cord (SC) and then to the brain. It is probable that preferences for one pathway or another depend on the site of inoculation and the post-infection time. Therefore, in the present study, we evaluated different vertebral segments and post-infection times, along with the location, number, and subpopulation of sensory neurons susceptible to infection after inoculating RABV in the footpads of adult mice. It was noted that the virus inoculated in the footpad preferentially entered the CNS through the large-sized DRG sensory neurons, while infection of the motor neurons occurred later. Further, it was found that the virus was dispersed in spinal cord trans-synaptically through the interneurons, arriving at both sensory neurons and contralateral motor neurons. In conclusion, we observed that RABV inoculated in the plantar footpad is captured preferentially by large sensory neurons and is transported to the DRG, where it replicates and is spread to the SC using transynaptic jumps, infecting sensory and motor neurons at the same level before ascending to the brain.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2013-08-20ORIGINALVelandia-Romero, Myriam L..pdfVelandia-Romero, Myriam L..pdfapplication/pdf676131https://repositorio.unbosque.edu.co/bitstreams/67b01bf1-6ca4-4582-8573-16e7971e466c/download8f75bfe095d06c032fae2d78abf9a32fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/dc47c5d6-db01-4458-ba62-c05192e0e994/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILVelandia-Romero, Myriam L..pdf.jpgVelandia-Romero, Myriam L..pdf.jpgIM Thumbnailimage/jpeg9068https://repositorio.unbosque.edu.co/bitstreams/cd7dd82e-77fa-45ad-a32f-8bdadcf863b7/download170464823eb010ec32e40f3144187ef1MD53TEXTVelandia-Romero, Myriam L..pdf.txtVelandia-Romero, Myriam L..pdf.txtExtracted texttext/plain37624https://repositorio.unbosque.edu.co/bitstreams/a77fbb1b-e12b-4c7f-85b5-35f1b84fae82/download3ed3401f025b08469e442d4e46f652f5MD5420.500.12495/4597oai:repositorio.unbosque.edu.co:20.500.12495/45972024-02-07 04:29:05.946open.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |