Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto

La Clorhexidina (CHX) es el agente antiplaca más usado para desinfección completa de la boca y en el control de la biopelícula dental en el periodo post operatorio, Sin embargo, algunos efectos colaterales han limitado su uso clínico. El ácido hipocloroso (HOCl) es una nueva sustancia antimicrobiana...

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Autores:: Plata González, Julio Cesar

Tipo de recurso:

Fecha de publicación:: 2017

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: spa

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network_name_str	Repositorio U. El Bosque
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dc.title.spa.fl_str_mv	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
title	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
spellingShingle	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto Clorhexidina HOCl Antiplaca Recolonización bacteriana Ácido hipocloroso Clorhexidina Periodontitis Chlorhexidine HOCl Antiplaque Bacterial recolonization WU 100
title_short	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
title_full	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
title_fullStr	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
title_full_unstemmed	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
title_sort	Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto
dc.creator.fl_str_mv	Plata González, Julio Cesar
dc.contributor.advisor.none.fl_str_mv	Lafaurie, Gloria Ines Castillo, Diana Diaz Baez, David Augusto Goretty Trujillo, Tammy
dc.contributor.author.none.fl_str_mv	Plata González, Julio Cesar
dc.subject.spa.fl_str_mv	Clorhexidina HOCl Antiplaca Recolonización bacteriana
topic	Clorhexidina HOCl Antiplaca Recolonización bacteriana Ácido hipocloroso Clorhexidina Periodontitis Chlorhexidine HOCl Antiplaque Bacterial recolonization WU 100
dc.subject.decs.spa.fl_str_mv	Ácido hipocloroso Clorhexidina Periodontitis
dc.subject.keywords.spa.fl_str_mv	Chlorhexidine HOCl Antiplaque Bacterial recolonization
dc.subject.nlm.none.fl_str_mv	WU 100
description	La Clorhexidina (CHX) es el agente antiplaca más usado para desinfección completa de la boca y en el control de la biopelícula dental en el periodo post operatorio, Sin embargo, algunos efectos colaterales han limitado su uso clínico. El ácido hipocloroso (HOCl) es una nueva sustancia antimicrobiana no antibiótica que ha mostrado alta susceptibilidad sobre bacterias asociada al biofilm dental. Comparar la efectividad clínica y la recolonización bacteriana de la placa subgingival a los 7, 21 y 90 días del HOCl 0.05%, 0,025% y CHX 0.2% y 0,12% durante el periodo post quirúrgico en pacientes con periodontitis crónica. Se realizó un estudio piloto, aleatorizado doble ciego donde se evaluaron 32 pacientes divididos aleatoriamente en dos grupos de 16 cada uno para recibir HOCl al 0,05% durante 7 días, seguido de HOCl al 0,025% o CHX 0.2% seguido de CHX al 0,12% hasta el día 21 después de cirugía periodontal con colgajo de Widman modificado en ausencia de higiene oral. Los pacientes fueron evaluados por índice de placa, índice gingival, profundidad de la bolsa y nivel de inserción y para recolonización bacteriana en placa subgingival por un período de 3 meses. Los datos fueron analizados por ANOVA de medidas repetidas y por modelos de efectos mixtos ajustados a tratamiento, tiempo e interacción tiempo-tratamiento. CHX mostró superioridad para la reducción de placa dental sobre HOCl (p<0.05). Para la reducción de la inflamación gingival, hemorragia al sondaje, reducción de las bolsas y la ganancia del nivel de inserción las diferencias no fueron significativas entre los grupos (p>0.05). En cuanto a la recolonización bacteriana ambos grupos se comportaron de manera similar para P. gingivalis, T. forsithya y T. denticola. A. antinomicentemcomitas y E. nodatum mostraron una rápida recolonización en la placa subgingival y los protocolos antiplaca no parecieron tener un efecto. HOCl muestra efectos similares a CHX en los índices clínicos y en la recolonización bacteriana sin embargo se observaron menos eventos adversos en el grupo del HOCl. El HOCl podría ser equivalente a la CHX como agente antiplaca en periodos post quirúrgicos.
publishDate	2017
dc.date.issued.none.fl_str_mv	2017
dc.date.accessioned.none.fl_str_mv	2021-09-10T16:30:09Z
dc.date.available.none.fl_str_mv	2021-09-10T16:30:09Z
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv	Tesis/Trabajo de grado - Monografía - Maestría
dc.type.hasversion.none.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12495/6047
dc.identifier.instname.spa.fl_str_mv	instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv	repourl:https://repositorio.unbosque.edu.co
url	http://hdl.handle.net/20.500.12495/6047
identifier_str_mv	instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	Addy M., L. Willis, J. Moran. Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol Volume 10, Issue 1 February 1983 Pages 89–99 Ali, R.W.; Lie, T.; Skaug, N. Early effects of periodontal therapy on the detections frequency of four putative periodontal pathogens in adults. J. Periodontol., Chicago, v.63, p.540-547, 1995 Allison DG. The biofilm matrix. Biofouling 2003: 19: 139–150. Armitage, G. C., Development of a classification system for periodontal diseases and conditions. Annals of Periodontology 4, 1–6, 1999 Arweiler NB, Boehnke N, Sculean A, Hellwig E, Auschill TM. Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4-day plaque regrowth study. J Clin Periodontol 2006; 33: 334–339 Arweiler NB. Auschill TM, Netuschil L, Brecx M, Reich E, Sculean A. Spatial distribution of vital and dead microorganisms in dental biofilms. Arch Oral Biol. 2001 May; 46(5):471-6. Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6 years. J Clin Periodontol. 1981 Jun; 8(3):239-48 Axelsson, P., & Lindhe, J. (1981). The significance of maintenance care in the treatment of periodontal disease. Journal of clinical periodontology, 8(4), 281294 Axelsson, P., Nyström, B. and Lindhe, J. (2004). The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Journal of Clinical Periodontology, 31: 749–757 Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. III. Single versus repeated instrumentation. J Clin Periodontol. 1984 Feb; 11(2):114-24. Bascones A. Periodoncia Clínica e Implantología Oral. Madrid: Ediciones; Avances Médico-Dentales 2001, pp 455-71 Bazzano G, Parodi R, Tabares S, Sembaj A. Evaluation of periodontal mechanical therapy in deep pockets: Clinical and bacteriological response. Rev. Clin. Periodoncia Implantol. Rehabil. Oral vol.5 no.3 Santiago dic. 2012 Bhat N, Mitra R, Oza S, Mantu VK, Bishnoi S, Gohil M, Gupta R. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. J Complement Integr Med. 2014 Jun; 11(2):129-37 Birkedal_Hansen, H. (1993). Role of matrix metalloproteinases in human periodontal disease. Journal of Periodontology 64, 474-484 Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. Periodontal pathogens: a quantitative comparison of anaerobic culture and realtime PCR. FEMS Immunol Med Microbiol. 2005 Aug 1; 45(2):191-9. Boutaga K., Arie Jan van Winkelhoff, Christina M. J. E. Vandenbroucke-Grauls & Paul H. M. Savelkoul. Comparison of Real-Time PCR and Culture for Detection of Porphyromonas gingivalis in Subgingival Plaque Samples. J Clin Microbiol. 2003 Nov; 41(11): 4950–4954. Bowen WH. Nature of plaque. Oral Sci Review. 1976; 9:321 18. Bragd, L.; Daklen, J.; Wikstrom, M.; Slots, J. The capability of A. actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius to indicate progressive periodontitis; a retrospective study. J. Clin Periodont 1987; 14:95-98. Branda SS, Vik S, Friedman L, and Kolter R. Biofilms: the matrix revisited. Trends Microbiol2005: 13: 20–2. Brecx M., E. Brownsfone, L. MacDonald, S. Gelskey and M. Cheang. Efficacy of Listerine®, Meridol® and chlorhexidine mouthrinses as supplements to regular tooth-cleaning measures. J Clin Periodontol. March 1992, Volume 19, Issue 3, Pages 155–224 Brecx, M., Netuschil, L., Reichert, B. and Schreil, G. (1990), Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. Journal of Clinical Periodontology, 17: 292–297 Breslin PA, Tharp CD. Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses. 2001 Feb; 26(2):105-16. