Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia

We need a better risk stratifcation system for the increasing number of survivors of extreme prematurity sufering the most severe forms of bronchopulmonary dysplasia (BPD). However, there is still a paucity of studies providing scientifc evidence to guide future updates of BPD severity defnitions. O...

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Autores:
Nino, Gustavo
Mansoor, Awais
Perez, Geovanny
Arroyo, Maria
Xu Chen, Xilei
Weinstock, Jered
Salka, Kyle
Said, Mariam
Acuña-Cordero, Ranniery
Sossa-Briceño, Monica P.
Rodríguez-Martínez, Carlos E.
Linguraru, Marius George
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1928
Acceso en línea:
http://hdl.handle.net/20.500.12495/1928
https://doi.org/10.1038/s41598-019-56355-5
Palabra clave:
Recien nacido prematuro
Enfermedades del recién nacido
Displasia broncopulmonar
Riesgo a la salud
Rights
License
Attribution 4.0 International
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network_name_str Repositorio U. El Bosque
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dc.title.spa.fl_str_mv Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
title Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
spellingShingle Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
Recien nacido prematuro
Enfermedades del recién nacido
Displasia broncopulmonar
Riesgo a la salud
title_short Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
title_full Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
title_fullStr Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
title_full_unstemmed Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
title_sort Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasia
dc.creator.fl_str_mv Nino, Gustavo
Mansoor, Awais
Perez, Geovanny
Arroyo, Maria
Xu Chen, Xilei
Weinstock, Jered
Salka, Kyle
Said, Mariam
Acuña-Cordero, Ranniery
Sossa-Briceño, Monica P.
Rodríguez-Martínez, Carlos E.
Linguraru, Marius George
dc.contributor.author.none.fl_str_mv Nino, Gustavo
Mansoor, Awais
Perez, Geovanny
Arroyo, Maria
Xu Chen, Xilei
Weinstock, Jered
Salka, Kyle
Said, Mariam
Acuña-Cordero, Ranniery
Sossa-Briceño, Monica P.
Rodríguez-Martínez, Carlos E.
Linguraru, Marius George
dc.subject.decs.spa.fl_str_mv Recien nacido prematuro
Enfermedades del recién nacido
Displasia broncopulmonar
Riesgo a la salud
topic Recien nacido prematuro
Enfermedades del recién nacido
Displasia broncopulmonar
Riesgo a la salud
description We need a better risk stratifcation system for the increasing number of survivors of extreme prematurity sufering the most severe forms of bronchopulmonary dysplasia (BPD). However, there is still a paucity of studies providing scientifc evidence to guide future updates of BPD severity defnitions. Our goal was to validate a new predictive model for BPD severity that incorporates respiratory assessments beyond 36 weeks postmenstrual age (PMA). We hypothesized that this approach improves BPD risk assessment, particularly in extremely premature infants. This is a longitudinal cohort of premature infants (≤32 weeks PMA, n=188; Washington D.C). We performed receiver operating characteristic analysis to defne optimal BPD severity levels using the duration of supplementary O2 as predictor and respiratory hospitalization after discharge as outcome. Internal validation included lung X-ray imaging and phenotypical characterization of BPD severity levels. External validation was conducted in an independent longitudinal cohort of premature infants (≤36 weeks PMA, n=130; Bogota). We found that incorporating the total number of days requiring O2 (without restricting at 36 weeks PMA) improved the prediction of respiratory outcomes according to BPD severity. In addition, we defned a new severity category (level IV) with prolonged exposure to supplemental O2 (≥120 days) that has the highest risk of respiratory hospitalizations after discharge. We confrmed these fndings in our validation cohort using ambulatory determination of O2 requirements. In conclusion, a new predictive model for BPD severity that incorporates respiratory assessments beyond 36 weeks improves risk stratifcation and should be considered when updating current BPD severity defnitions.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-02-11T19:03:26Z
dc.date.available.none.fl_str_mv 2020-02-11T19:03:26Z
dc.date.issued.none.fl_str_mv 2020
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 2045-2322
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1928
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1038/s41598-019-56355-5
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/1928
https://doi.org/10.1038/s41598-019-56355-5
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Scientific Reports, 2045-2322, 2020, p. 1-10
dc.relation.uri.none.fl_str_mv https://www.nature.com/articles/s41598-019-56355-5
dc.rights.*.fl_str_mv Attribution 4.0 International
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dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
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dc.rights.creativecommons.none.fl_str_mv 2020
rights_invalid_str_mv Attribution 4.0 International
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2020
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dc.publisher.journal.spa.fl_str_mv Scientific Reports
institution Universidad El Bosque
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spelling Nino, GustavoMansoor, AwaisPerez, GeovannyArroyo, MariaXu Chen, XileiWeinstock, JeredSalka, KyleSaid, MariamAcuña-Cordero, RannierySossa-Briceño, Monica P.Rodríguez-Martínez, Carlos E.Linguraru, Marius George2020-02-11T19:03:26Z2020-02-11T19:03:26Z20202045-2322http://hdl.handle.net/20.500.12495/1928https://doi.org/10.1038/s41598-019-56355-5instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengNature Publishing GroupScientific ReportsScientific Reports, 2045-2322, 2020, p. 1-10https://www.nature.com/articles/s41598-019-56355-5Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf3792020http://purl.org/coar/access_right/c_abf2Validation of a new predictive model to improve risk stratifIcation in bronchopulmonary dysplasiaarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Recien nacido prematuroEnfermedades del recién nacidoDisplasia broncopulmonarRiesgo a la saludWe need a better risk stratifcation system for the increasing number of survivors of extreme prematurity sufering the most severe forms of bronchopulmonary dysplasia (BPD). However, there is still a paucity of studies providing scientifc evidence to guide future updates of BPD severity defnitions. Our goal was to validate a new predictive model for BPD severity that incorporates respiratory assessments beyond 36 weeks postmenstrual age (PMA). We hypothesized that this approach improves BPD risk assessment, particularly in extremely premature infants. This is a longitudinal cohort of premature infants (≤32 weeks PMA, n=188; Washington D.C). We performed receiver operating characteristic analysis to defne optimal BPD severity levels using the duration of supplementary O2 as predictor and respiratory hospitalization after discharge as outcome. Internal validation included lung X-ray imaging and phenotypical characterization of BPD severity levels. External validation was conducted in an independent longitudinal cohort of premature infants (≤36 weeks PMA, n=130; Bogota). We found that incorporating the total number of days requiring O2 (without restricting at 36 weeks PMA) improved the prediction of respiratory outcomes according to BPD severity. In addition, we defned a new severity category (level IV) with prolonged exposure to supplemental O2 (≥120 days) that has the highest risk of respiratory hospitalizations after discharge. We confrmed these fndings in our validation cohort using ambulatory determination of O2 requirements. 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