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004; 303(5663):1532–1535. Busscher HJ, Norde W, Van Der Mei HC. Specific molecular recognition and nonspecific contributions to bacterial interaction forces. Appl Environ Microbiol 2008: 74: 2559–2564. Calderón J. L. Artículo de Revisión ÁCIDO HIPOCLOROSO (HOCl) “Una nueva alternativa en antisepsia y desinfección desarrollada en Colombia” Laboratorio Actual Año 26 No. 42, Septiembre de 2010. °Cao, C. F., Aeppli, D. M., Liljemark, W. F., Bloomquist, C. G., Bandt, C. L. & Wolff, L. F. (1990) Comparison of plaque microﬂora between Chinese and Caucasian population groups. Journal of Clinical Periodontology 17, 115–118. Carlen, A., Olsson, J. & Ramberg, P. (1996) Saliva mediated adherence, aggregation and prevalence in dental plaque of Streptococcus mutans, Streptococcus sanguis and Actinomyces spp, in young and elderly humans. Archives of Oral Biology 41, 1133–1140. Carlos JP, Wolfe MD, Zambon JJ, Kingman A. Periodontal disease in adolescents: some clinical and microbiologic correlates of attachment loss. J Dent Res. 1988; 67:1510-4. Carvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2004) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. Clinical results. Journal of Clinical Periodontology 31, 1070–1076 Carvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2005) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. II. Microbiological results. Journal of Clinical Periodontology 32, 406–411. Casado JA, Merino J, Cid J, Subirá ML, Sánchez-Ibarrola A. Oxidantes y radicales libres en la Biomedicina. Rev Med Univ Navarra 1996; 34:165-74. Castillo DM, Castillo Y, Delgadillo NA, Neuta Y, Jola J, Calderón JL, Lafaurie GI. Viability and Effects on Bacterial Proteins by Oral Rinses with Hypochlorous Acid as Active Ingredient. Braz Dent J. 2015 Oct; 26(5):519-24 Caton J: Consensus report: periodontal diagnosis and diagnostics aids: In Proceedings of the World Workshop in Clinical Periodontics, Chicago, 1989 Choi YS, Kim YC, Jo AR et al. Porphyromonas gingivalis and dextran sulfate sodium induce periodontitis through the disruption of physical barriers in mice. Eur J Inflamm 2013; 11:419–431 Chong-Hou, S. & Hsein-Kun, L. The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. J. Dent. Sci. 4: 45-4, 2009. Colombo, A. P., Haffajee, A. D., Dewhirst, F. E., Paster, B. J., Smith, C. M., Cugini, M. A. & Socransky, S. S. (1998) Clinical and microbiological features of refractory periodontitis subjects. Journal of Clinical Periodontology 25, 169–180. Colombo, A. P., Teles, R. P., Torres, M. C., Rosalem, W., Mendes, M. C., Souto, R. M. & Uzeda, M. (2005) Effects of non-surgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results. Journal of Periodontology 76, 778–784. Cortelli, J. R., Barbosa, M. D. S., & Westphal, M. A. (2008). Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research, 22, 44-54 Cortelli, J.R. et al. Detection of periodontal pathogens in oral mucous membranes of edentulous individuals. J. Periodontol., Chicago, v.79, n.10, p.1962-1965, Oct 2008 Cortelli, S. C., Cavallini, F., Alves, M. F. R., Bezerra, A. A., Queiroz, C. S., & Cortelli, J. R. (2009). Clinical and microbiological effects of an essential-oilcontaining mouth rinse applied in the “one-stage full-mouth disinfection” protocol—a randomized double-blinded preliminary study. Clinical oral investigations, 13(2), 189. Cortelli, S.C. et al. Essential oils in one-stage full-mouth disinfection: doubleblind, randomized clinical trial of long-term clinical, microbial and salivary effects. J. Clin. Periodontol. Copenhagen, v.36, n.4, p.333-342, Apr. 2009 Costerton, J.W., Lewandowski, Z., Caldwell, D.E., Korber, D.R. & Lappin_Scott, H.M. (1995). Microbial biofilms. Annual Reviews of Microbiology 49, 711-745 Costerton, J.W., Stewart, P.S., and Greenberg, E.P. (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322. Cousido MC et al., In vivo substantivity of 0.12% and 0.2% chlorhexidine mouthrinses on salivary bacteria. Clin Oral Invest (2010) 14:397–402 Cugini MA, Haffajee AD, Smith C, Kent RL, Socransky SS. The effect of scaling and root planning on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000; 27: 30–36., Cusimano, R.; Cusimano, M. & Cusimano, S. The genius of Alexis Carrel. Can. Med. Assoc. J., 131(9):1142-50, 1984. Dahlén G, Manji F, Baelum V, Fejerskov O. Black-pigmented Bacteroides species and Actinobacillus actinomycetemcomitans in subgingival plaque of adult Kenyans. J Clin Periodontol. 1989; 16:305–10. Dakic, A., Boillot, A., Colliot, C., Carra, M. C., Czernichow, S., & Bouchard, P. (2016). Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis. Frontiers in microbiology, 7. Danser, M.M. et al. Short-term effect of full-mouth extraction on periodontal pathogens colonizing the oral mucous membranes. J. Clin. Periodontol. Copenhagen, v.21, n.7, p.484-489, Aug. 1994 Danser, M.M. et al. The effect of periodontal treatment on periodontal bacteria on the oral mucous membranes. J. Periodontol., Chicago, v.67, n.5, p.478-485, May 1996 Dashper SG, Ang CS, Veith PD, Mitchell HL, Lo AW, Seers CA, Walsh KA, Slakeski N, Chen D, Lissel JP, Butler CA, O’Brien-Simpson NM, Barr IG, Reynolds EC. Response of Porphyromonas gingivalis to heme limitation in continuous culture. J Bacteriol2009: 191: 1044–1055. DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukocyte Biol 1996; 60:677-91. Dentino A., Lee S., Mailhot J & Hefti AF. Principles of Periodontology. Periodontology 200 Vol 61, 2013, 16-53 DeSouza R.F. Nascimento C. et al. Effects of the domestic use of a disclosing solution on the denture biofilm: a preliminary study. Volume 36, Issue 7, July 2009, Pages 491–497 Duss C, Lang NP, Cosyn J, Persson GR. A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery. J Clin Periodontol 2010; 37: 988–997. Eberhard J, Jervøe-Storm P-M, Needleman I, Worthington H, Jepsen S. Fullmouth treatment concepts for chronic periodontitis: a systematic review. J Clin Periodontol 2008; 35: 591–604 Egelberg, J. (1965) Local effect of diet on plaque formation and development of gingivitis in dogs. Effect of hard and soft diets. Odontologisk Revy 6, 31–41. Eldridge, K. R., Finnie, S. F., Stephens, J. A., Mauad, A. M., Munoz, C. A., & Kettering, J. D. (1998). Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent. The Journal of prosthetic dentistry, 80(6), 685-690 Ernst CP, Canbek K, Dillenburger A, Willershausen B. Clinical study on the effectiveness and side effects of hexetidine and chlorhexidine mouthrinses versus a negative control. Quintessence Int. 2005 Sep; 36(8):641-52. Falagas ME., Anastasios M. Kapaskelis, Vasilios D. Kouranos, Ourania K. Kakisi, Zoe Athanassa, Drosos E. Karageorgopoulos Outcome of Antimicrobial Therapy in Documented Biofilm-Associated Infections. July 2009, Volume 69, Issue 10, pp 1351–1361 Fang H, Han M, Li Q-L, Cao CY, Xia R, Zhang Z-H. Comparison of full-mouth disinfection and quadrant-wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta-analysis. J Periodont Res 2016; 51: 417–430 Faveri M, Gursky LC, Feres M, Shibli JA, Salvador SL, de Figueiredo LC. Scaling and root planning and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Clin Periodontol 2006; 33: 819–828 Feres, M., Haffajee, A. D., Gonçalves, C., Allard, K., Som, S., Smith, C., Goodson, M. & Socransky, S. S. (1999) Systemic doxycycline administration in the treatment of periodontal infections (I). Effect on the subgingival microbiota. Journal of Clinical Periodontology 26, 775–783. Fine DH. Mouthrinses as adjuncts for plaque and gingivitis management. A status report for the American Journal of Dentistry. Am J Dent. 1988 Dec; 1(6):259-63. Fine, D. H., Kaplan, J. B., Kachlany, S. C., & Schreiner, H. C. (2006). How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontology 2000, 42(1), 114-157. Flötra L, Gjermo P, Röla G & Waerhaug J. Side effects of chlorhexidine mouthwashes. Scand J Dent Res 1971; 79: 119-25. Forng, R.-Y., Champagne, C., Simpson, W. and Genco, C. (2000), Oral Microbiology: Environmental cues and gene expression in Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Diseases, 6: 351–365. Francetti L., Del Fabbro M, Testori T, Weinstein RL. Chlorhexidine spray versus chlorhexidine mouthwash in the control of dental plaque after periodontal surgery. J Clin Periodontol. 2000 Jun; 27(6):425-30. Frank, D.N., Zhu, W., Sartor, R.B & Li, E. Investigating the biological and clinical significance of human dysbioses. 2011; Trends in Microbiology 19, 427-434 Garmyn, P., van Steenberghe, D. & Quirynen, M. (1998) Efficacy of plaque control in the maintenance of gingival health: plaque control in primary and secondary prevention. In: Lang, N.P., et al. Proceedings of the European Workshop on Mechanical Plaque Control. Chicago: Quintessence Publishing Co., Inc., pp. 107-120 Genco R, Kornman K, Williams R. Informe de consenso. Las enfermedades periodontales: patogénesis y los factores microbianos. Ann Periodontol 1996; 1: 926 - 32. Gjermo P. Chlorhexidine in dental practice. J Clin Periodontol.n1974; 1(3):14352. Grisi, D. C., Salvador, S. L., Figueiredo, L. C., Souza, S. L., Novaes, A. B. & Grisi, M. F. (2002) Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome. Journal of Clinical Periodontology 29, 875–881. Grossi SG., Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, Norderyd OM, Genco RJ. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol. 1994 Mar; 65(3):260-7. Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. JADA. 2006; 137(12): 1649-57. Gürgan CA., Eylem Zaim, Isxıl Bakirsoy, and Emel Soykan. Short-Term Side Effects of 0.2% Alcohol-Free Chlorhexidine Mouthrinse Used as an Adjunct to Non-Surgical Periodontal Treatment: A Double-Blind Clinical Study. J Periodontol 2006; 77:370-384. Gusberti, F. A., Sampathkumar, P., Siegrist, B. E., & Lang, N. P. (1988). Microbiological and clinical effects of chlorhexidine digluconate and hydrogen peroxide mouthrinses on developing plaque and gingivitis. Journal of clinical periodontology, 15(1), 60-67 Haffaje, A.D., Smith C., Torresyap, G. et al. (2001). Efficacy of manual and powered toothbrushes (II). Effect on microbiological parameters. Journal of Clinical Periodontology 28,947-54 Haffajee AD et al. Controlling the Plaque Biofilm. Int Dent J 53 Suppl 3, 191-199. 2003 Haffajee AD, Socransky SS, Patel MR, Song X. Microbial complexes in supragingival plaque. Oral Microbiol Immunol. 2008 Jun; 23(3):196-205. Haffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006; 42 219-58 Haffajee AD1, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994 Jun; 5:78-111. Haffajee, A. D., Cugini, M. A., Dibart, S., Smith, C., Kent, R. L. Jr. & Socransky, S. S. (1997) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology 24, 324–334 Hall-Stoodley, L., Costerton, J.W., and Stoodley, P. (2004) Bacterial bioﬁlms: from the environment to infectious disease. Nat Rev Microbiol 2: 95–108. Hannig C, Hannig M, Attin T. Enzymes in the acquired enamel pellicle. Eur J Oral Sci 2005: 113: 2–13. Hannig C, Hoch J, Becker K, et al: Lysozyme activity in the initially formed in situ pellicle. 2005; Arch Oral Biol 50:821 Hata S, Mayanagi H. Acid diffusion through extracellular polysaccharides produced by various mutants of Streptococcus mutans. Arch Oral Biol 2003: 48: 431–438. Hill, D.A. & Artis, D. Intestinal bacteria and the regulation of immune cells homeostasis. 2010; Annual Review of Immunology 28, 623-667 Hornef MW, Wick MJ, Rhen M, Normark S. Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol2002: 3: 1033–1040. http://www.ncbi.nlm.nih.gov/tools/primer-blast/ http://www.wipo.int/portal/index.html.es. revisado junio 2007 Jenkins S, Addy M, Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent. 1989; 11(6):12-6. Jenkins S, Addy M, Wade W. The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol. 1988 Aug; 15(7):415-24. Jervøe-Storm P-M, AlAhdab H, Semaan E, Fimmers R, Jepsen S. Microbiological outcomes of quadrant versus full-mouth root planning as monitored by real-time PCR. J Clin Periodontol 2007; 34: 156–163. Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000. 1997; 15:55-62 Kaldahl WB, Kalkwarf KL, Patil K. A review of longitudinal studies that compared periodontal therapies. J Periodontol 1993; 64: 243–253. Kirk, E.C. “The chemical bleaching of teeth” Dent Cosmos, 1989, Vol 31, 273-5 Knöfler G, Purschwitz R, Jentsch H. Clinical evaluation of partial- and full-mouth scaling in the treatment of chronic periodontitis. J Periodontol 2007; 78: 2135–2142.) Kolenbrander PE, Egland PG, Diaz PI, Palmer RJ Jr. Genome–genome interactions: bacterial communities in initial dental plaque. Trends Microbiol2005: 13: 11–15. Kolenbrander PE. Oral microbial communities: biofilms, interactions, and genetic systems. Annu Rev Microbiol. 2000; 54:413-37. Kolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79 Kolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79 Kolenbrander, PE, Palmer, R.J. Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev 2010; 8:471 – 480 Kumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S. Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. Int J Dent Hygiene 2013 Feb; 11 (1):35-40 Kuramitsu HK, He X, Lux R, Anderson MH, Shi W. Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev2007: 71: 653–670. Lafaurie et al. Evaluation of the hypochlorous acid substantivity as anti-plaque agent. A randomized controlled trial. 2016 Lafaurie, GI.; Calderón, JL.; Zaror, C.; Millán, lV. & Castillo, DM. Ácido hipocloroso: una nueva alternativa como agente antimicrobiano y para la proliferación celular para uso en odontología. Int. J. Odontostomat., 9(3):475481, 2015. Lafaurie, Gl, Aya MR, Arboleda S. Escalante A, Castillo DM, Millan LV, Calderon JL, Ruiz BN. Eficacia desinfectante del ácido hipocloroso sobre cepas con poder patogénico de cavidad oral. Rev Colombiana de Investigación en Odontologia 2009; 1:3-11 Lang NP, Tan WC, Kra ¨henmann MA, Zwahlen M. A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 2008; 35 (Suppl. 8): 8–21. Lang, Niklaus P. & Brecx, M. C. (1986), Chlorhexidine digluconate–an agent for chemical plaque control and prevention of gingival inflammation. Journal of Periodontal Research, 21: 74–89. Laskaris, G. & Scully, C. (2003). Periodontal manifestations of local and systemic diseases: colour atlas and text. Levine JM. Dakin's solution: past, present, and future. Adv Skin Wound Care. 2013 Sep; 26(9):410-4 Levy, R. M., Giannobile, W. V., Feres, M., Haffajee, A. D., Smith, C. & Socransky, S. S. (2002) The effect of apically repositioned flap surgery on clinical parameters and the composition of the subgingival microbiota: 12-month data. International Journal of Periodontics and Restorative Dentistry 22, 209–219 Lindhe J, Nyman S. The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease. J Clin Periodontol. 1975 Apr; 2(2):67-79. Löe H, Theilade E & Jensen S. Experimental gingivitis in man. J Periodontol 1965: 36: 177–187 Lorenz K., G. Bruhn, C. Heumann, L. Netuschil, M. Brecx, T. HoffmannLorenz. Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. J Clin Periodontol. Volume 33, Issue 8, August 2006 Pages 561–567 Mackler, B.F., Frostad, K. B., Robertson, P.B. & Levy, B.M. (1977). Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease. Journal of Periodontal Research 12, 37-45 Magnusson I, Lindhe J, Yoneyama T, Liljenberg B Recolonization of a subgingival microbiota following scaling in deep pockets. J Clin Periodontol. 1984 Mar; 11(3):193-207. 119. Maia LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature. Journal of Dentistry, Volume 35, Issue 5, May 2007, Pages 359-37 Mainnemare A, Megarbane B, Soueidan A, Daniel A. Chapple IL. Hypochlorous acid and taurine-N-monochloramine in periodontal diseases. J Dent Res 2004; 83:823-31 Mandel, I. D. (1994) Antimicrobial mouthrinses: overview and update. Journal of the American Dental Association125, 2S–10S. Marinone MG, Savoldi E. Chlorhexidine and taste. Influence of mouthwashes concentration and of rinsing time. Minerva Stomatol. 2000 May; 49(5):221-6. Marsh PD, Percival RS. The oral microflora friend or foe? Can we decide? Int Dent J 2006: 56 (Suppl. 1): 233 – 239. Marsh, P. Dental plaque: biological significance of a biofilm and community lifestyle, Journal of Clinical Periodontology, 2005; 32 Suppl 6, 7-15 Marsh, P.D. & Devine, D.A. How is the development of dental biofilms influenced by the host? Journal of Clinical Periodontology, 2011: 38 Suppl 11, 28-35 Marsh, P.D. & Martin, M.V. Oral Microbiology, 5 th ed. Edinburgh: Churchill Livingstone. 2009. Mckenna, S. M. & Davies, K. J. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem. J., 254(3):685-92, 1988 Ministerio de Salud. Estudio Nacional de Salud Bucal ENSAB IV. Situación de Salud Bucal. Sistema Internacional de Clasificación de la Enfermedad Periodontal y Condiciones Asociadas. Bogotá (DC): Ministerio de Salud; 2014 Mombelli A, Gmur R, Gobbi C, Lang NP. Actinobacillus actinomycetemcomitans in adult periodontitis. I. Topographic distribution before and after treatment. J Periodontol 1994: 65: 820–826. Mombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia⁄nigrescens, and Actinobacillus actinomycetemcomitans after mechanical therapy of periodontal disease. J Periodontol 2000: 71: 14–21. Morillo JM., et al. Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol. Vol 31, Issue 12 December 2004 Pages 1054–1060. Newman M.G. et al. Effect of 0.12% Chlorhexidine on Bacterial Recolonization Following Periodontal Surgery. J Periodontol 1989; 60:577-581 Niklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 10. Infecciones periodontales; Ed. Medica Panamericana, Sixth edition 2017 Niklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 36. Control mecánico de la placa supragingival; Ed. Medica Panamericana, Sixth edition 2017 Nobbs, A.H., Jenkinson, H.F. & Jakubovics, N.S. Stick to your gums: mechanisms of oral microbial adherence. 2011; Journal of Dental Research 90, 1271-1278 Nørskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. Nov., comb. nov., Aggregatibacter aphrophilus comb. Nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factorindependent isolates. Int J Syst Evol Microbiol. 2006 Sep; 56(Pt 9):2135-46. Oliver, R. C., Holm-Pedersen, P. & Löe, H. (1969) The correlation between clinical scoring exudate measurements and microscopic evaluation of inflammation in the gingiva. Journal of Periodontal Research4, 160. Journal of periodontal Investigation 4: 160. Olsson H. Asklöw B. Johansson E. Slotte C. Rinsing with alcohol-free or alcohol based chlorhexidine solutions after periodontal surgery. A doubleblind, randomized, crossover, pilot study. Swed Dent J 2012; 36: 91-99 Ozan F, Sumer Z. Akin Z, Er, K, Ozan U & Deger O. (2007). Effects of mouthrinse containing propolis on oral microorganisms and human gingival fibroblast. European journal of dentistry, 195-201 Page RC, Periodontal Therapy: prospects for the future. J Periodontol 1993; 64(8 Suppl): 744-53 Page, R.C. & Schroeder, H.E. (1976). Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigations 34, 235-249 Papapanou PN. Et al., Checkerboard Assessments of Periodontal Microbiota and Serum Antibody Responses: A Case-Control Study. Journal of Periodontology, June 2000, Vol. 71, No. 6, Pages 885-897 Petrosian EA y col. Sodium hypochlorite in the treatment of suppurative wounds. Vestn Khir Im II Grek 1991; 146: 40-3 Pulcher JJ, Daniel JC. (1992). The effect of chlorhexidine digluconato on human fibroblasts in vitro. J Periodontol 63(6):526-532 Quirynen M, Soers C, Desnyder M, Dekeyser C, Pauwels M, van Steenberghe D. A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy. J Clin Periodontol 2005; 32:390–400 Quirynen N, Bollen CM, Vanderkerckhove BN, Dekeyser C, Papaioannou N, Eyssen H. Full versus partial mouth disinfection in the treatment of periodontal infectious: short term clinical and microbiological observation. J Dent Res 1995, 74:1459- 1467. Quirynen, M., Mongardini, C., De Soete, M., Pauwels, M., Coucke, W. & Van Eldere, J. (2000) The role of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis – long term clinical and microbiological observations. Journal of Clinical Periodontology 27, 578–589 Ramfjord SP, Caffesse RG, Morrison EC et al. Four modalities OD periodontal treatment compared over two years. J Periodontol 1981; 52: 655-62 Rams TE. Et al. Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol 1996, Vol 23, Issue 4, Pages 346–354. Renvert S. et al. Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis from periodontal pockets. J Clin Periodontol Volume 17, Issue 6 July 1990 Pages 345–350 Renvert, S et al. The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers. J. Clin Periodontol., Chicago, v.25, n.2, p.153-157, Feb. 1998 Renvert, S et al. Treatment of periodontal disease based on microbiological diagnosis. Relation between microbiological and clinical parameters during 5 years. J. Periodontol., Chicago, v.67, n.6, p.562-571, June 1996 Reynolds, J.J. & Meikle, M.C. (1997). Mechanisms of connective tissue matrix destruction in periodontitis. Periodontology 2000 14, 144-157 Robson M.C., Payne W.G., Ko F., Mentis M., Donati G., Shafii S.M., Culverhouse S., Wang L., Khosrovi B., Najafi R., Cooper D.M., Bassiri M. Hypochlorous Acid as a Potential Wound Care Agent. Part II. Stabilized Hypochlorous Acid: It’s Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing. J Burns Wounds. 11:6, e6, 80-90.2007. Rosen, H. & Klebanoff, S. J. Oxidation of Escherichia coli iron centers by themyeloperoxidase- mediated microbicidal system. J. Biol. Chem.,257(22):13731-5, 1982 Round JL, Mazmanian SK. The gut microbiota shapes intestinal immuneresponses during health and disease. Nat Rev Immunol 9(5):313-323 (2009) Rudney JD et al. Actinobacillus Actinomycetemcomitans, PorphyromonasGingivalis, and Tannerella Forsythensis Are Components of a PolymicrobialIntracellular Flora Within Human Buccal Cells. J Dent Res 84 (1), 59-63. 12005. Rutala William A., Cole E., Thomann C., Weber David J. 1991. Stability andBactericidal Activity of Chlorine Solutions. Inf. Control Hosp. Epidem.19(5):323327. Sam, C. H. & Lu, H. K. The role of hypochlorous acid as one of the reactiveoxygen species in periodontal disease. J. Dent. Sci., 4(2):45-54, 2009. Sanz M, G. Newman, L. Anderson, W. Matoska, J. Otomo Corgel C. Saltini.Clinical Enhancement of Post-Periodontal Surgical Therapy by a 0.12%Chlorhexidine Gluconate Mouthrinse. Journal of Periodontology October1989, Vol. 60, No. 10, Pages 570-576 Secuencia cirugía Widman modificado. Tomada de Periodontology 2000 Volumen 71, Issue 1, pages 128-139, 4 APR 2016 Seki, M., Yamashita, Y., Shibata, Y., Torigoe, H., Tsuda, H. & Maeno, M. (2006) Effect of mixed mutans streptococci colonization on caries development. Oral Microbiology and Immunology 21, 47–52. Seymour G.J. & Greenspan, J.S. (1979). The phenotypic characterization oflymphocyte subpopulations in established human periodontal disease. Journalof Periodontal Research 14, 39-46 Seymour, G.J., Powell, R.N. & Davies, W.I. (1979) Conversion of a stable Tcell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: a hypothesis. Journal of Clinical Periodontology 6, 267-277 Shapiro S, Giertsen E, Guggenheim B. An in vitro oral biofilm model forcomparing the efficacy of antimicrobial mouthrinses. Caries Res. 2002 MarApr; 36(2):93-100. Sharma NC, Galustians HJ, Qaqish J, Charles CH, Vincent JW, McGuire JA: Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash. J Clin Periodontol 2003; 30: 590–594. Shiloah, J, Patters, H. Dean, J. Bland P & Toledo G. The survival rate of Actinobacillus actinomicetemcomitans, Porphyromonas gingivalis and Bacteroides forsythus following 4 randomized treatment modalities. J Periodontol 1997; 68:720-728 Siegrist B. E., Gusberti F. A., M. C. Brecx, H. P. Weber, N. P. Lang. Efficacy of supervised rinsing with chlorhexidine digluconate in comparison to phenolic and plant alkaloid compounds Volume 21, Issue s16, November 1986, Pages 60–73. Slots, J.; Rams, T.E. New views on periodontal microbiota in special patient categories. J. Clin. Periodontol. Copenhagen, v.18, n.6, p.411-420, July 1991 Socransky SS, Haffajee AD Periodontal microbial ecology. Periodontol 2000. 2005; 38:135-87. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb; 25(2):134-44. Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000, 2002: 28: 12–55. Socransky SS, Haffajee AD. Microbiología de la enfermedad periodontal. En: Lindhe J, Karring T, Lang NP, ed. Clinical Periodontology y la implantología dental. Copenhague: Munksgaard, 1997: 138 - 88. Socransky, S.S.; Haffajee, A.D. The bacterial etiology of destructive periodontal disease: current concepts. J. Periodontol., Chicago, v.63, n.4, p.322-331, Apr. 1992 Sreenivasan P, Gaffar A. Antiplaque biocides and bacterial resistance: A review. J Clin Periodontol 2002; 29(11):965-974. Tatevossian A. The effects of heat inactivation, tortuosity, extracellular polyglucan and ion-exchange sites on the diffusion of [14C]-sucrose in human dental plaque residue in vitro. Arch Oral Biol1985: 30: 365–371. Teughels, W. et al. One-stage, full-mouth disinfection: fiction or reality? Periodontol. 2000, Munksgaard, v.50, n.1, p.39-51, June 2009 Tomás I, García-Caballero L, Cousido MC, Limeres J, Alvarez M, Diz P. Evaluation of chlorhexidine substantivity on salivary flora by epifluorescence microscopy. Oral Dis. 2009 Sep; 15(6):428-33. Vacca-Smith AM, Venkitaraman AR, Schilling KM & Bowen WH. Characterization of glucosyltransferase of human saliva adsorbed onto hydroxyapatite surfaces. Caries Res. 1996; 30(5):354-60. Van Der Velden, U. et al. The habitat of periodontophatic micro-organisms. J. Clin Periodontol., Cophenagen, v.13, n.3, p.243-248, Mar. 1986 Verkaik MJ et al. Oral Biofilm Models for Mechanical Plaque Removal. Clin Oral Investig 14 (4), 403-409. 2009 Jun 30. Vissers MC, Winterbourn CC. Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid. Biochem J. 1995; 307(Pt 1):57–62. Vroom JM, De Grauw KJ, Gerritsen HC, Bradshaw DJ, Marsh PD, Watson GK, Allison C, Birmingham JJ. Depth penetration and detection of pH gradients in biofilms using two-photon excitation microscopy. Appl Environ Microbiol1999: 65: 3502–3511. W.B. Hugo. & A.R. Longworth. Cytological aspects of the mode of action of chlorhexidine diacetate. Journal of Pharmacy and Pharmacology, Volume 17, Issue 1, January 1965, Pages 28–32 Wade, W.G. & Addy, M. (1989). In vitro activity of a chlorhexidine – containing mouthwash against subgingival bacteria. Journal of periodontology 60, 521523 Walker, C. B. (1988), Microbiological effects of mouthrinses containing antimicrobials. Journal of Clinical Periodontology, 15: 499–505. Wang L., Bassiri M., Najafi R., Najafi K., Yang J., Khos-rovi B., Hwong W., Barati E., Belisle B., Celeri C., Robson M.C. Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds.11: 65-79, 2007 Watts A, Addy M. (2001), Tooth discoloration and staining: a review of the literature. Br Dent J. 2001 Mar 24; 190(6):309-16. Weiss SJ, Klein R, Slavika A. Chlorination of Taurine by Human Neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 1982 Sept; 70(3):598-607. Weiss SJ. Tissue Destruction by Neutrophils. The New England Journal of Medicine 1989 February 9; 320(6):365-376. Wennström JL, Heijl L, Dahlén G, Gröndahl K. Periodic subgingival antimicrobial irrigation of periodontal pockets (I). Clinical observations. J Clin Periodontol. 1987 Oct; 14(9):541-50. Westfelt E, Nyman S, Lindhe J, Socransky S. Use of chlorhexidine as a plaque control measure following surgical treatment of periodontal disease. J Clin Periodontol. 1983 Jan; 10(1):22-36. Whittaker CJ, Klier CM, Kolenbrander PE. Mechanisms of adhesion by oral bacteria. Annu Rev Microbiol1996: 50: 513–552. Wille, T et al. “rheological characteristics of thooth bleaching materials”. Journal of Oral Rehabilitation, 2000, Vol 27, 1060-1063 Wilson, M. Microbial Inhabitants of Humans. Their Ecology and Role in the Health and Disease. 2005; Cambridge: Cambridge University Press. Winkel EG, van Winkelhoff AJ, Timmerman MF, Vangsted T, van der Velden U. Effects of metronidazole in patients with “refractory” periodontitis associated with Bacteroides forsythus. J Clin Periodontol 1997; 24: 573-9 Ximenez-Fyvie, L. A., Haffajee, A. D. & Socransky, S. S. (2000b) Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. Journal of Clinical Periodontology 27, 722–732. Yates R, Shearer BH, Huntington E and Addy M. A method to compare four mouthrinses. J Clin Periodontol 2002: 29: 519–523. Yoshida A., Shiori Nagashima, Toshihiro Ansai, Masayo Tachibana, Hiroaki Kato, Hajime Watari, Tsugunori Notomi & Tadamichi Takehara. Loop Mediated Isothermal Amplification Method for Rapid Detection of the Periodontopathic Bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. J. Clin. Microbiol. May 2005 vol. 43 no. 5 24182424 200. Zijnge V, Meijer HF, Lie MA, Tromp JAH, Degener JE, Harmsen HJM, Abbas F: The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial. J Clin Periodontol 2010; 37: 518–525
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spelling	Lafaurie, Gloria InesCastillo, DianaDiaz Baez, David AugustoGoretty Trujillo, TammyPlata González, Julio Cesar2021-09-10T16:30:09Z2021-09-10T16:30:09Z2017http://hdl.handle.net/20.500.12495/6047instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLa Clorhexidina (CHX) es el agente antiplaca más usado para desinfección completa de la boca y en el control de la biopelícula dental en el periodo post operatorio, Sin embargo, algunos efectos colaterales han limitado su uso clínico. El ácido hipocloroso (HOCl) es una nueva sustancia antimicrobiana no antibiótica que ha mostrado alta susceptibilidad sobre bacterias asociada al biofilm dental. Comparar la efectividad clínica y la recolonización bacteriana de la placa subgingival a los 7, 21 y 90 días del HOCl 0.05%, 0,025% y CHX 0.2% y 0,12% durante el periodo post quirúrgico en pacientes con periodontitis crónica. Se realizó un estudio piloto, aleatorizado doble ciego donde se evaluaron 32 pacientes divididos aleatoriamente en dos grupos de 16 cada uno para recibir HOCl al 0,05% durante 7 días, seguido de HOCl al 0,025% o CHX 0.2% seguido de CHX al 0,12% hasta el día 21 después de cirugía periodontal con colgajo de Widman modificado en ausencia de higiene oral. Los pacientes fueron evaluados por índice de placa, índice gingival, profundidad de la bolsa y nivel de inserción y para recolonización bacteriana en placa subgingival por un período de 3 meses. Los datos fueron analizados por ANOVA de medidas repetidas y por modelos de efectos mixtos ajustados a tratamiento, tiempo e interacción tiempo-tratamiento. CHX mostró superioridad para la reducción de placa dental sobre HOCl (p<0.05). Para la reducción de la inflamación gingival, hemorragia al sondaje, reducción de las bolsas y la ganancia del nivel de inserción las diferencias no fueron significativas entre los grupos (p>0.05). En cuanto a la recolonización bacteriana ambos grupos se comportaron de manera similar para P. gingivalis, T. forsithya y T. denticola. A. antinomicentemcomitas y E. nodatum mostraron una rápida recolonización en la placa subgingival y los protocolos antiplaca no parecieron tener un efecto. HOCl muestra efectos similares a CHX en los índices clínicos y en la recolonización bacteriana sin embargo se observaron menos eventos adversos en el grupo del HOCl. El HOCl podría ser equivalente a la CHX como agente antiplaca en periodos post quirúrgicos.Magíster en Ciencias OdontológicasMaestríaChlorhexidine (CHX) is the most used antiplaque agent for complete disinfection of the mouth and in the control of dental biofilm in the postoperative period. However, some side effects have limited its clinical use. Hypochlorous acid (HOCl) is a novel non-antibiotic antimicrobial substance that has shown high susceptibility to bacteria associated with dental biofilm. To compare the clinical effectiveness and bacterial recolonization of subgingival plaques at 7, 21 and 90 days of HOCl 0.05%, 0.025% and CHX 0.2% and 0.12% during the post-surgical period in patients with chronic periodontitis. A randomized, double-blind pilot study was conducted in which 32 patients were randomly divided into two groups of 16 each to receive 0.05% HOCl for 7 days, followed by 0.025% HOCl or CHX 0.2% followed of CHX to 0.12% until day 21 after periodontal surgery with modified Widman flap in the absence of oral hygiene. Patients were evaluated by plaque index, gingival index, pocket depth and insertion level and for bacterial recolonization in subgingival plaque for a period of 3 months. The data were analyzed by repeated-measures ANOVA and mixed effects models adjusted to treatment, time and time-treatment interaction. CHX showed superiority for reduction of dental plaque over HOCl (p <0.05). For the reduction of gingival inflammation, bleeding to probing, reduction of pockets and gain of insertion level the differences were not significant between the groups (p> 0.05). As for bacterial recolonization, both groups behaved similarly for P. gingivalis, T. forsithya and T. denticola. A. antinomicentemcomitas and E. nodatum showed rapid recolonization in the subgingival plaque and anti-plaque protocols did not appear to have an effect. HOCl shows similar effects to CHX in clinical indexes and in bacterial recolonization, however, fewer adverse events were observed in the HOCl group. HOCl could be equivalent to CHX as an antiplaque agent in post-surgical periods.application/pdfspaAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf22017ClorhexidinaHOClAntiplacaRecolonización bacterianaÁcido hipoclorosoClorhexidinaPeriodontitisChlorhexidineHOClAntiplaqueBacterial recolonizationWU 100Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio pilotoMaestría en Ciencias OdontológicasUniversidad El BosqueFacultad de OdontologíaTesis/Trabajo de grado - Monografía - Maestríainfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisAddy M., L. Willis, J. Moran. Effect of toothpaste rinses compared with chlorhexidine on plaque formation during a 4-day period. J Clin Periodontol Volume 10, Issue 1 February 1983 Pages 89–99Ali, R.W.; Lie, T.; Skaug, N. Early effects of periodontal therapy on the detections frequency of four putative periodontal pathogens in adults. J. Periodontol., Chicago, v.63, p.540-547, 1995Allison DG. The biofilm matrix. Biofouling 2003: 19: 139–150.Armitage, G. C., Development of a classification system for periodontal diseases and conditions. Annals of Periodontology 4, 1–6, 1999Arweiler NB, Boehnke N, Sculean A, Hellwig E, Auschill TM. Differences in efficacy of two commercial 0.2% chlorhexidine mouthrinse solutions: a 4-day plaque regrowth study. J Clin Periodontol 2006; 33: 334–339Arweiler NB. Auschill TM, Netuschil L, Brecx M, Reich E, Sculean A. Spatial distribution of vital and dead microorganisms in dental biofilms. Arch Oral Biol. 2001 May; 46(5):471-6.Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6 years. J Clin Periodontol. 1981 Jun; 8(3):239-48Axelsson, P., & Lindhe, J. (1981). The significance of maintenance care in the treatment of periodontal disease. Journal of clinical periodontology, 8(4), 281294Axelsson, P., Nyström, B. and Lindhe, J. (2004). The long-term effect of a plaque control program on tooth mortality, caries and periodontal disease in adults. Journal of Clinical Periodontology, 31: 749–757Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. III. Single versus repeated instrumentation. J Clin Periodontol. 1984 Feb; 11(2):114-24.Bascones A. Periodoncia Clínica e Implantología Oral. Madrid: Ediciones; Avances Médico-Dentales 2001, pp 455-71Bazzano G, Parodi R, Tabares S, Sembaj A. Evaluation of periodontal mechanical therapy in deep pockets: Clinical and bacteriological response. Rev. Clin. Periodoncia Implantol. Rehabil. Oral vol.5 no.3 Santiago dic. 2012Bhat N, Mitra R, Oza S, Mantu VK, Bishnoi S, Gohil M, Gupta R. The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. J Complement Integr Med. 2014 Jun; 11(2):129-37Birkedal_Hansen, H. (1993). Role of matrix metalloproteinases in human periodontal disease. Journal of Periodontology 64, 474-484Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. Periodontal pathogens: a quantitative comparison of anaerobic culture and realtime PCR. FEMS Immunol Med Microbiol. 2005 Aug 1; 45(2):191-9.Boutaga K., Arie Jan van Winkelhoff, Christina M. J. E. Vandenbroucke-Grauls & Paul H. M. Savelkoul. Comparison of Real-Time PCR and Culture for Detection of Porphyromonas gingivalis in Subgingival Plaque Samples. J Clin Microbiol. 2003 Nov; 41(11): 4950–4954.Bowen WH. Nature of plaque. Oral Sci Review. 1976; 9:321 18. Bragd, L.; Daklen, J.; Wikstrom, M.; Slots, J. The capability of A. actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius to indicate progressive periodontitis; a retrospective study. J. Clin Periodont 1987; 14:95-98.Branda SS, Vik S, Friedman L, and Kolter R. Biofilms: the matrix revisited. Trends Microbiol2005: 13: 20–2.Brecx M., E. Brownsfone, L. MacDonald, S. Gelskey and M. Cheang. Efficacy of Listerine®, Meridol® and chlorhexidine mouthrinses as supplements to regular tooth-cleaning measures. J Clin Periodontol. March 1992, Volume 19, Issue 3, Pages 155–224Brecx, M., Netuschil, L., Reichert, B. and Schreil, G. (1990), Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality. Journal of Clinical Periodontology, 17: 292–297Breslin PA, Tharp CD. Reduction of saltiness and bitterness after a chlorhexidine rinse. Chem Senses. 2001 Feb; 26(2):105-16.Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004; 303(5663):1532–1535.Busscher HJ, Norde W, Van Der Mei HC. Specific molecular recognition and nonspecific contributions to bacterial interaction forces. Appl Environ Microbiol 2008: 74: 2559–2564.Calderón J. L. Artículo de Revisión ÁCIDO HIPOCLOROSO (HOCl) “Una nueva alternativa en antisepsia y desinfección desarrollada en Colombia” Laboratorio Actual Año 26 No. 42, Septiembre de 2010.°Cao, C. F., Aeppli, D. M., Liljemark, W. F., Bloomquist, C. G., Bandt, C. L. & Wolff, L. F. (1990) Comparison of plaque microﬂora between Chinese and Caucasian population groups. Journal of Clinical Periodontology 17, 115–118.Carlen, A., Olsson, J. & Ramberg, P. (1996) Saliva mediated adherence, aggregation and prevalence in dental plaque of Streptococcus mutans, Streptococcus sanguis and Actinomyces spp, in young and elderly humans. Archives of Oral Biology 41, 1133–1140.Carlos JP, Wolfe MD, Zambon JJ, Kingman A. Periodontal disease in adolescents: some clinical and microbiologic correlates of attachment loss. J Dent Res. 1988; 67:1510-4.Carvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2004) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. Clinical results. Journal of Clinical Periodontology 31, 1070–1076Carvalho, L. H., D'Ávila, G. B., Leão, A., Haffajee, A. D., Socransky, S. S. & Feres, M. (2005) Scaling and root planning, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. II. Microbiological results. Journal of Clinical Periodontology 32, 406–411.Casado JA, Merino J, Cid J, Subirá ML, Sánchez-Ibarrola A. Oxidantes y radicales libres en la Biomedicina. Rev Med Univ Navarra 1996; 34:165-74.Castillo DM, Castillo Y, Delgadillo NA, Neuta Y, Jola J, Calderón JL, Lafaurie GI. Viability and Effects on Bacterial Proteins by Oral Rinses with Hypochlorous Acid as Active Ingredient. Braz Dent J. 2015 Oct; 26(5):519-24Caton J: Consensus report: periodontal diagnosis and diagnostics aids: In Proceedings of the World Workshop in Clinical Periodontics, Chicago, 1989Choi YS, Kim YC, Jo AR et al. Porphyromonas gingivalis and dextran sulfate sodium induce periodontitis through the disruption of physical barriers in mice. Eur J Inflamm 2013; 11:419–431Chong-Hou, S. & Hsein-Kun, L. The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease. J. Dent. Sci. 4: 45-4, 2009.Colombo, A. P., Haffajee, A. D., Dewhirst, F. E., Paster, B. J., Smith, C. M., Cugini, M. A. & Socransky, S. S. (1998) Clinical and microbiological features of refractory periodontitis subjects. Journal of Clinical Periodontology 25, 169–180.Colombo, A. P., Teles, R. P., Torres, M. C., Rosalem, W., Mendes, M. C., Souto, R. M. & Uzeda, M. (2005) Effects of non-surgical mechanical therapy on the subgingival microbiota of Brazilians with untreated chronic periodontitis: 9-month results. Journal of Periodontology 76, 778–784.Cortelli, J. R., Barbosa, M. D. S., & Westphal, M. A. (2008). Halitosis: a review of associated factors and therapeutic approach. Brazilian oral research, 22, 44-54Cortelli, J.R. et al. Detection of periodontal pathogens in oral mucous membranes of edentulous individuals. J. Periodontol., Chicago, v.79, n.10, p.1962-1965, Oct 2008Cortelli, S. C., Cavallini, F., Alves, M. F. R., Bezerra, A. A., Queiroz, C. S., & Cortelli, J. R. (2009). Clinical and microbiological effects of an essential-oilcontaining mouth rinse applied in the “one-stage full-mouth disinfection” protocol—a randomized double-blinded preliminary study. Clinical oral investigations, 13(2), 189.Cortelli, S.C. et al. Essential oils in one-stage full-mouth disinfection: doubleblind, randomized clinical trial of long-term clinical, microbial and salivary effects. J. Clin. Periodontol. Copenhagen, v.36, n.4, p.333-342, Apr. 2009Costerton, J.W., Lewandowski, Z., Caldwell, D.E., Korber, D.R. & Lappin_Scott, H.M. (1995). Microbial biofilms. Annual Reviews of Microbiology 49, 711-745Costerton, J.W., Stewart, P.S., and Greenberg, E.P. (1999) Bacterial biofilms: a common cause of persistent infections. Science 284: 1318-1322.Cousido MC et al., In vivo substantivity of 0.12% and 0.2% chlorhexidine mouthrinses on salivary bacteria. Clin Oral Invest (2010) 14:397–402Cugini MA, Haffajee AD, Smith C, Kent RL, Socransky SS. The effect of scaling and root planning on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol 2000; 27: 30–36.,Cusimano, R.; Cusimano, M. & Cusimano, S. The genius of Alexis Carrel. Can. Med. Assoc. J., 131(9):1142-50, 1984.Dahlén G, Manji F, Baelum V, Fejerskov O. Black-pigmented Bacteroides species and Actinobacillus actinomycetemcomitans in subgingival plaque of adult Kenyans. J Clin Periodontol. 1989; 16:305–10.Dakic, A., Boillot, A., Colliot, C., Carra, M. C., Czernichow, S., & Bouchard, P. (2016). Detection of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans after Systemic Administration of Amoxicillin plus Metronidazole as an Adjunct to Non-surgical Periodontal Therapy: A Systematic Review and Meta-Analysis. Frontiers in microbiology, 7.Danser, M.M. et al. Short-term effect of full-mouth extraction on periodontal pathogens colonizing the oral mucous membranes. J. Clin. Periodontol. Copenhagen, v.21, n.7, p.484-489, Aug. 1994Danser, M.M. et al. The effect of periodontal treatment on periodontal bacteria on the oral mucous membranes. J. Periodontol., Chicago, v.67, n.5, p.478-485, May 1996Dashper SG, Ang CS, Veith PD, Mitchell HL, Lo AW, Seers CA, Walsh KA, Slakeski N, Chen D, Lissel JP, Butler CA, O’Brien-Simpson NM, Barr IG, Reynolds EC. Response of Porphyromonas gingivalis to heme limitation in continuous culture. J Bacteriol2009: 191: 1044–1055.DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukocyte Biol 1996; 60:677-91.Dentino A., Lee S., Mailhot J & Hefti AF. Principles of Periodontology. Periodontology 200 Vol 61, 2013, 16-53DeSouza R.F. Nascimento C. et al. Effects of the domestic use of a disclosing solution on the denture biofilm: a preliminary study. Volume 36, Issue 7, July 2009, Pages 491–497Duss C, Lang NP, Cosyn J, Persson GR. A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery. J Clin Periodontol 2010; 37: 988–997.Eberhard J, Jervøe-Storm P-M, Needleman I, Worthington H, Jepsen S. Fullmouth treatment concepts for chronic periodontitis: a systematic review. J Clin Periodontol 2008; 35: 591–604Egelberg, J. (1965) Local effect of diet on plaque formation and development of gingivitis in dogs. Effect of hard and soft diets. Odontologisk Revy 6, 31–41.Eldridge, K. R., Finnie, S. F., Stephens, J. A., Mauad, A. M., Munoz, C. A., & Kettering, J. D. (1998). Efficacy of an alcohol-free chlorhexidine mouthrinse as an antimicrobial agent. The Journal of prosthetic dentistry, 80(6), 685-690Ernst CP, Canbek K, Dillenburger A, Willershausen B. Clinical study on the effectiveness and side effects of hexetidine and chlorhexidine mouthrinses versus a negative control. Quintessence Int. 2005 Sep; 36(8):641-52.Falagas ME., Anastasios M. Kapaskelis, Vasilios D. Kouranos, Ourania K. Kakisi, Zoe Athanassa, Drosos E. Karageorgopoulos Outcome of Antimicrobial Therapy in Documented Biofilm-Associated Infections. July 2009, Volume 69, Issue 10, pp 1351–1361Fang H, Han M, Li Q-L, Cao CY, Xia R, Zhang Z-H. Comparison of full-mouth disinfection and quadrant-wise scaling in the treatment of adult chronic periodontitis: a systematic review and meta-analysis. J Periodont Res 2016; 51: 417–430Faveri M, Gursky LC, Feres M, Shibli JA, Salvador SL, de Figueiredo LC. Scaling and root planning and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Clin Periodontol 2006; 33: 819–828Feres, M., Haffajee, A. D., Gonçalves, C., Allard, K., Som, S., Smith, C., Goodson, M. & Socransky, S. S. (1999) Systemic doxycycline administration in the treatment of periodontal infections (I). Effect on the subgingival microbiota. Journal of Clinical Periodontology 26, 775–783.Fine DH. Mouthrinses as adjuncts for plaque and gingivitis management. A status report for the American Journal of Dentistry. Am J Dent. 1988 Dec; 1(6):259-63.Fine, D. H., Kaplan, J. B., Kachlany, S. C., & Schreiner, H. C. (2006). How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontology 2000, 42(1), 114-157.Flötra L, Gjermo P, Röla G & Waerhaug J. Side effects of chlorhexidine mouthwashes. Scand J Dent Res 1971; 79: 119-25.Forng, R.-Y., Champagne, C., Simpson, W. and Genco, C. (2000), Oral Microbiology: Environmental cues and gene expression in Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Diseases, 6: 351–365.Francetti L., Del Fabbro M, Testori T, Weinstein RL. Chlorhexidine spray versus chlorhexidine mouthwash in the control of dental plaque after periodontal surgery. J Clin Periodontol. 2000 Jun; 27(6):425-30.Frank, D.N., Zhu, W., Sartor, R.B & Li, E. Investigating the biological and clinical significance of human dysbioses. 2011; Trends in Microbiology 19, 427-434Garmyn, P., van Steenberghe, D. & Quirynen, M. (1998) Efficacy of plaque control in the maintenance of gingival health: plaque control in primary and secondary prevention. In: Lang, N.P., et al. Proceedings of the European Workshop on Mechanical Plaque Control. Chicago: Quintessence Publishing Co., Inc., pp. 107-120Genco R, Kornman K, Williams R. Informe de consenso. Las enfermedades periodontales: patogénesis y los factores microbianos. Ann Periodontol 1996; 1: 926 - 32.Gjermo P. Chlorhexidine in dental practice. J Clin Periodontol.n1974; 1(3):14352.Grisi, D. C., Salvador, S. L., Figueiredo, L. C., Souza, S. L., Novaes, A. B. & Grisi, M. F. (2002) Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters of periodontal syndrome. Journal of Clinical Periodontology 29, 875–881.Grossi SG., Zambon JJ, Ho AW, Koch G, Dunford RG, Machtei EE, Norderyd OM, Genco RJ. Assessment of risk for periodontal disease. I. Risk indicators for attachment loss. J Periodontol. 1994 Mar; 65(3):260-7.Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. JADA. 2006; 137(12): 1649-57.Gürgan CA., Eylem Zaim, Isxıl Bakirsoy, and Emel Soykan. Short-Term Side Effects of 0.2% Alcohol-Free Chlorhexidine Mouthrinse Used as an Adjunct to Non-Surgical Periodontal Treatment: A Double-Blind Clinical Study. J Periodontol 2006; 77:370-384.Gusberti, F. A., Sampathkumar, P., Siegrist, B. E., & Lang, N. P. (1988). Microbiological and clinical effects of chlorhexidine digluconate and hydrogen peroxide mouthrinses on developing plaque and gingivitis. Journal of clinical periodontology, 15(1), 60-67Haffaje, A.D., Smith C., Torresyap, G. et al. (2001). Efficacy of manual and powered toothbrushes (II). Effect on microbiological parameters. Journal of Clinical Periodontology 28,947-54Haffajee AD et al. Controlling the Plaque Biofilm. Int Dent J 53 Suppl 3, 191-199. 2003Haffajee AD, Socransky SS, Patel MR, Song X. Microbial complexes in supragingival plaque. Oral Microbiol Immunol. 2008 Jun; 23(3):196-205.Haffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006; 42 219-58Haffajee AD1, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000. 1994 Jun; 5:78-111.Haffajee, A. D., Cugini, M. A., Dibart, S., Smith, C., Kent, R. L. Jr. & Socransky, S. S. (1997) The effect of SRP on the clinical and microbiological parameters of periodontal diseases. Journal of Clinical Periodontology 24, 324–334Hall-Stoodley, L., Costerton, J.W., and Stoodley, P. (2004) Bacterial bioﬁlms: from the environment to infectious disease. Nat Rev Microbiol 2: 95–108.Hannig C, Hannig M, Attin T. Enzymes in the acquired enamel pellicle. Eur J Oral Sci 2005: 113: 2–13.Hannig C, Hoch J, Becker K, et al: Lysozyme activity in the initially formed in situ pellicle. 2005; Arch Oral Biol 50:821Hata S, Mayanagi H. Acid diffusion through extracellular polysaccharides produced by various mutants of Streptococcus mutans. Arch Oral Biol 2003: 48: 431–438.Hill, D.A. & Artis, D. Intestinal bacteria and the regulation of immune cells homeostasis. 2010; Annual Review of Immunology 28, 623-667Hornef MW, Wick MJ, Rhen M, Normark S. Bacterial strategies for overcoming host innate and adaptive immune responses. Nat Immunol2002: 3: 1033–1040.http://www.ncbi.nlm.nih.gov/tools/primer-blast/http://www.wipo.int/portal/index.html.es. revisado junio 2007Jenkins S, Addy M, Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent. 1989; 11(6):12-6.Jenkins S, Addy M, Wade W. The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol. 1988 Aug; 15(7):415-24.Jervøe-Storm P-M, AlAhdab H, Semaan E, Fimmers R, Jepsen S. Microbiological outcomes of quadrant versus full-mouth root planning as monitored by real-time PCR. J Clin Periodontol 2007; 34: 156–163.Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000. 1997; 15:55-62Kaldahl WB, Kalkwarf KL, Patil K. A review of longitudinal studies that compared periodontal therapies. J Periodontol 1993; 64: 243–253.Kirk, E.C. “The chemical bleaching of teeth” Dent Cosmos, 1989, Vol 31, 273-5Knöfler G, Purschwitz R, Jentsch H. Clinical evaluation of partial- and full-mouth scaling in the treatment of chronic periodontitis. J Periodontol 2007; 78: 2135–2142.)Kolenbrander PE, Egland PG, Diaz PI, Palmer RJ Jr. Genome–genome interactions: bacterial communities in initial dental plaque. Trends Microbiol2005: 13: 11–15.Kolenbrander PE. Oral microbial communities: biofilms, interactions, and genetic systems. Annu Rev Microbiol. 2000; 54:413-37.Kolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79Kolenbrander, PE, Palmer, R.J. Jr., Rickard, A.H. et al. Bacterial interactions and successions during plaque development. Periodontology 2000. 2006; 42 47-79Kolenbrander, PE, Palmer, R.J. Periasamy S, Jakubovics NS. Oral multispecies biofilm development and the key role of cell-cell distance. Nat Rev 2010; 8:471 – 480Kumar S, Patel S, Tadakamadla J, Tibdewal H, Duraiswamy P, Kulkarni S. Effectiveness of a mouthrinse containing active ingredients in addition to chlorhexidine and triclosan compared with chlorhexidine and triclosan rinses on plaque, gingivitis, supragingival calculus and extrinsic staining. Int J Dent Hygiene 2013 Feb; 11 (1):35-40Kuramitsu HK, He X, Lux R, Anderson MH, Shi W. Interspecies interactions within oral microbial communities. Microbiol Mol Biol Rev2007: 71: 653–670.Lafaurie et al. Evaluation of the hypochlorous acid substantivity as anti-plaque agent. A randomized controlled trial. 2016Lafaurie, GI.; Calderón, JL.; Zaror, C.; Millán, lV. & Castillo, DM. Ácido hipocloroso: una nueva alternativa como agente antimicrobiano y para la proliferación celular para uso en odontología. Int. J. Odontostomat., 9(3):475481, 2015.Lafaurie, Gl, Aya MR, Arboleda S. Escalante A, Castillo DM, Millan LV, Calderon JL, Ruiz BN. Eficacia desinfectante del ácido hipocloroso sobre cepas con poder patogénico de cavidad oral. Rev Colombiana de Investigación en Odontologia 2009; 1:3-11Lang NP, Tan WC, Kra ¨henmann MA, Zwahlen M. A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol 2008; 35 (Suppl. 8): 8–21.Lang, Niklaus P. & Brecx, M. C. (1986), Chlorhexidine digluconate–an agent for chemical plaque control and prevention of gingival inflammation. Journal of Periodontal Research, 21: 74–89.Laskaris, G. & Scully, C. (2003). Periodontal manifestations of local and systemic diseases: colour atlas and text.Levine JM. Dakin's solution: past, present, and future. Adv Skin Wound Care. 2013 Sep; 26(9):410-4Levy, R. M., Giannobile, W. V., Feres, M., Haffajee, A. D., Smith, C. & Socransky, S. S. (2002) The effect of apically repositioned flap surgery on clinical parameters and the composition of the subgingival microbiota: 12-month data. International Journal of Periodontics and Restorative Dentistry 22, 209–219Lindhe J, Nyman S. The effect of plaque control and surgical pocket elimination on the establishment and maintenance of periodontal health. A longitudinal study of periodontal therapy in cases of advanced disease. J Clin Periodontol. 1975 Apr; 2(2):67-79.Löe H, Theilade E & Jensen S. Experimental gingivitis in man. J Periodontol 1965: 36: 177–187Lorenz K., G. Bruhn, C. Heumann, L. Netuschil, M. Brecx, T. HoffmannLorenz. Effect of two new chlorhexidine mouthrinses on the development of dental plaque, gingivitis, and discolouration. A randomized, investigator-blind, placebo-controlled, 3-week experimental gingivitis study. J Clin Periodontol. Volume 33, Issue 8, August 2006 Pages 561–567Mackler, B.F., Frostad, K. B., Robertson, P.B. & Levy, B.M. (1977). Immunoglobulin bearing lymphocytes and plasma cells in human periodontal disease. Journal of Periodontal Research 12, 37-45Magnusson I, Lindhe J, Yoneyama T, Liljenberg B Recolonization of a subgingival microbiota following scaling in deep pockets. J Clin Periodontol. 1984 Mar; 11(3):193-207. 119. Maia LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature. Journal of Dentistry, Volume 35, Issue 5, May 2007, Pages 359-37Mainnemare A, Megarbane B, Soueidan A, Daniel A. Chapple IL. Hypochlorous acid and taurine-N-monochloramine in periodontal diseases. J Dent Res 2004; 83:823-31Mandel, I. D. (1994) Antimicrobial mouthrinses: overview and update. Journal of the American Dental Association125, 2S–10S.Marinone MG, Savoldi E. Chlorhexidine and taste. Influence of mouthwashes concentration and of rinsing time. Minerva Stomatol. 2000 May; 49(5):221-6.Marsh PD, Percival RS. The oral microflora friend or foe? Can we decide? Int Dent J 2006: 56 (Suppl. 1): 233 – 239.Marsh, P. Dental plaque: biological significance of a biofilm and community lifestyle, Journal of Clinical Periodontology, 2005; 32 Suppl 6, 7-15Marsh, P.D. & Devine, D.A. How is the development of dental biofilms influenced by the host? Journal of Clinical Periodontology, 2011: 38 Suppl 11, 28-35Marsh, P.D. & Martin, M.V. Oral Microbiology, 5 th ed. Edinburgh: Churchill Livingstone. 2009.Mckenna, S. M. & Davies, K. J. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem. J., 254(3):685-92, 1988Ministerio de Salud. Estudio Nacional de Salud Bucal ENSAB IV. Situación de Salud Bucal. Sistema Internacional de Clasificación de la Enfermedad Periodontal y Condiciones Asociadas. Bogotá (DC): Ministerio de Salud; 2014Mombelli A, Gmur R, Gobbi C, Lang NP. Actinobacillus actinomycetemcomitans in adult periodontitis. I. Topographic distribution before and after treatment. J Periodontol 1994: 65: 820–826.Mombelli A, Schmid B, Rutar A, Lang NP. Persistence patterns of Porphyromonas gingivalis, Prevotella intermedia⁄nigrescens, and Actinobacillus actinomycetemcomitans after mechanical therapy of periodontal disease. J Periodontol 2000: 71: 14–21.Morillo JM., et al. Quantitative real-time polymerase chain reaction based on single copy gene sequence for detection of periodontal pathogens. J Clin Periodontol. Vol 31, Issue 12 December 2004 Pages 1054–1060.Newman M.G. et al. Effect of 0.12% Chlorhexidine on Bacterial Recolonization Following Periodontal Surgery. J Periodontol 1989; 60:577-581Niklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 10. Infecciones periodontales; Ed. Medica Panamericana, Sixth edition 2017Niklaus P- Lang & Jan Lindhe. Periodontology and implant dentistry, Capitulo 36. Control mecánico de la placa supragingival; Ed. Medica Panamericana, Sixth edition 2017Nobbs, A.H., Jenkinson, H.F. & Jakubovics, N.S. Stick to your gums: mechanisms of oral microbial adherence. 2011; Journal of Dental Research 90, 1271-1278Nørskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. Nov., comb. nov., Aggregatibacter aphrophilus comb. Nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factorindependent isolates. Int J Syst Evol Microbiol. 2006 Sep; 56(Pt 9):2135-46.Oliver, R. C., Holm-Pedersen, P. & Löe, H. (1969) The correlation between clinical scoring exudate measurements and microscopic evaluation of inflammation in the gingiva. Journal of Periodontal Research4, 160. Journal of periodontal Investigation 4: 160.Olsson H. Asklöw B. Johansson E. Slotte C. Rinsing with alcohol-free or alcohol based chlorhexidine solutions after periodontal surgery. A doubleblind, randomized, crossover, pilot study. Swed Dent J 2012; 36: 91-99Ozan F, Sumer Z. Akin Z, Er, K, Ozan U & Deger O. (2007). Effects of mouthrinse containing propolis on oral microorganisms and human gingival fibroblast. European journal of dentistry, 195-201Page RC, Periodontal Therapy: prospects for the future. J Periodontol 1993; 64(8 Suppl): 744-53Page, R.C. & Schroeder, H.E. (1976). Pathogenesis of inflammatory periodontal disease. A summary of current work. Laboratory Investigations 34, 235-249Papapanou PN. Et al., Checkerboard Assessments of Periodontal Microbiota and Serum Antibody Responses: A Case-Control Study. Journal of Periodontology, June 2000, Vol. 71, No. 6, Pages 885-897Petrosian EA y col. Sodium hypochlorite in the treatment of suppurative wounds. Vestn Khir Im II Grek 1991; 146: 40-3Pulcher JJ, Daniel JC. (1992). The effect of chlorhexidine digluconato on human fibroblasts in vitro. J Periodontol 63(6):526-532Quirynen M, Soers C, Desnyder M, Dekeyser C, Pauwels M, van Steenberghe D. A 0.05% cetyl pyridinium chloride/0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy. J Clin Periodontol 2005; 32:390–400Quirynen N, Bollen CM, Vanderkerckhove BN, Dekeyser C, Papaioannou N, Eyssen H. Full versus partial mouth disinfection in the treatment of periodontal infectious: short term clinical and microbiological observation. J Dent Res 1995, 74:1459- 1467.Quirynen, M., Mongardini, C., De Soete, M., Pauwels, M., Coucke, W. & Van Eldere, J. (2000) The role of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis – long term clinical and microbiological observations. Journal of Clinical Periodontology 27, 578–589Ramfjord SP, Caffesse RG, Morrison EC et al. Four modalities OD periodontal treatment compared over two years. J Periodontol 1981; 52: 655-62Rams TE. Et al. Utility of 5 major putative periodontal pathogens and selected clinical parameters to predict periodontal breakdown in patients on maintenance care. J Clin Periodontol 1996, Vol 23, Issue 4, Pages 346–354.Renvert S. et al. Effect of root debridement on the elimination of Actinobacillus actinomycetemcomitans and Bacteroides gingivalis from periodontal pockets. J Clin Periodontol Volume 17, Issue 6 July 1990 Pages 345–350Renvert, S et al. The clinical and microbiological effects of non-surgical periodontal therapy in smokers and non-smokers. J. Clin Periodontol., Chicago, v.25, n.2, p.153-157, Feb. 1998Renvert, S et al. Treatment of periodontal disease based on microbiological diagnosis. Relation between microbiological and clinical parameters during 5 years. J. Periodontol., Chicago, v.67, n.6, p.562-571, June 1996Reynolds, J.J. & Meikle, M.C. (1997). Mechanisms of connective tissue matrix destruction in periodontitis. Periodontology 2000 14, 144-157Robson M.C., Payne W.G., Ko F., Mentis M., Donati G., Shafii S.M., Culverhouse S., Wang L., Khosrovi B., Najafi R., Cooper D.M., Bassiri M. Hypochlorous Acid as a Potential Wound Care Agent. Part II. Stabilized Hypochlorous Acid: It’s Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing. J Burns Wounds. 11:6, e6, 80-90.2007.Rosen, H. & Klebanoff, S. J. Oxidation of Escherichia coli iron centers by themyeloperoxidase- mediated microbicidal system. J. Biol. Chem.,257(22):13731-5, 1982Round JL, Mazmanian SK. The gut microbiota shapes intestinal immuneresponses during health and disease. Nat Rev Immunol 9(5):313-323 (2009)Rudney JD et al. Actinobacillus Actinomycetemcomitans, PorphyromonasGingivalis, and Tannerella Forsythensis Are Components of a PolymicrobialIntracellular Flora Within Human Buccal Cells. J Dent Res 84 (1), 59-63. 12005.Rutala William A., Cole E., Thomann C., Weber David J. 1991. Stability andBactericidal Activity of Chlorine Solutions. Inf. Control Hosp. Epidem.19(5):323327.Sam, C. H. & Lu, H. K. The role of hypochlorous acid as one of the reactiveoxygen species in periodontal disease. J. Dent. Sci., 4(2):45-54, 2009.Sanz M, G. Newman, L. Anderson, W. Matoska, J. Otomo Corgel C. Saltini.Clinical Enhancement of Post-Periodontal Surgical Therapy by a 0.12%Chlorhexidine Gluconate Mouthrinse. Journal of Periodontology October1989, Vol. 60, No. 10, Pages 570-576Secuencia cirugía Widman modificado. Tomada de Periodontology 2000 Volumen 71, Issue 1, pages 128-139, 4 APR 2016Seki, M., Yamashita, Y., Shibata, Y., Torigoe, H., Tsuda, H. & Maeno, M. (2006) Effect of mixed mutans streptococci colonization on caries development. Oral Microbiology and Immunology 21, 47–52.Seymour G.J. & Greenspan, J.S. (1979). The phenotypic characterization oflymphocyte subpopulations in established human periodontal disease. Journalof Periodontal Research 14, 39-46Seymour, G.J., Powell, R.N. & Davies, W.I. (1979) Conversion of a stable Tcell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: a hypothesis. Journal of Clinical Periodontology 6, 267-277Shapiro S, Giertsen E, Guggenheim B. An in vitro oral biofilm model forcomparing the efficacy of antimicrobial mouthrinses. Caries Res. 2002 MarApr; 36(2):93-100.Sharma NC, Galustians HJ, Qaqish J, Charles CH, Vincent JW, McGuire JA: Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash. J Clin Periodontol 2003; 30: 590–594.Shiloah, J, Patters, H. Dean, J. Bland P & Toledo G. The survival rate of Actinobacillus actinomicetemcomitans, Porphyromonas gingivalis and Bacteroides forsythus following 4 randomized treatment modalities. J Periodontol 1997; 68:720-728Siegrist B. E., Gusberti F. A., M. C. Brecx, H. P. Weber, N. P. Lang. Efficacy of supervised rinsing with chlorhexidine digluconate in comparison to phenolic and plant alkaloid compounds Volume 21, Issue s16, November 1986, Pages 60–73.Slots, J.; Rams, T.E. New views on periodontal microbiota in special patient categories. J. Clin. Periodontol. Copenhagen, v.18, n.6, p.411-420, July 1991Socransky SS, Haffajee AD Periodontal microbial ecology. Periodontol 2000. 2005; 38:135-87.Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998 Feb; 25(2):134-44.Socransky SS, Haffajee AD. Dental biofilms: difficult therapeutic targets. Periodontol 2000, 2002: 28: 12–55.Socransky SS, Haffajee AD. Microbiología de la enfermedad periodontal. En: Lindhe J, Karring T, Lang NP, ed. Clinical Periodontology y la implantología dental. Copenhague: Munksgaard, 1997: 138 - 88.Socransky, S.S.; Haffajee, A.D. The bacterial etiology of destructive periodontal disease: current concepts. J. Periodontol., Chicago, v.63, n.4, p.322-331, Apr. 1992Sreenivasan P, Gaffar A. Antiplaque biocides and bacterial resistance: A review. J Clin Periodontol 2002; 29(11):965-974.Tatevossian A. The effects of heat inactivation, tortuosity, extracellular polyglucan and ion-exchange sites on the diffusion of [14C]-sucrose in human dental plaque residue in vitro. Arch Oral Biol1985: 30: 365–371.Teughels, W. et al. One-stage, full-mouth disinfection: fiction or reality? Periodontol. 2000, Munksgaard, v.50, n.1, p.39-51, June 2009Tomás I, García-Caballero L, Cousido MC, Limeres J, Alvarez M, Diz P. Evaluation of chlorhexidine substantivity on salivary flora by epifluorescence microscopy. Oral Dis. 2009 Sep; 15(6):428-33.Vacca-Smith AM, Venkitaraman AR, Schilling KM & Bowen WH. Characterization of glucosyltransferase of human saliva adsorbed onto hydroxyapatite surfaces. Caries Res. 1996; 30(5):354-60.Van Der Velden, U. et al. The habitat of periodontophatic micro-organisms. J. Clin Periodontol., Cophenagen, v.13, n.3, p.243-248, Mar. 1986Verkaik MJ et al. Oral Biofilm Models for Mechanical Plaque Removal. Clin Oral Investig 14 (4), 403-409. 2009 Jun 30.Vissers MC, Winterbourn CC. Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid. Biochem J. 1995; 307(Pt 1):57–62.Vroom JM, De Grauw KJ, Gerritsen HC, Bradshaw DJ, Marsh PD, Watson GK, Allison C, Birmingham JJ. Depth penetration and detection of pH gradients in biofilms using two-photon excitation microscopy. Appl Environ Microbiol1999: 65: 3502–3511.W.B. Hugo. & A.R. Longworth. Cytological aspects of the mode of action of chlorhexidine diacetate. Journal of Pharmacy and Pharmacology, Volume 17, Issue 1, January 1965, Pages 28–32Wade, W.G. & Addy, M. (1989). In vitro activity of a chlorhexidine – containing mouthwash against subgingival bacteria. Journal of periodontology 60, 521523Walker, C. B. (1988), Microbiological effects of mouthrinses containing antimicrobials. Journal of Clinical Periodontology, 15: 499–505.Wang L., Bassiri M., Najafi R., Najafi K., Yang J., Khos-rovi B., Hwong W., Barati E., Belisle B., Celeri C., Robson M.C. Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds.11: 65-79, 2007Watts A, Addy M. (2001), Tooth discoloration and staining: a review of the literature. Br Dent J. 2001 Mar 24; 190(6):309-16.Weiss SJ, Klein R, Slavika A. Chlorination of Taurine by Human Neutrophils. Evidence for hypochlorous acid generation. J Clin Invest. 1982 Sept; 70(3):598-607.Weiss SJ. Tissue Destruction by Neutrophils. The New England Journal of Medicine 1989 February 9; 320(6):365-376.Wennström JL, Heijl L, Dahlén G, Gröndahl K. Periodic subgingival antimicrobial irrigation of periodontal pockets (I). Clinical observations. J Clin Periodontol. 1987 Oct; 14(9):541-50.Westfelt E, Nyman S, Lindhe J, Socransky S. Use of chlorhexidine as a plaque control measure following surgical treatment of periodontal disease. J Clin Periodontol. 1983 Jan; 10(1):22-36.Whittaker CJ, Klier CM, Kolenbrander PE. Mechanisms of adhesion by oral bacteria. Annu Rev Microbiol1996: 50: 513–552.Wille, T et al. “rheological characteristics of thooth bleaching materials”. Journal of Oral Rehabilitation, 2000, Vol 27, 1060-1063Wilson, M. Microbial Inhabitants of Humans. Their Ecology and Role in the Health and Disease. 2005; Cambridge: Cambridge University Press.Winkel EG, van Winkelhoff AJ, Timmerman MF, Vangsted T, van der Velden U. Effects of metronidazole in patients with “refractory” periodontitis associated with Bacteroides forsythus. J Clin Periodontol 1997; 24: 573-9Ximenez-Fyvie, L. A., Haffajee, A. D. & Socransky, S. S. (2000b) Microbial composition of supra- and subgingival plaque in subjects with adult periodontitis. Journal of Clinical Periodontology 27, 722–732.Yates R, Shearer BH, Huntington E and Addy M. A method to compare four mouthrinses. J Clin Periodontol 2002: 29: 519–523.Yoshida A., Shiori Nagashima, Toshihiro Ansai, Masayo Tachibana, Hiroaki Kato, Hajime Watari, Tsugunori Notomi & Tadamichi Takehara. Loop Mediated Isothermal Amplification Method for Rapid Detection of the Periodontopathic Bacteria Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. J. Clin. Microbiol. May 2005 vol. 43 no. 5 24182424 200. Zijnge V, Meijer HF, Lie MA, Tromp JAH, Degener JE, Harmsen HJM, Abbas F: The recolonization hypothesis in a full-mouth or multiple-session treatment protocol: a blinded, randomized clinical trial. 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Comparación de la eficacia del ácido hipocloroso y la clorhexidina como agente antimicrobiano post-quirúrgico en periodontitis crónica. Estudio piloto

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